The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Therapeutic alliance as a mediator of change: A systematic review and evaluation of research
Abstract
The alliance-outcome relationship has been consistently linked to positive treatment outcomes irrespective of psychotherapy modality. However, beyond its general links to favorable treatment outcomes, it is less clear whether the alliance is a specific mediator of change and thus a possible mechanism underlying psychotherapy response. This systematic review evaluated research examining the alliance as a potential mediator of symptom change, reviewing study characteristics of 37 relevant articles examining the alliance-outcome relationship and the extent to which these studies met recommended criteria for mechanistic research. Alliance mediated therapeutic outcomes in 70.3% of the studies. We observed significant heterogeneity across studies in terms of methodology, including timing of alliance assessment, study design, constructs used in mediation models, and analytic approaches. Building on recent methodological advancements, we propose directions for future research examining the putative mediational role of alliance, such as greater uniformity in and attention to study design and statistical methodology. This review highlights the importance of alliance in therapeutic change and discusses how adhering to requirements for process research will improve our ability to more precisely estimate how and to what extent alliance drives therapeutic change.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“By processing these relational patterns, within the therapeutic relationship, patients can experience corrective emotional experiences that help shift maladaptive interaction styles toward healthier, more reciprocal ones (166–168).”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [166]
In the citing paper
“Studies indicate that the therapist-patient relationship is one of the strongest predictors of treatment success across psychotherapeutic approaches, including PAT (166, 169–171).”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [166]
Citations
Cites
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
(2013) · Cited by 44,563
SPSS and SAS procedures for estimating indirect effects in simple mediation models
Preacher, K. J., & Hayes, A. F. (2004) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03206553 · Cited by 17,383
Mediation in experimental and nonexperimental studies: New procedures and recommendations.
Shrout, P. E., & Bolger, N. (2002) · Psychological Methods · doi:10.1037/1082-989x.7.4.422 · Cited by 11,335
A comparison of methods to test mediation and other intervening variable effects
MacKinnon, D. P., Lockwood, C. M., Hoffman, J. M., West, S. G., & Sheets, V. (2002) · Psychological Methods · doi:10.1037/1082-989x.7.1.83 · Cited by 9,406
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965
MacKinnon, D. P., Fairchild, A. J., & Fritz, M. S. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085542 · Cited by 5,688
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–440 of 440
Mitchell, K. E., Kirkman, A., & Taylor, E. (2026) · British Journal of Guidance and Counselling · doi:10.1080/03069885.2026.2663162
Guillotte, A.-A., & Beaudoin, M.-C. L. (2026) · Humain et Organisation · doi:10.7202/1124958ar
Ward, E. J., Hawrilenko, M., Brown, M. D., & Chekroud, A. M. (2026) · Research Square · doi:10.21203/rs.3.rs-9589129/v1
Levis, M., Dimambro, M., Levy, J., Tchizick, A., Nerish, M., Watts, B., & Shiner, B. R. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121952
Franchini, C., Andreassi, S., Sciabica, G. M., Morelli, M., Chirumbolo, A., Fortunato, A., & Speranza, A. M. (2026) · Measurement and Evaluation in Counseling and Development · doi:10.1080/07481756.2026.2665457
Yeung, A., Deng, H., Feng, W., Wu, Y., & Mischoulon, D. (2026) · Psychiatry Research Case Reports · doi:10.1016/j.psycr.2026.100331
Potts, S., Gupta, M., & Daly, N. (2026) · Advances in Simulation · doi:10.1186/s41077-026-00446-7
Predicting Disengagement from Therapy Based On First-Session TranscriptsPreprint
Ward, E. J., Dworkin, E. R., Hawrilenko, M., Brown, M. D., & Chekroud, A. M. (2026) · Research Square · doi:10.21203/rs.3.rs-9717903/v1
Reuter, L., Klapprott, F., Wulf, S., Frey, L., Nitzsche, A., & Gumz, A. (2026) · Counselling and Psychotherapy Research · doi:10.1002/capr.70117
Therapeutic Alliance and Autism: A Scoping Review
Losh, A., & Russell, K. (2026) · Counselling and Psychotherapy Research · doi:10.1002/capr.70142
Online Psychological Counseling Based on Cognitive Behavioral Theraphy in Depression A Case Study
Korkmaz, K., & Çekiç, A. (2026) · Sinop Üniversitesi Sosyal Bilimler Dergisi · doi:10.30561/sinopusd.1835154
Archandani, Z. H., Rahimian-Boogar, I., & Eisazadeh, F. (2026) · مجله علمی دانشگاه علوم پزشکی رفسنجان · doi:10.66224/jrums.24.11.1025
Cognitive Restructuring Within Cognitive Behavioral Therapy With Youth With Internalizing Disorders
Everson, K., & Terjesen, M. D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29009-1.00074-3
The Influence of Relationships Within Behavioral Weight Management Interventions: An Overview
Torrens, C., Campbell, P., Findlay, S. D., Cowie, J., O’Carroll, R. E., Hoddinott, P., Özakinci, G., & Farquharson, B. (2026) · Obesity Reviews · doi:10.1111/obr.70176
Le Grand Livre de la relation psychothérapeutique
Bioy, A., & Smith, J. (2025) · Dunod eBooks · doi:10.3917/dunod.bioy.2025.01.0463
Casari, L. M., Areas, M., Gómez, B., Babl, A., Ison, M. S., Roussos, A., & Penedo, J. M. G. (2026) · CES Psicología · doi:10.21615/cesp.8013
Nissen, E. K., Zehnder, T., Wehlage, C., & Gaab, J. (2026) · Psychotherapy Research · doi:10.1080/10503307.2026.2686684
Processes in psychotherapy: A scoping review with LLM-assisted clustering
Hofmann, S. G., Pahlen, L., Westhoff, M., Hossner, K., Quintarelli, H., Usée, F., Stenzel, K. L., & Stangier, U. (2026) · Clinical Psychology Review · doi:10.1016/j.cpr.2026.102782 · Cited by 1
Margetts, E., Elahi, A., & Bowe, J. (2026) · British Journal of Clinical Psychology · doi:10.1111/bjc.70079
Luercio, M., Markle, P., & Khan, A. (2026) · Hospital Pediatrics · doi:10.1542/hpeds.2026-009376
Stańska, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15145378
Äng, N. H., Särnholm, J., Andersson, G., Johansson, P., & Mourad, G. (2026) · BMC Psychology · doi:10.1186/s40359-026-05179-w
Coolen, B., Smits, F., de Weijer, A. D., & Geuze, E. (2026) · Chronic Stress · doi:10.1177/24705470261471309
From Mineral Waters to Mental Wellbeing: A Biopsychosocial Framework for Health Resort Medicine
Regazzo, G., Maraver, F., Fioravanti, A., & Masiero, S. (2026) · Water · doi:10.3390/w18141755
The Impact of the Strengths Model Strengths‐Based Practice on Mental Health Care: A Meta‐Ethnography
Pullman, J., Beckett, P., Katayama, M., & Molloy, L. (2026) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/jpm.70188
Une psychiatrie du sommeil augmentée
Stern, É., & Geoffroy, P. A. (2025) · Elsevier eBooks · doi:10.1016/b978-2-294-78711-9.00035-9
Quartiroli, A. (2026) · Journal of Sport Psychology in Action · doi:10.1080/21520704.2026.2721989
Posa, A. (2026) · PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie · doi:10.1055/a-2928-0255
Parri, L. A., Lau, R., & Addy, K. B. E. (2026) · JMIR Formative Research · doi:10.2196/95939
Boecking, B. (2026) · Psychotherapie: Praxis · doi:10.1007/978-3-662-72268-8_110
Barra, D., Telles‐Correia, D., & Pascoal, P. M. (2026) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeag062
Milgram, L., Jensen‐Doss, A., Rosenfield, D., Timpano, K. R., Ginsburg, G. S., & Ehrenreich, J. T. (2026) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2026.2731342
Balaraman, A., & Bauer, A. G. (2026) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2026.2673848
Predicting Symptom Change in Mental Health Chatbot Interventions: A Meta-Analysis
Saucier, C. J., Li, H., Calabrese, C. R., Baker, A. M., & Park, J. (2026) · Health Communication · doi:10.1080/10410236.2026.2734165
Vollebregt, R., Bornemann, L. R., Bruijniks, S. J. E., & Salah, A. A. (2026) · INTERNATIONAL CONFERENCE ON MULTIMODAL INTERACTION · doi:10.1145/3776574.3831165
Bakken, A. K., Mengshoel, A. M., & Synnes, O. (2026) · International Journal of Qualitative Studies on Health and Well-Being · doi:10.1080/17482631.2026.2745089
Seynaeve, M., Schneider, L., Roullier, I., Lazenby, K., Lilley, C., Lobo, S., Ermakova, A. O., Wells, H., Cleare, A. J., & Rucker, J. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1682810
Belashchenko, A., Rothgeb, L., Elrokhsi, N., Youngblood, O., Krohn, D., Croomes, M., Pavlova, A., Kuo, K., & Nelson, K. J. (2026) · Progress in brain research · doi:10.1016/bs.pbr.2026.09.006
Metadata
- Authors
- Baier, A. L., Kline, A. C., & Feeny, N. C.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Baier, Allison L.
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 82
- Pages
- 101921
- ISSN
- 0272-7358 (ISSN-L)
- OpenAlex
- W3087180323
- Cited by
- 441
- References
- 118
- Citations by year
- 2026: 79 · 2025: 111 · 2024: 105 · 2023: 74 · 2022: 60 · 2021: 12
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Psychology Review (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH066348)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Social Sciences › Psychology › Clinical Psychology › Counseling Practices and Supervision
- Keywords
- therapeutic relationship, psychotherapy outcome, symptom change, process research, mechanistic research, mediation analysis, psychotherapy response
- MeSH terms
- Therapeutic Alliance, Humans, Professional-Patient Relations, Psychotherapy, Research Design, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review