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Test-retest reliability of 3D EPI MR elastography of the pancreas
Abstract
Aim To determine the repeatability of three-dimensional echo planar imaging magnetic resonance (MR) elastography (3D EPI MRE) for assessing pancreatic stiffness in healthy volunteers, patients with chronic pancreatitis, and patients with pancreatic ductal adenocarcinoma (PDAC). Materials and methods 3D EPI MRE was used to assess pancreatic stiffness in five healthy volunteers, and five and three patients with histopathologically confirmed chronic pancreatitis and PDAC, respectively. The study participants underwent two scans, separated by a 1-day interval (referred to as time point 1 and time point 2). Scanning was performed using a 3 T MR machine using a multi-section EPI pulse sequence to assess the mean stiffness of the tumours in PDAC cases, and pancreatic parenchyma in chronic pancreatitis cases and healthy volunteers. A direct-inversion algorithm with 3D post-processing was used to estimate shear stiffness and generate elastograms. Stiffness was measured independently by two analysts. Results Between the two analysts, the mean stiffness of all 13 pancreases was highly reproducible, with an intraclass correlation coefficient (ICC) of 0.975 (95% confidence interval [CI]: 0.945-0.989) across the two time points (r=0.973, p Conclusion 3D-MRE is a highly reproducible method for assessing pancreatic stiffness.
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“In pathological conditions, such as pancreatic ductal adenocarcinoma 35 and chronic pancreatitis 36 , the stiffness increases to approximately 2.89 -4.3 kPa, reaching values as high as 5.8 kPa in long-term chronic pancreatitis.”
From Soft tissue-mimicking hydrogel stiffness modulates polarisation of human monocyte-derived macrophages (2025) · cites this paper as [35]
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Feasibility of using 3D MR elastography to determine pancreatic stiffness in healthy volunteers
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The stiffness of living tissues and its implications for tissue engineering
Guimarães, C. F., Gasperini, L., Marques, A. P., & Reis, R. L. (2020) · Nature Reviews Materials · doi:10.1038/s41578-019-0169-1 · Cited by 1,515
Kolipaka, A., Schroeder, S., Mo, X., Shah, Z., Hart, P. A., & Conwell, D. L. (2017) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2017.04.015 · Cited by 60
Coser, C., Ghaemmaghami, A. M., & Yang, J. (2025) · Biomaterials Science · doi:10.1039/d5bm01187f · Cited by 17
Metadata
- Authors
- An, H., Shi, Y., Guo, Q., & Liu, Y.
- Affiliations
- Sheng Jing Hospital (CN)
- Corresponding author
- Guo, Q.
- Venue
- Clinical Radiology
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 71
- Issue
- 10
- Pages
- 1068.e7-1068.e12
- ISSN
- 0009-9260 (ISSN-L)
- OpenAlex
- W2344595777
- Cited by
- 48
- References
- 20
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 1 · 2016: 1
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- Locations
- Clinical Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Keywords
- magnetic resonance elastography, pancreatic stiffness, test-retest reliability, chronic pancreatitis, pancreatic ductal adenocarcinoma, shear stiffness, elastograms, interobserver agreement, pancreatic parenchyma
- MeSH terms
- Adult, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Pancreas, Pancreatic Diseases, Prospective Studies, Reproducibility of Results, Echo-Planar Imaging, Imaging, Three-Dimensional, Elasticity Imaging Techniques
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- An, H., Shi, Y., Guo, Q., & Liu, Y. (2016). Test-retest reliability of 3D EPI MR elastography of the pancreas. Clinical Radiology. https://doi.org/10.1016/j.crad.2016.03.014
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