Cited by 266Alzheimer's disease research and treatmentsNeurobiology and Insect Physiology ResearchGenetics, Aging, and Longevity in Model Organisms

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model

Open access

Khurana, Vikram, Lu, Yiran, Steinhilb, Michelle L., Oldham, Sean, Shulman, Joshua M., Feany, Mel B.·2006·Current Biology

DOI 10.1016/j.cub.2005.12.042

Open this paper in CoChat — free account Open PDF

Abstract

Background Previous studies have demonstrated reexpression of cell-cycle markers within postmitotic neurons in neurodegenerative tauopathies, including Alzheimer's disease (AD). However, the critical questions of whether cell-cycle activation is causal or epiphenomenal to tau-induced neurodegeneration and which signaling pathways mediate cell-cycle activation in tauopathy remain unresolved. Results Cell-cycle activation accompanies wild-type and mutant tau-induced neurodegeneration in Drosophila, and genetically interfering with cell-cycle progression substantially reduces neurodegeneration. Our data support a role for cell-cycle activation downstream of tau phosphorylation, directly preceding apoptosis. We accordingly show that ectopic cell-cycle activation leads to apoptosis of postmitotic neurons in vivo. As in AD, TOR (target of rapamycin kinase) activity is increased in our model and is required for neurodegeneration. TOR activation enhances tau-induced neurodegeneration in a cell cycle-dependent manner and, when ectopically activated, drives cell-cycle activation and apoptosis in postmitotic neurons. Conclusions TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model, identifying TOR and the cell cycle as potential therapeutic targets in tauopathies and AD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cub.2005.12.042

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498
Neurodegenerative Tauopathies
Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480
A Drosophila model of Parkinson's disease
Feany, M. Β., & Bender, W. W. (2000) · Nature · doi:10.1038/35006074 · Cited by 2,156
Self-citation
The tor pathway: a target for cancer therapy
Bjornsti, M., & Houghton, P. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1362 · Cited by 1,318
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293
Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body
Scott, R. C., Schuldiner, O., & Neufeld, T. P. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.009 · Cited by 979
Akt regulates growth by directly phosphorylating Tsc2
Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959
Tauopathy in Drosophila : Neurodegeneration Without Neurofibrillary Tangles
Wittmann, C. W., Wszolek, M. F., Shulman, J. M., Salvaterra, P. M., Lewis, J., Hutton, M., & Feany, M. B. (2001) · Science · doi:10.1126/science.1062382 · Cited by 939
Self-citation
A conditional tissue-specific transgene expression system using inducible GAL4
Osterwalder, T., Yoon, K. S., White, B. H., & Keshishian, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221303298 · Cited by 804
Drosophila S6 kinase: a regulator of cell size.
Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S., & Thomas, G. (1999) · Science · doi:10.1126/science.285.5436.2126 · Cited by 785

Flagged first, then by citations

Show all 52 references

Sorted by citations

Items 101–200 of 266

Rapamycin, proliferation and geroconversion to senescence
Blagosklonny, M. V. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1554781 · Cited by 65
Programmed Cell Death in the Honey Bee (Apis mellifera) (Hymenoptera: Apidae) Worker Brain Induced by Imidacloprid
Wu, Y., Zhou, T., Wang, Q., Dai, P., Xu, S., Jia, H., & Wang, X. (2015) · Journal of Economic Entomology · doi:10.1093/jee/tov146 · Cited by 62
Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer’s disease
van Leeuwen, L. A. G., & Hoozemans, J. J. M. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1382-7 · Cited by 64
Drosophila Models of Tauopathies: What Have We Learned?
Gistelinck, M., Lambert, J., Callaerts, P., Dermaut, B., & Dourlen, P. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/970980 · Cited by 60
A neuroprotective role for the DNA damage checkpoint in tauopathy
Khurana, V., Merlo, P., DuBoff, B., Fulga, T. A., Sharp, K. A., Campbell, S. D., Götz, J., & Feany, M. Β. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00778.x · Cited by 58
Self-citation
mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons
Lee, H.-K., Kwon, B., Lemere, C. A., de la Monte, S., Itamura, K., Ha, A. Y., & Querfurth, H. W. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161029 · Cited by 57
The protein phosphatase PP2A-B′ subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism inDrosophila
Vereshchagina, N., Ramel, M., Bitoun, E., & WILSON, C. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.035220 · Cited by 59
Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases
Jackson, W. S., Borkowski, A. W., Watson, N., King, O. D., Faas, H., Jasanoff, A., & Lindquist, S. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312006110 · Cited by 53
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
Bardai, F. H., Ordonez, D. G., Bailey, R. M., Hamm, M. J., Lewis, J. M., & Feany, M. Β. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006265 · Cited by 55
Self-citation
Alzheimer’s disease and related tauopathies: disorders of disrupted neuronal identity
Frost, B. E. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.07.006 · Cited by 57
Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions
Jahrling, J. B., & Laberge, R.-M. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150610125856 · Cited by 55
Drosophila Models of Proteinopathies: the Little Fly that Could
Rincón-Limas, D. E., Jensen, K., & Fernández-Fúnez, P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315894 · Cited by 51
Physical Activity Alleviates Cognitive Dysfunction of Alzheimer’s Disease through Regulating the mTOR Signaling Pathway
Kou, X., Chen, D., & Chen, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071591 · Cited by 52
The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death.
Copani, A., Caraci, F., Hoozemans, J., Calafiore, M., Sortino, M., & Nicoletti, F. (2007) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2006.10.016 · Cited by 57
Drosophila comet assay: insights, uses, and future perspectives
Gaivão, I., & Sierra, L. M. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00304 · Cited by 48
mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer’s disease
Ma, Y., Wu, D., & LIU, J.-K. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.1186 · Cited by 49
Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila
Bolkan, B. J., & Kretzschmar, D. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22199 · Cited by 47
Multiple drug treatments that increase cAMP signaling restore long-term memory and aberrant signaling in fragile X syndrome models
Choi, C. H., Schoenfeld, B. P., Bell, A. J., Hinchey, J., Rosenfelt, C., Gertner, M. J., Campbell, S. R., Emerson, D., Hinchey, P., Kollaros, M., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00136 · Cited by 46
Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila
Talmat-Amar, Y., Arribat, Y., Redt‐Clouet, C., Feuillette, S., Bougé, A.-L., Lecourtois, M., & Parmentier, M. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr290 · Cited by 48
Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models
Malmanche, N., Dourlen, P., Gistelinck, M., Demiautte, F., Link, N., Dupont, C., Broeck, L. V., Werkmeister, E., Amouyel, P., Bongiovanni, A., et al. (2017) · Scientific Reports · doi:10.1038/srep40764 · Cited by 48
Alzheimer's Disease and tauopathy studies in flies and worms
Wentzell, J. S., & Kretzschmar, D. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.007 · Cited by 46
Nanoparticles as a potential teratogen: a lesson learnt from fruit fly
Barik, B. K., & Mishra, M. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1530393 · Cited by 43
Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosis
Verdaguer, E., Susana, G. D. A., Allgaier, C., Pallàs, M., & Camins, A. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.11.001 · Cited by 43
Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications
Jha, N. K., Jha, N. K., Nuli, M. V., Gupta, S. K., Kanna, S., Gahtani, R. M., Hani, U., Singh, A. K., Abomughaid, M. M., Abomughayedh, A. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102224 · Cited by 43
Accelerated Tau Aggregation, Apoptosis and Neurological Dysfunction Caused by Chronic Oral Administration of Aluminum in a Mouse Model of Tauopathies
Oshima, E., Ishihara, T., Yokota, O., Nakashima‐Yasuda, H., Nagao, S., Ikeda, C., Naohara, J., Terada, S., & Uchitomi, Y. (2013) · Brain Pathology · doi:10.1111/bpa.12059 · Cited by 44
Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease
Galván, V., & Hart, M. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.010 · Cited by 41
Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells
Chatterjee, S., Ambegaokar, S. S., Jackson, G. R., & Mudher, A. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00801 · Cited by 40
Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation
Milošević, J., Schwarz, S. C., Ogunlade, V., Meyer, A. K., Storch, A., & Schwarz, J. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-25 · Cited by 38
Re-cycling Paradigms: Cell Cycle Regulation in Adult Hippocampal Neurogenesis and Implications for Depression
Patrício, P., Mateus‐Pinheiro, A., Sousa, N., & Pinto, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8422-x · Cited by 39
Tau Mutations Serve as a Novel Risk Factor for Cancer
Rossi, G., Redaelli, V., Contiero, P., Fabiano, S., Tagliabue, G., Perego, P., Benussi, L., Bruni, A. C., Filippini, G., Farinotti, M., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3175 · Cited by 38
Expression of Alzheimer-like pathological human tau induces a behavioral motor and olfactory learning deficit in Drosophila melanogaster
Beharry, C., Alaniz, M. E., & Alonso, A. D. C. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130617 · Cited by 39
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
Bardai, F. H., Wang, L., Mutreja, Y., Yenjerla, M., Gamblin, T. C., & Feany, M. B. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1550-17.2017 · Cited by 37
Self-citation
Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies
Yang, T., Tran, K. C., Zeng, A. Y., Massa, S. M., & Longo, F. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-77210-y · Cited by 40
Tau in MAPK Activation
Leugers, C. J., Koh, J. Y., Hong, W., & Lee, G. S. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00161 · Cited by 34
Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders
Soo, S. K., Rudich, P. D., Traa, A., Harris-Gauthier, N., Shields, H. J., & Raamsdonk, J. M. V. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111297 · Cited by 37
Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder
Lundberg, M., Millischer, V., Backlund, L., Martinsson, L., Stenvinkel, P., Sellgren, C. M., Lavebratt, C., & Schalling, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.586083 · Cited by 38
Tau‐induced deficits in nonsense‐mediated mRNA decay contribute to neurodegeneration
Zuniga, G., Levy, S. A., Ramirez, P., Mange, J. D., Gonzalez, E. M., Gamez-Guijarro, M., & Frost, B. E. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12653 · Cited by 37
Distinct Chronology of Neuronal Cell Cycle Re-Entry and Tau Pathology in the 3xTg-AD Mouse Model and Alzheimer's Disease Patients
Hradek, A. C., Lee, H.-P., Siedlak, S. L., Torres, S. L., Jung, W., Han, A. H., & Lee, H.-G. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141083 · Cited by 34
Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β
Povellato, G., Tuxworth, R. I., Hanger, D. P., & Tear, G. (2013) · Biology Open · doi:10.1242/bio.20136692 · Cited by 35
Temporally distinct phosphorylations differentiate Tau-dependent learning deficits and premature mortality in Drosophila
Papanikolopoulou, K., & Skoulakis, E. M. C. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu726 · Cited by 33
Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium
Mahoney, R. E., Ochoa, E., Ramirez, P., Miller, H. E., Beckmann, A., Zuniga, G., Dobrowolski, R., & Frost, B. E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107900 · Cited by 33
Study of tauopathies by comparing Drosophila and human tau in Drosophila
Chen, X., Li, Y., Huang, J., Cao, D., Yang, G., Liu, W., Lu, H., & Guo, A. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0401-y · Cited by 35
Modeling Tauopathy in the Fruit Fly Drosophila melanogaster
Khurana, V. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15403 · Cited by 31
Self-citation
RETRACTED: Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease
Caccamo, A., Belfiore, R., & Oddo, S. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.032 · Cited by 31
Retracted
Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy
Sarkar, S., Murphy, M. A., Dammer, E. B., Olsen, A. L., Rangaraju, S., Fraenkel, E., & Feany, M. Β. (2020) · npj Parkinson s Disease · doi:10.1038/s41531-020-00143-w · Cited by 30
Self-citation
An assessment of the translational relevance of Drosophila in drug discovery
Papanikolopoulou, K., Mudher, A. K., & Skoulakis, E. M. C. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1569624 · Cited by 32
The distinctive role of tau and amyloid beta in mitochondrial dysfunction through alteration in Mfn2 and Drp1 mRNA Levels: A comparative study in Drosophila melanogaster
Abtahi, S., Masoudi, R., & Haddadi, M. (2020) · Gene · doi:10.1016/j.gene.2020.144854 · Cited by 31
Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans Models
Giong, H.-K., Subramanian, M., Yu, K., & Lee, J.-S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168465 · Cited by 31
Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer’s disease
Denéchaud, M., Geurs, S., Comptdaer, T., Bégard, S., García-Núñez, A., Pechereau, L.-A., Bouillet, T., Vermeiren, Y., Deyn, P. P. D., Perbet, R., et al. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102386 · Cited by 29
Quantitative Global Proteomics of Yeast PBP1 Deletion Mutants and Their Stress Responses Identifies Glucose Metabolism, Mitochondrial, and Stress Granule Changes
Seidel, G., Meierhofer, D., Şen, N.-E., Guenther, A., Krobitsch, S., & Auburger, G. W. J. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00647 · Cited by 30
An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration
Leventhal, M. J., Zanella, C. A., Kang, B., Peng, J., Gritsch, D., Liao, Z., Bukhari, H., Wang, T., Pao, P., Danquah, S. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59654-w · Cited by 35
Self-citation
Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration
Ryan, K. C., Ashkavand, Z., Sarasija, S., Laboy, J. T., Samarakoon, R., & Norman, K. R. (2021) · Aging Cell · doi:10.1111/acel.13472 · Cited by 27
Nuclear dynamics and stress responses in Alzheimer’s disease
Iatrou, A., Clark, E. M., & Wang, Y. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00489-6 · Cited by 31
NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases
Na, D., Rouf, M., O’Kane, C. J., Rubinsztein, D. C., & Gsponer, J. A. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-52 · Cited by 27
Pharmacological Treatment of Alzheimer’s Disease: Insights from Drosophila melanogaster
Cheng, X., Song, C., Du, Y., Gaur, U., & Yang, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134621 · Cited by 28
Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases
Liu, D., Ander, B. P., & Sharp, F. R. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.013 · Cited by 27
The Power and Richness of Modelling Tauopathies in Drosophila
Papanikolopoulou, K., & Skoulakis, E. M. C. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8193-1 · Cited by 29
Aging and cancer: can mTOR inhibitors kill two birds with one drug?
Sharp, Z. D., & Richardson, A. G. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0168-7 · Cited by 27
Studying tauopathies in Drosophila: A fruitful model
Sun, M., & Chen, L. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.029 · Cited by 27
Cell Cycle Inhibition without Disruption of Neurogenesis Is a Strategy for Treatment of Aberrant Cell Cycle Diseases: An Update
Liu, D., & Ander, B. P. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/491737 · Cited by 26
Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity
Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809819106 · Cited by 27
Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer’s disease
Beckmann, A., Ramirez, P., Gamez-Guijarro, M., Gonzalez, E. M., Mange, J. D., Bieniek, K. F., Ray, W. J., & Frost, B. E. (2023) · iScience · doi:10.1016/j.isci.2023.106152 · Cited by 24
Genotoxic Effects of Heavy Metal Mixture in Drosophila melanogaster: Expressions of Heat Shock Proteins, RAPD Profiles and Mitochondrial DNA Sequence
Doğanlar, Z. B., Doğanlar, O., & Tabakçioğlu, K. (2014) · Water Air & Soil Pollution · doi:10.1007/s11270-014-2104-9 · Cited by 25
Animal Models of Alzheimer’s Disease
Newman, M., Kretzschmar, D., Khan, I., Chen, M., Verdile, G., & Lardelli, M. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00040-1 · Cited by 25
Everolimus, a mammalian target of rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in male rats
Fanoudi, S., Hosseini, M., Alavi, M. S., Boroushaki, M. T., Hosseini, A., & Sadeghnia, H. R. (2018) · EXCLI journal · doi:10.17179/excli2018-1626 · Cited by 25
Excitatory and Mitogenic Signaling in Cell Death, Blood–brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage
Liu, D., & Sharp, F. R. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0147-z · Cited by 25
Modelling Tauopathies in Drosophila : Insights from the Fruit Fly
Cowan, C. M., Sealey, M. A., Quraishe, S., Targett, M.-T., Marcellus, K. A., Allan, D. W., & Mudher, A. K. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/598157 · Cited by 26
Connecting cell-cycle activation to neurodegeneration in Drosophila
Khurana, V., & Feany, M. Β. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.007 · Cited by 24
Self-citation
An evaluation of Drosophila as a model system for studying tauopathies such as Alzheimer’s disease
Sivanantharajah, L., Mudher, A. K., & Shepherd, D. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.01.001 · Cited by 23
Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster
Shim, K.-H., Kim, S.-H., Hur, J., Kim, D., Demirev, A. V., & Yoon, S. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104519 · Cited by 23
Identification of cis-acting determinants mediating the unconventional secretion of tau
Katsinelos, T., McEwan, W. A., Jahn, T. R., & Nickel, W. (2021) · Scientific Reports · doi:10.1038/s41598-021-92433-3 · Cited by 16
Regulatory mechanism of cyclins and cyclin-dependent kinases in post-mitotic neuronal cell division
Gupta, R. V., Jha, A., Ambasta, R. K., & Kumar, P. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120006 · Cited by 19
The interplay between tauopathy and aging through interruption of UPR/Nrf2/autophagy crosstalk in the Alzheimer’s disease transgenic experimental models
Amini, J., Sanchooli, N., Milajerdi, M.-H., Baeeri, M., Haddadi, M., & Sanadgol, N. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2023.2210409 · Cited by 19
Unraveling Alzheimer’s Disease Using Drosophila
Yeates, C. J., Sarkar, A., Kango‐Singh, M., & Singh, A. (2019) · Springer eBooks · doi:10.1007/978-981-13-2218-1_9 · Cited by 18
A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model
Cho, H.-J., Lee, W. S., Jeong, J., & Lee, J.-S. (2022) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2022.109428 · Cited by 21
CDK1-FOXO1: A mitotic signal takes center stage in post-mitotic neurons
Kim, A. H., & Bonni, A. (2008) · Cell Cycle · doi:10.4161/cc.7.24.7215 · Cited by 17
Drosophila Orthologues to Human Disease Genes: An Update on Progress
Doronkin, S., & Reiter, L. T. (2008) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)00001-9 · Cited by 17
New Approaches to the Pathology and Genetics of Neurodegeneration
Feany, M. Β. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091077 · Cited by 17
Self-citation
Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.
Zhang, X., Zhang, Y., Liu, S., Bulloj, A., Tong, G., Zhang, Z., Liao, F., & Xu, H. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-7 · Cited by 17
Ashwagandha- Withania somnifera (L.) Dunal as a multipotent neuroprotective remedy for genetically induced motor dysfunction and cellular toxicity in human neurodegenerative disease models of Drosophila
Murthy, M. N., & Shyamala, B. V. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116897 · Cited by 16
Melatonin as a Harmonizing Factor of Circadian Rhythms, Neuronal Cell Cycle and Neurogenesis: Additional Arguments for Its Therapeutic Use in Alzheimer’s Disease
Shukla, M., & Vincent, B. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230314142505 · Cited by 17
Pathogenic tau induces an adaptive elevation in mRNA translation rate at early stages of disease
Zuniga, G., Katsumura, S., Mange, J. D., Ramirez, P., Atrian, F., Morita, M., & Frost, B. E. (2024) · Aging Cell · doi:10.1111/acel.14245 · Cited by 15
Targeting Gonadotropins: An Alternative Option for Alzheimer Disease Treatment
Casadesús, G., Puig, E. R., Webber, K. M., Atwood, C., Escuer, M. C., Bowen, R. L., Perry, G. L., & Smith, M. A. (2006) · BioMed Research International · doi:10.1155/jbb/2006/39508 · Cited by 15
Oxidative Stress and Nuclear Reprogramming: A Pilot Study of the Effects of Reactive Oxygen Species on Architectural and Epigenetic Landscapes
Casali, C., Siciliani, S., Galgano, L., & Biggiogera, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010153 · Cited by 14
The Drosophila model system to study tau action
Trotter, M., Stephens, T. D., McGrath, J. P., & Steinhilb, M. L. (2017) · Methods in cell biology · doi:10.1016/bs.mcb.2017.06.006 · Cited by 15
Self-citation
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
Sarkar, S., Bardai, F. H., Olsen, A. L., Lohr, K. M., Zhang, Y., & Feany, M. Β. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00454-3 · Cited by 13
Self-citation
Immunolocalization of phospho-S6 kinases: a new way to detect mitosis in tissue sections and in cell culture
Schmidt, T., Wahl, P. R., Wuthrich, R. P., Vogetseder, A., Picard, N., Kaissling, B., & Hir, M. L. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0255-5 · Cited by 14
Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster
Mensah, L. B., Davison, C., Fan, S., Morris, J. F., Goberdhan, D. C. I., & WILSON, C. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143818 · Cited by 13
Reduced amyloidogenic processing of the amyloid β-protein precursor by the small-molecule Differentiation Inducing Factor-1
Myre, M. A., Washicosky, K. J., Moir, R. D., Tesco, G., Tanzi, R. E., & Wasco, W. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.12.008 · Cited by 13
Stress granules in the spinal muscular atrophy and amyotrophic lateral sclerosis: The correlation and promising therapy
Hu, L., Mao, S., Li, L., Bai, G., Liu, B., & Mao, J. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105749 · Cited by 13
Microtubule disruption upon CNS damage triggers mitotic entry via TNF signaling activation
Barros, C. S., & Bossing, T. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109325 · Cited by 11
Tau Protein: Function and Pathology
Rosenmann, H., Blum, D. L., Kayed, R., & Ittner, L. M. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/707482 · Cited by 12
Therapeutic Targets in Alzheimer's Disease and Related Tauopathies
Corbo, C. P., & Alonso, A. D. C. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00002-8 · Cited by 13
The microtubule-associated protein Tau suppresses the axonal distribution of PDF neuropeptide and mitochondria in circadian clock neurons
Zhang, M. Y., Lear, B. C., & Allada, R. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab303 · Cited by 11
Investigation of PI3K/PKB/mTOR/S6K1 signaling pathway in relationship of type 2 diabetes and Alzheimer's disease.
Ma, Y., Wu, D., Zhang, W., Liu, J., Chen, S., & Hua, B. (2015) · PubMed Central · Cited by 11
S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy
Chiku, T., Motoki, H., Saito, T., Oka, M., Shinno, K., Ohtake, Y., Shimizu, S., Asada, A., Hisanaga, S., Iijima, K., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.07.021 · Cited by 10
Mammalian target of rapamycin/p70 ribosomal S6 protein kinase signaling is altered by sevoflurane and/or surgery in aged rats.
Liu, Y.-Z., Ma, L., Jiao, L.-B., Gao, M.-L., Guo, W.-Z., Chen, L., Pan, N., & Ma, Y.-Q. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4444 · Cited by 11
Insights from Drosophila on Aβ- and tau-induced mitochondrial dysfunction: mechanisms and tools
Varte, V., Munkelwitz, J. W., & Rincón-Limas, D. E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1184080 · Cited by 9
Unraveling the Basis of Neurodegeneration using the Drosophila Eye
Fernández-Fúnez, P., Sanchez-Garcia, J., & Rincón-Limas, D. E. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8232-1_10 · Cited by 9
A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in AdultDrosophila
Loewen, C. A., Boekhoff‐Falk, G., Ganetzky, B., & Chtarbanova, S. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200627 · Cited by 9

Authors: Khurana, V., Lu, Y., Steinhilb, M. L., Oldham, S., Shulman, J. M., & Feany, M. B.
Affiliations: Brigham and Women's Hospital (US)
Sanford Burnham Prebys Medical Discovery Institute (US)
ORCID: Khurana, Vikram
Steinhilb, Michelle L.
Shulman, Joshua M.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2006-02
Volume: 16
Issue: 3
Pages: 230-241
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2005.12.042
OpenAlex: W2064587868
Cited by: 266
References: 52
Citations by year: 2026: 4 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 12 · 2018: 14 · 2017: 9 · 2016: 10 · 2015: 18 · 2014: 17 · 2013: 16 · 2012: 18
FWCI: 11.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2759 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-19790, AG88001, R01AG019790)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: tauopathy, neurodegeneration, TOR signaling, cell cycle re-entry, postmitotic neurons, tau phosphorylation, apoptosis, Alzheimer's disease, Drosophila model, therapeutic target
MeSH terms: Animals, Cell Cycle, Drosophila, Enzyme Activation, Immunohistochemistry, Neurons, Protein Kinases, Blotting, Western, Signal Transduction, Apoptosis, Phosphatidylinositol 3-Kinases, In Situ Nick-End Labeling, Tauopathies, Drosophila Proteins, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks