The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Yeast metabolic engineering for hemicellulosic ethanol production
Abstract
Efficient fermentation of hemicellulosic sugars is critical for the bioconversion of lignocellulosics to ethanol. Efficient sugar uptake through the heterologous expression of yeast and fungal xylose/glucose transporters can improve fermentation if other metabolic steps are not rate limiting. Rectification of cofactor imbalances through heterologous expression of fungal xylose isomerase or modification of cofactor requirements in the yeast oxidoreductase pathway can reduce xylitol production while increasing ethanol yields, but these changes often occur at the expense of xylose utilization rates. Genetic engineering and evolutionary adaptation to increase glycolytic flux coupled with transcriptomic and proteomic studies have identified targets for further modification, as have genomic and metabolic engineering studies in native xylose fermenting yeasts.
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“Brennan et al. have devised an extraction method for glucose and xylose recovery from [C 2 C 1 im][MeCO 2 ] using boronates such as naphthalene-2-boronate.”
From Deconstruction of lignocellulosic biomass with ionic liquids (2013) · cites this paper as [182]
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Cites
Towards industrial pentose-fermenting yeast strains
Hahn‐Hägerdal, B., Karhumaa, K., Fonseca, C., Spencer‐Martins, I., & Gorwa‐Grauslund, M. F. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0827-2 · Cited by 784
Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis
Jeffries, T. W., Grigoriev, I. V., Grimwood, J., Laplaza, J. M., Aerts, A. L., Salamov, A. A., Schmutz, J., Lindquist, E., Dehal, P., Shapiro, H., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1290 · Cited by 492
Self-citationKarhumaa, K., Sánchez, R. G., Hahn‐Hägerdal, B., & Gorwa‐Grauslund, M. F. (2007) · Microbial Cell Factories · doi:10.1186/1475-2859-6-5 · Cited by 292
Metabolic Engineering for Pentose Utilization in Saccharomyces cerevisiae
Hahn‐Hägerdal, B., Karhumaa, K., Jeppsson, M., & Gorwa‐Grauslund, M. F. (2007) · Springer eBooks · doi:10.1007/10_2007_062 · Cited by 280
Rapid whole-genome mutational profiling using next-generation sequencing technologiesPreprint
Smith, D. R., Quinlan, A. R., Peckham, H. E., Makowsky, K., Tao, W., Woolf, B., Shen, L., Donahue, W. F., Tusneem, N. A., Strömberg, M. P., et al. (2008) · Genome Research · doi:10.1101/gr.077776.108 · Cited by 260
Self-citationWisselink, H. W., Toirkens, M. J., Wu, Q., Pronk, J. T., & van Maris, A. J. A. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02268-08 · Cited by 247
van Maris, A. J. A., Winkler, A. A., Kuyper, M., de Laat, W. T. A. M., van Dijken, J. P., & Pronk, J. T. (2007) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2007_057 · Cited by 245
Saloheimo, A., Rauta, J., Stasyk, O. V., Sibirny, A. А., Penttilä, M. E., & Ruohonen, L. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0747-1 · Cited by 210
Watanabe, S., Kodaki, T., & Makino, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409443200 · Cited by 195
Watanabe, S., Saleh, A. A., Pack, S. P., Annaluru, N., Kodaki, T., & Makino, K. (2007) · Microbiology · doi:10.1099/mic.0.2007/007856-0 · Cited by 189
Cited by
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Hemicelluloses for fuel ethanol: A review
Gírio, F. M., Fonseca, C., Carvalheiro, F., Duarte, L. C., Marques, S., & Bogel‐Łukasik, R. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.01.088 · Cited by 1,648
Deconstruction of lignocellulosic biomass with ionic liquids
Brandt, A., Gräsvik, J., Hallett, J. P., & Welton, T. (2013) · Green Chemistry · doi:10.1039/c2gc36364j · Cited by 1,557
Technological trends, global market, and challenges of bio-ethanol production
Mussatto, S. I., Dragone, G., Guimarães, P. M. R., Silva, J. P. A., Carneiro, L. M., Roberto, I. C., Vicente, A. A., Domingues, L., & Teixeira, J. A. (2010) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.07.001 · Cited by 730
Sandberg, T. E., Salazar, M. J., Weng, L. L., Palsson, B. Ø., & Feist, A. M. (2019) · Metabolic Engineering · doi:10.1016/j.ymben.2019.08.004 · Cited by 585
Improving industrial yeast strains: exploiting natural and artificial diversity
Steensels, J., Snoek, T., Meersman, E., Nicolino, M. P., Voordeckers, K., & Verstrepen, K. J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12073 · Cited by 513
Metadata
- Authors
- Van Vleet, J., & Jeffries, T.
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 20
- Issue
- 3
- Pages
- 300-306
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2068003115
- Cited by
- 241
- References
- 51
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 15 · 2019: 6 · 2018: 15 · 2017: 15 · 2016: 21 · 2015: 9 · 2014: 26 · 2013: 25 · 2012: 34
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- U.S. Department of Agriculture
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- yeast metabolic engineering, xylose fermentation, xylose transporters, xylose isomerase, xylitol production, lignocellulosic biomass, glycolytic flux, xylose-fermenting yeast, heterologous expression
- MeSH terms
- Ethanol, Aldehyde Reductase, Pichia, Polysaccharides, Xylose, Yeasts, Protein Engineering, Aldose-Ketose Isomerases, D-Xylulose Reductase
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