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Correlation between Genetic and Geographic Structure in Europe
Open accessAbstract
Understanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies. Previous population genetic analyses with autosomal markers in Europe either had a wide geographic but narrow genomic coverage [1, 2], or vice versa [3-6]. We therefore investigated Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations, widely spread over Europe. Although we found only a low level of genetic differentiation between subpopulations, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance. Furthermore, mean heterozygosity was larger, and mean linkage disequilibrium smaller, in southern as compared to northern Europe. Both parameters clearly showed a clinal distribution that provided evidence for a spatial continuity of genetic diversity in Europe. Our comprehensive genetic data are thus compatible with expectations based upon European population history, including the hypotheses of a south-north expansion and/or a larger effective population size in southern than in northern Europe. By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry.
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“European Americans, however, have a history of admixture of many genetically distinct European populations.27,28”
From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [28]
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Metadata
- Authors
- Lao, O., Lu, T. T., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L. A., Comas, D., Holmlund, G., Kouvatsi, A., Macek, M., Mollet, I., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A., Gether, U., Werge, T., Rivadeneira, F., Hofman, A., Uitterlinden, A. G., Gieger, C., Wichmann, H.-E., Rüther, A., Schreiber, S., Becker, C., Nürnberg, P., Nelson, M. R., Krawczak, M., & Kayser, M.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Universitat Pompeu Fabra (ES)
- Haukeland University Hospital (NO)
- Swedish National Board of Forensic Medicine (SE)
- Aristotle University of Thessaloniki (GR)
- Innsbruck Medical University (AT)
- University of Helsinki (FI)
- University of Copenhagen (DK)
- Sankt Hans Hospital (DK)
- Erasmus MC (NL)
- Helmholtz Munich (DE)
- University of Cologne (DE)
- GlaxoSmithKline (United States) (US)
- Corresponding author
- Kayser, Manfred
- ORCID
- Lu, Timothy T.
- Nothnagel, Michael
- Caliebe, Amke
- Bertranpetit, Jaume
- Bindoff, Laurence A.
- Comas, David
- Parson, Walther
- Palo, Jukka
- Sajantila, Antti
- Tagliabracci, Adriano
- Gether, Ulrik
- Werge, Thomas
- Rivadeneira, Fernando
- Uitterlinden, André G.
- Gieger, Christian
- Wichmann, Heinz-Erich
- Schreiber, Stefan
- Becker, Christian
- Nürnberg, Peter
- Nelson, Matthew R.
- Krawczak, Michael
- Kayser, Manfred
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 18
- Issue
- 16
- Pages
- 1241-1248
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1984358340
- Cited by
- 503
- References
- 45
- Citations by year
- 2026: 6 · 2025: 48 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 8 · 2020: 17 · 2019: 16 · 2018: 23 · 2017: 19 · 2016: 27 · 2015: 33 · 2014: 33 · 2013: 37 · 2012: 41
- FWCI
- 29.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1847 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Site cant be reached (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (cc-by)
- Funders
- Gentofte Hospital
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- heterozygosity, linkage disequilibrium, effective population size, demographic history
- MeSH terms
- Europe, Genetics, Population, Genotype, Geography, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide, White People
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