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Applications of viral nanoparticles in medicine
Open accessAbstract
Several nanoparticle platforms are currently being developed for applications in medicine, including both synthetic materials and naturally-occurring bionanomaterials such as viral nanoparticles (VNPs) and their genome-free counterparts, virus-like particles (VLPs). A broad range of genetic and chemical engineering methods have been established that allow VNP/VLP formulations to carry large payloads of imaging reagents or drugs. Furthermore, targeted VNPs and VLPs can be generated by including peptide ligands on the particle surface. In this article, we highlight state-of-the-art virus engineering principles and discuss recent advances that bring potential biomedical applications a step closer. Viral nanotechnology has now come of age and it will not be long before these formulations assume a prominent role in the clinic.
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Cites
Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications
Qiao, R., Yang, C., & Gao, M. (2009) · Journal of Materials Chemistry · doi:10.1039/b902394a · Cited by 685
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Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873
Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery
Mikkilä, J., Eskelinen, A.-P., Niemelä, E. H., Linko, V., Frilander, M. J., Törmä, P., & Kostiainen, M. A. (2014) · Nano Letters · doi:10.1021/nl500677j · Cited by 308
Metadata
- Authors
- Yildiz, I., Shukla, S., & Steinmetz, N. F.
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 22
- Issue
- 6
- Pages
- 901-908
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W1975592104
- Cited by
- 299
- References
- 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- green
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