Novel Evolutionary Engineering Approach for Accelerated Utilization of Glucose, Xylose, and Arabinose Mixtures by Engineered Saccharomyces cerevisiae Strains

Wisselink, H. Wouter; Toirkens, Maurice J.; Wu, Qixiang; Pronk, Jack T.; van Maris, Antonius J. A.

doi:10.1128/aem.02268-08

Cited by 247Biofuel production and bioconversionMicrobial Metabolic Engineering and BioproductionFungal and yeast genetics research

Novel Evolutionary Engineering Approach for Accelerated Utilization of Glucose, Xylose, and Arabinose Mixtures by Engineered Saccharomyces cerevisiae Strains

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Wisselink, H. Wouter, Toirkens, Maurice J., Wu, Qixiang, Pronk, Jack T., van Maris, Antonius J. A.·2009·Applied and Environmental Microbiology

DOI 10.1128/aem.02268-08PMC PMC2643596

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Abstract

Lignocellulosic feedstocks are thought to have great economic and environmental significance for future biotechnological production processes. For cost-effective and efficient industrial processes, complete and fast conversion of all sugars derived from these feedstocks is required. Hence, simultaneous or fast sequential fermentation of sugars would greatly contribute to the efficiency of production processes. One of the main challenges emerging from the use of lignocellulosics for the production of ethanol by the yeast Saccharomyces cerevisiae is efficient fermentation of d -xylose and l -arabinose, as these sugars cannot be used by natural S. cerevisiae strains. In this study, we describe the first engineered S. cerevisiae strain (strain IMS0003) capable of fermenting mixtures of glucose, xylose, and arabinose with a high ethanol yield (0.43 g g −1 of total sugar) without formation of the side products xylitol and arabinitol. The kinetics of anaerobic fermentation of glucose-xylose-arabinose mixtures were greatly improved by using a novel evolutionary engineering strategy. This strategy included a regimen consisting of repeated batch cultivation with repeated cycles of consecutive growth in three media with different compositions (glucose, xylose, and arabinose; xylose and arabinose; and only arabinose) and allowed rapid selection of an evolved strain (IMS0010) exhibiting improved specific rates of consumption of xylose and arabinose. This evolution strategy resulted in a 40% reduction in the time required to completely ferment a mixture containing 30 g liter −1 glucose, 15 g liter −1 xylose, and 15 g liter −1 arabinose.

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A similar study with a different selection procedure identified mutations in glpF and fabA, accompanied with increased membrane fatty acid saturation, as critical factors towards increased thermo-tolerance.
“whereas a similar study with a different selection procedure identified mutations in glpF and fabA, accompanied with increased membrane fatty acid saturation as critical factors towards increased thermo-tolerance [90].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [90]

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Authors: Wisselink, H. W., Toirkens, M. J., Wu, Q., Pronk, J. T., & van Maris, A. J. A.
Affiliations: Delft University of Technology (NL)
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
ORCID: Pronk, Jack T.
Venue: Applied and Environmental Microbiology
Publisher: American Society for Microbiology
Published: 2009-02-15
Volume: 75
Issue: 4
Pages: 907-914
ISSN: 0099-2240 (ISSN-L)
1098-5336
DOI: 10.1128/aem.02268-08
PMC: PMC2643596
OpenAlex: W2146497852
Cited by: 247
References: 28
Citations by year: 2026: 5 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 18 · 2018: 15 · 2017: 22 · 2016: 13 · 2015: 16 · 2014: 19 · 2013: 25 · 2012: 23
FWCI: 13.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Applied and Environmental Microbiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Repository (Delft University of Technology) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Saccharomyces cerevisiae, xylose fermentation, arabinose fermentation, lignocellulosic biomass, ethanol production, evolutionary engineering, adaptive laboratory evolution, xylitol, arabinitol, fermentation kinetics
MeSH terms: Ethanol, Anaerobiosis, Arabinose, Fermentation, Glucose, Lignin, Saccharomyces cerevisiae, Xylitol, Xylose

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Novel Evolutionary Engineering Approach for Accelerated Utilization of Glucose, Xylose, and Arabinose Mixtures by Engineered Saccharomyces cerevisiae Strains

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