Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity
Open accessAbstract
The inflammasome is a cytosolic protein complex regulating the activation of caspase-1, which cleaves the pro-inflammatory cytokines IL-1beta and IL-18 into their active form. The inflammasome is composed of a NACHT-, LRR- and pyrin (NALP) family member that acts as a sensor for danger signals and the adaptor protein apoptosis-associated speck-like protein containing a CARD domain (ASC), which allows the recruitment of caspase-1 in the complex. In the skin, exposure to contact sensitizers (CS) such as trinitro-chlorobenzene causes an immune response called contact hypersensitivity (CHS) or eczema. In this delayed-type hypersensitivity response, efficient priming of the adaptive immunity depends on the concomitant activation of the innate immune system, including IL-1beta/IL-18 activation in the skin. To determine if the inflammasome contributes to CHS, we have analyzed its capacity to react to CS in vitro and in vivo. We show here that key components of the inflammasome are present in human keratinocytes and that CS like trinitro-chlorobenzene induce caspase-1/ASC dependent IL-1beta and IL-18 processing and secretion. We also show that ASC- and NALP3-deficient mice display an impaired response to CS. These findings suggest that CS act as danger signals that activate the inflammasome in the skin, and reveal a new role of NALP3 and ASC as regulators of innate immunity in CHS.
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Contact hypersensitivity appears to be mediated by the inflammasome/IL-1β pathway.
“and contact hypersensitivity appears to be mediated by the inflammasome/IL-1β pathway (44,45).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [44]
Both murine and human keratinocytes express inflammasome components NLRP-3, ASC, caspase-1, IL-1β, and IL-18.
“For example, both murine and human keratinocytes express inflammasome components NLRP-3, ASC, caspase-1, IL-1β, and IL-18 (43,44).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [44]
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Cites
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312 · see citing works
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works
Self-citationThe Danger Model: A Renewed Sense of Self
Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205 · see citing works
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Thornberry, N., Bull, H., Calaycay, J., Chapman, K., Howard, A., Kostura, M., Miller, D. K., Molineaux, S., Weidner, J., Auniņš, J., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,725 · see citing works
Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works
Molecular identification of a danger signal that alerts the immune system to dying cells
Shi, Y., Evans, J. E., & Rock, K. L. (2003) · Nature · doi:10.1038/nature01991 · Cited by 1,684 · see citing works
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production
Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A. B., Quintal, L. J., Sekut, L., Talanian, R. V., Paskind, M. P., et al. (1997) · Nature · doi:10.1038/386619a0 · Cited by 1,204 · see citing works
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Kanneganti, T., Özören, N., Body–Malapel, M., Amer, A. O., Park, J., Franchi, L., Whitfield, J. R., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006) · Nature · doi:10.1038/nature04517 · Cited by 1,149 · see citing works
Molecular Cloning of the Interleukin-1β Converting Enzyme
Cerretti, D. P., Kozlosky, C. J., Mosley, B., Nelson, N. C., Ness, K. V., Greenstreet, T. A., March, C. J., Kronheim, S. R., Druck, T., Cannizzaro, L. A., et al. (1992) · Science · doi:10.1126/science.1373520 · Cited by 1,147 · see citing works
Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980 · see citing works
Martinon, F., & Tschopp, J. (2004) · Cell · doi:10.1016/j.cell.2004.05.004 · Cited by 940 · see citing works
NLRs join TLRs as innate sensors of pathogens
Martinon, F., & Tschopp, J. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.06.004 · Cited by 673 · see citing works
Interleukin-1–Receptor Antagonist in the Muckle–Wells Syndrome
Hawkins, P. N., Lachmann, H. J., & McDermott, M. F. (2003) · New England Journal of Medicine · doi:10.1056/nejm200306193482523 · Cited by 654 · see citing works
Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.
Kaplan, D., Jenison, M., Saeland, S., Shlomchik, W. D., & Shlomchik, M. (2005) · Immunity · doi:10.1016/j.immuni.2005.10.008 · Cited by 601 · see citing works
Faria, A. M. C., & Weiner, H. L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00280.x · Cited by 601 · see citing works
Hiscott, J., Marois, J., Garoufalis, J., D'Addario, M., Roulston, A., Kwan, I., Pepin, N., Lacoste, J., Nguyen, H., & Bensi, G. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6231 · Cited by 585 · see citing works
The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1
Srinivasula, S. M., Poyet, J.-L., Razmara, M., Datta, P., Zhang, Z., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200179200 · Cited by 573 · see citing works
Hoffman, H. M., Rosengren, S., Boyle, D. L., Cho, J. Y., Nayar, J., Mueller, J. L., Anderson, J. P., Wanderer, A. A., & Firestein, G. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17401-1 · Cited by 552 · see citing works
Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
Grabbe, S., & Schwarz, T. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01186-9 · Cited by 513 · see citing works
Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea
Dinarello, C. A. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08307.x · Cited by 497 · see citing works
Enk, A., Angeloni, V. L., Udey, M. C., & Katz, S. I. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.9.3698 · Cited by 423 · see citing works
Rosenstiel, P. C., Fantini, M. C., Bräutigam, K., Waetzig, G., Kuehbacher, T., Seegert, D., & Schreiber, S. (2003) · Gastroenterology · doi:10.1053/gast.2003.50157 · Cited by 423 · see citing works
Mizutani, H., Schechter, N. M., Lazarus, G. S., Black, R. A., & Kupper, T. S. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.4.821 · Cited by 317 · see citing works
Kitagaki, H., Ono, N., Hayakawa, K., Kitazawa, T., Watanabe, K., & Shiohara, T. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.5.2484 · Cited by 245 · see citing works
Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone.
Shornick, L. P., Togni, P. D., Mariathasan, S., Goellner, J. J., Strauss‐Schoenberger, J., Karr, R. W., Ferguson, T. A., & Chaplin, D. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1427 · Cited by 237 · see citing works
Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity.
Murphy, J., Robert, C., & Kupper, T. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00917.x · Cited by 214 · see citing works
Naik, S. M., Cannon, G., Burbach, G. J., Parker, S. R. S., Swerlick, R. A., Ansel, J. C., Caughman, S. W., & Wilcox, J. N. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00750.x · Cited by 157 · see citing works
Grabbe, S., Steinert, M., Mahnke, K., Schwartz, A., Luger, T. A., & Schwarz, T. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118899 · Cited by 155 · see citing works
Yamanaka, K., Tanaka, M., Tsutsui, H., Kupper, T. S., Asahi, K., Okamura, H., Nakanishi, K., Suzuki, M., Kayagaki, N., Black, R. A., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.997 · Cited by 135 · see citing works
Antonopoulos, C., Cumberbatch, M., Dearman, R. J., Daniel, R. J., Kimber, I., & Groves, R. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.3672 · Cited by 114 · see citing works
Cumberbatch, M., Bhushan, M., Dearman, R. J., Kimber, I., & Griffiths, C. E. M. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02146.x · Cited by 107 · see citing works
Cytokines and Langerhans cell mobilisation in mouse and man
Griffiths, C. E. M., Dearman, R. J., Cumberbatch, M., & Kimber, I. (2005) · Cytokine · doi:10.1016/j.cyto.2005.07.011 · Cited by 105 · see citing works
Ashikaga, T., de la Hoya, M., Itagaki, H., Katsumura, Y., & Aiba, S. (2002) · Toxicology in Vitro · doi:10.1016/s0887-2333(02)00060-7 · Cited by 95 · see citing works
Cumberbatch, M. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9442 · Cited by 85 · see citing works
Contribution of Langerhans Cell-Derived IL-18 to Contact Hypersensitivity
Wang, B., Feliciani, C., Howell, B. G., Freed, I., Cai, Q., Watanabe, H., & Sauder, D. N. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3303 · Cited by 68 · see citing works
Blockade of Experimental Atopic Dermatitis via Topical NF-κB Decoy Oligonucleotide
Dajee, M., Muchamuel, T., Schryver, B. B., Oo, A., Alleman-Sposeto, J., Vry, C. G. D., Prasad, S., Ruhrmund, D., Shyamsundar, R., Mutnick, D., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700307 · Cited by 59 · see citing works
Kawase, Y., Yokota, K., Kuzuhara, A., Kirii, Y., Nishiwaki, E., Maeda, Y., Yoshino, K., Hoshino, T., Takeda, J., Okamoto, M., et al. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12407.x · Cited by 53 · see citing works
Bigby, M. E., KWAN, T. H., & Y, M. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12460983 · Cited by 47 · see citing works
Epidermal cells: methods and protocols
Turksen, K. (2005) · Melanoma Research · doi:10.1097/00008390-200504000-00010 · Cited by 46 · see citing works
Primary Mouse Keratinocyte Culture
Pirrone, A., Hager, B., & Fleckman, P. H. (2004) · Humana Press eBooks · doi:10.1385/1-59259-830-7:003 · Cited by 29 · see citing works
Riemann, H., Loser, K., Beissert, S., Fujita, M., Schwarz, A., Schwarz, T., & Grabbe, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5866 · Cited by 18 · see citing works
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Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works
Caspase Functions in Cell Death and DiseasePreprint
McIlwain, D. R., Berger, T., & Mak, T. W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008656 · Cited by 2,607 · see citing works
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works
Self-citationThe Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618 · see citing works
Epithelialization in Wound Healing: A Comprehensive Review
Pastar, I., Stojadinović, O., Yin, N. C., Ramirez, H. A., Nusbaum, A. G., Sawaya, A. P., Patel, S. B., Khalid, L., Isseroff, R. R., & Tomic‐Canic, M. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0473 · Cited by 1,549 · see citing works
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,431 · see citing works
The IL-1 family: regulators of immunity
Sims, J. E., & Smith, D. E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2691 · Cited by 1,416 · see citing works
Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?
Abais, J. M., Xia, M., Zhang, Y., Boini, K. M., & Li, P. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5994 · Cited by 936 · see citing works
Pattern recognition receptors and control of adaptive immunity
Palm, N. W., & Medzhitov, R. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00731.x · Cited by 724 · see citing works
The inflammasome: a danger sensing complex triggering innate immunity
Pétrilli, V., Dostert, C., Muruve, D. A., & Tschopp, J. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.09.002 · Cited by 700 · see citing works
Self-citationChiricozzi, A., Guttman-Yassky, E., Suárez-Fariñas, M., Nograles, K. E., Tian, S., Cardinale, I., Chimenti, S., & Krueger, J. G. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.340 · Cited by 686 · see citing works
The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes
Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D. (2007) · Current Biology · doi:10.1016/j.cub.2007.05.074 · Cited by 544 · see citing works
Early immune events in the induction of allergic contact dermatitis
Kaplan, D. H., Igyártó, B. Z., & Gaspari, A. A. (2012) · Nature reviews. Immunology · doi:10.1038/nri3150 · Cited by 517 · see citing works
Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens
Dudeck, A., Dudeck, J., Scholten, J., Petzold, A., Surianarayanan, S., Köhler, A., Peschke, K., Voehringer, D., Waskow, C., Krieg, T. M., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.028 · Cited by 455 · see citing works
Molecular Mechanism of NLRP3 Inflammasome Activation
Jin, C., & Flavell, R. A. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9440-3 · Cited by 440 · see citing works
Gris, D., Ye, Z., Iocca, H. A., Wen, H., Craven, R. R., Gris, P., Huang, M., Schneider, M., Miller, S. D., & Ting, J. P.-Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904145 · Cited by 429 · see citing works
Keratin 6, 16 and 17—Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis
Zhang, X., Yin, M., & Zhang, L. (2019) · Cells · doi:10.3390/cells8080807 · Cited by 411 · see citing works
Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis
Gasse, P., Riteau, N., Charron, S., Girre, S., Fick, L., Pétrilli, V., Tschopp, J., Lagente, V., Quesniaux, V. F. J., Ryffel, B., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200808-1274oc · Cited by 410 · see citing works
Cell Volume Regulation Modulates NLRP3 Inflammasome Activation
Compan, V., Baroja‐Mazo, A., López‐Castejón, G., Gomez, A. I., Martínez, C. M., Angosto-Bazarra, D., Montero, M. T., Herranz, A. S., Bazán, E., Reimers, D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.013 · Cited by 390 · see citing works
The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
Menu, P., & Vince, J. E. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04440.x · Cited by 387 · see citing works
Honda, T., Egawa, G., Grabbe, S., & Kabashima, K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.284 · Cited by 365 · see citing works
Meng, G., Zhang, F., Fuss, I. J., Kitani, A., & Strober, W. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.012 · Cited by 365 · see citing works
Peiser, M., Tralau, T., Heidler, J., Api, A. M., Arts, J. H. E., Basketter, D. A., English, J. S. C., Diepgen, T. L., Fuhlbrigge, R. C., Gaspari, A. A., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0846-8 · Cited by 361 · see citing works
Differential Expression of NLRP3 among Hematopoietic Cells
Guarda, G., Zenger, M., Yazdi, A. S., Schroder, K., Ferrero, I., Menu, P., Tardivel, A., Mattmann, C., & Tschopp, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002720 · Cited by 350 · see citing works
The Inflammasomes in Kidney Disease
Anders, H., & Muruve, D. A. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080798 · Cited by 349 · see citing works
Inflammasomes: too big to miss
Stutz, A., Golenbock, D. T., & Latz, E. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40599 · Cited by 345 · see citing works
Mirza, R. E., Fang, M. M., Weinheimer-Haus, E. M., Ennis, W. J., & Koh, T. J. (2014) · Diabetes · doi:10.2337/db13-0927 · Cited by 319 · see citing works
Primer: inflammasomes and interleukin 1β in inflammatory disorders
Church, L. D., Cook, G. P., & McDermott, M. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0681 · Cited by 312 · see citing works
Salminen, A., Ojala, J. O., Kaarniranta, K., & Kauppinen, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0962-0 · Cited by 304 · see citing works
Okamoto, M., Liu, W., Luo, Y., Tanaka, A., Cai, X., Norris, D. A., Dinarello, C. A., & Fujita, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064907 · Cited by 293 · see citing works
Tseng, W. A., Thein, T., Kinnunen, K., Lashkari, K., Gregory, M. S., D'Amore, P. A., & Ksander, B. R. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10655 · Cited by 287 · see citing works
Mechanisms of chemical-induced innate immunity in allergic contact dermatitis
Martin, S. F., Esser, P. R., Weber, F. C., Jakob, T., Freudenberg, M. A., Schmidt, M., & Goebeler, M. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02652.x · Cited by 290 · see citing works
A review of the health hazards posed by cobalt
Paustenbach, D. J., Tvermoes, B. E., Unice, K. M., Finley, B. L., & Kerger, B. D. (2013) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.779633 · Cited by 281 · see citing works
Epithelial decision makers: in search of the 'epimmunome'
Swamy, M., Jamora, C., Havran, W. L., & Hayday, A. (2010) · Nature Immunology · doi:10.1038/ni.1905 · Cited by 269 · see citing works
Bryan, N. B., Dorfleutner, A., Rojanasakul, Y., & Stehlik, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802367 · Cited by 260 · see citing works
Caicedo, M. S., Desai, R., McAllister, K., Reddy, A., Jacobs, J. J., & Hallab, N. J. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20826 · Cited by 257 · see citing works
Maverakis, E. M., Miyamura, Y., Bowen, M. P., Correa, G., Ono, Y., & Goodarzi, H. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.011 · Cited by 252 · see citing works
Chapter 3 Cellular and Molecular Mechanisms in Atopic Dermatitis
Oyoshi, M. K., He, R., Kumar, L., Yoon, J., & Geha, R. S. (2009) · Advances in immunology · doi:10.1016/s0065-2776(09)01203-6 · Cited by 242 · see citing works
IL-1β Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo
Kistowska, M., Gehrke, S., Jankovic, D. L., Kerl, K., Fettelschoss‐Gabriel, A., Feldmeyer, L., Fenini, G., Kolios, A. G. A., Navarini, A. A., Gancevičienė, R., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.438 · Cited by 239 · see citing works
The cutaneous innate immune response in patients with atopic dermatitis
Kuo, I., Yoshida, T., Benedetto, A. D., & Beck, L. A. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1563 · Cited by 232 · see citing works
NALP Inflammasomes: a central role in innate immunity
Martinon, F., Gaide, O., Pétrilli, V., Mayor, A., & Tschopp, J. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0079-y · Cited by 218 · see citing works
Self-citationTargeting the Redox Balance in Inflammatory Skin Conditions
Wagener, F. A. D. T. G., Carels, C. E. L., & Lundvig, D. M. S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059126 · Cited by 219 · see citing works
The NLRP3 inflammasome: A sensor of immune danger signals
Cassel, S. L., Joly, S., & Sutterwala, F. S. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.05.002 · Cited by 217 · see citing works
Lack of the purinergic receptor P2X7 results in resistance to contact hypersensitivity
Weber, F. C., Esser, P. R., Müller, T., Ganesan, J., Pellegatti, P., Simon, M. M., Zeiser, R., Idzko, M., Jakob, T., & Martin, S. F. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092489 · Cited by 209 · see citing works
Regulation of the T Cell Response by CD39
Takenaka, M. C., Robson, S. C., & Quintana, F. J. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.009 · Cited by 203 · see citing works
Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance
Yu, J., & Lee, M. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0827-4 · Cited by 207 · see citing works
NOD-like receptors and the innate immune system: Coping with danger, damage and death
Kersse, K., Bertrand, M. J. M., Lamkanfi, M., & Vandenabeele, P. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.09.003 · Cited by 202 · see citing works
Propionibacterium acnes Induces IL-1β Secretion via the NLRP3 Inflammasome in Human Monocytes
Qin, M., Pirouz, A., Kim, M., Krutzik, S. R., Garbán, H., & Kim, J. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.309 · Cited by 201 · see citing works
Contact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid Degradation
Esser, P. R., Wölfle, U., Dürr, C., von Loewenich, F. D., Schempp, C. M., Freudenberg, M. A., Jakob, T., & Martin, S. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041340 · Cited by 185 · see citing works
Natsch, A. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp228 · Cited by 183 · see citing works
Toll-Like Receptor 4 Has an Essential Role in Early Skin Wound Healing
Chen, L., Guo, S., Ranzer, M. J., & DiPietro, L. A. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.267 · Cited by 180 · see citing works
Yuan, X., Liu, W., Zhang, P., Wang, R., & Guo, J. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.12.007 · Cited by 172 · see citing works
Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs
Becker, C., & O'Neill, L. A. J. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0081-4 · Cited by 163 · see citing works
Hirota, J. A., Hirota, S. A., Warner, S., Stefanowicz, D., Shaheen, F., Beck, P. L., MacDonald, J. A., Hackett, T., Sin, D. D., van Eeden, S. F., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.033 · Cited by 161 · see citing works
Alarmins, inflammasomes and immunity
Ojcius, D. M., & Sadier, N. S. (2012) · Biomedical Journal · doi:10.4103/2319-4170.104408 · Cited by 163 · see citing works
NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy
Loukovaara, S., Piippo, N., Kinnunen, K., Hytti, M., Kaarniranta, K., & Kauppinen, A. (2017) · Acta Ophthalmologica · doi:10.1111/aos.13427 · Cited by 160 · see citing works
Cho, K., Suh, J. W., Lee, K. H., Kang, J. L., & Woo, S. (2011) · International Immunology · doi:10.1093/intimm/dxr110 · Cited by 154 · see citing works
The microbial and danger signals that activate Nod-like receptors
Benkő, S., Philpott, D. J., & Girardin, S. E. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.013 · Cited by 153 · see citing works
Arthur, J. C., Lich, J. D., Ye, Z., Allen, I. C., Gris, D., Wilson, J. E., Schneider, M., Roney, K. E., O’Connor, B. P., Moore, C. B., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002227 · Cited by 153 · see citing works
Drexler, S. K., Bonsignore, L., Masin, M., Tardivel, A., Jackstadt, R., Hermeking, H., Schneider, P., Groß, O., Tschopp, J., & Yazdi, A. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209171109 · Cited by 150 · see citing works
Inflammasome and IL-1β-Mediated Disorders
Hoffman, H. M., & Wanderer, A. A. (2010) · Current Allergy and Asthma Reports · doi:10.1007/s11882-010-0109-z · Cited by 151 · see citing works
Interleukin-1, inflammasomes and the skin
Feldmeyer, L., Werner, S., French, L. E., & Beer, H. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.04.008 · Cited by 151 · see citing works
Propionibacterium acnes Activates the NLRP3 Inflammasome in Human Sebocytes
Li, Z. J., Choi, D. K., Sohn, K., Seo, M. S., Lee, H. E., Lee, Y., Seo, Y., Lee, Y., Shi, G., Zouboulis, C. C., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.221 · Cited by 152 · see citing works
Organization of the skin immune system and compartmentalized immune responses in infectious diseases
Quaresma, J. A. S. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-18 · Cited by 149 · see citing works
Abais, J. M., Zhang, C., Xia, M., Liu, Q., Gehr, T. W. B., Boini, K. M., & Li, P. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4666 · Cited by 147 · see citing works
Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophages
Sandberg, W. J., Låg, M., Holme, J. A., Friede, B., Gualtieri, M., Kruszewski, M. K., Schwarze, P. E., Skuland, T., & Refsnes, M. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-32 · Cited by 142 · see citing works
Cryopyrin-Associated Periodic Syndrome: An Update on Diagnosis and Treatment Response
Yu, J. R., & Leslie, K. S. (2010) · Current Allergy and Asthma Reports · doi:10.1007/s11882-010-0160-9 · Cited by 138 · see citing works
Caicedo, M. S., Pennekamp, P. H., McAllister, K., Jacobs, J. J., & Hallab, N. J. (2009) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32627 · Cited by 136 · see citing works
Detection of immune danger signals by NALP3
Martinon, F. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607362 · Cited by 134 · see citing works
COPs and POPs: modulators of inflammasome activity
Stehlik, C., & Dorfleutner, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.7993 · Cited by 130 · see citing works
Interleukin-1, inflammasomes, autoinflammation and the skin
Contassot, E., Beer, H.-D., & French, L. E. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13590 · Cited by 130 · see citing works
Self-citationNatural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1 β Production
Tőzsér, J., & Benkő, S. (2016) · Mediators of Inflammation · doi:10.1155/2016/5460302 · Cited by 129 · see citing works
Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases
Marzano, A. V., Ortega‐Loayza, A. G., Heath, M. S., Morse, D., Genovese, G., & Cugno, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01059 · Cited by 126 · see citing works
Fenini, G., Grossi, S., Contassot, E., Biedermann, T., Reichmann, E., French, L. E., & Beer, H.-D. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.07.016 · Cited by 125 · see citing works
Liu, T., Li, L., Fu, C., Liu, H., Chen, D., & Tang, F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.008 · Cited by 125 · see citing works
Bryan, N. B., Dorfleutner, A., Kramer, S. J., Yun, C., Rojanasakul, Y., & Stehlik, C. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-23 · Cited by 117 · see citing works
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
Ratsimandresy, R. A., Dorfleutner, A., & Stehlik, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00440 · Cited by 109 · see citing works
Expression and function of the NALP3 inflammasome in rheumatoid synovium
Kolly, L., Busso, N., Palmer, G., Talabot‐Ayer, D., Chobaz, V., & So, A. K.-L. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03174.x · Cited by 109 · see citing works
Genetic support for the role of the NLRP 3 inflammasome in psoriasis susceptibility
Carlström, M., Ekman, A., Petersson, S., Söderkvist, P., & Enerbäck, C. (2012) · Experimental Dermatology · doi:10.1111/exd.12049 · Cited by 108 · see citing works
Inflammasomes in wound healing and fibrosis
Artlett, C. M. (2012) · The Journal of Pathology · doi:10.1002/path.4116 · Cited by 108 · see citing works
Inflammasome Activation of IL‐1 Family Mediators in Response to Cutaneous Photodamage†
Nasti, T. H., & Timares, L. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01182.x · Cited by 106 · see citing works
Mason, D. R., Beck, P. L., & Muruve, D. A. (2011) · Journal of Innate Immunity · doi:10.1159/000334247 · Cited by 106 · see citing works
Danger signals activating innate immunity in graft-versus-host disease
Zeiser, R., Penack, O., Holler, E., & Idzko, M. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0767-x · Cited by 105 · see citing works
IL-18 and Cutaneous Inflammatory Diseases
Lee, J. H., Cho, D., & Park, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226172 · Cited by 104 · see citing works
Keratinocytes in allergic skin diseases
Albanesi, C. (2010) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32833e08ae · Cited by 102 · see citing works
Purinergic mechanisms in neuroinflammation: An update from molecules to behavior
Beamer, E. H., Gölöncsér, F., Horváth, G., Bekő, K., Otrokocsi, L., Koványi, B., & Sperlágh, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.019 · Cited by 103 · see citing works
NLRs, inflammasomes, and viral infection
Jacobs, S. R., & Damania, B. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0312132 · Cited by 101 · see citing works
Watanabe, H., Gehrke, S., Contassot, E., Roques, S., Tschopp, J., Friedmann, P. S., French, L. E., & Gaide, O. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5826 · Cited by 101 · see citing works
The inflammasome, autoinflammatory diseases, and gout
Pétrilli, V., & Martinon, F. (2007) · Joint Bone Spine · doi:10.1016/j.jbspin.2007.04.004 · Cited by 101 · see citing works
Chen, Z., Jin, S., Wang, M., Jin, X., Lv, C., Deng, Y., & Wang, J. (2014) · The Anatomical Record · doi:10.1002/ar.23059 · Cited by 100 · see citing works
Patra, V., Wagner, K., Arulampalam, V., & Wolf, P. (2019) · iScience · doi:10.1016/j.isci.2019.04.026 · Cited by 99 · see citing works
Lachner, J., Mlitz, V., Tschachler, E., & Eckhart, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-17782-4 · Cited by 98 · see citing works
Dickel, H., Gambichler, T., Kamphowe, J., Altmeyer, P. J., & Skrygan, M. (2010) · Contact Dermatitis · doi:10.1111/j.1600-0536.2010.01769.x · Cited by 97 · see citing works
Jiang, W., Lv, H., Wang, H., Wang, D., Sun, S., Jia, Q., Wang, P., Song, B., & Ni, L. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2118-7 · Cited by 98 · see citing works
Weinheimer-Haus, E. M., Mirza, R. E., & Koh, T. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119106 · Cited by 95 · see citing works
Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?
Voß, M., Kotrba, J., Gaffal, E., Katsoulis‐Dimitriou, K., & Dudeck, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094589 · Cited by 95 · see citing works
Tran, N. T., Winichagoon, P., Dijkhuizen, M. A., Khẩn, N. C., Wasantwisut, E., Furr, H. C., & Wieringa, F. T. (2009) · Journal of Nutrition · doi:10.3945/jn.108.099754 · Cited by 95 · see citing works
P2Y6 Receptor Signaling Pathway Mediates Inflammatory Responses Induced by Monosodium Urate Crystals
Uratsuji, H., Tada, Y., Kawashima, T., Kamata, M., Hau, C. S., Asano, Y., Sugaya, M., Kadono, T., Asahina, A., Sato, S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003746 · Cited by 93 · see citing works
Contact dermatitis: from pathomechanisms to immunotoxicology
Martin, S. F. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01471.x · Cited by 92 · see citing works
- Authors
- Watanabe, H., Gaide, O., Pétrilli, V., Martinon, F., Contassot, E., Roques, S., Kummer, J. A., Tschopp, J., & French, L. E.
- Affiliations
- University of Geneva (CH)
- University of Lausanne (CH)
- University Medical Center Utrecht (NL)
- University Hospital Zurich (CH)
- Corresponding author
- Gaide, Olivier
- French, Lars E.
- ORCID
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 127
- Issue
- 8
- Pages
- 1956-1963
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1963492948
- Cited by
- 416
- References
- 43
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 19 · 2019: 22 · 2018: 15 · 2017: 21 · 2016: 30 · 2015: 19 · 2014: 35 · 2013: 28 · 2012: 36
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- National Science Foundation
- Louis-Jeantet Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- inflammasome, NLRP3, ASC, caspase-1, IL-1β processing, contact hypersensitivity, contact sensitizers, keratinocytes, innate immunity, damage-associated molecular patterns
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Carrier Proteins, Cells, Cultured, Cytoskeletal Proteins, Dermatitis, Contact, Dinitrofluorobenzene, Humans, Immunity, Innate, Inflammation, Picryl Chloride, Keratinocytes, Caspase 1, Interleukin-18, CARD Signaling Adaptor Proteins, Interleukin-1beta
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