The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The NK homeobox gene cluster predates the origin of Hox genes.
Open accessAbstract
Hox and other Antennapedia (ANTP)-like homeobox gene subclasses - ParaHox, EHGbox, and NK-like - contribute to key developmental events in bilaterians [1-4]. Evidence of physical clustering of ANTP genes in multiple animal genomes [4-9] suggests that all four subclasses arose via sequential cis-duplication events. Here, we show that Hox genes' origin occurred after the divergence of sponge and eumetazoan lineages and occurred concomitantly with a major evolutionary transition in animal body-plan complexity. By using whole genome information from the demosponge Amphimedon queenslandica, we provide the first conclusive evidence that the earliest metazoans possessed multiple NK-like genes but no Hox, ParaHox, or EHGbox genes. Six of the eight NK-like genes present in the Amphimedon genome are clustered within 71 kb in an order akin to bilaterian NK clusters. We infer that the NK cluster in the last common ancestor to sponges, cnidarians, and bilaterians consisted of at least five genes. It appears that the ProtoHox gene originated from within this ancestral cluster after the divergence of sponge and eumetazoan lineages. The maintenance of the NK cluster in sponges and bilaterians for greater than 550 million years is likely to reflect regulatory constraints inherent to the organization of this ancient cluster.
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“Along with the diversification signalling pathways in eumetazoans was the origination of Hox genes [24] and expansion of a range of developmental transcription factor gene families [23], [28, unpublished], which enabled further elaboration of ancestral gene regulatory networks.”
From Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning (2007) · cites this paper as [24]
Citations
Cites
The Regulatory Genome: Gene Regulatory Networks In Development And Evolution
Davidson, E. H. (2006) · Thammasat University Digital Collections · Cited by 1,048
The genesis and evolution of homeobox gene clusters
García‐Fernàndez, J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1723 · Cited by 490
The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster
Brooke, N. M., Garcia-Fernàndez, J., & Holland, P. W. H. (1998) · Nature · doi:10.1038/31933 · Cited by 468
Origins of Bilateral Symmetry: Hox and Dpp Expression in a Sea Anemone
Finnerty, J. R., Pang, K., Burton, P., Paulson, D., & Martindale, M. Q. (2004) · Science · doi:10.1126/science.1091946 · Cited by 407
Genomic Evolution of Hox Gene Clusters
Lemons, D., & McGinnis, W. (2006) · Science · doi:10.1126/science.1132040 · Cited by 385
Peterson, K. J., & Butterfield, N. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503660102 · Cited by 361
Epigenetic mechanisms of character origination
Newman, S. A., & M�ller, G. (2000) · Journal of Experimental Zoology · doi:10.1002/1097-010x(20001215)288:4 · Cited by 334
Simionato, E., Ledent, V., Richards, G. S., Thomas‐Chollier, M., Kerner, P., Coornaert, D., Degnan, B. M., & Vervoort, M. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-33 · Cited by 292
Sponge paraphyly and the origin of Metazoa
Borchiellini, C., Manuel, M., Alivon, E., Boury-Esnault, N., Vacelet, J., & Le Parco, Y. (2001) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.2001.00244.x · Cited by 275
Mitochondrial genome of Trichoplax adhaerens supports Placozoa as the basal lower metazoan phylum
Dellaporta, S. L., Xu, A., Sagasser, S., Jakob, W., Moreno, M. A., Buss, L. W., & Schierwater, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602076103 · Cited by 252
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The TALE face of Hox proteins in animal evolution
Merabet, S., & Galliot, B. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00267 · Cited by 22
Schierwater, B., Eitel, M., Osigus, H., von der Chevallerie, K., Bergmann, T., Hadrys, H., Cramm, M., Heck, L., Jakob, W., Lang, M., et al. (2010) · Science Publishers eBooks · doi:10.1201/b10425-17 · Cited by 17
Sponge Cytogenetics — Mitotic Chromosomes of Ten Species of Freshwater Sponge
Ishijima, J., Iwabe, N., Masuda, Y., Watanabe, Y., & Matsuda, Y. (2008) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.25.480 · Cited by 16
“Numerous genetic studies on sponges have recently the evolutionary process of the gene structure and multiple gene families associated with the acquisition of multicellularity (Iwabe et al., 1996; Müller, 1998; Patthy, 2003; Larroux et al., 2007).”
Hox, homology, and parsimony: An organismal perspective
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A Look Back Over 20 Years of Evo-Devo Studies on Sponges: A Challenged View of Urmetazoa
Schenkelaars, Q., Vernale, A., Fierro‐Constaín, L., Borchiellini, C., & Renard, E. (2019) · Springer eBooks · doi:10.1007/978-3-030-30363-1_7 · Cited by 13
Deutsch, J. S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6673-5 · Cited by 15
Raincrow, J., Dewar, K., Stocsits, C., Prohaska, S. J., Amemiya, C. T., Stadler, P. F., & Chiu, C.-H. (2011) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21420 · Cited by 12
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BackgroundSymmetry Transformations in Metazoan Evolution and Development
Isaeva, V. V., & Kasyanov, N. V. (2021) · Symmetry · doi:10.3390/sym13020160 · Cited by 13
The Early Evolution of Hox Genes: A Battle of Belief?
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Treffkorn, S., & Mayer, G. (2019) · BMC Developmental Biology · doi:10.1186/s12861-019-0185-9 · Cited by 12
Mikšiūnas, R., Mobasheri, A., & Bironaitė, D. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_349 · Cited by 12
The Cambrian explosion triggered by critical turning point in genome size evolution
Li, D. J., & Zhang, S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.032 · Cited by 10
“in biogeochemistry, molecular systematics and developmen tal genetics [4][5][6][7].”
BackgroundRegulation of Hox Activity: Insights from Protein Motifs
Merabet, S., Sambrani, N., Pradel, J., & Graba, Y. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6673-5_1 · Cited by 10
Origin and evolution of the Rax homeobox gene by comprehensive evolutionary analysis
Kon, T., & Furukawa, T. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12832 · Cited by 11
HOM-C genes, Wnt signaling and axial patterning in the C. elegans posterior ventral epidermis
Li, X., Kulkarni, R., Hill, R. J., & Chamberlin, H. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.567 · Cited by 10
Sea anemone genomes reveal ancestral metazoan chromosomal macrosyntenyPreprint
Technau, U., Robb, S. M. C., Genikhovich, G., Montenegro, J. D., Fropf, W., Weinguny, L., He, S., Chen, S., Lovegrove‐Walsh, J., Hill, E. M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-796229/v1 · Cited by 10
Concerning one obsolete tradition: Does gastrulation in sponges exist?
Dondua, A. K., & Kostyuchenko, R. P. (2013) · Russian Journal of Developmental Biology · doi:10.1134/s1062360413050020 · Cited by 9
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“The Hox genes that only Eumetazoa have are also of special interest (Larroux et al., 2007).”
BackgroundHmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development
England, S. J., Cerda, G. A., Kowalchuk, A. M., Sorice, T., Grieb, G., & Lewis, K. E. (2020) · Genetics · doi:10.1534/genetics.120.303748 · Cited by 8
“For some experiments (indicated in the results) we added 5% dextran sulfate to thehybridizationbuffer.Dextran sulfate can increase specific staining in in situ hybridization experiments as it facilitates molecular crowding (Ku et al. 2004; Lauter et al. 2011).”
MethodProtein evolution of ANTP and PRD homeobox genes
Fonseca, N. A., Vieira, C. P., Holland, P. W., & Vieira, J. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-200 · Cited by 7
“Furthermore, the ANTP Demox class found in Demospongiae and apparently absent in all other animals [19], is characterized by the presence of the ANTP-PRD, and ANTP 1 and 2 patterns, as expected for ANTP genes that do not belong to the HOXL or NKL lineage (Table 3). Although there are no true Hox genes in sponges [ 20…”
BackgroundGraphTeams: a method for discovering spatial gene clusters in Hi-C sequencing data
Schulz, T., Stoye, J., & Doerr, D. (2018) · BMC Genomics · doi:10.1186/s12864-018-4622-0 · Cited by 7
“HOX genes are transcription factors that regulate the embryological development of the metazoan body plan [6].”
BackgroundWhen is a Hox gene not a Hox gene? The importance of gene nomenclature
Ferrier, D. E. K. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541582.014 · Cited by 6
Schöneberg, Y., Audisio, T. L., Hamadou, A. B., Forman, M., Král, J., Kořínková, T., Líznarová, E., Mayer, C., Prokopcová, L., Krehenwinkel, H., et al. (2024) · Molecular Ecology Resources · doi:10.1111/1755-0998.14038 · Cited by 5
Parallel Evolution of Transcription Factors in Basal Metazoans
Mukherjee, K., & Moroz, L. L. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3642-8_20 · Cited by 5
The evolutionary foundations of transcriptional regulation in animals
Coyle, M. C., & King, N. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-025-00864-9 · Cited by 8
“Additionally, many TFs important for animal development and cell-type specification derive from the expansion of pre-animal TF families, including the Fork-head, T-box and homeobox families 88–92 .”
Hox, Parahox, Ehgbox, and NK Genes in Bivalve Molluscs: Evolutionary Implications
Pérez‐Parallé, M. L., Pazos, A. J., Mesías-Gansbiller, C., & Sánchez, J. L. (2016) · Journal of Shellfish Research · doi:10.2983/035.035.0119 · Cited by 5
“Members of this gene family have been reported in bilaterians, cnidarians (Larroux et al. 2007), placozoans (Jakob et al.”
BackgroundKlementz, B. C., Kulkarni, S., Abshire, K. M., & Sharma, P. P. (2025) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2025.108380 · Cited by 6
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“…the genes of which encode evolutionarily conserved broad-spectrum transcription factors that determine the patterning of the body plan of an organism and its type of development (see Larroux et al., 2007; Butts et al., 2010; Holland et al., 2015; Ferrier, 2019; Mio et al., 2023; Wanninger, 2024).”
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Origin of Metazoan Patterning Systems and the Role of ANTP ‐Class Homeobox Genes
Thomas‐Chollier, M., & Martı́nez, P. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022852.pub2 · Cited by 3
Liu, P., Chiu, W.-C., Lim, S. L., Chen, H., Chen, Y., Wang, H.-I., Yang, C., Chen, C., Nozawa, Y., Yamashiro, H., et al. (2025) · BMC Genomics · doi:10.1186/s12864-025-11962-7 · Cited by 2
“Moreover, homeobox gene duplications are associated with increased morphological complexity in sponges and other metazoans, emphasizing their role in body plan evolution [38, 39].”
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Nakagawa, S., Carnevali, D., Tan, X., Alvarez, M. J., Parfitt, D.-E., Vicino, U. D., Arumugam, K., Shin, W., Aranda, S., Normanno, D., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.04.004 · Cited by 2
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Evo-devo: methods and materials
Minelli, A. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541582.010 · Cited by 2
Le génome de l’épongeAmphimedon queenslandicanous aide à reconstruire notre ancêtre précambrien
Larroux, C. (2011) · médecine/sciences · doi:10.1051/medsci/2011272138 · Cited by 2
“Les fameux gènes Hox ainsi que les gènes Snail et Zic semblent avoir évolué dans la lignée eumétazoaire [2, 9].”
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Peterson, K. J. (2008) · The Paleontological Society Papers · doi:10.1017/s1089332600001637 · Cited by 2
Developmental Symbiosis: A Sponge Larva Needs Symbiotic Bacteria to Succeed on the Benthos
Hadfield, M. G. . (2021) · Current Biology · doi:10.1016/j.cub.2020.11.007 · Cited by 2
Homeosis and Beyond. What Is the Function of the Hox Genes?
Deutsch, J. S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6673-5_12 · Cited by 2
Evolutionary Developmental Biology:HoxGene Evolution
Nolte, C., Ahn, Y., & Krumlauf, R. K. (2012) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0001063.pub3 · Cited by 2
Characterization of the Wnt signalling system in the coral Acropora millepora
Ukolova, S. (2023) · ResearchOnline - JCU (James Cook University) · doi:10.25903/eyhz-7977 · Cited by 2
Genotyping Individual Amphimedon Embryos, Larvae, and AdultsPreprint
Degnan, B. M., Craigie, A., & Degnan, B. M. (2008) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5098 · Cited by 2
“Amphimedon development and developmental gene structure and expression have been studied extensively (Leys and Degnan 2001, 2002; Degnan et al. 2005; Larroux et al. 2006, 2007, 2008a; Adamska et al. 2007a,b; Sakarya et al. 2007; Fahey et al. 2008; Gauthier and Degnan 2008a,b).”
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Moreno, E., & Martı́nez, P. (2010) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022852 · Cited by 2
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Santini, S., Schenkelaars, Q., Jourda, C., Duschene, M., Belahbib, H., Rocher, C., Selva, M., Riesgo, A., Vervoort, M., Leys, S. P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.26.501511 · Cited by 2
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Copley, R. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.14.532566 · Cited by 2
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“The Amphimedon complement of Lhx proteins consists of members of the Islet, Lhx3/4 and Lhx1/5 families [46,47].”
BackgroundSelf-citationAdamska, M. (2021) · CRC Press eBooks · doi:10.1201/9781003217503-4 · Cited by 1
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Kulakova, M. A., Maslakov, G. P., & Poliushkevich, L. O. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924060014 · Cited by 1
Fenner, J. L., Wang, B., Ka, C., Gautam, S., & Range, R. (2025) · Journal of Developmental Biology · doi:10.3390/jdb13040036 · Cited by 1
First evidence of the presence ofNK2andTlxgenes in bivalve molluscs
Mesías-Gansbiller, C., Pazos, A. J., Sánchez, J. L., & Pérez‐Parallé, M. L. (2013) · Canadian Journal of Zoology · doi:10.1139/cjz-2012-0296 · Cited by 1
Ivanović, Z., & Vlaski‐Lafarge, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800540-8.00011-9 · Cited by 1
Takahashi, T., McDougall, C., Chen, W.-C., Shimeld, S. M., & Ferrier, D. E. K. (2009) · Mechanisms of Development · doi:10.1016/j.mod.2009.06.647 · Cited by 1
Ivanišević, J. (2011) · theses.fr (ABES) · doi:10.70675/6797e502z87aaz4438z85eez039ab1ede89b · Cited by 1
Ball, E. E., de Jong, D., Schierwater, B., Shinzato, C., Hayward, D. C., & Miller, D. J. (2010) · Science Publishers eBooks · doi:10.1201/b10425-12 · Cited by 1
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Patterson, D. A., & Poggio, A. A. (2011)
ESPONJAS MARINAS: ¿PRODUCCIÓN BIOTECNOLÓGICA SOSTENIBLE?
Blandón, L., ESTRADA, N., López, J. A., & Fernández, M. E. M. (2014) · Revista de la Facultad de Ciencias
IGFBP-3 mediates the effect of tumor suppressor NKX3.1 on prostate cancer cell proliferation
Muhlbradt, E. (2008) · ProQuest Demo Repository
Goymer, P. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2114
Regulatory evolution, Hox genes, and larvae of bilateral animals
Бакаленко, Н. И., Novikova, E. L., & Kulakova, M. A. (2012) · Biology Bulletin · doi:10.1134/s1062359012020033
“In this case the genes of the ancestral cluster—possibly, a sin gle ancestral gene recently separated from the NK ancestor (Larroux et al., 2007)—could be involved in tissue specific differentiations according BIOLOGY BULLETIN Vol. 39 No. 2 2012 REGULATORY EVOLUTION, Hox GENES, AND LARVAE 209 to…”
BackgroundA expressão dos Genes HOX e a má formação da coluna vertebral
Silva, C. A., Silva, B. F. G. E., Richard, R., Souza, A. R. T., & Paulino, P. C. (2017) · Saúde em Revista · doi:10.15600/2238-1244/sr.v17n46p59-65
Finding Teams in Graphs and Its Application to Spatial Gene Cluster Discovery
Schulz, T., Stoye, J., & Doerr, D. (2017) · Lecture notes in computer science · doi:10.1007/978-3-319-67979-2_11
“HOX genes are transcription factors that regulate the embryological development of the metazoan body plan [12].”
BackgroundA toolkit for caste differentiation
Kocher, S. D. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0705-1
Raible, F., & Steinmetz, P. R. H. (2010) · Springer eBooks · doi:10.1007/978-90-481-8639-6_5
Newman, S. A., Bhat, R., & Mezentseva, N. V. (2009) · Journal of Biosciences · doi:10.1007/s12038-009-0001-y
Zardoya, R. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1102060.557136
Irreducible Complexity of Hox Gene: A Path to the Canonical Function of the Hox Cluster (Review)
Kulakova, M. A., Maslakov, G. P., & Polyushkevich, L. O. (2024) · Biochemistry (Moscow) · doi:10.31857/s0320972524060012
Characterization of the Hox patterning genes in acoel flatworms
González, E. M. (2010) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Condamine, T. (2018) · theses.fr (ABES) · doi:10.70675/7bd509e2z4d99z495czafd0z1adf840e0228
“S’appuyant sur l’absence de gènes Hox et ParaHox dans le génome d’A. queenslandica, Larroux et al. (2007) avaient proposé que le groupe de gènes NK identifiés chez les éponges (Seimiya et al., 1994; Manuel and Le Parco, 2000) représente l’état plésiomorphe, et que le cluster ancestral correspondant…”
Janßen, R., Cabello, L. I., & Aase-Remedios, M. E. (2026) · BMC Ecology and Evolution · doi:10.1186/s12862-026-02513-z
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Kulkarni, S., Klementz, B. C., Ballesteros, J. A., Abshire, K. M., Cunha, T. J., Hassan, M. K., Laumer, E. M., de Medeiros, B. A. S., Neu, S., Pankey, M. S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.22.733561 · Cited by 2
“…myriapod outgroup; Supplementary Table S2) for five gene clusters that have been shown to retain duplicated paralogs with high fidelity in animal genomes: the Hox, Nk, Iroquois, HRO, and SINE clusters (Laga-Trillo and Meyer 2001; Larroux et al. 2007; Nong et al. 2021; Aase-Remedios et al. 2023).”
Metadata
- Authors
- Larroux, C., Fahey, B., Degnan, S. M., Adamski, M., Rokhsar, D. S., & Degnan, B. M.
- Affiliations
- The University of Queensland (AU)
- Joint Genome Institute (US)
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 17
- Issue
- 8
- Pages
- 706-710
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1998231969
- Cited by
- 173
- References
- 31
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 9
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2299 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Australian Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- ParaHox genes, gene cluster evolution, sponge evolution, Amphimedon queenslandica, last common ancestor, animal evolution
- MeSH terms
- Animals, Cnidaria, Embryo, Nonmammalian, Genes, Homeobox, Multigene Family, Invertebrates, Porifera, Genome, DNA, Complementary, Evolution, Molecular, Gastropoda, Antennapedia Homeodomain Protein
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