Cited by 154Plant Stress Responses and ToleranceHeavy metals in environmentAluminum toxicity and tolerance in plants and animals

The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.

Omics approaches for understanding heavy metal responses and tolerance in plants

Open access

Jamla, Monica, Khare, Tushar, Joshi, Shrushti, Patil, Suraj, Penna, Suprasanna, Kumar, Vinay·2021·Current Plant Biology

DOI 10.1016/j.cpb.2021.100213

Open this paper in CoChat — free account Open PDF

Abstract

Recent years have witnessed a gradual increase in the bioavailability and groundwater leaching of toxic heavy metals (HMs) in the environment, driven mainly by anthropogenic invasions. HMs, especially ranked as toxic/carcinogenic non-essential ones including Cadmium (Cd), Arsenic (As), Aluminium (Al), Mercury (Hg) and Lead (Pb) have emerged as the major soil, air and water contaminants affecting food production, quality and security worldwide. HMs affect plant growth and crop yield. Plants have developed intricate defense mechanisms for safeguarding themselves against the toxic effects imposed by HMs, including compartmentalization and sequestration in cell-organelles, inactivation by complex formation with the organic ligands and their exclusion using transporters, ion channels, transcription factors and signaling molecules, beside others. Omics approaches have generated significant resources and updates on the plant genome, transcriptome and metabolome plasticity against HM-induced stress stimuli. Omics technologies are pragmatic and seen as feasible approaches for characterizing the roles of genomes (genomics), coding (transcriptomics) and non-coding (miRNAomics) RNA transcripts, and metabolites (metabolomics) including metals (metallomics), which can ultimately be used for improving stress tolerance or generating resilience plant systems. This review aims to summarize the current understandings on the mechanistic insights of selected toxic (Cd, As, Al, Hg and Pb) HM-plant interactions, including their uptake, transport, toxicity and chelation/sequestration in cellular components, besides how plants respond and adapt to these stress factors. State-of-the-art in Omics approaches including genomics, transcriptomics, metabolomics, miRNAomics and metallomics for plant HM research have been presented. Present status, challenges and future prospects are also discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cpb.2021.100213

Cites

250 of 250 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: A critical review of mercury speciation, bioavailability, toxicity and detoxification in soil-plant environment: Ecotoxicology and health risk assessment
Natasha, N., Shahid, M. A. R., Khalid, S., Bibi, I., Bundschuh, J., Niazi, N. K., & Dumat, C. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134749 · Cited by 298
Retracted
Toxicity, mechanism and health effects of some heavy metals
Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B. B., & Beeregowda, K. N. (2014) · Interdisciplinary Toxicology · doi:10.2478/intox-2014-0009 · Cited by 6,402
MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis
Tsugawa, H., Čajka, T., Kind, T., Ma, Y., Higgins, B. T., Ikeda, K., Kanazawa, M., VanderGheynst, J. S., Fiehn, O., & Arita, M. (2015) · Nature Methods · doi:10.1038/nmeth.3393 · Cited by 3,495
The role of site accessibility in microRNA target recognition
Kertesz, M., Iovino, N., Unnerstall, U., Gaul, U., & Segal, E. (2007) · Nature Genetics · doi:10.1038/ng2135 · Cited by 2,460
Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA
Jones-Rhoades, M. W., & Bartel, D. P. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.027 · Cited by 2,257
GenePattern 2.0
Reich, M. M., Liefeld, T., Gould, J., Lerner, J., Tamayo, P., & Mesirov, J. P. (2006) · Nature Genetics · doi:10.1038/ng0506-500 · Cited by 2,053
Heavy metal hyperaccumulating plants: how and why do they do it? And what makes them so interesting
Rascio, N., & Navari-Izzo, F. (2011) · Plant Science · doi:10.1016/j.plantsci.2010.08.016 · Cited by 2,012
miRDB: an online resource for microRNA target prediction and functional annotations
Wong, N. W., & Wang, X. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1104 · Cited by 1,789
The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview
Rahman, Z., & Singh, V. P. (2019) · Environmental Monitoring and Assessment · doi:10.1007/s10661-019-7528-7 · Cited by 1,535
Molecular and cellular mechanisms of cadmium carcinogenesis
Waisberg, M., Joseph, P., Hale, B. A., & Beyersmann, D. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00305-6 · Cited by 1,478

Show all 250 references

Sorted by citations

Comprehensive Mechanisms of Heavy Metal Toxicity in Plants, Detoxification, and Remediation
Ghuge, S. A., Nikalje, G. C., Kadam, U. S., Suprasanna, P., & Hong, J. C. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131039 · Cited by 372
Heavy Metals, Their Phytotoxicity, and the Role of Phenolic Antioxidants in Plant Stress Responses with Focus on Cadmium: Review
Goncharuk, E. A., & Загоскина, Н. В. (2023) · Molecules · doi:10.3390/molecules28093921 · Cited by 295
The Classification, Molecular Structure and Biological Biosynthesis of Flavonoids, and Their Roles in Biotic and Abiotic Stresses
Zhuang, W., Li, Y.-H., Shu, X., Pu, Y.-T., Wang, X., Wang, T., & Wang, Z. (2023) · Molecules · doi:10.3390/molecules28083599 · Cited by 262
Analysis of Heavy Metal Impacts on Cereal Crop Growth and Development in Contaminated Soils
Vasilachi, I. C., Stoleru, V., & Gavrilescu, M. (2023) · Agriculture · doi:10.3390/agriculture13101983 · Cited by 210
Role of phytohormones in heavy metal tolerance in plants: A review
Rahman, S. U., Li, Y., Hussain, S., Hussain, B., Khan, W., Riaz, L., Ashraf, M. N., Khaliq, M. A., Du, Z., & Cheng, H. (2022) · Ecological Indicators · doi:10.1016/j.ecolind.2022.109844 · Cited by 164
Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential
Asiminicesei, D.-M., Ferţu, D. I., & Gavrilescu, M. C. (2024) · Plants · doi:10.3390/plants13060913 · Cited by 155
Advances in “Omics” Approaches for improving toxic metals/metalloids tolerance in plants
Raza, A., Tabassum, J., Zahid, Z., Charagh, S., Bashir, S., Barmukh, R., Khan, R. S. A., Barbosa, F., Zhang, C., Chen, H., et al. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2021.794373 · Cited by 132
Impact of industrial effluents on the environment and human health and their remediation using MOFs-based hybrid membrane filtration techniques
Saravanakumar, K., Silva, S. D., Santosh, S. S., Sathiyaseelan, A., Ganeshalingam, A., Jamla, M., Sankaranarayanan, A., Veeraraghavan, V. P., MubarakAli, D., Lee, J., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135593 · Cited by 116
Self-citation
Survey on Multi-omics, and Multi-omics Data Analysis, Integration and Application
Shahrajabian, M. H., & Sun, W. (2023) · Current Pharmaceutical Analysis · doi:10.2174/1573412919666230406100948 · Cited by 116
Cadmium toxicity in medicinal plants: An overview of the tolerance strategies, biotechnological and omics approaches to alleviate metal stress
Al-Khayri, J. M., Banadka, A., Ramakrishnan, R., Nagella, P., Alessa, F. M., & Almaghasla, M. I. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1047410 · Cited by 113
State-of-the-Art OMICS Strategies against Toxic Effects of Heavy Metals in Plants: A Review
Rahman, S. U., Nawaz, M. F., Gul, S., Yasin, G., Hussain, B., Li, Y., & Cheng, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113952 · Cited by 106
Micro/nanoplastics: Critical review of their impacts on plants, interactions with other contaminants (antibiotics, heavy metals, and polycyclic aromatic hydrocarbons), and management strategies
Khan, A. R., Ulhassan, Z., Li, G., Lou, J., Iqbal, B., Salam, A., Azhar, W., Batool, S., Zhao, T., Li, K., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169420 · Cited by 102
Transcriptomics, proteomics, and metabolomics interventions prompt crop improvement against metal(loid) toxicity
Raza, A., Salehi, H., Bashir, S., Tabassum, J., Jamla, M., Charagh, S., Barmukh, R., Mir, R. A., Bhat, B. A., Javed, M. A., et al. (2024) · Plant Cell Reports · doi:10.1007/s00299-024-03153-7 · Cited by 90
Self-citation
Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration
Bhat, B. A., Rather, M. A., Bilal, T., Nazir, R., Qadir, R. U., & Mir, R. A. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1631378 · Cited by 68
“In addition, inactive accumulation of metals occurs from the soil through roots and their transport through the xylem to the aerial parts of plants, such as stems, leaves, and other parts of shoots, by diverse classes of metal ion transporters (Feki et al., 2021; Jamla et al., 2021).”
Research progress of the detection and analysis methods of heavy metals in plants
He, S., Niu, Y., Xing, L., Liang, Z., Song, X., Ding, M., & Huang, W. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1310328 · Cited by 61
Phytohormones-mediated strategies for mitigation of heavy metals toxicity in plants focused on sustainable production
Zhang, Y., Yang, C., Liu, S., Xie, Z., Chang, H., & Wu, T. (2024) · Plant Cell Reports · doi:10.1007/s00299-024-03189-9 · Cited by 54
Trends in the Application of “Omics” to Ecotoxicology and Stress Ecology
Ebner, J. N. (2021) · Genes · doi:10.3390/genes12101481 · Cited by 53
Metallophenolomics: A Novel Integrated Approach to Study Complexation of Plant Phenolics with Metal/Metalloid Ions
Fedenko, V. S., Landi, M., & Shemet, S. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911370 · Cited by 52
Unveiling the mechanism of micro-and-nano plastic phytotoxicity on terrestrial plants: A comprehensive review of omics approaches
Jamil, A., Ahmad, A., Din, M., Zhang, Y., Zhao, Y., Chen, X., Cui, X., Tong, Y., & Liu, X. (2025) · Environment International · doi:10.1016/j.envint.2025.109257 · Cited by 46
Antimony-complexed heavy metal wastewater in antimony mining areas: Source, risk and treatment
Deng, S., Ren, B., Hou, B., Deng, R., & Cheng, S. (2023) · Environmental Technology & Innovation · doi:10.1016/j.eti.2023.103355 · Cited by 44
Advancements and prospects of CRISPR/Cas9 technologies for abiotic and biotic stresses in sugar beet
Misra, V., Mall, A. K., Pandey, H., Srivastava, S., & Sharma, A. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1235855 · Cited by 43
Signal Transduction in Cereal Plants Struggling with Environmental Stresses: From Perception to Response
Nykiel, M., Gietler, M., Fidler, J., Prabucka, B., Rybarczyk, A., Graska, J., Boguszewska‐Mańkowska, D., Muszyńska, E., Morkunas, I., & Labudda, M. (2022) · Plants · doi:10.3390/plants11081009 · Cited by 43
Land application of industrial wastes: impacts on soil quality, biota, and human health
Silva, S. D., Carson, P., Indrapala, D. V., Warwick, B., & Reichman, S. M. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26893-7 · Cited by 43
Exploring Aluminum Tolerance Mechanisms in Plants with Reference to Rice and Arabidopsis: A Comprehensive Review of Genetic, Metabolic, and Physiological Adaptations in Acidic Soils
Chakraborty, N., Das, A., Pal, S., Roy, S., Sil, S. K., Adak, M. K., & Hasanuzzaman, M. (2024) · Plants · doi:10.3390/plants13131760 · Cited by 41
Plant Biostimulants: Mechanisms and Applications for Enhancing Plant Resilience to Abiotic Stresses
Khalid, F., Rasheed, Y., Asif, K., Ashraf, H., Maqsood, M. F., Shahbaz, M., Zulfiqar, U., Sardar, R., & Haider, F. U. (2024) · Journal of soil science and plant nutrition · doi:10.1007/s42729-024-01996-3 · Cited by 40
Leveraging multi-omics tools to comprehend responses and tolerance mechanisms of heavy metals in crop plants
Charagh, S., Wang, H., Wang, J., Raza, A., Hui, S., Cao, R., Zhou, L., Tang, S., Hu, P., & Hu, S. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01481-1 · Cited by 37
Ecological and human health risk assessment of metals in soils and wheat along Sutlej river (India)
Setia, R. K., Dhaliwal, S. S., Singh, R., Singh, B. P., Kukal, S. S., & Pateriya, B. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137331 · Cited by 33
Transporters and phytohormones analysis reveals differential regulation of ryegrass (Lolium perenne L.) in response to cadmium and arsenic stresses
Li, W., Li, J., Hussain, K., Peng, K., Yu, J., Xu, M., & Yang, S. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134228 · Cited by 32
Toxicity of copper oxide nanoparticles in barley: induction of oxidative stress, hormonal imbalance, and systemic resistances
Abbasirad, S., & Ghotbi‐Ravandi, A. A. (2025) · BMC Plant Biology · doi:10.1186/s12870-025-06213-6 · Cited by 32
Plant Defense Strategies and Biomarkers against Heavy Metal-Induced Stress: A Comprehensive Review
Tyagi, S., Dhiman, V. K., Dhiman, V. K., Pandey, H., Singh, D., Sharma, A., Sharma, P., Kumar, R., Lee, K.-J., & Saharan, B. S. (2024) · ACS Agricultural Science & Technology · doi:10.1021/acsagscitech.3c00271 · Cited by 30
Biotechnological approaches for enhancement of heavy metal phytoremediation capacity of plants
Shourie, A., Mazahar, S., & Singh, A. (2024) · Environmental Monitoring and Assessment · doi:10.1007/s10661-024-12940-4 · Cited by 29
The current view on heavy metal remediation: The relevance of the plant interaction with arbuscular mycorrhizal fungi
Crișan, I., Balestrini, R., & Pagliarani, C. (2024) · Plant Stress · doi:10.1016/j.stress.2024.100439 · Cited by 27
Iron Plaque: A Shield against Soil Contamination and Key to Sustainable Agriculture
He, Z., Chen, J., Yuan, S., Chen, S., Hu, Y., Zheng, Y., & Li, D. (2024) · Plants · doi:10.3390/plants13111476 · Cited by 28
Potential implementation of trees to remediate contaminated soil in Egypt
Bedair, H., Ghosh, S., Abdelsalam, I. M., Keerio, A. A., & AlKafaas, S. S. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-22984-z · Cited by 26
Advanced omics approach and sustainable strategies for heavy metal microbial remediation in contaminated environments
Kumar, V., Singh, V., & Pandit, S. (2025) · Bioresource Technology Reports · doi:10.1016/j.biteb.2025.102040 · Cited by 26
Self-citation
MicroRNA-mediated bioengineering for climate-resilience in crops
Patil, S., Joshi, S., Jamla, M., Zhou, X., Taherzadeh, M. J., Suprasanna, P., & Kumar, V. (2021) · Bioengineered · doi:10.1080/21655979.2021.1997244 · Cited by 25
Self-citation
Navigating Through Harsh Conditions: Coordinated Networks of Plant Adaptation to Abiotic Stress
Shakespear, S., Sivaji, M., Kumar, V., Pillai, M. A., Wani, S. H., Suprasanna, P., & Yasin, J. K. (2024) · Journal of Plant Growth Regulation · doi:10.1007/s00344-023-11224-4 · Cited by 24
Self-citation
Genome-wide identification of heavy-metal ATPases genes in Areca catechu: investigating their functionality under heavy metal exposure
Khan, N. M., Ali, A., Wan, Y., & Zhou, G. (2024) · BMC Plant Biology · doi:10.1186/s12870-024-05201-6 · Cited by 24
Adverse Effects of Arsenic Uptake in Rice Metabolome and Lipidome Revealed by Untargeted Liquid Chromatography Coupled to Mass Spectrometry (LC-MS) and Regions of Interest Multivariate Curve Resolution
Pérez-Cova, M., Tauler, R., & Jaumot, J. (2022) · Separations · doi:10.3390/separations9030079 · Cited by 24
Salinity and temperature influence removal levels of heavy metals and chloride from water by wetland plants
Schück, M., & Greger, M. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26490-8 · Cited by 24
Insights into mode of action mediated responses following pharmaceutical uptake and accumulation in plants
Garduño-Jiménez, A.-L., & Carter, L. (2024) · Frontiers in Agronomy · doi:10.3389/fagro.2023.1293555 · Cited by 24
Microbial nanotechnology for producing stress smart crops
Shaikh, A., Jamla, M., Joshi, S., Patil, S., Oak, U., & Kumar, V. (2024) · Plant Nano Biology · doi:10.1016/j.plana.2024.100063 · Cited by 22
Self-citation
A perspective review on medicinal plant resources for their antimutagenic potentials
Malik, S., Kaur, K., Prasad, S., Jha, N. K., & Kumar, V. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16057-w · Cited by 22
Self-citation
Production of grains with ultra‐low heavy metal accumulation by pyramiding novel Alleles of OsNramp5 and OsLsi2 in two‐line hybrid rice
Hu, S., Zhou, L., Wang, J., Mawia, A. M., Hui, S., Xu, B., Jiao, G., Sheng, Z., Shao, G., Wei, X., et al. (2024) · Plant Biotechnology Journal · doi:10.1111/pbi.14414 · Cited by 21
Unlocking Biochar’s Potential: Innovative Strategies for Sustainable Remediation of Heavy Metal Stress in Tobacco Plants
Shar, A. G., Zhang, L., Lu, A., Ahmad, M., Saqib, M., Hussain, S., Zulfiqar, U., Wang, P., Zhang, L., & Rahimi, M. (2025) · Scientifica · doi:10.1155/sci5/6302968 · Cited by 21
MicroRNAs and Their Exploration for Developing Heavy Metal-tolerant Plants
Jamla, M., Patil, S., Joshi, S., Khare, T. R., & Kumar, V. (2021) · Journal of Plant Growth Regulation · doi:10.1007/s00344-021-10476-2 · Cited by 21
Self-citation
Endophytic yeast protect plants against metal toxicity by inhibiting plant metal uptake through an ethylene‐dependent mechanism
Domka, A., Jędrzejczyk, R. J., Ważny, R., Gustab, M., Kowalski, M. B., Nosek, M., Bizan, J., Puschenreiter, M., Vaculík, M., Kováč, J., et al. (2022) · Plant Cell & Environment · doi:10.1111/pce.14473 · Cited by 21
Duckweed: a potential phytosensor for heavy metals
Sharma, R., & Lenaghan, S. C. (2022) · Plant Cell Reports · doi:10.1007/s00299-022-02913-7 · Cited by 20
Nanozymes: An innovative approach to regulating heavy metal accumulation in plants and alleviating toxicity-A comprehensive review
Wang, Y., Gu, X., Zhao, L., & Zhou, D. (2025) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2024.2448048 · Cited by 20
Metal(loid) tolerance, accumulation, and phytoremediation potential of wetland macrophytes for multi-metal(loid)s polluted water
Khan, A. H. A., Soto, A., Rad, C., Curiel-Alegre, S., Rumbo, C., Velasco‐Arroyo, B., Wilde, H. D., Pérez‐de‐Mora, A., Martel-Martín, S., & Barros, R. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-35519-5 · Cited by 18
Comprehensive review of multiomics applications and remediation of plant heavy metal toxicity
Khan, T., Shah, L. R., Khan, S., Wani, O. A., Sheikh, Z. N., Afroza, B., Rashid, R., Baloch, F. S., & Mansoor, S. (2025) · Stress Biology · doi:10.1007/s44154-025-00233-w · Cited by 18
Integrating metabolomics and transcriptomics for SynCom-driven rhizomicrobiome engineering in salinity-stressed rice
Simarmata, T., Irwandhi, I., Khumairah, F. H., Hibatullah, F. H., Ambarita, D. D. M., Kamaluddin, N. N., Nurbaity, A., Herdiyantoro, D., Sayyed, R. Z., & Barasarathi, J. (2025) · Journal of Plant Interactions · doi:10.1080/17429145.2025.2567358 · Cited by 18
From signal perception to adaptive responses: A comprehensive review of plant mechanisms under cadmium, lead, and aluminum stress
Krówczyńska, N., & Pietrowska‐Borek, M. (2025) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2025.106240 · Cited by 17
The Binding Ability of Mercury (Hg) to Photosystem I and II Explained the Difference in Its Toxicity on the Two Photosystems of Chlorella pyrenoidosa
Wang, S., Duo, J., Wufuer, R., Li, W., & Pan, X. (2022) · Toxics · doi:10.3390/toxics10080455 · Cited by 17
Assessment of the Cadmium and Copper Phytoremediation Potential of the Lobularia maritima Thioredoxin 2 Gene Using Genetically Engineered Tobacco
Saad, R. B., Romdhane, W. B., Baazaoui, N., Bouteraa, M. T., Hsouna, A. B., Mishra, A., & Zeljkovıć, S. Ć. (2023) · Agronomy · doi:10.3390/agronomy13020399 · Cited by 17
Omics advancements towards exploring arsenic toxicity and tolerance in plants: a review
Hassan, S. H., Simiele, M., Scippa, G. S., Morabito, D., & Trupiano, D. (2025) · Planta · doi:10.1007/s00425-025-04646-9 · Cited by 16
Nanoparticle-driven plant signaling for advancing stress resilience and agricultural productivity-A review
Pal, P., Prakash, O., Parveen, A., Singh, A. K., Gupta, R., Sarangi, P. K., Sahoo, U. K., Rathore, S. S., & Singh, R. K. (2025) · Journal of Nanoparticle Research · doi:10.1007/s11051-025-06449-1 · Cited by 16
Gas Chromatography Mass Spectrometry based metabolomic investigation on five different rice cutivars (Oryza sativa L.) under different induced Cadmium stress
Paul, A., & Das, S. (2023) · Food Chemistry Advances · doi:10.1016/j.focha.2022.100175 · Cited by 16
Pseudochrobactrum asaccharolyticum mitigates arsenic induced oxidative stress of maize plant by enhancing water status and antioxidant defense system
Waheed, Z., Iqbal, S., Irfan, M., Jabeen, K., Umar, A., Aljowaie, R. M., Almutairi, S. M., & Gancarz, M. (2024) · BMC Plant Biology · doi:10.1186/s12870-024-05496-5 · Cited by 15
Smart reprogramming of plants against cadmium toxicity using membrane transporters and modern tools
Charagh, S., Wang, J., Hui, S., Raza, A., Cao, R., Zhou, L., Yang, L., Xu, B., Zhang, Y., Mawia, A. M., et al. (2025) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2025.109919 · Cited by 15
Decoding oxidative stress regulation in food crops exposed to heavy metals: interdisciplinary strategies for sustainable mitigation
Thakur, N., Sharma, P., Negi, N., Sharma, N., & Sharma, P. (2025) · Discover Sustainability · doi:10.1007/s43621-025-00912-8 · Cited by 15
Physiological and FtCHS Gene Expression Responses to PEG-Simulated Drought and Cadmium Stresses in Tartary Buckwheat Seedlings
Li, L., Yan, X., Li, J., & Tian, Y. (2021) · Journal of Plant Growth Regulation · doi:10.1007/s00344-021-10530-z · Cited by 15
Transcriptome Dynamics of Common Bean Roots Exposed to Various Heavy Metals Reveal Valuable Target Genes and Promoters for Genetic Engineering
Fang, P., Hu, Y., Xia, W., Wu, X., Sun, T., Pandey, A. K., Ning, K., Zhu, C., & Xu, P. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06301 · Cited by 15
Review and future prospects on the impact of abiotic stresses and tolerance strategies in medicinal and aromatic plants
Yadav, P., Ansari, M. W., Saini, S., Punia, S., Kaula, B. C., Rani, V., Gill, S. S., & Tuteja, N. (2024) · Revista Brasileira de Botânica · doi:10.1007/s40415-024-01004-z · Cited by 15
Speciation of metals in indigenous plants growing in post-mining areas: Dihydroxynicotianamine identified as the most abundant Cu and Zn ligand in Hypericum laricifolium
Kińska, K., Cruzado-Tafur, E., Parailloux, M., Torró, L., Łobiński, R., & Szpunar, J. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151090 · Cited by 15
Advanced Techniques in Omics Research in Relation to Heavy Metal/Metalloid Toxicity and Tolerance in Plants
Raza, A., Bashir, S., Salehi, H., Jamla, M., Charagh, S., Rad, A. C., & Hossain, M. A. (2023) · Wiley eBooks · doi:10.1002/9781119906506.ch2 · Cited by 15
Self-citation
Salinity alleviates arsenic stress-induced oxidative damage via antioxidative defense and metabolic adjustment in the root of the halophyte Salvadora persica
Patel, M., & Parida, A. K. (2023) · Planta · doi:10.1007/s00425-023-04263-4 · Cited by 14
Genome-Wide analysis of the NRAMP gene family in Arabidopsis thaliana: identification, expression and response to multiple heavy metal stresses and phytohormones
Arif, M., Abbas, H., Mahmood, N., Uzair, M., Manzoor, M. A., Tung, S. A., Xin, Y., Xu, R., & Li, L. (2025) · BMC Plant Biology · doi:10.1186/s12870-025-07396-8 · Cited by 12
Mechanisms of Bacterial Resistance to Heavy Metals: A Mini Review
Fardami, A. Y., Umar, B. I., Sabitu, M., Abduljalil, L., Mahdi, A. A., Aliyu, A., Lawal, I., Abdullahi, I. D., Muhammad, S. Z., & Ahmadu, A. F. (2023) · UMYU Scientifica · doi:10.56919/usci.2123.010 · Cited by 12
Understanding the possible cellular responses in plants under micro(nano)-plastic (MNPs): Balancing the structural harmony with functions
Mandal, M., Roy, A., & Sarkar, A. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.177732 · Cited by 12
A review on strategies for crop improvement against drought stress through molecular insights
Sharma, A., Dheer, P., Rautela, I., Thapliyal, P. N., Thapliyal, P., Bajpai, A. B., & Sharma, M. D. (2024) · 3 Biotech · doi:10.1007/s13205-024-04020-8 · Cited by 12
Increasing Salinity and Cadmium Enhanced Leaf Membrane Damage and H2O2 Production Irrespective of Reduced Sodium and Cadmium Accumulation in Wheat (Triticum aestivum L.)
Masood, S., Ashraf, M., Hussain, M., Azhar, M. F., Zafar-ul-Hye, M., Farooq, O., Aon, M., & Javed, M. T. (2025) · Journal of soil science and plant nutrition · doi:10.1007/s42729-025-02260-y · Cited by 11
Metabolic Responses of Amaranthus caudatus Roots and Leaves to Zinc Stress
Osmolovskaya, N., Bilova, T. E., Gurina, A., Orlova, A. A., Vu, V. D., Сухих, С. А., Zhilkina, T., Frolova, N., Tarakhovskaya, E., Kamionskaya, A. M., et al. (2025) · Plants · doi:10.3390/plants14142119 · Cited by 11
An insight into stress induced phytocompounds produced in common crops related to metal survival
Rizvi, A., Ahmed, B., & Khan, M. S. (2022) · Plant Growth Regulation · doi:10.1007/s10725-022-00928-4 · Cited by 11
Comparative transcriptome combined with physiological analyses revealed key genes and pathways for cadmium tolerance in wild-type and mutant microalgae Dunaliella salina
Zhu, Q., Wu, M., Xiao, J., Gao, L., Song, R., Yang, Z., Xia, L., Zheng, J., & Liu, J. (2024) · Algal Research · doi:10.1016/j.algal.2024.103475 · Cited by 10
Harnessing the interplay of protein posttranslational modifications: Enhancing plant resilience to heavy metal toxicity
Srivastava, A. K., Kumari, S., Singh, R. P., Khan, M., Mishra, P., & Xie, X. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128112 · Cited by 10
Multivariate Analysis of Maize Varieties: Roles of Ionomic Shifts, Antioxidant Defense, and Chloroplast Structural Integrity in Arsenic Stress Tolerance
Shah, M. A., Chen, T. Y., Khan, R., Ahmad, H., Khan, K., Ali, S., Lv, J. Z., Yang, H., & Zhou, X. B. (2025) · Plant Cell & Environment · doi:10.1111/pce.70125 · Cited by 10
Integrated transcriptomic and metabolomic analysis reveals the potential mechanisms underlying indium-induced inhibition of root elongation in wheat plants
Qian, R., Li, Y., Liu, Y., Sun, N., Liu, L., Lin, X., & Sun, C. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168477 · Cited by 10
Macrophyte assisted phytoremediation and toxicological profiling of metal(loid)s polluted water is influenced by hydraulic retention time
Khan, A. H. A., Soto-Cañas, A., Rad, C., Curiel-Alegre, S., Rumbo, C., Velasco‐Arroyo, B., Wilde, H. D., Pérez‐de‐Mora, A., Martel-Martín, S., & Barros, R. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-33934-2 · Cited by 9
Multi-omics analysis of Nicotiana tabacum unveils tissue-specific regulatory expression strategies for cadmium accumulation
Zheng, X., Wang, C., Xu, Y., Kang, Z., Cao, P., Zhang, H., & Chen, Q. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.119661 · Cited by 9
Mycorrhizopshere bacteria alleviated arsenic toxicity by regulating organic acids, glyoxalase defense system, and metal transporters in soybean plants
Khan, Z., Khan, S. R., Almansour, M. I., Asad, M., Ansari, M. J., Khan, H., & Ahmad, I. (2024) · South African Journal of Botany · doi:10.1016/j.sajb.2024.11.026 · Cited by 9
Indole-3-acetic acid improves growth, physiology, photosynthesis, and ion balance under cadmium stress in Sorghum bicolor
Bibi, A., Ullah, M. S., Mahmood, A., Shahzad, M., Javaid, M. M., Nadeem, M., Altihani, F. A., Hashem, M., & Qari, S. H. (2025) · Scientific Reports · doi:10.1038/s41598-025-10900-7 · Cited by 9
Antibiotic-heavy metals pollution in the rhizosphere: Environmental effects and potential solutions
Hussain, A., Liu, S., Li, H., Ullah, K., Armand, A. S., Li, F., & Hua, T. (2025) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.120764 · Cited by 8
Mechanistic insights into heavy metals detoxification and signaling in plants: Molecular coordination and stress tolerance an updated overview
Kolhi, M. L., Hussain, A., Junejo, A. R., Zhang, L., Gu, Y., Zhu, Y., Wang, P., & Liu, H. (2026) · Plant Stress · doi:10.1016/j.stress.2026.101284 · Cited by 8
Trends in micronutrient research since the SDGs: a global perspective
Abafe, E. A., Smith, N. W., Maxwell, T. M. R., & McNabb, W. C. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2483801 · Cited by 8
Enhancing Sugar Crop Resilience to Abiotic Stress Using CRISPR/Cas Tools
Pandey, H., Misra, V., Mall, A. K., Sharma, A., Hillary, V. E., & Ceasar, S. A. (2025) · Sugar Tech · doi:10.1007/s12355-025-01561-x · Cited by 7
Hydrothermal treatment of contaminated sorghum: Hydrochar properties and characterization/phytotoxicity evaluation of the liquid phase
Mehrez, K., Fryda, L. E., Djelal, H., Mercier, M., Wray, H. E., Kane, A., Leblanc, N., & Visser, R. (2025) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.117710 · Cited by 7
Integrated assessment of phytotoxicity, stress responses, and bioaccumulative mechanisms of the arsenic-contaminated agricultural runoff using a soilless cultivation system
Chow, Y. N., & Foo, K. Y. (2021) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2021.12.057 · Cited by 7
Differential behaviour of four genotypes of Andrographis paniculata (Burm.f.) Nees toward combined toxicity of As, Cd, and Pb: An ionomics and metabolic interpretation
Pandey, V., Yadav, R., Singh, A., Mishra, D., Shanker, K., Singh, S., & Khare, P. (2023) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2023.100274 · Cited by 7
Chromium Toxicity and Tolerance in Plants
Dubey, S., Shri, M., & Chakrabarty, D. (2023) · Wiley eBooks · doi:10.1002/9781119906506.ch6 · Cited by 7
Impact of mercury toxicity on plant growth and development: an overview on physiological, biochemical, and mitigation aspects
Viswanathan, S., & Nagella, P. (2026) · Environmental Science and Pollution Research · doi:10.1007/s11356-026-37638-7 · Cited by 6
Arsenic Induced Toxicity and Regulation Through Metabolomic, Hormonal and Signaling Hubs in Plants
Shukla, A., Srivastava, S., Mishra, V., Kumar, K., & Suprasanna, P. (2024) · Signaling and communication in plants · doi:10.1007/978-3-031-59024-5_9 · Cited by 6
Understanding heavy metal accumulation in crops: sources, plant responses, tolerance mechanisms, and environmental effects
Sinha, S., Basak, A., & Mondol, M. S. A. (2025) · Journal of Environmental Science and Health Part C · doi:10.1080/26896583.2025.2521207 · Cited by 6
Physiological insights into the responses of tea plants to aluminum through an integrated transcriptomic and metabolomic analysis
Zhang, X., Luo, S., Ye, X., Liu, L., Jia, X., Jiang, D., & Wen, W. (2025) · Horticulture Advances · doi:10.1007/s44281-025-00074-7 · Cited by 5
Exogenous Melatonin Application Alleviates Microplastics and Cadmium‐Induced Phytotoxicity in Maize ( Zea mays L.) Plants: Insights From Physiological and Metabolomic Analyses
Song, X., Sun, Y., Yang, S., Liang, S., & Teng, L. (2025) · Journal of Pineal Research · doi:10.1111/jpi.70091 · Cited by 5
Havadaki Metal Kirliliğinin (Ca, Mg, Mn) Tespitinde Kent Merkezindeki Mavi Ladin (Picea pungens) Ağacının Yaprak ve Dallarının Biyomonitör Olarak Kullanılabilirliği
Ateya, T. A. A., Bayraktar, O. Y., & Koç, İ. (2023) · Bartın Orman Fakültesi Dergisi · doi:10.24011/barofd.1210376 · Cited by 5
The Alleviating Effect of Brassinosteroids on Cadmium Stress in Potato Plants: Insights from StDWF4 Gene Overexpression
Zhou, X., Miao, R., Luo, J., Tang, W., Liu, K., Li, C., & Zhang, D. (2025) · Agronomy · doi:10.3390/agronomy15071503 · Cited by 4
Mechanisms by Which Increased pH Ameliorates Copper Excess in Citrus sinensis Roots: Insight from a Combined Analysis of Physiology, Transcriptome, and Metabolome
Zhang, J., Huang, W.-L., Chen, W., Rao, R.-Y., Lai, N.-W., Huang, Z.-R., Yang, L.-T., & Chen, L. (2024) · Plants · doi:10.3390/plants13213054 · Cited by 4
Multi-omics integration uncovers the zinc metabolic regulatory network in the hyperaccumulating ecotype of Sedum alfredii Hance
Shohag, M. J. I., Yang, Q., He, Z. L., Mostafa, I., Chen, S., & Yang, X. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138523 · Cited by 4
Omics Approaches in Food and Environmental Analysis
Farré, M. (2022) · The handbook of environmental chemistry · doi:10.1007/698_2022_893 · Cited by 4

Authors: Jamla, M., Khare, T., Joshi, S., Patil, S., Penna, S., & Kumar, V.
Affiliations: Savitribai Phule Pune University (IN)
Corresponding author: Kumar, Vinay
ORCID: Jamla, Monica
Khare, Tushar
Joshi, Shrushti
Patil, Suraj
Penna, Suprasanna
Kumar, Vinay
Venue: Current Plant Biology
Publisher: Elsevier BV
Published: 2021-09
Volume: 27
Pages: 100213
ISSN: 2214-6628 (ISSN-L)
DOI: 10.1016/j.cpb.2021.100213
OpenAlex: W3173956329
Cited by: 152
References: 250
Citations by year: 2026: 9 · 2025: 43 · 2024: 39 · 2023: 33 · 2022: 20 · 2021: 8
FWCI: 15.17
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Current Plant Biology (publishedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Department of Biotechnology, Ministry of Science and Technology, India
Department of Science and Technology, Ministry of Science and Technology, India (SR/ FST/COLLEGE-/19/568)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
Keywords: heavy metal toxicity, heavy metal tolerance, plants, cadmium, arsenic, aluminum, mercury, lead, plant stress response, transcriptomics, metabolomics, metallomics, omics approaches, metal transporters, transcription factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Omics approaches for understanding heavy metal responses and tolerance in plants

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks