Chinese herbal medicine for female infertility: An updated meta-analysis
Abstract
Objectives To assess the effect of Traditional Chinese herbal medicine (CHM) in the management of female infertility and on pregnancy rates compared with Western medical (WM) treatment and update previous meta-analyses. Methods We searched the Medline and Cochrane databases until December 2013 for randomized controlled trials and meta-analyses investigating Chinese herbal medicine therapy for female infertility and compared clinical pregnancy rates achieved with CHM versus WM drug treatment. Results Forty RCTs involving 4247 women with infertility were included in our systematic review. Meta-analysis suggested a 1.74 higher probability of achieving a pregnancy with CHM therapy than with WM therapy alone (risk ratio 1.74, 95%CI: 1.56-1.94; p<0.0001; odds ratio 3.14; 95%CI: 2.72-3.62; p<0.0001) in women with infertility. Trials included women with PCOS, endometriosis, anovulation, fallopian tube blockage, or unexplained infertility. Mean pregnancy rates in the CHM group were 60% compared with 33% in the WM group. Conclusions Our review suggests that management of female infertility with Chinese herbal medicine can improve pregnancy rates 2-fold within a 3-6 month period compared with Western medical fertility drug therapy. In addition, fertility indicators such as ovulation rates, cervical mucus score, biphasic basal body temperature, and appropriate thickness of the endometrial lining were positively influenced by CHM therapy, indicating an ameliorating physiological effect conducive for a viable pregnancy.
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A Cochrane 2015 review of five RCTs (414 participants) found low-quality evidence that Chinese herbal medicine combined with clomiphene citrate possibly increases pregnancy rates compared to CC alone.
“A review conducted by Cochrane in 2015, with Ried as the author, analyzed five randomized controlled trials with the participation of 414 participants and found low-quality evidence showing that Chinese herbal medicine combined with clomiphene citrate (CC) would possibly increase pregnancy rates compared to CC alone [201].”
There was no significant difference when comparing Chinese herbal medicine alone to CC, and no studies reported on live birth rates.
“However, there was no significant difference when comparing Chinese herbal medicine alone to CC, and no studies reported on live birth rates, indicating a lack of strong evidence to support its effectiveness in treating PCOS-related infertility.”
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- Authors
- Ried, K.
- Affiliations
- National Institute of Integrative Medicine (AU)
- Corresponding author
- Ried, Karin
- ORCID
- Ried, Karin
- Venue
- Complementary Therapies in Medicine
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 23
- Issue
- 1
- Pages
- 116-128
- ISSN
- 0965-2299 (ISSN-L)
- OpenAlex
- W2073400731
- Cited by
- 96
- References
- 43
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 11 · 2022: 18 · 2021: 9 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 5 · 2016: 8 · 2015: 5
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Complementary Therapies in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Medical Research and Treatments
- Keywords
- Chinese herbal medicine, female infertility, pregnancy rate, polycystic ovary syndrome, endometriosis, anovulation, fallopian tube blockage, unexplained infertility, ovulation rate, basal body temperature, endometrial thickness
- MeSH terms
- Drugs, Chinese Herbal, Female, Humans, Infertility, Female, Medicine, Chinese Traditional, Phytotherapy
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