Harnessing actin dynamics for clathrin-mediated endocytosis
Abstract
Actin polymerization often occurs at the plasma membrane to drive the protrusion of lamellipodia and filopodia at the leading edge of migrating cells. A role for actin polymerization in another cellular process that involves the reshaping of the plasma membrane--namely endocytosis--has recently been established. Live-cell imaging studies are shedding light on the order and timing of the molecular events and mechanisms of actin function during endocytosis.
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CME is a major endocytic route driven by clathrin.
“A major endocytic route is clathrin-mediated endocytosis (CME), a vesicle budding event on the plasma membrane driven by the coat protein clathrin (13, 14).”
From Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module (2023) · cites this paper as [14]
Cites
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<i>Candida albicans</i>internalization by host cells is mediated by a clathrin-dependent mechanism
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Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module
Wang, S., Chen, X., Crisman, L., Dou, X., Winborn, C. S., Wan, C., Puscher, H., Yin, Q., Kennedy, M. J., & Shen, J. (2023) · Science Advances · doi:10.1126/sciadv.ade2540 · Cited by 14 · see citing works
- Authors
- Kaksonen, M., Toret, C. P., & Drubin, D. G.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Drubin, David G.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2006-06
- Volume
- 7
- Issue
- 6
- Pages
- 404-414
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2012107438
- Cited by
- 706
- References
- 2
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 21 · 2020: 20 · 2019: 24 · 2018: 37 · 2017: 23 · 2016: 31 · 2015: 48 · 2014: 42 · 2013: 38 · 2012: 43
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- actin dynamics, clathrin-mediated endocytosis, actin polymerization, membrane deformation, live-cell imaging, lamellipodia, filopodia, cell migration, endocytic pathway
- MeSH terms
- Actins, Animals, Cell Membrane, Cell Movement, Clathrin, Endocytosis, Pseudopodia
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