TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model

Khurana, Vikram, Lu, Yiran, Steinhilb, Michelle L., Oldham, Sean, Shulman, Joshua M., Feany, Mel B.·2006·Current Biology

Cited by (266)

Items 201–266 of 266

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    Hassan Bukhari, Vanitha Nithianandam, Rachel A. Battaglia, Anthony Cicalo, Souvarish Sarkar, Aram Comjean, Yanhui Hu, Matthew Joseph Leventhal, Xianjun Dong, Mel Β. Feany · 2024 · Genome Research
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    Morgane Denus, Aurore Filaquier, William Fargues, Éloïse Néel, Sarah E. Stewart, Maëlle Colladant, Thomas Curel, Alexandre Mezghrani, Philippe Marin, Sylvie Claeysen et al. · 2025 · Traffic
  3. PIWIL1 protein power targets tau therapy
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  4. Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells
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    Arnaud Francois, Julie Vérité, Agnès Rioux Bilan, Thierry Janet, Frédéric Calon, Bernard Fauconneau, Marc Paccalin, Guylène Page · 2016 · Elsevier eBooks
  7. Testing the Genotoxic Potential of Nanomaterials Using Drosophila
    Mohamed A. Abdalaziz, Balasubramanyam Annangi, Ricard Marcos · 2014 · Methods in pharmacology and toxicology
  8. Human Tau isoform-specific presynaptic deficits in a Drosophila Central Nervous System circuit
    Dimitrios Kadas, Katerina Papanikolopoulou, Sophia Xirou, Christos Consoulas, Efthimios M. C. Skoulakis · 2018 · Neurobiology of Disease
  9. Mitochondrial Fragmentation Due to Inhibition of Fusion Increases Cyclin B through Mitochondrial Superoxide Radicals
    Tejas M. Gupte · 2015 · PLoS ONE
  10. IGF/mTORC1/S6 Signaling Is Potentiated and Prolonged by Acute Loading of Subtoxicological Manganese Ion
    Xue-Qi Tang, Rekha C. Balachandran, Michael Aschner, Aaron B. Bowman · 2023 · Biomolecules
  11. Tau Protein in Lung Smooth Muscle Cells
    Nataliia V. Shults, Sarah Seeherman, Nurefsan E. Sariipek, Vladyslava Rybka, Lucia Marcocci, Sergiy G. Gychka, Yasmine F. Ibrahim, Yuichiro Suzuki · 2020 · Journal of Respiration
  12. FTD-associated mutations in Tau result in a combination of dominant and recessive phenotypes
    Alexander D. Law, Marlène Cassar, Dani M. Long, Eileen S. Chow, Jadwiga Maria Giebultowicz, Anjana Venkataramanan, Roland Strauß, Doris Kretzschmar · 2022 · Neurobiology of Disease
  13. Bar-coding neurodegeneration: Identifying sub-cellular effects of human neurodegenerative disease proteins using Drosophila leg neurons
    Josefin Fernius, Annika Starkenberg, Stefan Thor · 2017 · Disease Models & Mechanisms
  14. The mTOR Pathway and Aging
    Katherine H. Schreiber, Monique N. O’Leary, Brian Keith Kennedy · 2015 · Elsevier eBooks
  15. Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets
    Yvan Arsenijévic · 2015 · Advances in experimental medicine and biology
  16. Genetic reduction of tyramine β hydroxylase suppresses Tau toxicity in a Drosophila model of tauopathy
    Varuna Nangia, Julia O’Connell, Kusha Chopra, Yaling Qing, Camille Reppert, Cynthia M. Chai, Kesshni Bhasiin, Kenneth J. Colodner · 2021 · Neuroscience Letters
  17. String/Cdc25 phosphatase is a suppressor of Tau-associated neurodegeneration
    Andreia C. Oliveira, Madalena Santos, Mafalda Pinho, Carla S. Lopes · 2023 · Disease Models & Mechanisms
  18. DJ-1-mediated repression of the RNA-binding protein FMRP is predicted to impact known Alzheimer's disease-related protein networks
    Ayse Uneri, Colin J. McArdle, Zhiyong Deng, Samuel H. Barth, Dirk Keene, Suzanne Craft, Kimberly F. Raab‐Graham · 2024 · Journal of Alzheimer s Disease
  19. Drosophila appear resistant to trans-synaptic tau propagation
    James H. Catterson, Edmond N Mouofo, Inés López De Toledo Soler, Gillian Lean, Stella Dlamini, Phoebe Liddell, Graham Voong, Taxiarchis Katsinelos, Yuchun Wang, Nils Schoovaerts et al. · 2024 · Brain Communications
  20. Lagging Brain Gene Expression Patterns of Drosophila melanogaster Young Adult Males Confound Comparisons Between Sexes
    Flannery McLamb, Zuying Feng, Jeanne P. Vu, Lindsey Griffin, Miguel F. Vasquez, Goran Bozinovic · 2024 · Molecular Neurobiology
  21. Cell Cycle Phase Transitions: Signposts for Aberrant Cell Cycle Reentry in Dying Mature Neurons
    Dazhi Liu · 2011 · Journal of Cytology & Histology
  22. Assessment of Genotoxicity of Potassium Nitrate and Sodium Benzoate in Drosophila melanogaster Using Smart and Comet Assays
    Amal Aledwany, Wesam Taha Basal, Neima K. Al-Senosy, Aliaa Mahmoud Issa · 2018 · Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
  23. Molecular Aspects of Memory Dysfunction in Alzheimer’s Disease
    Jeannie Chin, Erik D. Roberson, Lennart Mucke · 2008 · Elsevier eBooks
  24. A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling
    Jiahui Li, Yuan Xu, Gianfranco Balboni, Ying Xia · 2025 · Frontiers in Aging Neuroscience
  25. NEURONAL FUNCTIONS OF PROTEIN PHOSPHATASE 2A
    Hung‐Tat Leung · 2013 · Neuroscience International
  26. TOR Signaling and Cell Death
    Tao Wang, Bruce A. Edgar · 2010 · The Enzymes
  27. Tau protein in smooth muscle cells and tissues
    Nataliia V. Shults, Sarah Seeherman, Nurefsan E. Sariipek, Vladyslava Rybka, Lucia Marcocci, Sergiy G. Gychka, Yasmine F. Ibrahim, Yuichiro Suzuki · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium Mediated by BK Channels
    Rebekah Elizabeth Mahoney, Elizabeth Ochoa, Paulino Ramirez, Henry E. Miller, Adrian Beckmann, Radek Dobrowolski, Bess E Frost · 2020 · SSRN Electronic Journal
  29. Drosophila Models of Tauopathy
    Yousuf Ali, Kai Ruan, Rong Grace Zhai · 2014 · Elsevier eBooks
  30. Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation
    Enrico M. Scarpelli, Van Y. Trinh, Zarrin Tashnim, Jacob L. Krans, Lani C. Keller, Kenneth J. Colodner · 2019 · PLoS ONE
  31. The Mechanism of Autophagy Regulation and The Role of Autophagy in Alzheimer′s Disease*
    Zhixue Liu, Jie Chen, Deyi Zhang · 2012 · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
  32. Toxicity in Amyloid Diseases
    Massimo Stefani · 2010 · Wiley eBooks
  33. Increased Mitochondrial Calcium Uptake and Concomitant Hyperactivity by Presenilin Loss Promotes mTORC1 Signaling to Drive Neurodegeneration
    Kerry C. Ryan, Zahra Ashkavand, Shaarika Sarasija, Jocelyn T. Laboy, Rohan Samarakoon, Kenneth R. Norman · 2020 · Research Square
  34. Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling
    Guangchun Fan, Fangzheng Chen, Min Liang, Ping Yang, Hongtian Dong, Jing Su, Mengqi Wang, Ziyuan Wang, Penggang Ning, Chenye Shen et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Human tau E14 Mutation Induced Neurodegeneration in Drosophila melanogaster is Ameliorated by Developmental Supplement of Ashwagandha Root Extract
    Mamatha Nagamadhu Murthy, Baragur Venkatanarayanasetty Shyamala · 2023 · Journal of Complementary and Alternative Medical Research
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    Gia Kang, Erik Webster, Daniel de Souza Delgado, Matthew R. Holahan, Rohan J. Banton, Oren E. Petel, Andrew R. Harris · 2025 · Biophysical Journal
  37. Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity
    Esti Yeger‐Lotem, Laura Riva, Linhui Julie Su, Aaron D. Gitler, Anil G. Cashikar, Oliver D. King, Pavan Kumar Auluck, Melissa L. Geddie, Julie S. Valastyan, David Ron Karger et al. · 2009
  38. Models of Alzheimer’s Disease
    Mengqi Chen, Doris Kretzschmar, Giuseppe Verdile, Michael T. Lardelli · 2013 · Elsevier eBooks
  39. Neurodegeneration models in Drosophila
    Bidisha Roy, George R. Jackson · 2014 · Cambridge University Press eBooks
  40. Tau in Tauopathies That Leads to Cognitive Disorders and in Cancer
    Md Nazmul Huda, Cheol‐Ho Pan · 2019 · IntechOpen eBooks
  41. Implication of Nanoparticles in Drosophila Toxicology Research
    Sumira Malik · 2020 · Advances in chemical and materials engineering book series
  42. Faculty Opinions recommendation of JNK3 perpetuates metabolic stress induced by Aβ peptides.
    Thomas J. Kodadek · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  43. Alzheimer Research Forum Live Discussion: Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look1
    2006 · Journal of Alzheimer s Disease
  44. Cell cycle re-entry in the aging Drosophila brain
    Deena Damschroder, Jenny Jia Sun, Katherine O. McDonald, Laura Buttitta · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Human tau compromises neuronal structural integrity in C. elegans promoted by age, stress and phosphorylation
    Maithili Joshi, Sanne J A van Falier, Tessa Sinnige · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Tau and neurofilament proteins in Alzheimer's disease and related cell models
    Cecilia Björkdahl · 2007 · Figshare
  47. Src Family Kinases in Intracerebral Hemorrhage
    Dazhi Liu · 2014 · InTech eBooks
  48. Dictyostelium discoideum: Novel Insights into the Cellular Biology of Neurological Disorders
    Michael A. · 2012 · InTech eBooks
  49. Modulation of growth factor-induced ERK signaling by the microtubule associated protein tau
    Chad J. Leugers · 2010
  50. Pseudophosphorylation of tau modulates its function and induces AD-like changes
    Qian Sun · 2009 · KU ScholarWorks (The University of Kansas)
  51. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer Disease
    Zhi Tang · 2014 · Figshare
  52. ReviewArticle Targeting Gonadotropins: An Alternative Option for Alzheimer Disease Treatment
    Gemma Casadesús, Emma Ramiro Puig, Kate M. Webber, Craig Atwood, Margarida Castell, Richard L. Bowen, George L. Perry, Mark A. Smith, William S. Middleton, Memorial Veterans · 2006
  53. Investigation into the effects and mechanisms of rapamycin treatment in two mouse models of Complex I-deficient neurological pathology
    Melana E. Yanos · 2014 · ResearchWorks at the University of Washington (University of Washington)
  54. The Neurobiology of Aging
    Tomohiro Nakamura, Malene Hansen, Sean Oldham, Stuart A. Lipton · 2010 · Elsevier eBooks
  55. NRF2 and RIP140 as new therapeutic targets for X-linked adrenoleukodystrophy (X-ALD): Control of redox/metabolic homeostasis and inflammation
    Pablo Ranea‐Robles · 2017 · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
  56. Mammalian target of rapamycin complexes
    Henry W. Querfurth, Hankyu Lee · 2020 · Elsevier eBooks
  57. Transcriptomic profiling of differentially expressed genes and related pathways in different brain regions of Parkinson’s disease
    Qinyu Ge, Erteng Jia, Min Pan, Zhiyu Liu, Ying Zhou, Xiangwei Zhao, Jian Dong, Yunfei Bai · 2019
  58. Faculty Opinions recommendation of Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies.
    Hyung Don Ryoo · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  59. Invertebrate and Vertebrate Models of Tauopathies
    Jürgen Götz, Lars Matthias Ittner, Naeman N. Götz, Hong Lam, Hannah Nicholas · 2011 · Royal Society of Chemistry eBooks
  60. Targeting mTOR restores tau-induced metabolic, mitochondrial, and cognitive deficits in a tauopathy mouse model
    Zhi Tang, Min Guo, Yuanting Ding, Yi Wen, Bo Li, Yan Xiao, Ruiqing Ni, Zhi-Zhong Guan, Xiaolan Qi · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Additional file 1 of Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
    Sarkar, Souvarish, Farah H. Bardai, Abby L. Olsen, Kelly M. Lohr, Zhang, Ying-Yi, Mel Β. Feany · 2021 · Figshare
  62. Implications of virus-induced stress granules in tauopathies
    Snigdda Sharma, Alex Vandenakker, Claudia Mariana Cortes-Pérez, Sarah Milne, Renée N. Douville · 2026 · Translational Neurodegeneration
  63. Actin cytoskeletal pathology in Alzheimer’s disease
    Subashchandrabose Chinnathambi, Sneha Malik, Madhura Chandrashekar, Nagaraj Rangappa · 2026 · Advances in pharmacology
  64. Interaction entre la protéine Tau et la protéine p54nrb : effet sur la maturation des miARN au sein des paraspeckles
    Marine Denéchaud · 2022 · theses.fr (ABES)
  65. Sexually dimorphic behavioural signatures of tau toxicity in adult Drosophila
    Edmond N Mouofo, Maxwell P Spires-Jones, Yuchun Wang, Nils Schoovaerts, Patrik Verstreken, Claire S. Durrant, James H. Catterson, Tara L. Spires‐Jones · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  66. Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a Drosophila tauopathy model
    Kendall Cottingham, Nima Goodarzi, David Fries, Geethma Lirushie, Hana Hall · 2026 · Frontiers in Aging Neuroscience