Cryptic genetic variation

Uncovering cryptic genetic variation

Gibson, G., & Dworkin, I. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1426 · Cited by 546 · see citing works

The Evolutionary Genetics of Canalization

Flatt, T. (2005) · The Quarterly Review of Biology · doi:10.1086/432265 · Cited by 459 · see citing works

The Population Genetic Theory of Hidden Variation and Genetic Robustness

Hermisson, J., & Wagner, G. P. (2004) · Genetics · doi:10.1534/genetics.104.029173 · Cited by 258 · see citing works

The differential genetic and environmental canalization of fitness components in Drosophila melanogaster

Stearns, S. C., Kaiser, M., & Kawecki, T. J. (1995) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.1995.8050539.x · Cited by 158 · see citing works

Genetic Variation for Phenotypically Invariant Traits Detected in Teosinte: Implications for the Evolution of Novel Forms

Lauter, N., & Doebley, J. (2002) · Genetics · doi:10.1093/genetics/160.1.333 · Cited by 116 · see citing works

Potential Variance Affecting Homeotic Ultrabithorax and Antennapedia Phenotypes in Drosophila melanogaster

Gibson, G. C., Wemple, M., & van Helden, S. (1999) · Genetics · doi:10.1093/genetics/151.3.1081 · Cited by 54 · see citing works

Robustness: mechanisms and consequences

Masel, J., & Siegal, M. L. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.07.005 · Cited by 348 · see citing works

The role of robustness in phenotypic adaptation and innovation

Wagner, A. (2012) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2011.2293 · Cited by 139 · see citing works

Drosophila as a Model for Diabetes and Diseases of Insulin Resistance

Graham, P. L., & Pick, L. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.07.011 · Cited by 132 · see citing works

Diet and hormonal manipulation reveal cryptic genetic variation: implications for the evolution of novel feeding strategies

Ledón‐Rettig, C. C., Pfennig, D. W., & Crespi, E. J. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.0877 · Cited by 101 · see citing works

Genotype-by-Diet Interactions Drive Metabolic Phenotype Variation inDrosophila melanogaster

Reed, L. K., Williams, S., Springston, M., Brown, J., Freeman, K., DESROCHES, C. E., Sokolowski, M. B., & Gibson, G. C. (2010) · Genetics · doi:10.1534/genetics.109.113571 · Cited by 94 · see citing works

Transcriptional enhancers and their communication with gene promoters

Ray-Jones, H., & Spivakov, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03903-w · Cited by 81 · see citing works

Systems Biology of Phenotypic Robustness and Plasticity

Nijhout, H. F., Sadre‐Marandi, F., Best, J. A., & Reed, M. C. (2017) · Integrative and Comparative Biology · doi:10.1093/icb/icx076 · Cited by 71 · see citing works

Incredible Utility: The Lost Causes and Causal Debris of Psychological Science

Richters, J. E. (2021) · Basic and Applied Social Psychology · doi:10.1080/01973533.2021.1979003 · Cited by 58 · see citing works

Does Phenological Plasticity Help or Hinder Range Shifts Under Climate Change?

Zettlemoyer, M. A., & DeMarche, M. L. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.689192 · Cited by 54 · see citing works

Climate change shifts natural selection and the adaptive potential of the perennial forbBoechera strictain the Rocky Mountains

Bemmels, J. B., & Anderson, J. T. (2019) · Evolution · doi:10.1111/evo.13854 · Cited by 48 · see citing works

Do traits separated by metamorphosis evolve independently? Concepts and methods

Collet, J. M., & Fellous, S. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.0445 · Cited by 41 · see citing works

Decanalizing thinking on genetic canalization

Geiler‐Samerotte, K., Sartori, F. M. O., & Siegal, M. L. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.008 · Cited by 40 · see citing works

Genetic assimilation and accommodation: Models and mechanisms

Nijhout, H. F., Kudla, A. M., & Hazelwood, C. C. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.11.006 · Cited by 37 · see citing works

Metabolomic and Gene Expression Profiles Exhibit Modular Genetic and Dietary Structure Linking Metabolic Syndrome Phenotypes in Drosophila

Williams, S., Dew-Budd, K., Davis, K. C., Anderson, J., Bishop, R., Freeman, K., Davis, D. G., Bray, K., Perkins, L., Hubickey, J., et al. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.023564 · Cited by 29 · see citing works

ERECTA receptor-kinases play a key role in the appropriate timing of seed germination under changing salinity

Nanda, A. K., Habti, A. E., Hocart, C. H., & Masle, J. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz385 · Cited by 28 · see citing works

Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations

Fröhlich, C., Gama, J. A., Harms, K., Hirvonen, V. H. A., Lund, B. A., van der Kamp, M. W., Johnsen, P. J., Samuelsen, Ø., & Leiros, H. S. (2021) · mSphere · doi:10.1128/msphere.00108-21 · Cited by 28 · see citing works

A novel genetic locus modulates infarct volume independently of the extent of collateral circulation

Chu, P., Keum, S., & Marchuk, D. A. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00063.2013 · Cited by 26 · see citing works

Genetic Complexity in aDrosophilaModel of Diabetes-Associated Misfolded Human Proinsulin

Park, S.-Y., Ludwig, M. Z., Tamarina, N. A., He, B., Carl, S. H., Dickerson, D. A., Barse, L. W., Arun, B., Williams, C., Miles, C. M., et al. (2013) · Genetics · doi:10.1534/genetics.113.157602 · Cited by 26 · see citing works

Interactive effects of early and later nutritional conditions on the adult antioxidant defence system in zebra finches

Noguera, J. C., Monaghan, P., & Metcalfe, N. B. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.120956 · Cited by 24 · see citing works

A sibling method for identifying vQTLs

Conley, D., Johnson, R., Domingue, B. W., Dawes, C. T., Boardman, J., & Siegal, M. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194541 · Cited by 21 · see citing works

Dearth of polymorphism associated with a sustained response to selection for flowering time in maize

Durand, É., Tenaillon, M. I., Raffoux, X., Thépot, S., Falque, M., Jamin, P., Bourgais, A., Ressayre, A., & Dillmann, C. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0382-5 · Cited by 20 · see citing works

The genetic control paradigm in biology: What we say, and what we are entitled to mean

McKenna, K. Z., Gawne, R., & Nijhout, H. F. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.02.003 · Cited by 19 · see citing works

Differential regulation of cryptic genetic variation shapes the genetic interactome underlying complex traits

Yadav, A., Dhole, K., & Sinha, H. (2016) · Genome Biology and Evolution · doi:10.1093/gbe/evw258 · Cited by 18 · see citing works

Plasticity and environment-specific relationships between gene expression and fitness in Saccharomyces cerevisiae

Siddiq, M. A., Duveau, F., & Wittkopp, P. J. (2024) · Nature Ecology & Evolution · doi:10.1038/s41559-024-02582-7 · Cited by 17 · see citing works

Junk DNA Contribution to Evolutionary Capacitance Can Drive Species Dynamics

Díaz-Castillo, C. (2016) · Evolutionary Biology · doi:10.1007/s11692-016-9404-5 · Cited by 16 · see citing works

Gene–gene and gene–environment interactions in complex traits in yeast

Yadav, A., & Sinha, H. (2018) · Yeast · doi:10.1002/yea.3304 · Cited by 16 · see citing works

A Cell Fate Switch in the Caenorhabditis elegans Seam Cell Lineage Occurs Through Modulation of the Wnt Asymmetry Pathway in Response to Temperature Increase

Hintze, M., Koneru, S. L., Gilbert, S. P. R., Katsanos, D., Lambert, J., & Barkoulas, M. (2020) · Genetics · doi:10.1534/genetics.119.302896 · Cited by 14 · see citing works

Short-term artificial adaptation of Rhizoglomus irregulare to high phosphate levels and its implications for fungal-plant interactions: phenotypic and transcriptomic insights

Lucic-Mercy, E., Mercy, L., Jeschke, A., Schneider, C., & Franken, P. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1385245 · Cited by 12 · see citing works

Evolved Phenological Cueing Strategies Show Variable Responses to Climate Change

Edwards, C. B., & Yang, L. H. (2020) · The American Naturalist · doi:10.1086/711650 · Cited by 10 · see citing works

Enhancing effect of phenotype mutational robustness on adaptation in Escherichia coli

Rigato, E., & Fusco, G. (2015) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22662 · Cited by 8 · see citing works

Whelks induce an effective defense against sea stars

Miner, B. G., Donovan, D., Portis, L., & Goulding, T. C. (2013) · Marine Ecology Progress Series · doi:10.3354/meps10501 · Cited by 8 · see citing works

Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye

Ali, S., Signor, S. A., Kozlov, K. N., & Nuzhdin, S. V. (2019) · Evolution & Development · doi:10.1111/ede.12283 · Cited by 6 · see citing works

Drivers of Genetic Diversity in Keystone Forest Species: Contrasting Responses of Rare and Common Saproxylic Beetles to Habitat Location and Naturalness

Amer, N. R., Krovi, R. S., Wierzbicka, A., Plewa, R., Kadej, M., Jaworski, T., Smolis, A., Oleksa, A., Szmatoła, T., Oczkowicz, M., et al. (2026) · Molecular Ecology · doi:10.1111/mec.70454 · Cited by 4 · see citing works

Transcriptome dynamics along axolotl regenerative development are consistent with an extensive reduction in gene expression heterogeneity in dedifferentiated cells

Díaz-Castillo, C. (2017) · PeerJ · doi:10.7717/peerj.4004 · Cited by 4 · see citing works

Effects of Phenotypic Robustness on Adaptive Evolutionary Dynamics

Rigato, E., & Fusco, G. (2020) · Evolutionary Biology · doi:10.1007/s11692-020-09506-w · Cited by 4 · see citing works

Challenges of Species Identification for Parasitic Helminths

Thaenkham, U., Chaisiri, K., & Chan, A. H. E. (2022) · Springer eBooks · doi:10.1007/978-981-19-1786-8_5 · Cited by 3 · see citing works

Physiological novelties for salinity tolerance created by transgressive effects and cryptic gene functions unlocked by alien introgression from Oryza rufipogon to Oryza sativa

Mandal, S. N., Kitazumi, A., van Beek, C. R., Pabuayon, I. C. M., Sanchez, J., & Reyes, B. G. D. L. (2025) · Current Plant Biology · doi:10.1016/j.cpb.2025.100477 · Cited by 2 · see citing works

Morphological and molecular assessment of muscle metacercariae infecting tench Tinca tinca from fish farms and wild populations in Germany

Mata-Marcano, C., Stöck, M., & Knopf, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-09396-y · Cited by 2 · see citing works

A heuristic model of the effects of phenotypic robustness in adaptive evolution

Rigato, E., & Fusco, G. (2020) · Theoretical Population Biology · doi:10.1016/j.tpb.2020.11.001 · Cited by 1 · see citing works

Family-based association analysis identifies variance-controlling loci without confounding by genotype-environment correlationsPreprint

Conley, D., Johnson, R., Domingue, B. W., Dawes, C. T., Boardman, J. D., & Siegal, M. L. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/175596 · Cited by 1 · see citing works

Canalization

Bhumika (2019) · Springer eBooks · doi:10.1007/978-3-319-47829-6_393-1 · Cited by 1 · see citing works

Evolución de la arquitectura genética del comportamiento olfativo en Drosophila

Lavagnino, N. (2011) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)

Determination of novel members in the Drosophila melanogaster anteriorposterior patterning system using natural variationPreprint

Jermusyk, A. A., Gharavi, S. E., Tingare, A. S., & Reeves, G. T. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/319434

Quantifying multivariate genotype-by-environment interactions, evolutionary potential and its context-dependence in natural populations of the water flea, Daphnia magnaPreprint

Brunner, F. S., Reynolds, A., Wilson, I. W., Price, S., Paterson, S., Atkinson, D., & Plaistow, S. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.28.424558

Peer Review #1 of "Transcriptome dynamics along axolotl regenerative development are consistent with an extensive reduction in gene expression heterogeneity in dedifferentiated cells (v0.2)"

(2017) · PeerJ · doi:10.7287/peerj.4004v0.2/reviews/1

Peer Review #1 of "Transcriptome dynamics along axolotl regenerative development are consistent with an extensive reduction in gene expression heterogeneity in dedifferentiated cells (v0.1)"

(2017) · PeerJ · doi:10.7287/peerj.4004v0.1/reviews/1

Peer Review #2 of "Transcriptome dynamics along axolotl regenerative development are consistent with an extensive reduction in gene expression heterogeneity in dedifferentiated cells (v0.1)"

(2017) · PeerJ · doi:10.7287/peerj.4004v0.1/reviews/2

Peer Review #3 of "Transcriptome dynamics along axolotl regenerative development are consistent with an extensive reduction in gene expression heterogeneity in dedifferentiated cells (v0.2)"

(2017) · PeerJ · doi:10.7287/peerj.4004v0.2/reviews/3

Canalization

Bhumika (2022) · Springer eBooks · doi:10.1007/978-3-319-55065-7_393

Mapping of genotype-by-environment interaction loci for Metabolic Syndrome-like traits using the multi-parent Drosophila Synthetic Population Resource determines that main genetic effects are distinct from environment dependent plastic lociPreprint

Dew-Budd, K., Mathur, R., Roy, S., Jarnigan, J., Moss, A., Bombin, A., Oza, V. H., Rele, C. P., Adams, A., Mendez, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.04.668530

Chemical challenge is an ancient evolutionary pressure

Costa, P. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-85779-6.00008-8

Uncovering cryptic genetic variation

Gibson, G., & Dworkin, I. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1426 · Cited by 546 · see citing works

Hidden Reaction Norms, Cryptic Genetic Variation, and Evolvability

Schlichting, C. D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1438.010 · Cited by 261 · see citing works

Complex mechanisms of cryptic genetic variation

Lee, J. T. (. (2019) · University of Southern California Digital Library · doi:10.25549/usctheses-c89-118339

Cryptic genetic variation: evolution's hidden substrate

Paaby, A. B., & Rockman, M. V. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3688 · Cited by 500 · see citing works

SYMPOSIUM Cryptic Genetic Variation in Natural Populations: A Predictive Framework

Ledón-Rettig, C. C., Pfennig, D. W., Chunco, A. J., & Dworkin, I. M. (2016)