The DOI matches its Crossref record; 291 of the 293 references it cites were found in a registry or an index.
Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn’s disease
Open accessAbstract
Children and adolescents with Crohn's disease (CD) present often with a more complicated disease course compared to adult patients. In addition, the potential impact of CD on growth, pubertal and emotional development of patients underlines the need for a specific management strategy of pediatric-onset CD. To develop the first evidenced based and consensus driven guidelines for pediatric-onset CD an expert panel of 33 IBD specialists was formed after an open call within the European Crohn's and Colitis Organisation and the European Society of Pediatric Gastroenterolog, Hepatology and Nutrition. The aim was to base on a thorough review of existing evidence a state of the art guidance on the medical treatment and long term management of children and adolescents with CD, with individualized treatment algorithms based on a benefit-risk analysis according to different clinical scenarios. In children and adolescents who did not have finished their growth, exclusive enteral nutrition (EEN) is the induction therapy of first choice due to its excellent safety profile, preferable over corticosteroids, which are equipotential to induce remission. The majority of patients with pediatric-onset CD require immunomodulator based maintenance therapy. The experts discuss several factors potentially predictive for poor disease outcome (such as severe perianal fistulizing disease, severe stricturing/penetrating disease, severe growth retardation, panenteric disease, persistent severe disease despite adequate induction therapy), which may incite to an anti-TNF-based top down approach. These guidelines are intended to give practical (whenever possible evidence-based) answers to (pediatric) gastroenterologists who take care of children and adolescents with CD; they are not meant to be a rule or legal standard, since many different clinical scenario exist requiring treatment strategies not covered by or different from these guidelines.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This interest and use of CAM is common in pediatric IBD, despite being limited evidence for the role of diet and other types of CAMs in inducing and maintaining disease remission in IBD (excluding exclusive enteral nutrition in pediatric Crohn’s disease) [22,23,24].”
From Online Acceptance and Commitment Therapy and Nutrition Workshop for Parents of Children with Inflammatory Bowel Disease: Feasibility, Acceptability, and Initial Effectiveness. (2021) · cites this paper as [22]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
Hanauer, S. B., Feagan, B. G., Lichtenstein, G. R., Mayer, L., Schreiber, S., Colombel, J., Rachmilewitz, D., Wolf, D. C., Olson, A. D., Bao, W., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08512-4 · Cited by 4,164
Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease
Colombel, J., Sandborn, W. J., Reinisch, W., Mantzaris, G. J., Kornbluth, A. A., Rachmilewitz, D., Lichtiger, S., D’Haens, G., Diamond, R. H., Broussard, D. L., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0904492 · Cited by 3,184
Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease
Present, D. H., Rutgeerts, P., Targan, S., Hanauer, S. B., Mayer, L., van Hogezand, R. A., Podolsky, D. K., Sands, B. E., Braakman, T., DeWoody, K. L., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199905063401804 · Cited by 2,748
Colombel, J., Sandborn, W. J., Rutgeerts, P. J., Enns, R. A., Hanauer, S. B., Panaccione, R., Schreiber, S., Byczkowski, D., Li, J., Kent, J. D., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.041 · Cited by 2,239
Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease
Baert, F., Noman, M., Vermeire, S., Assche, G. V., Haens, G. D., Carbonez, A., & Rutgeerts, P. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020888 · Cited by 2,012
Mechanisms involved in the side effects of glucocorticoids
SCHACKE, H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00297-8 · Cited by 1,847
Hanauer, S. B., Sandborn, W. J., Rutgeerts, P. J., Fedorak, R. N., Lukáš, M., MacIntosh, D. G., Panaccione, R., Wolf, D. C., & Pollack, P. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.030 · Cited by 1,711
Pediatric modification of the Montreal classification for inflammatory bowel disease
Levine, A., Griffiths, A. M., Markowitz, J. F., Wilson, D. C., Turner, D., Russell, R. K., Fell, J. M. E., Ruemmele, F. M., Walters, T. D., Sherlock, M. E., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21493 · Cited by 1,518
Dignass, A. U., Assche, G. V., Lindsay, J. O., Lémann, M., Söderholm, J. D., Colombel, J., Danese, S., D’Hoore, A., Gassull, M. À., Gomollón, F., et al. (2010) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.12.002 · Cited by 1,508
Levine, A., Koletzko, S., Turner, D., Escher, J. C., Cucchiara, S., de Ridder, L., Kolho, K., Veres, G., Russell, R. K., Pærregaard, A., et al. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000239 · Cited by 1,403
Rahier, J. F., Ben-Horin, S., Chowers, Y., Conlon, C., Munter, P. D., D’Haens, G., Domènech, E., Eliakim, R., Eser, A., Frater, J., et al. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.02.010 · Cited by 1,247
National Cooperative Crohn's Disease Study: Results of drug treatment
Summers, R. W., Switz, D. M., Sessions, J. T., Becktel, J. M., Best, W. R., Kern, F., & Singleton, J. W. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90385-8 · Cited by 1,238
D’Haens, G., Baert, F., Assche, G. V., Caenepeel, P., Vergauwe, P. L., Tuynman, H. A. R. E., Vos, M. D., van Deventer, S. J. H., Stitt, L., Donner, A. P., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60304-9 · Cited by 1,230
Mucosal Healing in Inflammatory Bowel Disease: Results From a Norwegian Population-Based Cohort
Frøslie, K. F., Jahnsen, J., Moum, B. A., & Vatn, M. H. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.051 · Cited by 1,121
Dubinsky, M. C., Lamothe, S., Yang, H. Y., Targan, S. R., Sinnett, D., Théorêt, Y., & Seidman, E. G. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70140-5 · Cited by 995
Adalimumab Induction Therapy for Crohn Disease Previously Treated with Infliximab
Sandborn, W. J., Rutgeerts, P. J., Enns, R., Hanauer, S. B., Colombel, J., Panaccione, R., D’Haens, G., Li, J., Rosenfeld, M. R., Kent, J. D., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00159 · Cited by 961
Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends
Benchimol, E. I., Fortinsky, K. J., Gozdyra, P., van den Heuvel, M., Limbergen, J. V., & Griffiths, A. M. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21349 · Cited by 953
Definition of Phenotypic Characteristics of Childhood-Onset Inflammatory Bowel Disease
Limbergen, J. V., Russell, R. K., Drummond, H. E., Aldhous, M. C., Round, N. K., Nimmo, E. R., Smith, L. A., Gillett, P. M., McGrogan, P., Weaver, L. T., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.081 · Cited by 953
Kappelman, M. D., Rifas‐Shiman, S. L., KLEINMAN, K. P., Ollendorf, D., Bousvaros, A., Grand, R. J., & Finkelstein, J. A. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.07.012 · Cited by 931
Hyams, J. S., Crandall, W., Kugathasan, S., Griffiths, A. M., Olson, A. D., Johanns, J., Liu, G., Travers, S., Heuschkel, R. B., Markowitz, J. F., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.12.003 · Cited by 876
Beaugerie, L., Seksik, P., Nion–Larmurier, I., Gendre, J., & Cosnes, J. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.12.019 · Cited by 863
Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease
Baert, F., Moortgat, L., Assche, G. V., Caenepeel, P., Vergauwe, P. L., Vos, M. D., Stokkers, P. C. F., Hommes, D. W., Rutgeerts, P. J., Vermeire, S., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.056 · Cited by 829
Mucosal healing in inflammatory bowel diseases: a systematic review
Neurath, M. F., & Travis, S. P. L. (2012) · Gut · doi:10.1136/gutjnl-2012-302830 · Cited by 822
Kandiel, A., Fraser, A. G., Korelitz, B. I., Brensinger, C., & Lewis, J. D. (2005) · Gut · doi:10.1136/gut.2004.049460 · Cited by 805
Lichtenstein, G. R., Feagan, B. G., Cohen, R. D., Salzberg, B. A., Diamond, R. H., Price, S., Langholff, W. K., Londhe, A., & Sandborn, W. J. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.218 · Cited by 791
Markowitz, J. F., Grancher, K., Kohn, N. E., LESSER, M. L., & Daum, F. (2000) · Gastroenterology · doi:10.1053/gast.2000.18144 · Cited by 714
Clinical, biological, and endoscopic picture of attacks of Crohn's disease
Modigliani, R., Mary, J.-Y., Simon, J.-F., Cortot, A., Soule, J.-C., Gendre, J.-P., & Rene, E. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90002-i · Cited by 699
Efficacy of Biological Therapies in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis
Ford, A. C., Sandborn, W. J., Khan, K. J., Hanauer, S. B., Talley, N. J., & Moayyedi, P. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.73 · Cited by 613
Dose-related patterns of glucocorticoid-induced side effects
Huscher, D., Thiele, K., Gromnica-Ihle, E., Hein, G., Demary, W., Dreher, R., Zink, A., & Buttgereit, F. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.092163 · Cited by 604
Enteral nutritional therapy for induction of remission in Crohn's disease
Zachos, M., Tondeur, M. C., & Griffiths, A. M. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000542.pub2 · Cited by 598
Natural History of Pediatric Crohn's Disease: A Population-Based Cohort Study
Vernier-Massouille, G., Balde, M., Salleron, J., Turck, D., Dupas, J. L., Mouterde, O., Merle, V., Salomez, J. L., Branche, J., Marti, R., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.079 · Cited by 596
Louis, E. J., Mary, J., Vernier-Massouille, G., Grimaud, J., Bouhnik, Y., Laharie, D., Dupas, J., Pillant, H., Picon, L., Veyrac, M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.034 · Cited by 593
Development of the Crohnʼs disease digestive damage score, the Lémann score
Pariente, B., Cosnes, J., Danese, S., Sandborn, W. J., Lewin, M., Fletcher, J. G., Chowers, Y., D’Haens, G., Feagan, B. G., Hibi∥, T., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21506 · Cited by 584
Antibiotic therapy in inflammatory bowel disease: A systematic review and meta-analysis
Khan, K. J., Ullman, T. A., Ford, A. C., Abreu, M. T., Abadir, A., Marshall, J. K., Talley, N. J., & Moayyedi, P. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.72 · Cited by 569
A controlled double blind study of azathioprine in the management of Crohn's disease.
Candy, S., Wright, J., Gerber, M., Adams, G., Gerig, M., & Goodman, R. (1995) · Gut · doi:10.1136/gut.37.5.674 · Cited by 567
Schnitzler, F., Fidder, H. H., Ferrante, M., Noman, M., Arijs, I., Assche, G. V., Hoffman, I. E. A., Steen, K. V., Vermeire, S., & Rutgeerts, P. (2008) · Gut · doi:10.1136/gut.2008.155812 · Cited by 534
Mackey, A. C., Green, L., Liang, L., Dinndorf, P. A., & Avigan, M. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31802f6424 · Cited by 506
Magnetic resonance imaging for evaluation of Crohnʼs disease
Rimola, J., Ordás, Í., Rodríguez, S., García‐Bosch, O., Aceituno, M., Llach, J., Ayuso, C., Ricart, E., & Panés, J. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21551 · Cited by 503
Assche, G. V., Magdelaine–Beuzelin, C., D’Haens, G., Baert, F., Noman, M., Vermeire, S., Ternant, D., Watier, H., Paintaud, G., & Rutgeerts, P. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.004 · Cited by 493
Peyrin‐Biroulet, L., Khosrotehrani, K., Carrat, F., Bouvier, A., Chevaux, J., Simon, T., Carbonnel, F., Colombel, J., Dupas, J., Godeberge, P., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.050 · Cited by 489
Dubinsky, M. C., Yang, H., Hassard, P. V., Seidman, E. G., Kam, L. Y., Abreu, M. T., Targan, S. R., & Vasiliauskas, E. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.32420 · Cited by 481
Κarmiris, K., Paintaud, G., Noman, M., Magdelaine–Beuzelin, C., Ferrante, M., Degenne, D., Claes, K., Coopman, T., Schuerbeek, N. V., Assche, G. V., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.062 · Cited by 478
Kotlyar, D. S., Osterman, M. T., Diamond, R. H., Porter, D. L., Blonski, W. C., Wasik, M. A., Sampat, S., Mendizábal, M., Lin, M. V., & Lichtenstein, G. R. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.09.016 · Cited by 476
Borrelli, O., Cordischi, L., Cirulli, M., Paganelli, M., Labalestra, V., Uccini, S., Russo, P. M., & Cucchiara, S. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.010 · Cited by 469
Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
Bouhnik, Y., Scemama, G., Taï, R., Matuchansky, C., Rambaud, J. C., Lémann, M., Modigliani, R., & Mary, J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90402-x · Cited by 466
Steenholdt, C., Brynskov, J., Thomsen, O. Ø., Munck, L. K., Fallingborg, J., Christensen, L. A., Pedersen, G., Kjeldsen, J., Jacobsen, B. A., Oxholm, A. S., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-305279 · Cited by 459
Hanauer, S. B., Korelitz, B. I., Rutgeerts, P. J., Peppercorn, M. A., Thisted, R. A., Cohen, R. D., & Present, D. H. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.002 · Cited by 458
Case Reports of Heart Failure after Therapy with a Tumor Necrosis Factor Antagonist
Kwon, H., Cot, T. R., Cuffe, M. S., Kramer, J. M., & Braun, M. M. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-10-200305200-00008 · Cited by 455
Fidder, H. H., Schnitzler, F., Ferrante, M., Noman, M., Katsanos, K. H., Segaert, S., Henckaerts, L., Assche, G. V., Vermeire, S., & Rutgeerts, P. (2008) · Gut · doi:10.1136/gut.2008.163642 · Cited by 448
Enteral Nutrition and Corticosteroids in the Treatment of Acute Crohn's Disease in Children
Heuschkel, R. B., Menache, C. C., Megerian, J. T., & Baird, A. E. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200007000-00005 · Cited by 411
Fell, Paintin, Arnaud‐Battandier, Beattie, R. M., Hollis, Kitching, Donnet‐Hughes, MacDonald, & Walker‐Smith (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00707.x · Cited by 407
Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease
Chande, N., Patton, P. H., Tsoulis, D. J., Thomas, B., & MacDonald, J. K. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000067.pub3 · Cited by 402
Turner, D., Levine, A., Escher, J., Griffiths, A., Russell, R., Dignass, A., Dias, J., Bronský, J., Braegger, C., Cucchiara, S., et al. (2012) · Journal of Pediatric Gastroenterology and Nutrition - JPGN · doi:10.1097/mpg.0b013e3182662233 · Cited by 402
Osterman, M. T., Kundu, R., Lichtenstein, G. R., & Lewis, J. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.046 · Cited by 393
Ramadas, A. V., Gunesh, S., Thomas, G. A. O., Williams, G. T., & Hawthorne, A. B. (2010) · Gut · doi:10.1136/gut.2009.202101 · Cited by 386
Specificities of inflammatory bowel disease in childhood
Griffiths, A. M. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2004.01.002 · Cited by 359
Ursing, B., Alm, T., Bárány, F., Bergelin, I. S. S., Ganrot-Norlin, K., Hoevels, J., Huitfeldt, B., Järnerot, G., Krause, U., Krook, A. L., et al. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80189-3 · Cited by 351
Lémann, M., Mary, J., Colombel, J., Duclos, B., Soulé, J., Lerebours, É., Modigliani, R., & Bouhnik, Y. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.031 · Cited by 348
Antibody Response to Infliximab and its Impact on Pharmacokinetics can be Transient
Casteele, N. V., Gils, A., Singh, S., Ohrmund, L., Hauenstein, S. I., Rutgeerts, P. J., & Vermeire, S. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.12 · Cited by 346
Crohn's disease: Influence of age at diagnosis on site and clinical type of disease
Polito, J., Childs, B., Ed, M., Tokayer, A., Harris, M., & Bayless, T. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8780560 · Cited by 340
DOUBLE-BLIND WITHDRAWAL TRIAL OF AZATHIOPRINE AS MAINTENANCE TREATMENT FOR CROHN'S DISEASE
O’Donoghue, D. P., Dawson, A. M., Powell-Tuck, J., Bown, R. L., & Lennard‐Jones, J. E. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92524-2 · Cited by 332
Feagan, B. G., McDonald, J. W., Panaccione, R., Enns, R. A., Bernstein, C. N., Ponich, T. P., Bourdages, R., MacIntosh, D. G., Dallaire, C., Cohen, A., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.024 · Cited by 331
Glucocorticosteroid Therapy in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis
Ford, A. C., Bernstein, C. N., Khan, K. J., Abreu, M. T., Marshall, J. K., Talley, N. J., & Moayyedi, P. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.70 · Cited by 329
Sipponen, T. M., Kärkkäinen, P. A., Savilahti, E., Kolho, K., Nuutinen, H. U., Turunen, U., & Färkkilä, M. A. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03835.x · Cited by 324
CONTROLLED TRIAL OF AZATHIOPRINE IN CROHN'S DISEASE
Willoughby, J. M. T., Beckett, J., Kumar, P., & Dawson, A. M. (1971) · The Lancet · doi:10.1016/s0140-6736(71)90268-6 · Cited by 314
Ben‐Horin, S., Waterman, M., Kopylov, U., Yavzori, M., Picard, O., Fudim, E., Awadie, H., Weiss, B., & Chowers, Y. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.10.020 · Cited by 313
Safety and Efficacy of Adalimumab for Moderate to Severe Crohn's Disease in Children
Hyams, J. S., Griffiths, A. M., Markowitz, J. F., Baldassano, R. N., Faubion, W. A., Colletti, R. B., Dubinsky, M. C., Kierkuś, J., Rosh, J. R., Wang, Y., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.046 · Cited by 310
D’Haens, G., Vermeire, S., Assche, G. V., Noman, M., Aerden, I., Olmen, G. V., & Rutgeerts, P. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.010 · Cited by 301
TAKAGI, S., UTSUNOMIYA, K., KURIYAMA, S., YOKOYAMA, H., TAKAHASHI, S., IWABUCHI, M., TAKAHASHI, H., TAKAHASHI, S., KINOUCHI, Y., HIWATASHI, N., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03120.x · Cited by 292
Natural history of Crohnʼs disease
Pigneur, B., Seksik, P., Viola, S., Viala, J., Beaugerie, L., Girardet, J.-P., Ruemmele, F. M., & Cosnes, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21152 · Cited by 291
Remission induced by an elemental diet in small bowel Crohn's disease.
Sanderson, I. R., Udeen, S., Davies, P., Savage, M. O., & Walker-Smith, J. A. (1987) · Archives of Disease in Childhood · doi:10.1136/adc.62.2.123 · Cited by 290
Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohn's disease
Akobeng, A. K., Zhang, D., Gordon, M. A., & MacDonald, J. K. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003715.pub3 · Cited by 289
Bailey, D. B. (1997) · International Journal of Sports Medicine · doi:10.1055/s-2007-972713 · Cited by 285
Thia, K. T. J., Mahadevan, U., Feagan, B. G., Wong, C. J., Cockeram, A. W., Bitton, A., Bernstein, C. N., & Sandborn, W. J. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20608 · Cited by 276
Omega-3 Free Fatty Acids for the Maintenance of Remission in Crohn Disease
Feagan, B. G., Sandborn, W. J., Mittmann, U., Bar–Meir, S., D’Haens, G., Bradette, M., Cohen, A., Dallaire, C., Ponich, T. P., McDonald, J. W., et al. (2008) · JAMA · doi:10.1001/jama.299.14.1690 · Cited by 275
Cleynen, I., González, J. R., Figueroa, C., Franke, A., McGovern, D. P. B., Bortlík, M., Crusius, B. J. A., Vecchi, M. L., Artieda, M., Szczypiorska, M., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-300777 · Cited by 275
Methotrexate for induction of remission in refractory Crohn's disease
McDonald, J. W., Wang, Y., Tsoulis, D. J., MacDonald, J. K., & Feagan, B. G. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003459.pub4 · Cited by 271
Allez, M., Lémann, M., Bonnet, J., Cattan, P., Jian, R., & Modigliani, R. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05614.x · Cited by 268
Cosnes, J., Bourrier, A., Laharie, D., Nahon, S., Bouhnik, Y., Carbonnel, F., Allez, M., Dupas, J., Reimund, J., Savoye, G., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.048 · Cited by 267
Budesonide for induction of remission in Crohn's disease
Rezaie, A. R., Kuenzig, M. E., Benchimol, E. I., Griffiths, A. M., Otley, A. R., Steinhart, A. H., Kaplan, G. G., & Seow, C. H. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000296.pub4 · Cited by 264
Dewint, P., Hansen, B. E., Verhey, E., Oldenburg, B., Hommes, D. W., Pierik, M. J., Ponsioen, C. Y., van Dullemen, H. M., Rüssel, M. G., Bodegraven, A. A. V., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-304488 · Cited by 263
Supplementary enteral nutrition maintains remission in paediatric Crohn's disease.
Wilschanski, M. A., Sherman, P. M., Pencharz, P. B., Davis, L., Corey, M. L., & Griffiths, A. M. (1996) · Gut · doi:10.1136/gut.38.4.543 · Cited by 262
Meta‐analysis: enteral nutrition in active Crohn’s disease in children
Dziechciarz, P., Horvath, A., Shamir, R., & Szajewska, H. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03431.x · Cited by 258
Colombel, J., Lémann, M., Cassagnou, M., Bouhnik, Y., Duclos, B., Dupas, J., Notteghem, B., & Mary, J. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.935_q.x · Cited by 253
Probiotics for maintenance of remission in Crohn's disease
Rolfe, V. E., Fortun, P., Hawkey, C. J., & Bath-Hextall, F. J. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004826.pub2 · Cited by 252
Diak, P., Siegel, J. N., Grenade, L. L., Choi, L. H., Lemery, S. J., & McMahon, A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27511 · Cited by 252
Chronic intermittent elemental diet improves growth failure in children with Crohn's disease
Belli, D. C., Seidman, E. G., Bouthillier, L., Weber, A. M., ROY, C. C., Pletincx, M., Beaulieu, M., & Morin, C. L. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90230-2 · Cited by 251
Early Azathioprine Therapy Is No More Effective Than Placebo for Newly Diagnosed Crohn's Disease
Panés, J., López–Sanromán, A., Bermejo, F., García-Sánchez, V., Esteve, M., Torres, Y., Domènech, E., Piqueras, M., Gómez–García, M., Gutiérrez, A., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.06.009 · Cited by 250
Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease
Ansari, A. R., Hassan, C., Duley, J. A., Marinaki, A. M., Shobowale–Bakre, E.-M., Seed, P. T., Meenan, J. K., Yim, A. Y. F. L., & Sanderson, J. D. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01353.x · Cited by 249
Johnson, T., Macdonald, S., Hill, S. M., Thomas, A. G., & Murphy, M. S. (2005) · Gut · doi:10.1136/gut.2004.062554 · Cited by 247
Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease
Kirschner, B. S. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70251-3 · Cited by 240
Peyrin‐Biroulet, L., Deltenre, P., Ardizzone, S., D’Haens, G., Hanauer, S. B., Herfarth, H. H., Lémann, M., & Colombel, J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.301 · Cited by 233
Prolonged duration of response to infliximab in early but not late pediatric Crohn's disease
Kugathasan, S., Werlin, S. L., Martinez, A., Rivera, M. T., Heikenen, J. B., & Binion, D. G. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03263.x · Cited by 228
Peyrin‐Biroulet, L., Oussalah, A., Williet, N., Pillot, C., Bresler, L., & Bigard, M. (2011) · Gut · doi:10.1136/gut.2010.227884 · Cited by 223
Endoscopic and histologic healing of Crohn's (ileo-) colitis with azathioprine
D’Haens, G., Geboes, K., & Rutgeerts, P. J. (1999) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(99)80017-0 · Cited by 216
Dervieux, T., & Boulieu, R. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.3.551 · Cited by 215
Interventions for prevention of post-operative recurrence of Crohn's disease
Doherty, G. A., Bennett, G., Patil, S. A., Cheifetz, A. S., & Moss, A. C. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006873.pub2 · Cited by 202
A controlled trial of azathioprine in Crohn's disease
Rosenberg, J. L., Levin, B., Wall, A. J., & Kirsner, J. B. (1975) · Digestive Diseases and Sciences · doi:10.1007/bf01070829 · Cited by 201
Use of Enteral Nutrition for the Control of Intestinal Inflammation in Pediatric Crohn Disease
Critch, J., Day, A. S., Otley, A. R., King‐Moore, C., Teitelbaum, J. E., & Shashidhar, H. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318235b397 · Cited by 194
Bannerjee, K., Camacho‐Hübner, C., Babinska, K., Dryhurst, K., Edwards, R., Savage, M. O., Sanderson, I. R., & Croft, N. M. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200403000-00007 · Cited by 192
Akobeng, A. K., Miller, V., Stanton, J., Elbadri, A., & Thomas, A. G. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00022 · Cited by 184
Turner, D., Shah, P. S., Steinhart, A. H., Zlotkin, S. H., & Griffiths, A. M. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21374 · Cited by 184
Methotrexate for maintenance of remission in Crohn's disease
Patel, V., Wang, Y., MacDonald, J. K., McDonald, J. W., & Chande, N. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006884.pub3 · Cited by 184
Long-term outcome of maintenance infliximab therapy in children with Crohnʼs disease
Hyams, J. S., Lerer, T., Griffiths, A. M., Pfefferkorn, M. D., Kugathasan, S., Evans, J., Otley, A. R., Carvalho, R. S., Mack, D. R., Bousvaros, A., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20845 · Cited by 182
Infliximab (REMICADE) therapy in the treatment of pediatric Crohn's disease
Baldassano, R. N., Braegger, C., Escher, J. C., DeWoody, K. L., Hendricks, D. F., Keenan, G. F., & Winter, H. S. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07343.x · Cited by 180
Canani, R. B., Terrin, G., Borrelli, O., Romano, M. T., Manguso, F., Coruzzo, A., D’Armiento, F. P., Romeo, E. F., & Cucchiara, S. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.10.005 · Cited by 178
Buchanan, E., GAUNT, W. W., Cardigan, T., Garrick, V., McGrogan, P., & Russell, R. K. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04067.x · Cited by 173
Verma, S., Brown, S., Kirkwood, B. R., & Giaffer, M. H. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01527.x · Cited by 170
Hindorf, U., LINDQVIST, M., Hildebrand, H., Fagerberg, U. L., & Almer, S. H. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02977.x · Cited by 170
Day, A. S., Whitten, K. E., Lemberg, D. A., Clarkson, C., Vitug‐Sales, M., Jackson, R., & Bohane, T. D. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04294.x · Cited by 168
Dubinsky, M. C., Reyes, E., Ofman, J. J., Chiou, C., Wade, S. W., & Sandborn, W. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41900.x · Cited by 167
Tréton, X., Bouhnik, Y., Mary, J., Colombel, J., Duclos, B., Soulé, J., Lerebours, É., Cosnes, J., & Lémann, M. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.08.028 · Cited by 167
Rubio, A., Pigneur, B., Garnier‐Lengliné, H., Talbotec, C., Schmitz, J., Canioni, D., Goulet, O., & Ruemmele, F. M. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04662.x · Cited by 166
Borrelli, O., Bascietto, C., Viola, F., de Mesquita, M. B., Barbato, M., Mancini, V., Bosco, S., & Cucchiara, S. (2004) · Digestive and Liver Disease · doi:10.1016/j.dld.2003.12.014 · Cited by 166
Infliximab Improves Quality of Life in Patients with Crohn's Disease
Lichtenstein, G. R., BALA, M. M., Han, C., DeWoody, K. L., & Schaible, T. (2002) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200207000-00001 · Cited by 165
Increased Risk of Nonmelanoma Skin Cancers Among Individuals With Inflammatory Bowel Disease
Singh, H., Nugent, Z. J., Demers, A. A., & Bernstein, C. N. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.039 · Cited by 164
Guidelines for the Management of Inflammatory Bowel Disease in Children in the United Kingdom
Sandhu, B. K., Fell, J. M. E., Beattie, R. M., Mitton, S. G., Wilson, D. C., Jenkins, H. R., & IBD Working Group of the British Society of Paediatric Gastroenterology, H. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181c92c53 · Cited by 164
Gearry, R. B., Barclay, M. L., Burt, M. J., Collett, J. A., & CHAPMAN, B. A. (2004) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.926 · Cited by 159
Dietary Intake and Nutritional Treatment in Childhood Crohnʼs Disease
Thomas, A. G., Taylor, F., & Miller, V. (1993) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199307000-00011 · Cited by 157
Mantzaris, G. J., Christidou, A., Sfakianakis, M. E., Roussos, A., Koilakou, S., Petraki, K., & Polyzou, P. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20777 · Cited by 155
Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease
Prefontaine, E., Sutherland, L. R., MacDonald, J. K., & Cepoiu‐Martin, M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000067.pub2 · Cited by 155
Sprakes, M. B., Ford, A. C., Warren, L. R., Greer, D., & Hamlin, P. J. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.07.011 · Cited by 152
Gisbert, J. P. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21154 · Cited by 150
Nutritional Status and Growth in Pediatric Crohn's Disease: A Population-Based Study
Vasseur, F., Gower‐Rousseau, C., Vernier-Massouille, G., Dupas, J. L., Merle, V., Merlin, B., Lerebours, É., Savoye, G., Salomez, J. L., Cortot, A., et al. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.20 · Cited by 148
Mechanisms of growth impairment in pediatric Crohn's disease
Walters, T. D., & Griffiths, A. M. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.124 · Cited by 146
Thiopurines prevent advanced colorectal neoplasia in patients with inflammatory bowel disease
van Schaik, F. D. M., van Oijen, M. G. H., Smeets, H. M., van der Heijden, G. J. M. G., Siersema, P. D., & Oldenburg, B. (2011) · Gut · doi:10.1136/gut.2011.237412 · Cited by 146
Response to infliximab is related to disease duration in paediatric Crohn's disease
Lionetti, P., Bronzini, F., Salvestrini, C., Bascietto, C., Canani, R. B., Angelis, G. L. D., Guariso, G., Martelossi, S., Papadatou, B., & Barabino, A. V. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01672.x · Cited by 144
Winter, J., Walker, A. W., Shapiro, D., Gaffney, D., Spooner, R. J., & Mills, P. R. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02124.x · Cited by 144
Systematic review: nutritional therapy in paediatric Crohn’s disease
Day, A. S., Whitten, K. E., Sidler, M. A., & Lemberg, D. A. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03578.x · Cited by 141
Factors affecting outcomes in Crohn's disease over 15 years
Cosnes, J., Bourrier, A., Nion–Larmurier, I., Sokol, H., Beaugerie, L., & Seksik, P. (2012) · Gut · doi:10.1136/gutjnl-2011-301971 · Cited by 141
Polgmeric nutrition as the primary therapy in children with small bowel Crohn's disease
Beattie, R. M., Schiffrin, E. J., Donnet‐Hughes, A., Huggett, A. C., DOMIZIO, P., MacDonald, T. T., & Walker-Smith, J. A. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00338.x · Cited by 140
Pfefferkorn, M. D., Burke, G., Griffiths, A. M., Markowitz, J. F., Rosh, J. R., Mack, D. R., Otley, A. R., Kugathasan, S., Evans, J., Bousvaros, A., et al. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318175ca7f · Cited by 140
Afzal, N. A., Davies, S., Paintin, M., Arnaud‐Battandier, F., Walker-Smith, J. A., MURCH, S. H., Heuschkel, R. B., & Fell, J. M. E. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2864-6 · Cited by 137
Infliximab dose intensification in Crohnʼs disease
Regueiro, M. D., Siemanowski, B., Kip, K. E., & Plevy, S. E. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20177 · Cited by 133
Kolho, K., Raivio, T., Lindahl, H. G., & Savilahti, E. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520500419623 · Cited by 133
Use of infliximab in the treatment of Crohn's disease in children and adolescents
Hyams, J. S., Markowitz, J. F., & Wyllie, R. (2000) · The Journal of Pediatrics · doi:10.1067/mpd.2000.107161 · Cited by 132
Katz, L. H., Gisbert, J. P., Manoogian, B., Lin, K. K., Steenholdt, C., Mantzaris, G. J., Atreja, A., Ron, Y., Swaminath, A. C., Shah, S., et al. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22902 · Cited by 132
Cézard, J., Nouaili, N., Talbotec, C., Hugot, J., Gobert, J., Schmitz, J., Mougenot, J., Alberti, C., & Goulet, O. (2003) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200305000-00007 · Cited by 132
Tung, J., Loftus, E. V., Freese, D. K., El‐Youssef, M., Zinsmeister, A. R., Melton, J. L., Harmsen, S. W., Sandborn, W. J., & Faubion, W. A. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000235835.32176.85 · Cited by 131
Olaison, G., Sjödahl, R., & Tagesson, C. (1990) · Gut · doi:10.1136/gut.31.3.325 · Cited by 128
Crandall, W., & Mackner, L. M. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01411.x · Cited by 128
Afzal, N. A., van der Zaag–Loonen, H. J., Arnaud‐Battandier, F., Davies, S. E., MURCH, S. H., Derkx, B., Heuschkel, R. B., & Fell, J. M. E. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02002.x · Cited by 125
Miele, E., Markowitz, J. E., Mamula, P., & Baldassano, R. N. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200405000-00008 · Cited by 125
Kugathasan, S., Levy, M. B., Saeian, K., Vasilopoulos, S., Kim, J. P., Prajapati, D. N., Emmons, J. E., Martínez, A., Kelly, K. J., & Binion, D. G. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05784.x · Cited by 123
Rosh, J. R., Lerer, T., Markowitz, J. F., Goli, S. R., Mamula, P., Noe, J. D., Pfefferkorn, M. D., Kelleher, K. T., Griffiths, A. M., Kugathasan, S., et al. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.493 · Cited by 122
Stephens, M. C., Shepanski, M. A., Mamula, P., Markowitz, J. E., Brown, K. A., & Baldassano, R. N. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07161.x · Cited by 121
Markowitz, J. F., Hyams, J. S., Mack, D. R., LeLeiko, N. S., Evans, J., Kugathasan, S., Pfefferkorn, M. D., Mezoff, A. G., Rosh, J. R., Tolia, V. K., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.05.011 · Cited by 119
Methotrexate Following Unsuccessful Thiopurine Therapy in Pediatric Crohn's Disease
Turner, D., Grossman, A. B., Rosh, J. R., Kugathasan, S., Gilman, A. R., Baldassano, R. N., & Griffiths, A. M. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01474.x · Cited by 118
Effect of early immunomodulator use in moderate to severe pediatric Crohn disease
Punati, J. B., Markowitz, J. F., Lerer, T., Hyams, J. S., Kugathasan, S., Griffiths, A. M., Otley, A. R., Rosh, J. R., Pfefferkorn, M. D., Mack, D. R., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20412 · Cited by 115
The efficacy of methotrexate for maintaining remission in inflammatory bowel disease
Fraser, A. G., Morton, D., McGovern, D. P. B., Travis, S. P. L., & Jewell, D. P. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01227.x · Cited by 114
Methotrexate for induction of remission in refractory Crohn's disease
Alfadhli, A., McDonald, J. W., & Feagan, B. G. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003459.pub2 · Cited by 114
Pariente, B., de Chambrun, G. P., Krzysiek, R., Desroches, M., Louis, G., Cassan, C. D., Baudry, C., Gornet, J., Desreumaux, P., Émilie, D., et al. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21839 · Cited by 112
Mackey, A. C., Green, L., Leptak, C., & Avigan, M. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181957a11 · Cited by 111
Hepatosplenic T-cell lymphoma in patients receiving TNF-α inhibitor therapy
Deepak, P., Sifuentes, H., Semer, R., & Ehrenpreis, E. D. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32834bb90a · Cited by 110
Budesonide versus prednisolone for the treatment of active Crohn's disease in children
Escher, J. C. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200401000-00008 · Cited by 109
Thayu, M., Leonard, M. B., Hyams, J. S., Crandall, W., Kugathasan, S., Otley, A. R., Olson, A. D., Johanns, J., Marano, C. W., Heuschkel, R. B., et al. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.07.010 · Cited by 109
Hyams, J. S., Walters, T. D., Crandall, W., Kugathasan, S., Griffiths, A. M., BLANK, M. A., Johanns, J., Lang, Y., Markowitz, J. F., Cohen, S. A., et al. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.547575 · Cited by 108
Li, Y., Chen, L., Chan, T. H. M., Liu, M., Kong, K., Qiu, J., Li, Y., Yuan, Y., & Guan, X. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.042 · Cited by 108
A meta-analysis of antimycobacterial therapy for Crohn's disease
Borgaonkar, M. R., MacIntosh, D. G., & Fardy, J. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01842.x · Cited by 107
Ruemmele, F. M., Lachaux, A., Cézard, J., Morali, A., Maurage, C., Giniès, J., Viola, S., Goulet, O., Lamireau, T., Scaillon, M., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20788 · Cited by 107
Budesonide for induction of remission in Crohn's disease
Seow, C. H., Benchimol, E. I., Griffiths, A. M., Otley, A. R., & Steinhart, A. H. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000296.pub3 · Cited by 106
Ludvigsson, J. F., Krantz, M., Bodin, L., Stenhammar, L., & Lindquist, B. (2004) · Acta Paediatrica · doi:10.1111/j.1651-2227.2004.tb02956.x · Cited by 106
Feller, M., Huwiler, K., Schoepfer, A. M., Shang, A., Furrer, H., & Egger, M. (2010) · Clinical Infectious Diseases · doi:10.1086/649923 · Cited by 105
Biologic therapy in the management of extraintestinal manifestations of inflammatory bowel disease
Barrie, A. M., & Regueiro, M. D. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20196 · Cited by 103
Ruuska, T. H., Savilahti, E. M., Mäki, M., Örmälä, T., & Visakorpi, J. K. (1994) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199408000-00006 · Cited by 101
Lennard, L. (1987) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(87)80340-7 · Cited by 101
Russell, R. K., Wilson, M. L., Loganathan, S., Bourke, B., Kiparissi, F., Mahdi, G., Torrente, F., Rodrigues, A. F., Davies, I., Thomas, A. G., et al. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04603.x · Cited by 101
Pascua, M. F., Su, C. G., Lewis, J. D., Brensinger, C. M., & Lichtenstein, G. R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03774.x · Cited by 99
Lazzerini, M., Martelossi, S., Magazzù, G., Pellegrino, S., Lucanto, M. C., Barabino, A. V., Calvi, A., Arrigo, S., Lionetti, P., Lorusso, M., et al. (2013) · JAMA · doi:10.1001/jama.2013.280777 · Cited by 99
Oussalah, A., Chevaux, J., Fay, R., Sandborn, W. J., Bigard, M., & Peyrin‐Biroulet, L. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.158 · Cited by 96
Long-term outcome of nutritional therapy in paediatric Crohn's disease
Knight, C., El‐Matary, W., Spray, C. H., & Sandhu, B. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.03.005 · Cited by 96
Priest, V., Begg, E. J., Gardiner, S. J., FRAMPTON, C. M. A., Gearry, R. B., Barclay, M. L., Clark, D. W. J., & Hansen, P. (2006) · PharmacoEconomics · doi:10.2165/00019053-200624080-00004 · Cited by 95
Clinical and biological consequences of immunization to infliximab in pediatric Crohn's disease
Candon, S., Mosca, A., Ruemmele, F. M., Goulet, O., Chatenoud, L., & Cézard, J. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.07.010 · Cited by 95
Crohn's-associated chronic recurrent multifocal osteomyelitis responsive to infliximab
Carpenter, E. S., Jackson, M. A., Friesen, C. A., Scarbrough, M., & Roberts, C. C. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.12.038 · Cited by 93
Jacobstein, D. A., Markowitz, J. E., Kirschner, B. S., Ferry, G. D., Cohen, S. A., Gold, B. D., Winter, H. S., Heyman, M. B., & Baldassano, R. N. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000158166.88238.ea · Cited by 92
Methotrexate in patients with Crohn's disease after 6-mercaptopurine
Mack, D. R., Young, R., Kaufman, S. S., Ramey, L., & Vanderhoof, J. A. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70313-0 · Cited by 92
Cameron, F., Gerasimidis, K., Papangelou, A., Missiou, D., Garrick, V., Cardigan, T., Buchanan, E., Barclay, A. R., McGrogan, P., & Russell, R. K. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12230 · Cited by 91
Laharie, D., Reffet, A., Belleannée, G., Chabrun, É., Subtil, C., Razaire, S., Capdepont, M., & de Lédinghen, V. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04569.x · Cited by 90
Dermatologic Manifestations of Crohn Disease in Children: Response to Infliximab
Kugathasan, S., Miranda, A., Nocton, J. J., Drolet, B. A., Raasch, C., & Binion, D. G. (2003) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200308000-00013 · Cited by 90
Waugh, A. W. G., Garg, S., Matic, K., Gramlich, L. M., Wong, C. K. W., Sadowski, D. C., Millan, M., Bailey, R. J., Todoruk, D., Cherry, R. D., et al. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04446.x · Cited by 90
Kopylov, U., Mantzaris, G. J., Katsanos, K. H., Reenaers, C., Ellul, P., Rahier, J. F., Israeli, E., Lakatos, P. L., Fiorino, G., Cesarini, M., et al. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04523.x · Cited by 90
Rapid improvement of bone metabolism after infliximab treatment in Crohn's disease
Franchimont, N., Putzeys, V., Collette, J., Vermeire, S., Rutgeerts, P., Vos, M. D., Gossum, A. V., Franchimont, D. P., Fiasse, R., Pelckmans, P. A., et al. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02152.x · Cited by 87
Kestens, C., van Oijen, M. G. H., Mulder, C. L. J., Bodegraven, A. A. V., Dijkstra, G. D. H., de Jong, D., Ponsioen, C. Y., van Tuyl, B. A. C., Siersema, P. D., Fidder, H. H., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.01.012 · Cited by 87
Renna, S., Cammà, C., Modesto, I., Cabibbo, G., Scimeca, D., Civitavecchia, G., Mocciaro, F., Orlando, A., Enea, M., & Cottone, M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.066 · Cited by 86
Reenaers, C., Louis, E. J., Bélaïche, J., Seidel, L., Keshav, S., & Travis, S. P. L. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12076 · Cited by 85
Meta‐analysis: targeting the intestinal microbiota in prophylaxis for post‐operative Crohn’s disease
Doherty, G. A., Bennett, G., Cheifetz, A. S., & Moss, A. C. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04231.x · Cited by 84
Efficacy of methotrexate in pediatric Crohnʼs disease: A French multicenter study
Uhlen, S., Belbouab, R., Narebski, K., Goulet, O., Schmitz, J., Cézard, J., Turck, D., & Ruemmele, F. M. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000235103.47280.bb · Cited by 83
Ryan, B., Russel, M., Schurgers, L., Wichers, M., Sijbrandij, J., Stockbrügger, R., & Schoon, E. (2004) · Alimentary Pharmacology and Therapeutics · doi:10.1111/j.1365-2036.2004.02097.x · Cited by 82
de Ridder, L., Escher, J. C., Bouquet, J., Schweizer, J. J., Rings, E. H. H. M., Tolboom, J. J. M., Houwen, R. H. J., Norbruis, O. F., Derkx, B., & Taminiau, J. A. J. M. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200407000-00010 · Cited by 82
Enteral nutrition for the maintenance of remission in Crohnʼs disease: a systematic review
Yamamoto, T., Nakahigashi, M., Umegae, S., & Matsumoto, K. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832c788c · Cited by 81
A Comparison of Budesonide and Prednisone for the Treatment of Active Pediatric Crohn Disease
Levine, A., Weizman, Z., Broide, E., Shamir, R., Shaoul, R. R., Pacht, A., Dinari, G., On, A., Weiss, B., & Bujanover, Y. (2003) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200302000-00017 · Cited by 81
Sandborn, W. J., Colombel, J., Schreiber, S., Plevy, S. E., Pollack, P. F., Robinson, A. M., Chao, J., & Mulani, P. M. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21328 · Cited by 80
Grogan, J., Casson, D. H., Terry, A., Burdge, G. C., El‐Matary, W., & Dalzell, M. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21690 · Cited by 80
International survey of enteral nutrition protocols used in children with Crohn's disease
Whitten, K. E., Rogers, P. L. B., Ooi, C. Y., & Day, A. S. (2011) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2011.00558.x · Cited by 79
Shih, D. Q., Nguyen, M., Zheng, L., Ibanez, P., Mei, L., Kwan, L. Y., Bradford, K., Ting, C. D., Targan, S. R., & Vasiliauskas, E. A. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05206.x · Cited by 79
Optimum Duration of Treatment With 6-Mercaptopurine for Crohn's Disease
Kim, P. S.-H., Zlatanic, J., Korelitz, B. I., & Gleim, G. W. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01532.x · Cited by 79
Cassan, C. D., Fiorino, G., & Danese, S. (2012) · Digestive Diseases · doi:10.1159/000338128 · Cited by 77
The duration of effect of infliximab maintenance treatment in paediatric Crohn’s disease is limited
de Bie, C. I., Hummel, T., Kindermann, A., Kokke, F. T., Damen, G. M., Kneepkens, C. M. F., van Rheenen, P. F., Schweizer, J. J., Hoekstra, J. H., Norbruis, O. F., et al. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04507.x · Cited by 75
Infliximab in Steroid-dependent Ulcerative Colitis
Armuzzi, A., Pugliese, D., Danese, S., Rizzo, G., Felice, C., Marzo, M., Andrisani, G., Fiorino, G., Sociale, O. R., Papa, A., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182802909 · Cited by 74
Flagged first, then by citations
2 of the 293 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Griffiths, 2004, Specificitiesofinflammatoryboweldiseaseinchildhood, BestPractResClinGastroenterol, 18, 509
- Seidman, 1991, Elemental diet versus prednisone as initial therapy in Crohn's disease: early and long term results, Gastroenterology, 100, A250
- Seidman, 1993, Semi-elemental (S-E) diet versus prednisone in pediatric Crohn's disease. Gastroenterology 1993, Gastroenterology, 104, A778
Cited by
Sorted by citations
Torres, J., Mehandru, S., Colombel, J., & Peyrin‐Biroulet, L. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31711-1 · Cited by 2,833
The Medical Management of Paediatric Crohn’s Disease: an ECCO-ESPGHAN Guideline Update
van Rheenen, P. F., Aloi, M., Assa, A., Bronský, J., Escher, J. C., Fagerberg, U. L., Gasparetto, M., Gerasimidis, K., Griffiths, A. M., Henderson, P., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa161 · Cited by 756
The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease
Uhlig, H. H., Schwerd, T., Koletzko, S., Shah, N., Kammermeier, J., Elkadri, A. A., Ouahed, J., Wilson, D. C., Travis, S. P. L., Turner, D., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.023 · Cited by 716
Levine, A., Wine, E., Assa, A., Boneh, R. S., Shaoul, R. R., Kori, M., Cohen, S., Peleg, S., Shamaly, H., On, A., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.021 · Cited by 714
ESPEN guideline: Clinical nutrition in inflammatory bowel disease
Forbes, A., Escher, J., Hébuterne, X., Kłęk, S., Krznaric, Z., Schneider, S., Shamir, R., Stardelova, K., Wierdsma, N., Wiskin, A. E., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.12.027 · Cited by 625
“Overall, the panel did not find enough evidence to make firm recommendations over and above previous European recommendations [13,137].”
BackgroundMethodInfluentialSelf-citationRetracted
Metadata
- Authors
- Ruemmele, F. M., Veres, G., Kolho, K. L., Griffiths, A., Levine, A., Escher, J. C., Amil Dias, J., Barabino, A., Braegger, C. P., Bronsky, J., Buderus, S., Martín-de-Carpi, J., De Ridder, L., Fagerberg, U. L., Hugot, J. P., Kierkus, J., Kolacek, S., Koletzko, S., Lionetti, P., Miele, E., Navas López, V. M., Paerregaard, A., Russell, R. K., Serban, D. E., Shaoul, R., Van Rheenen, P., Veereman, G., Weiss, B., Wilson, D., Dignass, A., Eliakim, A., Winter, H., & Turner, D.
- Affiliations
- Hôpital Necker-Enfants Malades (FR)
- Semmelweis University (HU)
- Helsinki University Hospital (FI)
- University of Toronto (CA)
- Tel Aviv University (IL)
- Erasmus MC (NL)
- Unit of Paediatric Gastroenterology, Hospital S. João, A Hernani Monteiro, 4202-451, Porto, Portugal
- Istituto Giannina Gaslini (IT)
- University Children's Hospital Zurich (CH)
- Department of Pediatrics, University Hospital Motol, Uvalu 84, 150 06 Prague, Czech Republic
- St. Marien-Hospital Bonn (DE)
- Department of Paediatric Gastroenterolgoy, Hepatology and Nutrition, Hospital Sant Joan de Déu, Paseo Sant Joan de Déu 2, 08950 Barcelona, Spain
- Department of Paediatric Gastroenterology, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, Netherlands
- Karolinska Institutet (SE)
- Sorbonne Paris Cité (FR)
- Department of Gastroenterology, Hepatology and Feeding Disorders, Instytut Pomnik Centrum Zdrowia Dziecka, Ul. Dzieci Polskich 20, 04-730 Warsaw, Poland
- Department of Paediatric Gastroenterology, Children's Hospital, University of Zagreb Medical School, Klaićeva 16, 10000 Zagreb, Croatia
- Department of Paediatric Gastroenterology, Dr. von Hauner Children's Hospital, Lindwurmstr. 4, 80337 Munich, Germany
- Meyer Children's Hospital (IT)
- University of Naples Federico II (IT)
- Paediatric Gastroenterology and Nutrition Unit, Hospital Materno Infantil, Avda. Arroyo de los Ángeles s/n, 29009 Málaga, Spain
- Department of Paediatrics 460, Hvidovre University Hospital, Kettegård Allé 30, 2650 Hvidovre, Denmark
- Department of Paediatric Gastroenterology, Yorkhill Hospital, Dalnair Street, Glasgow G3 8SJ, United Kingdom
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Rambam Health Care Campus (IL)
- Department of Paediatric Gastroenterology, Hepatology and Nutrition, University Medical Center Groningen, P.O. Box 30001, 9700 RB Groningen, Netherlands
- Queen Fabiola Children's University Hospital (BE)
- Sheba Medical Center (IL)
- Royal Hospital for Sick Children (GB)
- Agaplesion Markus Hospital (DE)
- Massachusetts General Hospital (US)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Ruemmele, F.M.
- ORCID
- Venue
- Journal of Crohn s and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-10-01
- Volume
- 8
- Issue
- 10
- Pages
- 1179-1207
- ISSN
- 1873-9946 (ISSN-L)
- 1876-4479
- OpenAlex
- W2135936774
- Cited by
- 1,083
- References
- 293
- Citations by year
- 2026: 61 · 2025: 60 · 2024: 71 · 2023: 97 · 2022: 83 · 2021: 123 · 2020: 117 · 2019: 136 · 2018: 92 · 2017: 122 · 2016: 61 · 2015: 52 · 2014: 5
- FWCI
- 52.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Crohn s and Colitis (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion, cc-by-nc-nd)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Surgery › Anorectal Disease Treatments and Outcomes
- Keywords
- pediatric Crohn's disease, medical management
- MeSH terms
- Adalimumab, Infliximab, Adolescent, Adrenal Cortex Hormones, Algorithms, Aminosalicylic Acids, Anti-Inflammatory Agents, Non-Steroidal, Anti-Bacterial Agents, Antibodies, Monoclonal, Azathioprine, Child, Crohn Disease, Enteral Nutrition, Humans, Immunosuppressive Agents, Methotrexate, Remission Induction, Thalidomide, Tumor Necrosis Factor-alpha, Mercaptopurine, Maintenance Chemotherapy, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
