TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model
Khurana, Vikram, Lu, Yiran, Steinhilb, Michelle L., Oldham, Sean, Shulman, Joshua M., Feany, Mel B.·2006·Current Biology
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Items 201–266 of 266
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- Drosophila as a Model for Human Viral NeuroinfectionsIlena Benoit, Domenico L. Di Curzio, Alberto Civetta, Renée N. Douville · 2022 · Cells
- The mTOR Signaling Pathway in Neurodegenerative DiseasesArnaud Francois, Julie Vérité, Agnès Rioux Bilan, Thierry Janet, Frédéric Calon, Bernard Fauconneau, Marc Paccalin, Guylène Page · 2016 · Elsevier eBooks
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- IGF/mTORC1/S6 Signaling Is Potentiated and Prolonged by Acute Loading of Subtoxicological Manganese IonXue-Qi Tang, Rekha C. Balachandran, Michael Aschner, Aaron B. Bowman · 2023 · Biomolecules
- Tau Protein in Lung Smooth Muscle CellsNataliia V. Shults, Sarah Seeherman, Nurefsan E. Sariipek, Vladyslava Rybka, Lucia Marcocci, Sergiy G. Gychka, Yasmine F. Ibrahim, Yuichiro Suzuki · 2020 · Journal of Respiration
- FTD-associated mutations in Tau result in a combination of dominant and recessive phenotypesAlexander D. Law, Marlène Cassar, Dani M. Long, Eileen S. Chow, Jadwiga Maria Giebultowicz, Anjana Venkataramanan, Roland Strauß, Doris Kretzschmar · 2022 · Neurobiology of Disease
- Bar-coding neurodegeneration: Identifying sub-cellular effects of human neurodegenerative disease proteins using Drosophila leg neuronsJosefin Fernius, Annika Starkenberg, Stefan Thor · 2017 · Disease Models & Mechanisms
- The mTOR Pathway and AgingKatherine H. Schreiber, Monique N. O’Leary, Brian Keith Kennedy · 2015 · Elsevier eBooks
- Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic TargetsYvan Arsenijévic · 2015 · Advances in experimental medicine and biology
- Genetic reduction of tyramine β hydroxylase suppresses Tau toxicity in a Drosophila model of tauopathyVaruna Nangia, Julia O’Connell, Kusha Chopra, Yaling Qing, Camille Reppert, Cynthia M. Chai, Kesshni Bhasiin, Kenneth J. Colodner · 2021 · Neuroscience Letters
- String/Cdc25 phosphatase is a suppressor of Tau-associated neurodegenerationAndreia C. Oliveira, Madalena Santos, Mafalda Pinho, Carla S. Lopes · 2023 · Disease Models & Mechanisms
- DJ-1-mediated repression of the RNA-binding protein FMRP is predicted to impact known Alzheimer's disease-related protein networksAyse Uneri, Colin J. McArdle, Zhiyong Deng, Samuel H. Barth, Dirk Keene, Suzanne Craft, Kimberly F. Raab‐Graham · 2024 · Journal of Alzheimer s Disease
- Drosophila appear resistant to trans-synaptic tau propagationJames H. Catterson, Edmond N Mouofo, Inés López De Toledo Soler, Gillian Lean, Stella Dlamini, Phoebe Liddell, Graham Voong, Taxiarchis Katsinelos, Yuchun Wang, Nils Schoovaerts et al. · 2024 · Brain Communications
- Lagging Brain Gene Expression Patterns of Drosophila melanogaster Young Adult Males Confound Comparisons Between SexesFlannery McLamb, Zuying Feng, Jeanne P. Vu, Lindsey Griffin, Miguel F. Vasquez, Goran Bozinovic · 2024 · Molecular Neurobiology
- Cell Cycle Phase Transitions: Signposts for Aberrant Cell Cycle Reentry in Dying Mature NeuronsDazhi Liu · 2011 · Journal of Cytology & Histology
- Assessment of Genotoxicity of Potassium Nitrate and Sodium Benzoate in Drosophila melanogaster Using Smart and Comet AssaysAmal Aledwany, Wesam Taha Basal, Neima K. Al-Senosy, Aliaa Mahmoud Issa · 2018 · Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
- Molecular Aspects of Memory Dysfunction in Alzheimer’s DiseaseJeannie Chin, Erik D. Roberson, Lennart Mucke · 2008 · Elsevier eBooks
- A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signalingJiahui Li, Yuan Xu, Gianfranco Balboni, Ying Xia · 2025 · Frontiers in Aging Neuroscience
- NEURONAL FUNCTIONS OF PROTEIN PHOSPHATASE 2AHung‐Tat Leung · 2013 · Neuroscience International
- TOR Signaling and Cell DeathTao Wang, Bruce A. Edgar · 2010 · The Enzymes
- Tau protein in smooth muscle cells and tissuesNataliia V. Shults, Sarah Seeherman, Nurefsan E. Sariipek, Vladyslava Rybka, Lucia Marcocci, Sergiy G. Gychka, Yasmine F. Ibrahim, Yuichiro Suzuki · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium Mediated by BK ChannelsRebekah Elizabeth Mahoney, Elizabeth Ochoa, Paulino Ramirez, Henry E. Miller, Adrian Beckmann, Radek Dobrowolski, Bess E Frost · 2020 · SSRN Electronic Journal
- Drosophila Models of TauopathyYousuf Ali, Kai Ruan, Rong Grace Zhai · 2014 · Elsevier eBooks
- Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formationEnrico M. Scarpelli, Van Y. Trinh, Zarrin Tashnim, Jacob L. Krans, Lani C. Keller, Kenneth J. Colodner · 2019 · PLoS ONE
- The Mechanism of Autophagy Regulation and The Role of Autophagy in Alzheimer′s Disease*Zhixue Liu, Jie Chen, Deyi Zhang · 2012 · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
- Toxicity in Amyloid DiseasesMassimo Stefani · 2010 · Wiley eBooks
- Increased Mitochondrial Calcium Uptake and Concomitant Hyperactivity by Presenilin Loss Promotes mTORC1 Signaling to Drive NeurodegenerationKerry C. Ryan, Zahra Ashkavand, Shaarika Sarasija, Jocelyn T. Laboy, Rohan Samarakoon, Kenneth R. Norman · 2020 · Research Square
- Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signalingGuangchun Fan, Fangzheng Chen, Min Liang, Ping Yang, Hongtian Dong, Jing Su, Mengqi Wang, Ziyuan Wang, Penggang Ning, Chenye Shen et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Human tau E14 Mutation Induced Neurodegeneration in Drosophila melanogaster is Ameliorated by Developmental Supplement of Ashwagandha Root ExtractMamatha Nagamadhu Murthy, Baragur Venkatanarayanasetty Shyamala · 2023 · Journal of Complementary and Alternative Medical Research
- Stabilizing microtubules increases acute cellular injury at high strain ratesGia Kang, Erik Webster, Daniel de Souza Delgado, Matthew R. Holahan, Rohan J. Banton, Oren E. Petel, Andrew R. Harris · 2025 · Biophysical Journal
- Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicityEsti Yeger‐Lotem, Laura Riva, Linhui Julie Su, Aaron D. Gitler, Anil G. Cashikar, Oliver D. King, Pavan Kumar Auluck, Melissa L. Geddie, Julie S. Valastyan, David Ron Karger et al. · 2009
- Models of Alzheimer’s DiseaseMengqi Chen, Doris Kretzschmar, Giuseppe Verdile, Michael T. Lardelli · 2013 · Elsevier eBooks
- Neurodegeneration models in DrosophilaBidisha Roy, George R. Jackson · 2014 · Cambridge University Press eBooks
- Tau in Tauopathies That Leads to Cognitive Disorders and in CancerMd Nazmul Huda, Cheol‐Ho Pan · 2019 · IntechOpen eBooks
- Implication of Nanoparticles in Drosophila Toxicology ResearchSumira Malik · 2020 · Advances in chemical and materials engineering book series
- Faculty Opinions recommendation of JNK3 perpetuates metabolic stress induced by Aβ peptides.Thomas J. Kodadek · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Alzheimer Research Forum Live Discussion: Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look12006 · Journal of Alzheimer s Disease
- Cell cycle re-entry in the aging Drosophila brainDeena Damschroder, Jenny Jia Sun, Katherine O. McDonald, Laura Buttitta · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Human tau compromises neuronal structural integrity in C. elegans promoted by age, stress and phosphorylationMaithili Joshi, Sanne J A van Falier, Tessa Sinnige · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Tau and neurofilament proteins in Alzheimer's disease and related cell modelsCecilia Björkdahl · 2007 · Figshare
- Src Family Kinases in Intracerebral HemorrhageDazhi Liu · 2014 · InTech eBooks
- Dictyostelium discoideum: Novel Insights into the Cellular Biology of Neurological DisordersMichael A. · 2012 · InTech eBooks
- Modulation of growth factor-induced ERK signaling by the microtubule associated protein tauChad J. Leugers · 2010
- Pseudophosphorylation of tau modulates its function and induces AD-like changesQian Sun · 2009 · KU ScholarWorks (The University of Kansas)
- The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer DiseaseZhi Tang · 2014 · Figshare
- ReviewArticle Targeting Gonadotropins: An Alternative Option for Alzheimer Disease TreatmentGemma Casadesús, Emma Ramiro Puig, Kate M. Webber, Craig Atwood, Margarida Castell, Richard L. Bowen, George L. Perry, Mark A. Smith, William S. Middleton, Memorial Veterans · 2006
- Investigation into the effects and mechanisms of rapamycin treatment in two mouse models of Complex I-deficient neurological pathologyMelana E. Yanos · 2014 · ResearchWorks at the University of Washington (University of Washington)
- The Neurobiology of AgingTomohiro Nakamura, Malene Hansen, Sean Oldham, Stuart A. Lipton · 2010 · Elsevier eBooks
- NRF2 and RIP140 as new therapeutic targets for X-linked adrenoleukodystrophy (X-ALD): Control of redox/metabolic homeostasis and inflammationPablo Ranea‐Robles · 2017 · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
- Mammalian target of rapamycin complexesHenry W. Querfurth, Hankyu Lee · 2020 · Elsevier eBooks
- Transcriptomic profiling of differentially expressed genes and related pathways in different brain regions of Parkinson’s diseaseQinyu Ge, Erteng Jia, Min Pan, Zhiyu Liu, Ying Zhou, Xiangwei Zhao, Jian Dong, Yunfei Bai · 2019
- Faculty Opinions recommendation of Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies.Hyung Don Ryoo · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Invertebrate and Vertebrate Models of TauopathiesJürgen Götz, Lars Matthias Ittner, Naeman N. Götz, Hong Lam, Hannah Nicholas · 2011 · Royal Society of Chemistry eBooks
- Targeting mTOR restores tau-induced metabolic, mitochondrial, and cognitive deficits in a tauopathy mouse modelZhi Tang, Min Guo, Yuanting Ding, Yi Wen, Bo Li, Yan Xiao, Ruiqing Ni, Zhi-Zhong Guan, Xiaolan Qi · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivoSarkar, Souvarish, Farah H. Bardai, Abby L. Olsen, Kelly M. Lohr, Zhang, Ying-Yi, Mel Β. Feany · 2021 · Figshare
- Implications of virus-induced stress granules in tauopathiesSnigdda Sharma, Alex Vandenakker, Claudia Mariana Cortes-Pérez, Sarah Milne, Renée N. Douville · 2026 · Translational Neurodegeneration
- Actin cytoskeletal pathology in Alzheimer’s diseaseSubashchandrabose Chinnathambi, Sneha Malik, Madhura Chandrashekar, Nagaraj Rangappa · 2026 · Advances in pharmacology
- Interaction entre la protéine Tau et la protéine p54nrb : effet sur la maturation des miARN au sein des paraspecklesMarine Denéchaud · 2022 · theses.fr (ABES)
- Sexually dimorphic behavioural signatures of tau toxicity in adult DrosophilaEdmond N Mouofo, Maxwell P Spires-Jones, Yuchun Wang, Nils Schoovaerts, Patrik Verstreken, Claire S. Durrant, James H. Catterson, Tara L. Spires‐Jones · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a Drosophila tauopathy modelKendall Cottingham, Nima Goodarzi, David Fries, Geethma Lirushie, Hana Hall · 2026 · Frontiers in Aging Neuroscience