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Cited by 309

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion

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Li, Ang, Dawson, John C., Forero-Vargas, Manuel, Spence, Heather J., Yu, Xinzi, König, Ireen, Anderson, Kurt, Machesky, Laura M.·2010·Current Biology
DOI 10.1016/j.cub.2009.12.035
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Abstract

Summary Fascin is an actin bundling protein involved in filopodia assembly and cancer invasion and metastasis of multiple epithelial cancer types. Fascin forms stable actin bundles with slow dissociation kinetics in vitro [1] and is regulated by phosphorylation of serine 39 by protein kinase C (PKC) [2]. Cancer cells use invasive finger-like protrusions termed invadopodia to invade into and degrade extracellular matrix. Invadopodia have highly dynamic actin that is assembled by both Arp2/3 complex and formins [3, 4]; they also contain components of membrane trafficking machinery such as dynamin and cortactin [5] and have been compared with focal adhesions and podosomes [6, 7]. We show that fascin is an integral component of invadopodia and that it is important for the stability of actin in invadopodia. The phosphorylation state of fascin at S39, a PKC site, contributes to its regulation at invadopodia. We further implicate fascin in invasive migration into collagen I-Matrigel gels and particularly in cell types that use an elongated mesenchymal type of motility in 3D. We provide a potential molecular mechanism for how fascin increases the invasiveness of cancer cells and we compare invadopodia with invasive filopod-like structures in 3D.

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Metadata

Authors
Li, A., Dawson, J. C., Forero-Vargas, M., Spence, H. J., Yu, X., König, I., Anderson, K., & Machesky, L. M.
Venue
Current Biology
Publisher
Elsevier BV
Published
2010-02
Volume
20
Issue
4
Pages
339-345
ISSN
0960-9822 (ISSN-L)
DOI
10.1016/j.cub.2009.12.035
OpenAlex
W2075127308
Cited by
309
References
33
FWCI
11.14
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion. https://app.cochat.ai/papers/10.1016/j.cub.2009.12.035
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Li, A., Dawson, J. C., Forero-Vargas, M., Spence, H. J., Yu, X., König, I., Anderson, K., & Machesky, L. M. (2010). The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion. Current Biology. https://doi.org/10.1016/j.cub.2009.12.035

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.