Multiple drug treatments that increase cAMP signaling restore long-term memory and aberrant signaling in fragile X syndrome models
Open accessAbstract
Fragile X is the most common monogenic disorder associated with intellectual disability (ID) and autism spectrum disorders (ASD). Additionally, many patients are afflicted with executive dysfunction, ADHD, seizure disorder and sleep disturbances. Fragile X is caused by loss of FMRP expression, which is encoded by the FMR1 gene. Both the fly and mouse models of fragile X are also based on having no functional protein expression of their respective FMR1 homologs. The fly model displays well defined cognitive impairments and structural brain defects and the mouse model, although having subtle behavioral defects, has robust electrophysiological phenotypes and provides a tool to do extensive biochemical analysis of select brain regions. Decreased cAMP signaling has been observed in samples from the fly and mouse models of fragile X as well as in samples derived from human patients. Indeed, we have previously demonstrated that strategies that increase cAMP signaling can rescue short term memory in the fly model and restore DHPG induced mGluR mediated long term depression (LTD) in the hippocampus to proper levels in the mouse model (McBride et al., 2005; Choi et al., 2011, 2015). Here, we demonstrate that the same three strategies used previously with the potential to be used clinically, lithium treatment, PDE-4 inhibitor treatment or mGluR antagonist treatment can rescue long term memory in the fly model and alter the cAMP signaling pathway in the hippocampus of the mouse model.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Animal studies have shown that a phosphordiasterase 4DE inhibitor can rescue features of FXS in the KO mouse model and Drosophila model and can raise cAMP levels to normal.
“Recent animal studies have shown that an inhibitor of cAMP breakdown called a phosphordiasterase 4DE inhibitor can rescue features of FXS in the KO mouse model and Drosophila model and can raise the cAMP levels to normal [141, 142].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [141]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545 · see citing works
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works
Siegel, S. (1957) · The American Statistician · doi:10.1080/00031305.1957.10501091 · Cited by 2,792 · see citing works
Self-citationA molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072 · see citing works
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,352 · see citing works
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349 · see citing works
Classical conditioning and retention in normal and mutantDrosophila melanogaster
Tully, T., & Quinn, W. G. (1985) · Journal of Comparative Physiology A · doi:10.1007/bf01350033 · Cited by 1,189 · see citing works
Hallcher, L. M., & Sherman, W. R. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70391-3 · Cited by 1,102 · see citing works
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,075 · see citing works
Inositol Trisphosphate and Calcium Signaling
Berridge, M. J. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb26646.x · Cited by 1,031 · see citing works
Neural and developmental actions of lithium: A unifying hypothesis
Berridge, M. J., Downes, C. P., & Hanley, M. R. (1989) · Cell · doi:10.1016/0092-8674(89)90026-3 · Cited by 1,016 · see citing works
Correction of Fragile X Syndrome in Mice
Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979 · see citing works
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959 · see citing works
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., & Darnell, R. B. (2001) · Cell · doi:10.1016/s0092-8674(01)00566-9 · Cited by 952 · see citing works
Genetic dissection of consolidated memory in Drosophila
Tully, T., Preat, T., Boynton, S. C., & Del Vecchio, M. (1994) · Cell · doi:10.1016/0092-8674(94)90398-0 · Cited by 924 · see citing works
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
Fang, X., Yu, S. X., Lu, Y., Bast, R. C., Woodgett, J. R., & Mills, G. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220413597 · Cited by 833 · see citing works
FMR1 and the fragile X syndrome: Human genome epidemiology review
Crawford, D. C., Acuña, J. M., & Sherman, S. L. (2001) · Genetics in Medicine · doi:10.1097/00125817-200109000-00006 · Cited by 711 · see citing works
Noble, W., Planel, E., Zehr, C., Olm, V., Meyerson, J., Suleman, F., Gaynor, K., Wang, L., LaFrancois, J., Feinstein, B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500466102 · Cited by 709 · see citing works
Impey, S., McCorkle, S., Cha‐Molstad, H., Dwyer, J. M., Yochum, G. S., Boss, J. M., McWeeney, S. K., Dunn, J. J., Mandel, G., & Goodman, R. H. (2004) · Cell · doi:10.1016/j.cell.2004.10.032 · Cited by 695 · see citing works
Hall, J. C. (1994) · Science · doi:10.1126/science.8209251 · Cited by 668 · see citing works
Conditioned Behavior in Drosophila melanogaster
Quinn, W. G., Harris, W. A., & Benzer, S. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.3.708 · Cited by 659 · see citing works
Yin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T. (1995) · Cell · doi:10.1016/0092-8674(95)90375-5 · Cited by 642 · see citing works
Zhang, Y., Bailey, A. M., Matthies, H. J. G., Renden, R., Smith, M. A., Speese, S. D., Rubin, G. M., & Broadie, K. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00589-x · Cited by 641 · see citing works
Jacquemont, S., Curie, A., des Portes, V., Torrioli, M. G., Berry-Kravis, E., Hagerman, R. J., Ramos, F. J., Cornish, K., He, Y., Paulding, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001708 · Cited by 609 · see citing works
Localization of a Short-Term Memory in Drosophila
Zars, T. D., Fischer, M., Schulz, R. A., & Heisenberg, M. (2000) · Science · doi:10.1126/science.288.5466.672 · Cited by 600 · see citing works
Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity
Kelleher, R. J., Govindarajan, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.013 · Cited by 592 · see citing works
(1994) · PubMed · Cited by 565 · see citing works
Dysregulation of mTOR signaling in fragile X syndrome
Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557 · see citing works
Self-citationVitolo, O. V., Sant'Angelo, A., Costanzo, V., Battaglia, F., Arancio, O., & Shelanski, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172504199 · Cited by 534 · see citing works
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
Yan, Q. J., Rammal, M., Tranfaglia, M., & Bauchwitz, R. P. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.06.004 · Cited by 521 · see citing works
Courtship Behavior in Drosophila
Spieth, H. T. (1974) · Annual Review of Entomology · doi:10.1146/annurev.en.19.010174.002125 · Cited by 494 · see citing works
Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
Michalon, A., Sidorov, M., Ballard, T. M., Ozmen, L., Spooren, W., Wettstein, J. G., Jaeschke, G., Bear, M. F., & Lindemann, L. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.009 · Cited by 489 · see citing works
Conditioned responses in courtship behavior of normal and mutant Drosophila
Siegel, R. W., & Hall, J. C. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3430 · Cited by 488 · see citing works
McBride, S. M. J., Choi, C. H., Wang, Y., Liebelt, D. A., Braunstein, E. M., Ferreiro, D., Sehgal, A., Siwicki, K. K., Dockendorff, T. C., Nguyen, H. T., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.038 · Cited by 473 · see citing works
Self-citationLithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3
Hong, M., Chen, D. C. R., Klein, P. S., & Lee, V. M. ‐. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25326 · Cited by 470 · see citing works
Hou, L., Antion, M. D., Hu, D., Spencer, C. M., Paylor, R., & Klann, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.005 · Cited by 469 · see citing works
CREB DNA binding activity is inhibited by glycogen synthase kinase‐3β and facilitated by lithium
Grimes, C. A., & Jope, R. S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00495.x · Cited by 437 · see citing works
The Courtship of Drosophila Melanogaster
Bastock, M., & Manning, A. (1955) · Behaviour · doi:10.1163/156853955x00184 · Cited by 411 · see citing works
CREB and the formation of long-term memory
Yin, J. C. P., & Tully, T. P. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80082-1 · Cited by 399 · see citing works
Osterweil, E. K., Krueger, D. D., Reinhold, K., & Bear, M. F. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3888-10.2010 · Cited by 384 · see citing works
Glycogen Synthase Kinase-3: a Putative Molecular Target for Lithium Mimetic Drugs
Gould, T. D., & Manji, H. K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300731 · Cited by 377 · see citing works
Martínez, F. J., Calverley, P. M. A., Goehring, U.-M., Brose, M., Fabbri, L. M., & Rabe, K. F. (2015) · The Lancet · doi:10.1016/s0140-6736(14)62410-7 · Cited by 376 · see citing works
Localization of Long-Term Memory Within the Drosophila Mushroom Body
Pascual, A., & Préat, T. (2001) · Science · doi:10.1126/science.1064200 · Cited by 368 · see citing works
Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β
Li, M., Wang, X., Meintzer, M. K., Laessig, T. A., Birnbaum, M. J., & Heidenreich, K. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9356-9363.2000 · Cited by 363 · see citing works
Targeting the CREB pathway for memory enhancers
Tully, T., Bourtchouladze, R., Scott, R., & Tallman, J. F. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1061 · Cited by 355 · see citing works
The fragile X prevalence paradox
Hagerman, P. J. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.059055 · Cited by 343 · see citing works
Deconstructing Memory in Drosophila
Margulies, C. E., Tully, T., & Dubnau, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.024 · Cited by 336 · see citing works
MAPK, CREB and zif268 are all required for the consolidation of recognition memory
Bozon, B., Kelly, A. M., Josselyn, S. A., Silva, A. J., Davis, S., & Laroche, S. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1224 · Cited by 327 · see citing works
Experiments on sex recognition and the problem of sexual selection in Drosoophilia.
Sturtevant, A. H. (1915) · Journal of Animal Behavior · doi:10.1037/h0074109 · Cited by 322 · see citing works
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
Small, S. A., & Gandy, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.001 · Cited by 320 · see citing works
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
de Vrij, F. M. S., Levenga, J., van der Linde, H. C., Koekkoek, S. K., De Zeeuw, C. I., Nelson, D. L., Oostra, B. A., & Willemsen, R. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.04.002 · Cited by 313 · see citing works
Yuan, S., Ryder, J. W., Li, B., Wu, X., Fox, N. W., Solenberg, P., Brune, K. A., Paul, S. M., Zhou, Y., Liu, F., et al. (2004) · Biochemistry · doi:10.1021/bi035627j · Cited by 295 · see citing works
Nosyreva, E. D., & Huber, K. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01316.2005 · Cited by 292 · see citing works
Dockendorff, T. C., Su, H. S., McBride, S. M. J., Yang, Z., Choi, C. H., Siwicki, K. K., Sehgal, A., & Jongens, T. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00724-9 · Cited by 284 · see citing works
Self-citationFragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1
Jacquemont, S., Hagerman, R. J., Hagerman, P. J., & Leehey, M. A. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70676-7 · Cited by 277 · see citing works
Chen, A. Y.-C., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., Cepeda, I. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00501-4 · Cited by 276 · see citing works
TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model
Khurana, V., Lu, Y., Steinhilb, M. L., Oldham, S., Shulman, J. M., & Feany, M. B. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.042 · Cited by 266 · see citing works
Function of the Drosophila CPEB protein Orb2 in long-term courtship memory
Keleman, K., Krüttner, S., Alenius, M., & Dickson, B. J. (2007) · Nature Neuroscience · doi:10.1038/nn1996 · Cited by 266 · see citing works
McBride, S. M. J., Giuliani, G., Choi, C. H., Krause, P., Correale, D., Watson, K. K., Baker, G., & Siwicki, K. K. (1999) · Neuron · doi:10.1016/s0896-6273(00)81043-0 · Cited by 261 · see citing works
Self-citationBanko, J. L., Hou, L., Poulin, F., Sonenberg, N., & Klann, E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5196-05.2006 · Cited by 245 · see citing works
A GENE MUTATION WHICH CHANGES A BEHAVIOR PATTERN
Bastock, M. (1956) · Evolution · doi:10.1111/j.1558-5646.1956.tb02868.x · Cited by 243 · see citing works
Yuskaitis, C. J., & Jope, R. S. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2008.10.014 · Cited by 240 · cited 1× · see citing works
“…found that audiogenic seizures, open field testing and cerebral protein synthesis phenotypes can be reliably obtained and rescued by lithium or GSK3B inhibition (Min et al., 2009a; Yuskaitis and Jope, 2009; Mines et al., 2010; Yuskaitis et al., 2010; Liu et al., 2011, 2012; Mines and Jope, 2011).”
BackgroundPasinetti, G. M., Wang, J., Ho, L., Zhao, W., & Dubner, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.006 · Cited by 238 · see citing works
Drosophila Fragile X Protein, DFXR, Regulates Neuronal Morphology and Function in the Brain
Morales, J., Hiesinger, P. R., Schroeder, A. J., Kume, K., Verstreken, P., Jackson, F. R., Nelson, D. L., & Hassan, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00731-6 · Cited by 238 · see citing works
Fragile-X Carrier Screening and the Prevalence of Premutation and Full-Mutation Carriers in Israel
Toledano‐Alhadef, H., Basel‐Vanagaite, L., Magal, N., Davidov, B., Ehrlich, S., Drasinover, V., Taub, E., Halpern, G. J., Ginott, N., & Shohat, M. (2001) · The American Journal of Human Genetics · doi:10.1086/321974 · Cited by 228 · see citing works
Engel, T., Goñi‐Oliver, P., Lucas, J. J., Avila, J., & Hernández, F. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04139.x · Cited by 223 · see citing works
Altered Representation of the Spatial Code for Odors after Olfactory Classical Conditioning
Yu, D., Ponomarev, A. L., & Davis, R. L. (2004) · Neuron · doi:10.1016/s0896-6273(04)00217-x · Cited by 222 · see citing works
Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders
Hashimoto, K., Malchow, B., Falkai, P., & Schmitt, A. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0399-y · Cited by 219 · see citing works
InsP3 Receptor Is Essential for Growth and Differentiation but Not for Vision in Drosophila
Acharya, J., Jalink, K., Hardy, R. W., Hartenstein, V., & Zuker, C. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80328-1 · Cited by 218 · see citing works
Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome
Berry-Kravis, E., Sumis, A., Hervey, C., Nelson, M., Porges, S. W., Weng, N., Weiler, I. J., & Greenough, W. T. (2008) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e31817dc447 · Cited by 215 · see citing works
The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits
Christie, S. B., Akins, M. R., Schwob, J. E., & Fallon, J. R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3937-08.2009 · Cited by 208 · see citing works
Mines, M. A., Yuskaitis, C. J., King, M. K., Beurel, E., & Jope, R. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009706 · Cited by 208 · see citing works
Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E., & Tassone, F. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00768.x · Cited by 198 · see citing works
Self-citationBDNF‐mediated signal transduction is modulated by GSK3β and mood stabilizing agents
Mai, L., Jope, R. S., & Li, X. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00939.x · Cited by 195 · see citing works
Walsh, C. A., Morrow, E. M., & Rubenstein, J. L. R. (2008) · Cell · doi:10.1016/j.cell.2008.10.015 · Cited by 194 · see citing works
Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory
Bolduc, F. V., Bell, K., Cox, H., Broadie, K. S., & Tully, T. (2008) · Nature Neuroscience · doi:10.1038/nn.2175 · Cited by 187 · see citing works
Self-citationYuskaitis, C. J., Mines, M. A., King, M. K., Sweatt, J. D., Miller, C. A., & Jope, R. S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.023 · Cited by 187 · see citing works
Chow, S., Patel, H., & Hedley, D. W. (2001) · Cytometry · doi:10.1002/cyto.1067 · Cited by 181 · see citing works
Hu, Y., Xu, P., Pigino, G. F., Brady, S. T., Larson, J., & Lazarov, O. (2010) · The FASEB Journal · doi:10.1096/fj.09-136945 · Cited by 168 · see citing works
Bullock, B. P., & Habener, J. F. (1998) · Biochemistry · doi:10.1021/bi970982t · Cited by 167 · see citing works
Functional neuroanatomy of Drosophila olfactory memory formationPreprint
Guven-Ozkan, T., & Davis, R. L. (2014) · Learning & Memory · doi:10.1101/lm.034363.114 · Cited by 166 · see citing works
Lithium and valproic acid: parallels and contrasts in diverse signaling contexts
Gurvich, N. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00299-1 · Cited by 162 · see citing works
Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome
Liu, Z., Chuang, D., & Smith, C. B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000520 · Cited by 159 · see citing works
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element
Cha‐Molstad, H., Keller, D. M., Yochum, G. S., Impey, S., & Goodman, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405587101 · Cited by 148 · see citing works
Prevalence of the fragile X syndrome in African‐Americans
Crawford, D. C., Meadows, K. L., Newman, J. L., Taft, L. F., Scott, E., Leslie, M., Shubeck, L., Holmgreen, P., Yeargin‐Allsopp, M., Boyle, C. A., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10427 · Cited by 147 · see citing works
Min, W. W., Yuskaitis, C. J., Yan, Q., Sikorski, C., Chen, S., Jope, R. S., & Bauchwitz, R. P. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.09.017 · Cited by 146 · see citing works
Baraban, J. M., Worley, P. F., & Snyder, S. H. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.10.1251 · Cited by 141 · see citing works
Tanji, C., Yamamoto, H., Yorioka, N., Kohno, N., Kikuchi, K., & Kikuchi, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206210200 · Cited by 140 · see citing works
Dumont, M., Stack, C., Elipenahli, C., Jainuddin, S., Gerges, M., Starkova, N. N., Yang, L., Starkov, A. A., & Beal, F. M. (2011) · The FASEB Journal · doi:10.1096/fj.11-186650 · Cited by 139 · see citing works
Son, H., Yu, I. T., Hwang, S., Kim, J. S., Lee, S., Lee, Y., & Kaang, B. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01725.x · Cited by 138 · see citing works
Learning Decreases Aβ*56 and Tau Pathology and Ameliorates Behavioral Decline in 3xTg-AD Mice
Billings, L. M., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4800-06.2007 · Cited by 138 · see citing works
Petry, F. R., Pelletier, J., Bretteville, A., Morin, F., Calon, F., Hébert, S. S., Whittington, R. A., & Planel, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094251 · Cited by 136 · see citing works
Kavanaugh, A., Mease, P. J., Gómez-Reino, J. J., Adebajo, A., Wollenhaupt, J., Gladman, D. D., Hochfeld, M., Teng, L. L., Schett, G. A., Lespessailles, É., et al. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.140647 · Cited by 135 · see citing works
Hu, Y.-S., Long, N., Pigino, G. F., Brady, S. T., & Lazarov, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064460 · Cited by 134 · see citing works
Molecular biology and anatomy of Drosophila olfactory associative learning
Roman, G., & Davis, R. L. (2001) · BioEssays · doi:10.1002/bies.1083 · Cited by 134 · see citing works
Cavallini, A., Brewerton, S., Bell, A., Sargent, S., Glover, S., Hardy, C., Moore, R., Calley, J., Ramachandran, D., Poidinger, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.463984 · Cited by 133 · cited 1× · see citing works
“One of the most well characterized substrates of GSK-3βmediated phosphorylation is the protein tau at serine 202, which was examined in order to get a more sensitive indication of GSK-3β activity (Dumont et al., 2011; Cavallini et al., 2013; Petry et al., 2014).”
BackgroundSelf-citationParmentier, M., Pin, J., Bockaert, J., & Grau, Y. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06687.1996 · Cited by 122 · see citing works
Inositol 1,4,5-trisphosphate receptor binding: autoradiographic localization in rat brain
Worley, P. F., Baraban, J. M., & Snyder, S. H. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-01-00339.1989 · Cited by 121 · see citing works
Social structures depend on innate determinants and chemosensory processing in Drosophila
Schneider, J., Dickinson, M. H., & Levine, J. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121252109 · Cited by 115 · see citing works
Spencer, C. M., Serysheva, E., Yuva‐Paylor, L. A., Oostra, B. A., Nelson, D. L., & Paylor, R. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl121 · Cited by 115 · see citing works
Fujii, S., Matsumoto, M., Igarashi, K., Kato, H., & Mikoshiba, K. (2000) · Learning & Memory · doi:10.1101/lm.34100 · Cited by 111 · see citing works
Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice
Westmark, C. J., Westmark, P. R., O'Riordan, K. J., Ray, B. C., Hervey, C. M., Salamat, M. S., Abozeid, S. H., Stein, K. M., Stodola, L. A., Tranfaglia, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026549 · Cited by 110 · see citing works
Metabolic effects of resveratrol: Addressing the controversies
Bitterman, J. L., & Chung, J. H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1808-8 · Cited by 109 · see citing works
Mapping of the Anatomical Circuit of CaM Kinase-Dependent Courtship Conditioning in DrosophilaPreprint
Joiner, M.-L. A., & Griffith, L. C. (1999) · Learning & Memory · doi:10.1101/lm.6.2.177 · Cited by 107 · see citing works
A Gene Mutation Which Changes a Behavior Pattern
Bastock, M. (1956) · Evolution · doi:10.2307/2407002 · Cited by 105 · see citing works
Choi, C. H., Schoenfeld, B. P., Bell, A. J., Hinchey, P., Kollaros, M., Gertner, M. J., Woo, N. H., Tranfaglia, M. R., Bear, M. F., Zukin, R. S., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.032 · Cited by 104 · see citing works
Self-citationMetabotropic Glutamate Receptor-Mediated LTD Involves Two Interacting Ca2+ Sensors, NCS-1 and PICK1
Jo, J., Seok, H., Kim, M. J., Son, G. H., Park, Y., Henley, J. M., Weiss, J. L., Sheng, M., Collingridge, G. L., & Cho, K. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.050 · Cited by 97 · see citing works
Understanding fragile X syndrome: insights from animal models
Bakker, C. E., & Oostra, B. A. (2003) · Cytogenetic and Genome Research · doi:10.1159/000072845 · Cited by 87 · see citing works
Bogdanik, L. P., Mohrmann, R., Ramaekers, A., Bockaert, J., Grau, Y., Broadie, K. S., & Parmentier, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2724-04.2004 · Cited by 86 · see citing works
The Cyclic AMP Cascade Is Altered in the Fragile X Nervous System
Kelley, D. J., Davidson, R. J., Elliott, J. L., Lahvis, G. P., Yin, J. C. P., & Bhattacharyya, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000931 · Cited by 81 · see citing works
Cyclic AMP metabolism in fragile X syndrome
Berry‐Kravis, E., & Huttenlocher, P. R. (1992) · Annals of Neurology · doi:10.1002/ana.410310105 · Cited by 81 · see citing works
Learning without Performance in PKC-Deficient Drosophila
Kane, N. S., Robichon, A., Dickinson, J. A., & Greenspan, R. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80270-6 · Cited by 75 · see citing works
Kanellopoulos, A. K., Σεμελίδου, Ο., Kotini, A. G., Anezaki, M., & Skoulakis, E. M. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1347-12.2012 · Cited by 72 · see citing works
Early‐phase ERK activation as a biomarker for metabolic status in fragile X syndrome
Weng, N., Weiler, I. J., Sumis, A. M., Berry‐Kravis, E., & Greenough, W. T. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30765 · Cited by 72 · see citing works
Kelly, M. P., Isiegas, C., Cheung, Y.-F., Tokarczyk, J., Yang, X., Esposito, M. F., Rapoport, D. A., Fabian, S., Siegel, S. J., Wand, G. S., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301099 · Cited by 71 · see citing works
Self-citationXie, J., Ponuwei, G. A., Moore, C. E., Willars, G. B., Tee, A. R., & Herbert, T. P. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.06.025 · Cited by 69 · see citing works
A prospective open-label study of aripiprazole in fragile X syndrome
Erickson, C. A., Stigler, K. A., Wink, L. K., Mullett, J. E., Kohn, A., Posey, D. J., & McDougle, C. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2194-7 · Cited by 69 · see citing works
Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome
Mines, M. A., & Jope, R. S. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00035 · Cited by 68 · see citing works
Pan, L., Woodruff, E. A., Liang, P., & Broadie, K. S. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.01.003 · Cited by 66 · see citing works
Reduced Cyclic AMP Production in Fragile X Syndrome: Cytogenetic and Molecular Correlations
Berry‐Kravis, E., Hicar, M. D., & Ciurlionis, R. (1995) · Pediatric Research · doi:10.1203/00006450-199511000-00002 · Cited by 66 · see citing works
Liu, Z., Huang, T., & Smith, C. B. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.037 · Cited by 64 · see citing works
Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue
Choi, C. H., McBride, S. M. J., Schoenfeld, B. P., Liebelt, D. A., Ferreiro, D., Ferrick, N. J., Hinchey, P., Kollaros, M., Ascunce, R. R., Terlizzi, A. M., et al. (2009) · Biogerontology · doi:10.1007/s10522-009-9259-6 · Cited by 62 · see citing works
Self-citationKim, S. H., Steele, J., Lee, S. W., Clemenson, G. D., Carter, T., Treuner, K., Gadient, R. A., Wedel, P. C., Glabe, C. G., Barlow, C., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.87 · Cited by 62 · see citing works
Acharya, J., Labarca, P. P., Delgado, R., Jalink, K., & Zuker, C. S. (1998) · Neuron · doi:10.1016/s0896-6273(00)80502-4 · Cited by 59 · see citing works
Choi, C. H., Schoenfeld, B. P., Weisz, E. D., Bell, A. J., Chambers, D. B., Hinchey, J., Choi, R. J., Hinchey, P., Kollaros, M., Gertner, M. J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1356-12.2015 · Cited by 57 · see citing works
Self-citationBanerjee, P., Schoenfeld, B. P., Bell, A. J., Choi, C. H., Bradley, M. P., Hinchey, P., Kollaros, M., Park, J. H., McBride, S. M. J., & Dockendorff, T. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6369-09.2010 · Cited by 55 · see citing works
Self-citationInvolvement of IP3 receptors in LTP and LTD induction in guinea pig hippocampal CA1 neuronsPreprint
Taufiq, A. M., Fujii, S., Yamazaki, Y., Sasaki, H., Kaneko, K., Li, J., Kato, H., & Mikoshiba, K. (2005) · Learning & Memory · doi:10.1101/lm.17405 · Cited by 55 · see citing works
Pan, L., & Broadie, K. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2970-07.2007 · Cited by 54 · see citing works
Gene Expression Profiles in a Transgenic Animal Model of Fragile X Syndrome
D’Agata, V., Warren, S. T., Zhao, W., Torre, E. R., Alkon, D. L., & Cavallaro, S. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0506 · Cited by 54 · see citing works
An Open-Label Naturalistic Pilot Study of Acamprosate in Youth with Autistic Disorder
Erickson, C. A., Early, M. C., Stigler, K. A., Wink, L. K., Mullett, J. E., & McDougle, C. J. (2011) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0034 · Cited by 53 · see citing works
Tong, F. K., Chow, S., & Hedley, D. W. (2006) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20092 · Cited by 52 · see citing works
Sugin Lal Jabaris, S., Sumathy, H., Kumar, R. S., Narayanan, S., Thanikachalam, S., & Chidambaram, S. B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.039 · Cited by 47 · see citing works
Ornstein, P. L., Arnold, M. B., Bieisch, T. J., Wright, R. A., Wheeler, W. J., & Schoepp, D. D. (1998) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(98)00329-1 · Cited by 43 · see citing works
McBride, S. M. J., Choi, C. H., Schoenfeld, B. P., Bell, A. J., Liebelt, D. A., Ferreiro, D. M., Choi, R. J., Hinchey, P., Kollaros, M., Terlizzi, A. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1017-10.2010 · Cited by 43 · see citing works
Self-citationAn assay for social interaction in Drosophila fragile X mutants
Bolduc, F. V., Valente, D., Nguyen, A. T., Mitra, P. P., & Tully, T. (2010) · Fly · doi:10.4161/fly.4.3.12280 · Cited by 42 · see citing works
Self-citationKreibich, T. A., Chalasani, S. H., & Raper, J. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0349-04.2004 · Cited by 42 · see citing works
Overexpression of fragile X gene (FMR-1) transcripts increases cAMP production in neural cells.
Berry‐Kravis, E. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980101)51:1 · Cited by 42 · see citing works
Flies, genes, learning, and memory
Greenspan, R. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90165-5 · Cited by 38 · see citing works
Spencer, K. (2000) · Prenatal Diagnosis · doi:10.1002/1097-0223(200008)20:8 · Cited by 37 · see citing works
Metabolic benefits of inhibiting cAMP-PDEs with resveratrol
Chung, J. H. (2012) · Adipocyte · doi:10.4161/adip.21158 · Cited by 35 · see citing works
Hou, J., Kuromi, H., Fukasawa, Y., Ueno, K., Sakai, T., & Kidokoro, Y. (2004) · Journal of Neurobiology · doi:10.1002/neu.20021 · Cited by 35 · see citing works
FMR1 Enhancer Is Regulated by cAMP Through a cAMP-Responsive Element
Hwu, W., WANG, T.-R., & LEE, Y.-M. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.449 · Cited by 30 · see citing works
Inhibitory effects of group II mGluR-related drugs on memory performance in mice
Sato, T., Tanaka, K., Ohnishi, Y., Teramoto, T., Irifune, M., & Nishikawa, T. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2003.12.010 · Cited by 29 · see citing works
Conditions Affecting Social Space in Drosophila melanogaster
McNeil, A. R., Jolley, S. N., Akinleye, A. A., Nurilov, M., Rouzyi, Z., Milunovich, A. J., Chambers, M. C., & Simon, A. F. (2015) · Journal of Visualized Experiments · doi:10.3791/53242 · Cited by 26 · see citing works
Inhibition of GSK-3β enhances reovirus-induced apoptosis in colon cancer cells
Chung (2009) · International Journal of Oncology · doi:10.3892/ijo_00000373 · Cited by 23 · see citing works
The Drosophila DmGluRA is required for social interaction and memory
Schoenfeld, B. P., Choi, R. J., Choi, C. H., Terlizzi, A. M., Hinchey, P., Kollaros, M., Ferrick, N. J., Koenigsberg, E., Ferreiro, D., Leibelt, D. A., et al. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00064 · Cited by 18 · see citing works
Self-citationExamination of methylphenidate-mediated behavior regulation by glycogen synthase kinase-3 in mice
Mines, M. A., Beurel, E., & Jope, R. S. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.10.018 · Cited by 16 · see citing works
Melancon, B. J., Utley, T. J., Sevel, C., Mattmann, M. E., Cheung, Y., Bridges, T. M., Morrison, R. D., Sheffler, D. J., Niswender, C. M., Daniels, J. S., et al. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.06.018 · Cited by 16 · see citing works
Davis, J. S., Weakland, L. L., Coffey, R. G., & West, L. A. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.3.e368 · Cited by 16 · see citing works
Turner (1996) · doi:10.1002/(sici)1096-8628(19960712)64:1
Flagged first, then by citations
Cited by
Sorted by citations
An Update on Psychopharmacological Treatment of Autism Spectrum Disorder
Aishworiya, R., Valica, T., Hagerman, R., & Restrepo, B. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01183-1 · Cited by 233 · see citing works
Of Men and Mice: Modeling the Fragile X Syndrome
Dahlhaus, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00041 · Cited by 118 · see citing works
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome
Thomson, S. R., Seo, S. S., Barnes, S. A., Louros, S. R., Muscas, M., Dando, O., Kirby, C., Wyllie, D. J. A., Hardingham, G. E., Kind, P. C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.013 · Cited by 100 · see citing works
Molecular Mechanisms of Synaptic Dysregulation in Fragile X Syndrome and Autism Spectrum Disorders
Telias, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00051 · Cited by 79 · see citing works
Altered dendritic spine function and integration in a mouse model of fragile X syndrome
Booker, S. A., Domanski, A. P. F., Dando, O., Jackson, A. D., Isaac, J. T. R., Hardingham, G. E., Wyllie, D. J. A., & Kind, P. C. (2019) · Nature Communications · doi:10.1038/s41467-019-11891-6 · Cited by 70 · see citing works
Sethna, F., Feng, W., Ding, Q., Robison, A. J., Feng, Y., & Wang, H. (2017) · Nature Communications · doi:10.1038/ncomms14359 · Cited by 60 · see citing works
McCamphill, P. K., Stoppel, L. J., Senter, R. K., Lewis, M. C., Heynen, A. J., Stoppel, D. C., Sridhar, V., Collins, K. A., Shi, X., Pan, J. Q., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aam8572 · Cited by 57 · see citing works
Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome
Maurin, T., Melancia, F., Jarjat, M., Castro, L. R., Costa, L., Delhaye, S., Khayachi, A., Castagnola, S., Mota, É., Giorgio, A. D., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy192 · Cited by 49 · see citing works
Costa, L., Sardone, L. M., Bonaccorso, C. M., D’Antoni, S., Spatuzza, M., Gulisano, W., Tropea, M. R., Puzzo, D., Leopoldo, M., Lacivita, E., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00353 · Cited by 49 · see citing works
Negative Effects of Chronic Rapamycin Treatment on Behavior in a Mouse Model of Fragile X Syndrome
Saré, R. M., Song, A., Loutaev, I., Cook, A. K., Maita, I., Lemons, A. H. S., Sheeler, C. A., & Smith, C. B. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00452 · Cited by 43 · see citing works
Long, J., Li, H., Liu, Y., Liao, X., Tang, Z., Han, K., Chen, J., & Zhang, H. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1364858 · Cited by 43 · see citing works
Repurposing available drugs for neurodevelopmental disorders: The fragile X experience
Tranfaglia, M. R., Thibodeaux, C., Mason, D. J., Brown, D., Roberts, I., Smith, R. J., Guilliams, T., & Cogram, P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.004 · Cited by 39 · see citing works
D’Antoni, C., Mautone, L., Sanchini, C., Tondo, L., Grassmann, G., Cidonio, G., Bezzi, P., Cordella, F., & Angelantonio, S. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310762 · Cited by 39 · see citing works
Resveratrol in Autism Spectrum Disorders: Behavioral and Molecular Effects
Malaguarnera, M., Khan, H. Z., & Cauli, O. (2020) · Antioxidants · doi:10.3390/antiox9030188 · Cited by 38 · see citing works
Fan, C.-X., Gao, Y., Liang, G., Huang, L., Wang, J., Yang, X., Shi, Y., Dräger, U. C., Zhong, M., Gao, T., et al. (2020) · Molecular Autism · doi:10.1186/s13229-020-0318-9 · Cited by 35 · see citing works
Excessive proteostasis contributes to pathology in fragile X syndrome
Louros, S. R., Seo, S. S., Maio, B., Martinez‐Gonzalez, C., Gonzalez‐Lozano, M. A., Muscas, M., Verity, N. C., Wills, J. C., Li, K. W., Nolan, M. F., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.11.012 · Cited by 30 · see citing works
Roseberry, K., Le-Niculescu, H., Levey, D. F., Bhagar, R., Soe, K. C., Rogers, J., Palkowitz, S., Piña, N. N., Anastasiadis, W. A., Gill, S., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01998-0 · Cited by 31 · see citing works
Pivotal role of cAMP‐PKA‐CREB signaling pathway in manganese‐induced neurotoxicity in PC12 cells
Yang, Y., Ma, S., Wei, F., Liang, G., Yang, X., Huang, Y., Wang, J., & Zou, Y. (2019) · Environmental Toxicology · doi:10.1002/tox.22776 · Cited by 29 · see citing works
D’Incal, C., Broos, J., Torfs, T., Kooy, R. F., & Vanden Berghe, W. (2022) · Cells · doi:10.3390/cells11081325 · Cited by 29 · see citing works
Mouse models of fragile X-related disorders
Willemsen, R., & Kooy, R. F. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049485 · Cited by 27 · see citing works
Ciranna, L., & Costa, L. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00524 · Cited by 28 · see citing works
Kaczorowski, J. A., Smith, T. F., Shrewsbury, A. M., Thomas, L. R., Knopik, V. S., & Acosta, M. T. (2020) · Behavior Genetics · doi:10.1007/s10519-020-09991-x · Cited by 24 · see citing works
Genovese, A., & Butler, M. G. (2025) · Genes · doi:10.3390/genes16020149 · Cited by 22 · see citing works
An “Omic” Overview of Fragile X Syndrome
Dionne, O., & Corbin, F. (2021) · Biology · doi:10.3390/biology10050433 · Cited by 22 · see citing works
Signaling Pathways Associated with Chronic Wound Progression: A Systems Biology Approach
Basu, P., & Martins‐Green, M. M. (2022) · Antioxidants · doi:10.3390/antiox11081506 · Cited by 20 · see citing works
Rosenheck, M., Sheeler, C. A., Saré, R. M., Gurney, M. E., & Smith, C. B. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105485 · Cited by 19 · see citing works
Roflumilast and cognition enhancement: A translational perspective
Prickaerts, J., Kerckhoffs, J., Possemis, N., van Overveld, W., Verbeek, F., Grooters, T., Sambeth, A., & Blokland, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117707 · Cited by 17 · see citing works
Liu, H., Yang, L., Wan, C., Li, Z., Yan, G., Han, Y., Sun, H., & Wang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.990996 · Cited by 17 · see citing works
Lin, R., Learman, L. N., Na, C. H., Renuse, S., Chen, K. T., Chen, P. Y., Lee, G.-H., Xiao, B., Resnick, S. M., Troncoso, J. C., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.10.012 · Cited by 16 · see citing works
Scope of adjuvant therapy using roflumilast, a PDE-4 inhibitor against COVID-19
Sugin Lal Jabaris, S., & Ranju, V. (2020) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2020.101978 · Cited by 14 · see citing works
An Update on Psychopharmacological Treatment of Autism Spectrum Disorder
Aishworiya, R., Valica, T., Hagerman, R. J., & Restrepo, B. (2024) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.24022006 · Cited by 15 · see citing works
Stress Odorant Sensory Response Dysfunction in Drosophila Fragile X Syndrome Mutants
Androschuk, A., He, R. X., Weber, S. M., Rosenfelt, C. S., & Bolduc, F. V. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00242 · Cited by 13 · see citing works
Self-citationAltered brain serotonin 5-HT1A receptor expression and function in juvenile Fmr1 knockout mice
Saraf, T. S., Chen, Y., Tyagi, R., & Canal, C. E. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109774 · Cited by 9 · see citing works
Testing Fmr1KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127
Westmark, P. R., Garrone, B., Ombrato, R., Milanese, C., Giorgio, F. P. D., & Westmark, C. J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.751307 · Cited by 9 · see citing works
Modeling neurodegenerative and neurodevelopmental disorders in theDrosophilamushroom bodyPreprint
Stahl, A., & Tomchik, S. M. (2024) · Learning & Memory · doi:10.1101/lm.053816.123 · Cited by 8 · see citing works
From Discovery to Innovative Translational Approaches in 80 Years of Fragile X Syndrome Research
van der Lei, M. B., & Kooy, R. F. (2025) · Biomedicines · doi:10.3390/biomedicines13040805 · Cited by 6 · see citing works
Khlaifia, A., Matias, I., Cota, D., & Tell, F. (2017) · The Journal of Physiology · doi:10.1113/jp273484 · Cited by 4 · see citing works
Stanfield, A. C., & McKechanie, A. G. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2510408 · Cited by 3 · see citing works
The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder
Thomas, S. D., Mohammed, H. A., Hamad, M. I. K., Öz, M., Statsenko, Y. A., & Sadek, B. S. (2025) · Pharmaceuticals · doi:10.3390/ph18101507 · Cited by 2 · see citing works
Budimirovic, D. B., & Protic, D. D. (2016) · Vojnosanitetski pregled · doi:10.2298/vsp161006315b · Cited by 2 · see citing works
Sleep problems in old age: metabotropic glutamate receptor to the rescue
Inami, S., Afonso, D. J. S., & Koh, K. (2023) · SLEEP · doi:10.1093/sleep/zsad044
Dissecting the role of calcium signaling in Fragile X syndrome
Castagnola, S. (2019) · theses.fr (ABES) · doi:10.70675/3d35096bz79d0z46edz8a70zb783a8f60257
Kim, J., Hwang, S.-H., Matson, C. W., Brooks, B. W., & Shin, H. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.142590
- Authors
- Choi, C. H., Schoenfeld, B. P., Bell, A. J., Hinchey, J., Rosenfelt, C., Gertner, M. J., Campbell, S. R., Emerson, D., Hinchey, P., Kollaros, M., Ferrick, N. J., Chambers, D. B., Langer, S., Sust, S., Malik, A., Terlizzi, A. M., Liebelt, D. A., Ferreiro, D., Sharma, A., Koenigsberg, E., Choi, R. J., Louneva, N., Arnold, S. E., Featherstone, R. E., Siegel, S. J., Zukin, R. S., McDonald, T. V., Bolduc, F. V., Jongens, T. A., & McBride, S. M. J.
- Affiliations
- Albert Einstein College of Medicine (US)
- University of Alberta (CA)
- University of Pennsylvania (US)
- Corresponding author
- McDonald, Thomas V.
- Jongens, Thomas A.
- McBride, Sean M. J.
- ORCID
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-06-30
- Volume
- 10
- Pages
- 136-136
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC4928101
- OpenAlex
- W2465376623
- Cited by
- 46
- References
- 152
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 1
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense (AR1101189)
- Autism Speaks
- FRAXA Research Foundation (AR1101189)
- University of Pennsylvania
- Yeshiva University
- Drexel University
- National Fragile X Foundation
- Canadian Child Health Clinician Scientist Program
- National Institutes of Health
- Albert Einstein College of Medicine, Yeshiva University
- National Institute of Mental Health (R25MH060490, R01MH092877)
- National Institute of General Medical Sciences (R01GM086902)
- National Institute of Neurological Disorders and Stroke (R01NS045693)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- fragile X syndrome, cAMP signaling, long-term memory, FMRP, lithium, phosphodiesterase-4 inhibitors, mGluR antagonists, DHPG, long-term depression, hippocampus, Drosophila model, mouse model, intellectual disability, autism spectrum disorder
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review