Taste receptor signaling in the mammalian gut
Open accessAbstract
Molecular sensing by gastrointestinal (GI) cells plays a crucial role in the control of multiple fundamental functions including digestion, regulation of caloric intake, pancreatic insulin secretion, and metabolism, as well as protection from ingested harmful drugs and toxins. These processes are likely to be mediated by the initiation of humoral and/or neural pathways through the activation of endocrine cells. However, the initial recognition events and mechanism(s) involved are still largely unknown. This article reviews the current evidence that the chemosensory machinery discovered in specialized neuroepithelial taste receptor cells of the lingual epithelium is operational in enteroendocrine open GI cells that sense the chemical composition of the luminal contents of the gut.
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The same taste receptors found in the oral cavity are also expressed in gut epithelial cells.
“The same taste receptors found in the oral cavity are also expressed in gut epithelial cells ([144](#B144))”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [144]
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References 40 · Cited by 203
- Authors
- Rozengurt, E., & Sternini, C.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Rozengurt, Enrique
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 7
- Issue
- 6
- Pages
- 557-562
- ISSN
- 1471-4892 (ISSN-L)
- PMC
- PMC2753238
- OpenAlex
- W2044174105
- Cited by
- 203
- References
- 40
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 12 · 2015: 18 · 2014: 13 · 2013: 11 · 2012: 20
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 41301, DK55003, R01DK054155, DK 54155, R01DK056930, P30DK041301, R01DK055003, DK-56930)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- enteroendocrine cells, taste cells, tongue epithelium, endocrine cells, digestion, insulin secretion
- MeSH terms
- Animals, Cell Line, Gastrointestinal Hormones, Humans, Taste Buds, Transducin, Signal Transduction, Enteroendocrine Cells, Gastrointestinal Tract, Receptors, G-Protein-Coupled
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