The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.
Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types
Open accessAbstract
The induction of apoptosis by the p53 protein is critical for its activity as a tumor suppressor. Although it is clear that p53 induces apoptosis at least in part by direct transcriptional activation of target genes, the set of p53 target genes that mediate p53 function in apoptosis in vivo remains to be well defined. The Perp (p53 apoptosis effector related to PMP-22) gene is highly expressed in cells undergoing p53-dependent apoptosis as compared to cells undergoing p53-dependent G1 arrest. Perp is a direct p53 target, and its overexpression is sufficient to induce cell death in fibroblasts, implicating it as an important component of p53 apoptotic function. Here, through the generation of Perp-deficient mice, we analyze the role of Perp in the p53 apoptosis pathway in multiple primary cell types by comparing the cell death responses of Perp null cells to those of wild-type and p53 null cells. These experiments demonstrate the involvement of Perp in p53-mediated cell death in thymocytes and neurons but not in E1A-expressing MEFs, indicating a cell type-specific role for Perp in the p53 cell death pathway. In addition, we show that Perp is not required for proliferation-associated functions of p53. Thus, Perp selectively mediates the p53 apoptotic response, and the requirement for Perp is dictated by cellular context.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“PERP is a novel type of effector involved in p53-dependent apoptosis (28).”
From Prediction of the response to chemotherapy in advanced esophageal cancer by gene expression profiling of biopsy samples (2010) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Live or let die: the cell's response to p53
Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,231
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
Lowe, S. W., Ruley, H. E., Jacks, T., & Housman, D. E. (1993) · Cell · doi:10.1016/0092-8674(93)90719-7 · Cited by 2,911
Self-citationp53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Self-citationThymocyte apoptosis induced by p53-dependent and independent pathways
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271
Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death
Knudson, C. M., Tung, K. S. K., Tourtellotte, W. G., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Science · doi:10.1126/science.270.5233.96 · Cited by 1,492
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
Flores, E. R., Tsai, K. Y., Crowley, D. G., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 815
Self-citationA subset of p53-deficient embryos exhibit exencephaly
Sah, V. P., Attardi, L. D., Mulligan, G., Williams, B. O., Bronson, R. T., & Jacks, T. (1995) · Nature Genetics · doi:10.1038/ng0695-175 · Cited by 594
Self-citation(1993) · PubMed · Cited by 469
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 familyPreprint
Attardi, L. D., Reczek, E. E., Cosmas, C., Demicco, E. G., McCurrach, M. E., Lowe, S. W., & Jacks, T. (2000) · Genes & Development · doi:10.1101/gad.14.6.704 · Cited by 397
Self-citation
Flagged first, then by citations
1 of the 18 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–118 of 118
MECHANISMS OF ANTICANCER DRUG ACTION Chapter II
Wesselborg, S., & Lauber, K. (2005)
Molecular Mechanisms of p63-Derived Ectodermal Dysplasia
Lustig, D. G. (2012) · TSpace (University of Toronto)
Kubanov, A. A., Валентиновна, М. А., Абрамова, Т. В., KOZHUSHNAYA, O. S., Frigo, N. V., & Znamenskaya, L. F. (2013) · Vestnik dermatologii i venerologii · doi:10.25208/vdv568
DNA Damage and the Regulation of Cell Fate
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. E. (2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch23
Wu, F., Wu, W., Ma, X., Xu, H., & Zhang, D. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112326 · Cited by 2
Epidemiology and Embryology of the Bladder Exstrophy: Epispadias Complex
Fernandez, N., Moreno, C., & Bägli, D. (2025) · Springer eBooks · doi:10.1007/978-3-031-91238-2_1
Virtual lineages: in silico lineage tracing from single-cell and spatial transcriptomesPreprint
Lin, Y., & Lin, Y. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.19.760045
Zhou, T. (2012) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/6kmg-k239
Metadata
- Authors
- Ihrie, R. A., Reczek, E., Horner, J. S., Khachatrian, L., Sage, J., Jacks, T., & Attardi, L. D.
- Affiliations
- Stanford Medicine (US)
- Massachusetts Institute of Technology (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Attardi, Laura D.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 13
- Issue
- 22
- Pages
- 1985-1990
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2095424453
- Cited by
- 118
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2022: 9 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3546 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA09302, R01CA093665, CA93665-01, T32CA009302)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- PERP, p53, apoptosis, p53 target genes, tumor suppressor, thymocytes, neurons, G1 cell cycle arrest
- MeSH terms
- Animals, Membrane Proteins, Mice, Mutant Strains, Blotting, Southern, Blotting, Northern, Tumor Suppressor Protein p53, Apoptosis, In Situ Nick-End Labeling, Gene Expression Profiling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
