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Cited by 36Phytoestrogen effects and researchPhytochemicals and Antioxidant ActivitiesNutrition, Genetics, and Disease

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Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis

Amerizadeh, Atefeh, Asgary, Sedigheh, Vaseghi, Golnaz, Farajzadegan, Ziba·2022·Current Problems in Cardiology
DOI 10.1016/j.cpcardiol.2021.100902
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Abstract

Genistein, an isoflavone in soybean products has potential cardio-protective effects and is used also as an alternative for estrogen therapy in postmenopausal women. However, results in this regard are inconsistent and also, not all risk factors related to cardiovascular supportive effects have been meta-analyzed. We searched PubMed, Scopus, ISI Web of Science, and Google Scholar from inception up to October 2020. Random-effects meta-analysis was used for data synthesis. The search included studies with information on genistein supplementation and lipid profile [triglycerides (TG), total cholesterol (TC),low-density lipoprotein (LDL-C), and high-density lipoprotein HDL-C)], systolic and diastolic blood pressure (SBP & DBP), body mass index [BMI] and body weight. Pooled results of studies showed that genistein intake significantly reduced TC [95%CI: -0.49(-0.80, -0.18); P=0.002)], LDL-C [95%CI: -0.60(-1.10, -0.10); P=0.018)] and SBP [95%CI: -0.52(-0.90, -0.14); P=0.007)]. DBP, HLD-C, TG, BMI, and body weight showed no meaningful improvement. Subgroup analysis showed that LDL-C and SBP were reduced more effectively in postmenopausal women with metabolic syndrome. Genistein intake more than 6 months showed a greater effect on lowering cholesterol -0.76(-1.27, -0.24), SBP [-0.39(-0.70, -0.08)] and DBP -0.40(-0.81, -0.00) and increasing TG and LDL-C. This meta-analysis provides consistent evidence that genistein intake reduces the CVD risk factors of TC, LDL-C, and SBP significant…

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Metadata

Authors
Amerizadeh, A., Asgary, S., Vaseghi, G., & Farajzadegan, Z.
Affiliations
Isfahan University of Medical Sciences (IR)
Corresponding author
Amerizadeh, Atefeh
ORCID
Venue
Current Problems in Cardiology
Publisher
Elsevier BV
Published
2022-09
Volume
47
Issue
9
Pages
100902
ISSN
0146-2806 (ISSN-L)
DOI
10.1016/j.cpcardiol.2021.100902
OpenAlex
W3172517704
Cited by
36
References
2
Citations by year
2026: 5 · 2025: 10 · 2024: 4 · 2023: 6 · 2022: 10
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Current Problems in Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
genistein, isoflavones, soy products, cardiovascular risk factors, lipid profile, total cholesterol, LDL cholesterol, systolic blood pressure, diastolic blood pressure, postmenopausal women, metabolic syndrome, body mass index, triglycerides, HDL cholesterol
MeSH terms
Heart Disease Risk Factors, Blood Pressure, Body Weight, Cholesterol, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Triglycerides, Genistein

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CoChat. (2026). Citation check: Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis. https://app.cochat.ai/papers/10.1016/j.cpcardiol.2021.100902
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Amerizadeh, A., Asgary, S., Vaseghi, G., & Farajzadegan, Z. (2022). Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis. Current Problems in Cardiology. https://doi.org/10.1016/j.cpcardiol.2021.100902