The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Ethanol and brain damage
Abstract
It is now well established that even uncomplicated alcoholics who have no specific neurological or hepatic problems show signs of regional brain damage and cognitive dysfunction. Improvements in neuroimaging technology, magnetic resonance imaging, magnetic resonance spectroscopy and positron emission tomography have contributed significantly, revealing alcoholic-specific changes in the CNS associated with neuropsychological abnormalities. Although greater efforts are needed, a human brain bank specifically targeting alcohol cases is now able to provide fresh and frozen tissue for alcohol researchers. These tissues can be used to test hypotheses developed using animal models and/or in vitro studies. The aim is to delineate mechanisms underlying alcohol-related brain damage in humans. The development of high-throughput, non-hypothesis-driven approaches using DNA microarrays and proteomics might also provide clues to this important problem.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Prolonged alcohol exposure also produces neurotoxic effects, including structural impairments in the prefrontal cortex and hippocampus – two regions essential for behavioral inhibition and emotional reasoning - thereby compounding the disinhibitory effects of acute intoxication (Harper And Matsumoto 2005; Oscar-Berman And Marinković 2007).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Harper And Matsumoto 2005
Citations
Cites
Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
Jack, C. R., Dickson, D. W., Parisi, J. E., Xu, Y. C., Cha, R. H., O’Brien, P. C., Edland, S. D., Smith, G. E., Boeve, B. F., Tangalos, E. G., et al. (2002) · Neurology · doi:10.1212/wnl.58.5.750 · Cited by 610
The cerebral cortex is damaged in chronic alcoholics
Kril, J. J., Halliday, G. M., Svoboda, M. D., & Cartwright, H. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00083-3 · Cited by 507
Frontal Lobe Volume Loss Observed with Magnetic Resonance Imaging in Older Chronic Alcoholics
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., & Lim, K. O. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03798.x · Cited by 492
Thomson, A. D. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.6.513 · Cited by 396
Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia
Harding, A. (2000) · Brain · doi:10.1093/brain/123.1.141 · Cited by 395
Are we drinking our neurones away?
Harper, C., Kril, J. J., & Daly, J. M. (1987) · BMJ · doi:10.1136/bmj.294.6571.534 · Cited by 231
Self-citationGlutamate-mediated transmission, alcohol, and alcoholism
Dodd, P. R., Beckmann, A. M., Davidson, M. S., & Wilce, P. A. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00061-9 · Cited by 216
Brain shrinkage in chronic alcoholics: a pathological study.
Harper, C., Kril, J. J., & HOLLOWAY, R. L. (1985) · BMJ · doi:10.1136/bmj.290.6467.501 · Cited by 214
Self-citationHarper, C. G., Dixon, G., Sheedy, D. L., & Garrick, T. M. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00155-6 · Cited by 209
Self-citationPostmortem MR imaging of formalin-fixed human brain
Pfefferbaum, A., Sullivan, E. V., Elfar Adalsteinsson, A., Garrick, T. M., & Harper, C. G. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.024 · Cited by 199
Self-citation
Cited by
Sorted by citations
Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management
Sechi, G., & Serra, A. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70104-7 · Cited by 1,286
Alcohol: Effects on Neurobehavioral Functions and the Brain
Oscar-Berman, M., & Marinković, K. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9038-6 · Cited by 619
Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0976-10.2010 · Cited by 579
The Neuropathology of Alcohol-Related Brain Damage
Harper, C. (2009) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn102 · Cited by 420
Self-citationChanraud, S., Martelli, C., Delain, F., Kostogianni, N., Douaud, G., Aubin, H., Reynaud, M., & Martinot, J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301219 · Cited by 438
Metadata
- Authors
- Harper, C., & Matsumoto, I.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Harper, Clive
- Matsumoto, Izuru
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 5
- Issue
- 1
- Pages
- 73-78
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2149927155
- Cited by
- 342
- References
- 55
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 22 · 2012: 24
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA012725)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- ethanol, alcohol-related brain damage, alcoholic brain damage, cognitive impairment, brain banks, human brain tissue, neuroimaging, magnetic resonance spectroscopy, positron emission tomography, animal models of alcoholism, DNA microarrays, proteomics, neuropsychological abnormalities
- MeSH terms
- Aged, Ethanol, Alcoholism, Brain, Central Nervous System Depressants, Cognition Disorders, Female, Humans, Male
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
