Cited by 1,098Frailty in Older AdultsNutrition and Health in AgingPharmaceutical Practices and Patient Outcomes

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Use of comprehensive geriatric assessment in older cancer patients:

Extermann, Martine, Aapro, Matti, Bernabei, Roberto, Cohen, Harvey Jay, Droz, Jean-Pierre, Lichtman, Stuart, Mor, Vincent, Monfardini, Silvio, Repetto, Lazzaro, Sørbye, Liv, Topinkova, Eva·2005·Critical Reviews in Oncology/Hematology

DOI 10.1016/j.critrevonc.2005.06.003

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Abstract

Background As more and more cancers occur in elderly people, oncologists are increasingly confronted with the necessity of integrating geriatric parameters in the treatment of their patients.Methods The International Society of Geriatric Oncology (SIOG) created a task force to review the evidence on the use of a comprehensive geriatric assessment (CGA) in cancer patients. A systematic review of the evidence was conducted.Results Several biological and clinical correlates of aging have been identified. Their relative weight and clinical usefulness is still poorly defined. There is strong evidence that a CGA detects many problems missed by a regular assessment in general geriatric and in cancer patients. There is also strong evidence that a CGA improves function and reduces hospitalization in the elderly. There is heterogeneous evidence that it improves survival and that it is cost-effective. There is corroborative evidence from a few studies conducted in cancer patients. Screening tools exist and were successfully used in settings such as the emergency room, but globally were poorly tested. The article contains recommendations for the use of CGA in research and clinical care for older cancer patients.Conclusions A CGA, with or without screening, and with follow-up, should be used in older cancer patients, in order to detect unaddressed problems, improve their functional status, and possibly their survival. The task force cannot recommend any specific tool or approach above others at this point and general geriatric experience should be used.

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Authors: Extermann, M., Aapro, M., Bernabei, R., Cohen, H. J., Droz, J.-P., Lichtman, S., Mor, V., Monfardini, S., Repetto, L., Sørbye, L., & Topinkova, E.
Affiliations: Moffitt Cancer Center (US)
Clinique de Genolier (CH)
Università Cattolica del Sacro Cuore (IT)
Duke University (US)
Centre Léon Bérard (FR)
Memorial Sloan Kettering Cancer Center (US)
Brown University (US)
Azienda Ospedale - Università Padova (IT)
Istituto Nazionale di Riposo e Cura per Anziani (IT)
Corresponding author: Extermann, Martine
ORCID: Extermann, Martine
Aapro, Matti
Bernabei, Roberto
Cohen, Harvey Jay
Droz, Jean-Pierre
Lichtman, Stuart
Mor, Vincent
Monfardini, Silvio
Venue: Critical Reviews in Oncology/Hematology
Publisher: Elsevier BV
Published: 2005-09
Volume: 55
Issue: 3
Pages: 241-252
ISSN: 1040-8428 (ISSN-L)
DOI: 10.1016/j.critrevonc.2005.06.003
OpenAlex: W2126277530
Cited by: 1,098
References: 105
Citations by year: 2026: 38 · 2025: 31 · 2024: 32 · 2023: 55 · 2022: 67 · 2021: 60 · 2020: 61 · 2019: 72 · 2018: 70 · 2017: 62 · 2016: 65 · 2015: 54 · 2014: 73 · 2013: 42 · 2012: 56
FWCI: 4.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Critical Reviews in Oncology/Hematology (publishedVersion)
PubMed (publishedVersion)
Funders: Amgen
European Society for Medical Oncology
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords: comprehensive geriatric assessment, elderly cancer patients, geriatric oncology, functional status, hospitalization, survival, cost-effectiveness, geriatric screening tools
MeSH terms: Aged, Female, Geriatrics, Health Planning Guidelines, Humans, Male, Medical Oncology, Societies, Medical, Geriatric Assessment, Advisory Committees

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