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Cited by 731

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Increasing Diversity in Clinical Trials: Overcoming Critical Barriers

Open access
Clark, Luther T., Watkins, Laurence, Piña, Ileana L., Elmer, Mary, Akinboboye, Ola, Gorham, Millicent, Jamerson, Brenda, McCullough, Cassandra, Pierre, Christine, Polis, Adam B., Puckrein, Gary, Regnante, Jeanne M.·2019·Current Problems in Cardiology
DOI 10.1016/j.cpcardiol.2018.11.002
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Abstract

Clinical trial results provide the critical evidence base for evaluating the safety and efficacy of new medicines and medical products. Efficacy and safety may differ among population subgroups depending on intrinsic/extrinsic factors, including sex, age, race, ethnicity, lifestyle, and genetic background. Racial and ethnic minorities continue to be underrepresented in cardiovascular and other clinical trials. Although barriers to diversity in trials are well recognized, sustainable solutions for overcoming them have proved elusive. We investigated barriers impacting minority patients' willingness to participate in trials and-based on literature review and evaluation, and input from key stakeholders, including minority patients, referring physicians, investigators who were minority-serving physicians, and trial coordinators-formulated potential solutions and tested them across stakeholder groups. We identified key themes from solutions that resonated with stakeholders using a transtheoretical model of behavior change and created a communications message map to support a multistakeholder approach for overcoming critical participant barriers.

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Registry

Crossref · 10.1016/j.cpcardiol.2018.11.002

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Metadata

Authors
Clark, L. T., Watkins, L., Piña, I. L., Elmer, M., Akinboboye, O., Gorham, M., Jamerson, B., McCullough, C., Pierre, C., Polis, A. B., Puckrein, G., & Regnante, J. M.
Venue
Current Problems in Cardiology
Publisher
Elsevier BV
Published
2019-05
Volume
44
Issue
5
Pages
148-172
ISSN
0146-2806 (ISSN-L)
DOI
10.1016/j.cpcardiol.2018.11.002
OpenAlex
W2900081888
Cited by
731
References
30
FWCI
29.51
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Increasing Diversity in Clinical Trials: Overcoming Critical Barriers. https://app.cochat.ai/papers/10.1016/j.cpcardiol.2018.11.002
The paper
Clark, L. T., Watkins, L., Piña, I. L., Elmer, M., Akinboboye, O., Gorham, M., Jamerson, B., McCullough, C., Pierre, C., Polis, A. B., Puckrein, G., & Regnante, J. M. (2019). Increasing Diversity in Clinical Trials: Overcoming Critical Barriers. Current Problems in Cardiology. https://doi.org/10.1016/j.cpcardiol.2018.11.002

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.