Cited by 342Alcoholism and Thiamine DeficiencyAlcohol Consumption and Health EffectsSubstance Abuse Treatment and Outcomes

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Ethanol and brain damage

Harper, Clive, Matsumoto, Izuru·2005·Current Opinion in Pharmacology

DOI 10.1016/j.coph.2004.06.011

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Abstract

It is now well established that even uncomplicated alcoholics who have no specific neurological or hepatic problems show signs of regional brain damage and cognitive dysfunction. Improvements in neuroimaging technology, magnetic resonance imaging, magnetic resonance spectroscopy and positron emission tomography have contributed significantly, revealing alcoholic-specific changes in the CNS associated with neuropsychological abnormalities. Although greater efforts are needed, a human brain bank specifically targeting alcohol cases is now able to provide fresh and frozen tissue for alcohol researchers. These tissues can be used to test hypotheses developed using animal models and/or in vitro studies. The aim is to delineate mechanisms underlying alcohol-related brain damage in humans. The development of high-throughput, non-hypothesis-driven approaches using DNA microarrays and proteomics might also provide clues to this important problem.

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Authors: Harper, C., & Matsumoto, I.
Affiliations: The University of Sydney (AU)
Corresponding author: Harper, Clive
Matsumoto, Izuru
Venue: Current Opinion in Pharmacology
Publisher: Elsevier BV
Published: 2005-02
Volume: 5
Issue: 1
Pages: 73-78
ISSN: 1471-4892 (ISSN-L)
DOI: 10.1016/j.coph.2004.06.011
OpenAlex: W2149927155
Cited by: 342
References: 55
Citations by year: 2026: 2 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 22 · 2012: 24
FWCI: 11.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA012725)
Topics: Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: ethanol, alcohol-related brain damage, alcoholic brain damage, cognitive impairment, brain banks, human brain tissue, neuroimaging, magnetic resonance spectroscopy, positron emission tomography, animal models of alcoholism, DNA microarrays, proteomics, neuropsychological abnormalities
MeSH terms: Aged, Ethanol, Alcoholism, Brain, Central Nervous System Depressants, Cognition Disorders, Female, Humans, Male

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