The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes
Open accessAbstract
It has long been known that human keratinocytes are a potent source of the proinflammatory cytokines proIL-1alpha and -1beta[1], which are activated and released in response to UV irradiation [2]. However, the intracellular pathways, which regulate maturation and secretion of IL-1 in keratinocytes, are unknown. Here we show that the UVB-mediated enhancement of cytoplasmic Ca(2+) is required for activation of the IL-1beta-converting enzyme caspase-1 by the inflammasome, a multiprotein innate immune complex [3, 4]. Caspase-1 in turn activates proIL-1beta, and keratinocytes secrete the cytokine as well as inflammasome components. These results demonstrate the presence of a proIL-1beta-processing inflammasome in nonprofessional immune cells and the necessity of inflammasome components for the UVB-induced secretion of IL-1beta. This supports the concept that keratinocytes are important immuno-competent cells under physiological and pathological conditions [5].
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In the citing paper
“Recent studies have implicated the inflammasome, a multiprotein complex of the innate immune system responsible for activation and release of IL-1β from several skin cell types, in the development of chronic wounds (31, 32).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [31]
In the citing paper
“We postulated that constitutive expression of pro-IL-1β by keratinocytes [20] as shown (Figure 2A) would prime them for activation of the inflammasome.”
From Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes (2012) · cites this paper as [20]
In the citing paper
“For example, both murine and human keratinocytes express inflammasome components NLRP-3, ASC, caspase-1, IL-1β, and IL-18 (43,44).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [43]
In the citing paper
“In addition, ultraviolet irradiation–induced IL-1β secretion from human keratinocytes in vitro appears to be mediated by the NLRP-3 inflammasome (43)”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [43]
Citations
Cites
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864
Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
Mariathasan, S., & Monack, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1997 · Cited by 879
Keratinocytes as initiators of inflammation
Barker, J. N., Griffiths, C. E. M., Nickoloff, B. J., Mitra, R. S., Dixit, V. M., & Nickoloff, B. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)92168-2 · Cited by 766
Early molecular events in the induction phase of contact sensitivity.
Enk, A., & Katz, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1398 · Cited by 650
Gurcel, L., Abrami, L., Girardin, S. E., Tschopp, J., & van der Goot, F. G. (2006) · Cell · doi:10.1016/j.cell.2006.07.033 · Cited by 508
Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea
Dinarello, C. A. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08307.x · Cited by 497
The Inflammasome: First Line of the Immune Response to Cell Stress
Ogura, Y., Sutterwala, F. S., & Flavell, R. A. (2006) · Cell · doi:10.1016/j.cell.2006.08.002 · Cited by 474
Andrei, C., Margiocco, P., Poggi, A. D., Lotti, L. V., Torrisi, M. R., & Rubartelli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308558101 · Cited by 423
Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity
Watanabe, H., Gaide, O., Pétrilli, V., Martinon, F., Contassot, E., Roques, S., Kummer, J. A., Tschopp, J., & French, L. E. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700819 · Cited by 416
Kupper, T. S., Ballard, D. W., Chua, A. O., McGuire, J., Flood, P. M., Horowitz, M. C., Langdon, R. C., Lightfoot, L., & Gubler, U. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.164.6.2095 · Cited by 386
Kupper, T. S., Chua, A. O., Flood, P. M., McGuire, J., & Gubler, U. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113090 · Cited by 343
Mizutani, H., Black, R. A., & Kupper, T. S. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115067 · Cited by 206
Ansel, J. C., Luger, T. A., & Green, I. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12522862 · Cited by 164
The expression and modulation of IL-1 alpha in murine keratinocytes.
Ansel, J. C., Luger, T. A., Lowry, D. T., Perry, P., Roop, D. R., & Mountz, J. D. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.7.2274 · Cited by 123
Zepter, K., Häffner, A. C., Soohoo, L., Luca, D. D., Tang, H. P., Fisher, P. B., Chavinson, J., & Elmets, C. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.12.6203 · Cited by 94
Human keratinocytes constitutively produce but do not process interleukin-18
Mee, J. B., Alam, Y., & Groves, R. W. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03759.x · Cited by 84
Braun, S., Krampert, M., Bodó, E., Kümin, A., Born-Berclaz, C., Paus, R., & Werner, S. (2006) · Journal of Cell Science · doi:10.1242/jcs.03259 · Cited by 82
Self-citationKondo, S., Sauder, D. N., Kono, T., Galley, K. A., & McKenzie, R. C. (1994) · Experimental Dermatology · doi:10.1111/j.1600-0625.1994.tb00263.x · Cited by 75
The estrogen-responsive B box protein: a novel enhancer of interleukin-1β secretion
Munding, C., Keller, M., Niklaus, G., Papin, S., Tschopp, J., Werner, S., & Beer, H. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401896 · Cited by 65
Self-citationThe Estrogen-responsive B Box Protein
Beer, H., Munding, C., Dubois, N. C., Mamie, C., Hohl, D., & Werner, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111233200 · Cited by 33
Self-citationLich, J. D., Arthur, J. C., & Ting, J. P. ‐. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.004 · Cited by 21
Ultraviolet action spectrum for intracellular free Ca2+ increase in human epidermal keratinocytes.
Nakagaki, T., Oda, J., Koizumi, H., Fukaya, T., Yasui, C., & Ueda, T. (1990) · Cell Structure and Function · doi:10.1247/csf.15.175 · Cited by 16
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Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
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Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288
Mechanism and Regulation of NLRP3 Inflammasome Activation
He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759
Metadata
- Authors
- Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D.
- Affiliations
- ETH Zurich (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Beer, Hans-Dietmar
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 17
- Issue
- 13
- Pages
- 1140-1145
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1999276471
- Cited by
- 544
- References
- 25
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 19 · 2023: 22 · 2022: 23 · 2021: 32 · 2020: 29 · 2019: 30 · 2018: 30 · 2017: 38 · 2016: 34 · 2015: 35 · 2014: 40 · 2013: 30 · 2012: 41
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- inflammasome, UVB irradiation, IL-1β, keratinocytes, caspase-1, intracellular calcium, innate immunity, skin inflammation
- MeSH terms
- Animals, Calcium, Cytoplasm, Dermatitis, Humans, Interleukin-1, Protein Precursors, Ultraviolet Rays, Keratinocytes, Cytokines, Mice, Knockout, Inflammation Mediators, Caspase 1, Multiprotein Complexes, Mice, Interleukin-1beta
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