The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery
Abstract
DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 cell line indicate that protein coating improves cellular attachment and delivery of origamis into the cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intracellular reactions by origami-based templates.
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Cites
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,354
Self-assembly of DNA into nanoscale three-dimensional shapes
Douglas, S. M., Dietz, H., Liedl, T., Högberg, B., Graf, F., & Shih, W. M. (2009) · Nature · doi:10.1038/nature08016 · Cited by 2,571
DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
Kuzyk, A., Schreiber, R., Fan, Z., Pardatscher, G., Roller, E.-M., Högele, A., Simmel, F. C., Govorov, A. O., & Liedl, T. (2012) · Nature · doi:10.1038/nature10889 · Cited by 2,216
A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
Douglas, S. M., Bachelet, I., & Church, G. M. (2012) · Science · doi:10.1126/science.1214081 · Cited by 2,180
Self-assembly of a nanoscale DNA box with a controllable lid
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B., Stark, H., Oliveira, C. L. P., et al. (2009) · Nature · doi:10.1038/nature07971 · Cited by 1,627
Folding DNA into Twisted and Curved Nanoscale Shapes
Dietz, H., Douglas, S. M., & Shih, W. M. (2009) · Science · doi:10.1126/science.1174251 · Cited by 1,335
Three-Dimensional Structures Self-Assembled from DNA Bricks
Ke, Y., Ong, L. L., Shih, W. M., & Yin, P. (2012) · Science · doi:10.1126/science.1227268 · Cited by 1,246
DNA Origami with Complex Curvatures in Three-Dimensional Space
Han, D., Pal, S., Nangreave, J., Deng, Z., Liu, Y., & Yan, H. (2011) · Science · doi:10.1126/science.1202998 · Cited by 1,214
Complex shapes self-assembled from single-stranded DNA tiles
Wei, B., Dai, M., & Yin, P. (2012) · Nature · doi:10.1038/nature11075 · Cited by 989
A primer to scaffolded DNA origami
Castro, C. E., Kilchherr, F., Kim, D.-N., Shiao, E. L., Wauer, T., Wortmann, P., Bathe, M., & Dietz, H. (2011) · Nature Methods · doi:10.1038/nmeth.1570 · Cited by 925
Cited by
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
Metadata
- Authors
- Mikkilä, J., Eskelinen, A.-P., Niemelä, E. H., Linko, V., Frilander, M. J., Törmä, P., & Kostiainen, M. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-03-19
- Volume
- 14
- Issue
- 4
- Pages
- 2196-2200
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2320579321
- Cited by
- 308
- References
- 41
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mikkilä, J., Eskelinen, A.-P., Niemelä, E. H., Linko, V., Frilander, M. J., Törmä, P., & Kostiainen, M. A. (2014). Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery. Nano Letters. https://doi.org/10.1021/nl500677j
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
