The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The staphylococcal exopolysaccharide PIA – Biosynthesis and role in biofilm formation, colonization, and infection
Open accessAbstract
Exopolysaccharide is a key part of the extracellular matrix that contributes to important mechanisms of bacterial pathogenicity, most notably biofilm formation and immune evasion. In the human pathogens Staphylococcus aureus and S. epidermidis, as well as in many other staphylococcal species, the only exopolysaccharide is polysaccharide intercellular adhesin (PIA), a cationic, partially deacetylated homopolymer of N-acetylglucosamine, whose biosynthetic machinery is encoded in the ica locus. PIA production is strongly dependent on environmental conditions and controlled by many regulatory systems. PIA contributes significantly to staphylococcal biofilm formation and immune evasion mechanisms, such as resistance to antimicrobial peptides and ingestion and killing by phagocytes, and presence of the ica genes is associated with infectivity. Due to its role in pathogenesis, PIA has raised considerable interest as a potential vaccine component or target.
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“Among the polymeric molecules involved in ECM, polysaccharide intercellular adhesion (PIA) (also known as poly-N-acetylglucosamine; PNAG) is an important factor in S. aureus biofilm formation [41].”
From A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism (2022) · cites this paper as [41]
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Hobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581
Izano, E. A., Amarante, M. A., Kher, W. B., & Kaplan, J. B. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02073-07 · Cited by 553
Kaplan, J. B., Ragunath, C., Ramasubbu, N., & Fine, D. H. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.16.4693-4698.2003 · Cited by 364
Itoh, Y., Wang, X., Hinnebusch, B. J., Preston, J. F., & Romeo, T. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.1.382-387.2005 · Cited by 322
Kaplan, J. B., Velliyagounder, K., Ragunath, C., Rohde, H., Mack, D., Knobloch, J. K.-M., & Ramasubbu, N. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.24.8213-8220.2004 · Cited by 301
Sadovskaya, I., Vinogradov, E., Flahaut, S., Kogan, G., & Jabbouri, S. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.3007-3017.2005 · Cited by 188
Lery, L. M., Frangeul, L., Tomas, A., Passet, V., Almeida, A. S., Bialek-Davenet, S., Barbe, V., Bengoechea, J. A., Sansonetti, P., Brisse, S., et al. (2014) · BMC Biology · doi:10.1186/1741-7007-12-41 · Cited by 181
Kaplan, J. B., Mlynek, K. D., Hettiarachchi, H., Alamneh, Y. A., Biggemann, L., Zurawski, D. V., Black, C. C., Bane, C. E., Kim, R. K., & Granick, M. S. (2018) · PLOS ONE · doi:10.1371/journal.pone.0205526 · Cited by 96
Cited by
A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism
Peng, Q., Tang, X., Dong, W., Sun, N., & Yuan, W. (2022) · Antibiotics · doi:10.3390/antibiotics12010012 · Cited by 440
Saidi, N., Saderi, H., Owlia, P., & Soleimani, M. (2023) · Advanced Biomedical Research · doi:10.4103/abr.abr_156_21 · Cited by 34
Metadata
- Authors
- Nguyen, H. T. T., Nguyen, T. H., & Otto, M.
- Venue
- Computational and Structural Biotechnology Journal
- Published
- 2020
- Volume
- 18
- Pages
- 3324-3334
- ISSN
- 2001-0370 (ISSN-L)
- OpenAlex
- W3094759425
- Cited by
- 242
- References
- 8
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nguyen, H. T. T., Nguyen, T. H., & Otto, M. (2020). The staphylococcal exopolysaccharide PIA – Biosynthesis and role in biofilm formation, colonization, and infection. Computational and Structural Biotechnology Journal. https://doi.org/10.1016/j.csbj.2020.10.027
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
