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Omics approaches for understanding heavy metal responses and tolerance in plants
Open accessAbstract
Recent years have witnessed a gradual increase in the bioavailability and groundwater leaching of toxic heavy metals (HMs) in the environment, driven mainly by anthropogenic invasions. HMs, especially ranked as toxic/carcinogenic non-essential ones including Cadmium (Cd), Arsenic (As), Aluminium (Al), Mercury (Hg) and Lead (Pb) have emerged as the major soil, air and water contaminants affecting food production, quality and security worldwide. HMs affect plant growth and crop yield. Plants have developed intricate defense mechanisms for safeguarding themselves against the toxic effects imposed by HMs, including compartmentalization and sequestration in cell-organelles, inactivation by complex formation with the organic ligands and their exclusion using transporters, ion channels, transcription factors and signaling molecules, beside others. Omics approaches have generated significant resources and updates on the plant genome, transcriptome and metabolome plasticity against HM-induced stress stimuli. Omics technologies are pragmatic and seen as feasible approaches for characterizing the roles of genomes (genomics), coding (transcriptomics) and non-coding (miRNAomics) RNA transcripts, and metabolites (metabolomics) including metals (metallomics), which can ultimately be used for improving stress tolerance or generating resilience plant systems. This review aims to summarize the current understandings on the mechanistic insights of selected toxic (Cd, As, Al, Hg and Pb) HM-plant interactions, including their uptake, transport, toxicity and chelation/sequestration in cellular components, besides how plants respond and adapt to these stress factors. State-of-the-art in Omics approaches including genomics, transcriptomics, metabolomics, miRNAomics and metallomics for plant HM research have been presented. Present status, challenges and future prospects are also discussed.
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“Consequently, the transport of HMs from roots to aerial parts involves active transporters found in the plasma membrane and vacuolar membrane, these transporters require energy, usually in form of ATP to concentrate metal ions into storage organelles, such as vacuoles ( Figure 3 ).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Jamla et al., 2021
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“In addition, inactive accumulation of metals occurs from the soil through roots and their transport through the xylem to the aerial parts of plants, such as stems, leaves, and other parts of shoots, by diverse classes of metal ion transporters (Feki et al., 2021; Jamla et al., 2021).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Jamla et al., 2021
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1 retracted
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RetractedToxicity, mechanism and health effects of some heavy metals
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Ghuge, S. A., Nikalje, G. C., Kadam, U. S., Suprasanna, P., & Hong, J. C. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131039 · Cited by 372
Goncharuk, E. A., & Загоскина, Н. В. (2023) · Molecules · doi:10.3390/molecules28093921 · Cited by 295
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Analysis of Heavy Metal Impacts on Cereal Crop Growth and Development in Contaminated Soils
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Role of phytohormones in heavy metal tolerance in plants: A review
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Metadata
- Authors
- Jamla, M., Khare, T., Joshi, S., Patil, S., Penna, S., & Kumar, V.
- Affiliations
- Savitribai Phule Pune University (IN)
- Corresponding author
- Kumar, Vinay
- Venue
- Current Plant Biology
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 27
- Pages
- 100213
- ISSN
- 2214-6628 (ISSN-L)
- OpenAlex
- W3173956329
- Cited by
- 152
- References
- 250
- Citations by year
- 2026: 9 · 2025: 43 · 2024: 39 · 2023: 33 · 2022: 20 · 2021: 8
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Current Plant Biology (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Department of Science and Technology, Ministry of Science and Technology, India (SR/ FST/COLLEGE-/19/568)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Keywords
- heavy metal toxicity, heavy metal tolerance, plants, cadmium, arsenic, aluminum, mercury, lead, plant stress response, transcriptomics, metabolomics, metallomics, omics approaches, metal transporters, transcription factors
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