Effectiveness of an ‘half elemental diet’ as maintenance therapy for Crohn's disease: a randomized-controlled trial
Abstract
BACKGROUND: Although thiopurines have a proven role in maintenance therapy for Crohn's disease, an alternative therapy is needed for patients intolerant or resistant to thiopurines. AIM: To evaluate the effectiveness of home enteral nutrition as a maintenance therapy regimen in which half of the daily calorie requirement is provided by an elemental diet and the remaining half by a free diet. We refer to this home enteral nutrition therapy as 'half elemental diet'. METHODS: Between 2002 and 2005, 51 patients in remission from two hospitals were randomly assigned to a half elemental diet group (n = 26) or a free diet group (n = 25). The primary outcome measure of this study was the occurrence of relapse over the 2-year period. RESULTS: The relapse rate in the half elemental diet group was significantly lower [34.6% vs. 64.0%; multivariate hazard ratio 0.40 (95% CI: 0.16-0.98)] than that in the free diet group after a mean follow-up of 11.9 months. Compliance was similar in the two groups. No adverse event occurred in any of the patients throughout the study. CONCLUSION: This randomized-controlled trial shows the effectiveness of an half elemental diet, which is a promising maintenance therapy for Crohn's disease patients.
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These EEN diets are also effective in maintaining remission.
“These diets are also effective in maintaining remission78.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [78]
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- Authors
- TAKAGI, S., UTSUNOMIYA, K., KURIYAMA, S., YOKOYAMA, H., TAKAHASHI, S., IWABUCHI, M., TAKAHASHI, H., TAKAHASHI, S., KINOUCHI, Y., HIWATASHI, N., FUNAYAMA, Y., SASAKI, I., TSUJI, I., & SHIMOSEGAWA, T.
- Affiliations
- Tohoku University (JP)
- Sendai Medical Center (JP)
- Iwaki Kyoritsu General Hospital (JP)
- Corresponding author
- TAKAGI, S.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2006-10-16
- Volume
- 24
- Issue
- 9
- Pages
- 1333-1340
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2119591540
- Cited by
- 292
- References
- 36
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 22 · 2023: 11 · 2022: 9 · 2021: 18 · 2020: 21 · 2019: 25 · 2018: 19 · 2017: 22 · 2016: 16 · 2015: 16 · 2014: 18 · 2013: 12 · 2012: 18
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Health Professions › Health Information Management › Dietetics, Nutrition, and Education
- Keywords
- Crohn's disease, maintenance therapy, home enteral nutrition, elemental diet, thiopurine intolerance, thiopurine resistance, relapse, remission
- MeSH terms
- Adult, Crohn Disease, Enteral Nutrition, Female, Follow-Up Studies, Food, Formulated, Humans, Male, Parenteral Nutrition, Recurrence, Treatment Outcome
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