The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Motor Coordination via a Tug-of-War Mechanism Drives Bidirectional Vesicle Transport
Open accessAbstract
The microtubule motors kinesin and dynein function collectively to drive vesicular transport. High-resolution tracking of vesicle motility in the cell indicates that transport is often bidirectional, characterized by frequent directional changes. However, the mechanisms coordinating the collective activities of oppositely oriented motors bound to the same cargo are not well understood. To examine motor coordination, we purified neuronal transport vesicles and analyzed their motility via automated particle tracking with nanometer resolution. The motility of purified vesicles reconstituted in vitro closely models the movement of LysoTracker-positive vesicles in primary neurons, where processive bidirectional motility is interrupted with frequent directional switches, diffusional movement, and pauses. Quantitative analysis indicates that vesicles copurify with a low number of stably bound motors: one to five dynein and one to four kinesin motors. These observations compare well to predictions from a stochastic tug-of-war model, where transport is driven by the force-dependent kinetics of teams of opposing motors in the absence of external regulation. Together, these observations indicate that vesicles move robustly with a small complement of tightly bound motors and suggest an efficient regulatory scheme for bidirectional motility where small changes in the number of engaged motors manifest in large changes in the motility of cargo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Support for this model includes studies of neuronal vesicles (Hendricks et al., 2010) and endosomes (Soppina et al., 2009).”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as Hendricks et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gillespie, D. T. (1976) · Journal of Computational Physics · doi:10.1016/0021-9991(76)90041-3 · Cited by 6,029
Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
Dixit, R., Ross, J. L., Goldman, Y. E., & Holzbaur, E. L. F. (2008) · Science · doi:10.1126/science.1152993 · Cited by 1,012
Self-citationForce generation of organelle transport measured in vivo by an infrared laser trap
Ashkin, A., Schütze, K., Dziedzic, J. M., Euteneuer, U., & Schliwa, M. (1990) · Nature · doi:10.1038/348346a0 · Cited by 530
Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors
Müller, M. J. I., Klumpp, S., & Lipowsky, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706825105 · Cited by 521
Cytoplasmic dynein functions as a gear in response to load
Mallik, R., Carter, B. C., Lex, S. A., King, S. J., & Gross, S. P. (2004) · Nature · doi:10.1038/nature02293 · Cited by 494
Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets
Shubeita, G. T., Tran, S. L., Xu, J., Vershinin, M. D., Cermelli, S., Cotton, S. L., Welte, M. A., & Gross, S. P. (2008) · Cell · doi:10.1016/j.cell.2008.10.021 · Cited by 375
One at a time, live tracking of NGF axonal transport using quantum dots
Cui, B., Wu, C., Chen, L., Ramı́rez, A., Bearer, E. L., Li, W., Mobley, W. C., & Chu, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706192104 · Cited by 364
Cargo transport: molecular motors navigate a complex cytoskeleton
Ross, J. L., Ali, M. Y., & Warshaw, D. M. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.11.006 · Cited by 360
Soppina, V., Rai, A. K., Ramaiya, A. J., Barak, P., & Mallik, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906524106 · Cited by 349
Huntingtin facilitates dynein/dynactin-mediated vesicle transport
Caviston, J. P., Ross, J. L., Antony, S. M., Tokito, M. K., & Holzbaur, E. L. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610628104 · Cited by 334
Cited by
Sorted by citations
Items 301–400 of 422
Crosstalk between non-processive myosin motors mediated by the actin filament elasticity
Farago, O., & Bernheim‐Groswasser, A. (2011) · Soft Matter · doi:10.1039/c0sm00927j · Cited by 4
Motor-mediated bidirectional transport along an antipolar microtubule bundle: A mathematical model
Lin, C., Ashwin, P., & Steinberg, G. (2013) · Physical Review E · doi:10.1103/physreve.87.052709 · Cited by 4
Intracellular Transport: New Tools Provide Insights into Multi-motor Transport
Hendricks, A. G., Twelvetrees, A. E., & Holzbaur, E. L. F. (2012) · Current Biology · doi:10.1016/j.cub.2012.11.009 · Cited by 4
Studying the Mechanochemistry of Processive Cytoskeletal Motors With an Optical Trap
Belyy, V., & Yıldız, A. (2016) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2016.09.037 · Cited by 4
Effects of dynein inhibitor on the number of motor proteins transporting synaptic cargos
Hayashi, K., Miyamoto, M. G., & Niwa, S. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.02.018 · Cited by 4
Collective motility of dynein linear arrays built on DNA nanotubes
Ibusuki, R., Shiraga, M., Furuta, A., Yoshio, M., Kojima, H., Oiwa, K., & Furuta, K. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.125 · Cited by 4
Cargo transportation by two species of motor protein
Zhang, Y. (2013) · Physical Review E · doi:10.1103/physreve.87.052705 · Cited by 4
In Vivo Characterization of Dynein-Driven nanovectors Using Drosophila Oocytes
Parassol, N., Bienvenu, C., Boglio, C., Fiorucci, S., Cérézo, D., Yu, X., Godeau, G., Greiner, J., Vierling, P., Noselli, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082908 · Cited by 4
Satarić, M. V., Sekulic, D. L., Zdravković, S., & Ralević, N. (2017) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2017.03.012 · Cited by 3
Presenilin PS 1∆E9 disrupts mobility of secretory organelles in rat astrocytes
Stenovec, M., Bobnar, S. T., Smolič, T., Kreft, M., Parpura, V., & Zorec, R. (2018) · Acta Physiologica · doi:10.1111/apha.13046 · Cited by 4
Torisawa, T., Saito, K., Furuta, K., & Kimura, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.23.595269 · Cited by 4
Mizuno, K., Sugahara, M., Kutomi, O., Kato, R., Itoh, T., Fujita, S., & Yamada, M. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108343 · Cited by 3
Wang, X., Ye, L., Banerjee, S., Feng, J., Liao, T., Wang, Z., Qin, J., Luo, J., Yang, W., Xu, J., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107196 · Cited by 3
Gómez‐Morón, Á., Tsukalov, I., Scagnetti, C., Pertusa, C., Lozano-Prieto, M., Martínez‐Fleta, P., Requena, S., Martı́n, P., Alfranca, A., Martín‐Gayo, E., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1411957 · Cited by 3
Motor clustering enhances kinesin-driven vesicle transport
Jiang, R., Feng, Q., Nong, D., Kang, Y. J., Sept, D., & Hancock, W. O. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.04.033 · Cited by 3
Ori-McKenney, K. M., McKenney, R. J., & Vallee, R. B. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382004-4.10016-0 · Cited by 3
Reconstitution of microtubule-based motility using cell extracts
Ayloo, S., & Holzbaur, E. L. F. (2015) · Methods in cell biology · doi:10.1016/bs.mcb.2015.02.002 · Cited by 3
Regulation of cytoplasmic dynein motility
McKenney, R. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809471-6.00015-2 · Cited by 3
Templating a Molecular Tug-of-War
Diehl, M. R. (2012) · Science · doi:10.1126/science.1230818 · Cited by 3
Mechanics of bidirectional cargo transport
Hancock, W. O. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809470-9.00007-2 · Cited by 3
Single‐Molecule Spectroscopy of Motor Proteins
Prevo, B., Açar, Ş., Kruijssen, D. L. H., & Peterman, E. J. G. (2000) · Wiley eBooks · doi:10.1002/9780470027318.a9267 · Cited by 3
Zheng, Y., Xu, D., Li, Y., Liu, L., Fu, D., Li, T., Liu, A., Liu, Y., Pang, D., & Tang, H. (2026) · ACS Nano · doi:10.1021/acsnano.6c00959 · Cited by 2
Liu, Y., Lu, Y., Tang, Z., Cao, Y., Huang, D., Wu, F. H., Zhang, Y., Li, C., Chen, G., & Wang, Q. (2022) · Biotechnology Journal · doi:10.1002/biot.202200006 · Cited by 2
Kumar, P., Chaudhury, D., Sanghavi, P., Meghna, A., & Mallik, R. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114252 · Cited by 2
Xu, J., & Gross, S. P. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382004-4.10006-8 · Cited by 2
Cellular Reconstitution of Actively Self-Organizing Systems
Siton-Mendelson, O., Gilboa, B., Ideses, Y., & Bernheim‐Groswasser, A. (2014) · CRC Press eBooks · doi:10.1201/b17612-4 · Cited by 2
Fluorescence microscopy applied to intracellular transport by microtubule motors
Pathak, D., Thakur, S., & Mallik, R. (2018) · Journal of Biosciences · doi:10.1007/s12038-018-9765-2 · Cited by 3
Cytoskeletal filament length controlled dynamic sequestering of intracellular cargoPreprint
Maelfeyt, B., & Gopinathan, A. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1907.06329 · Cited by 2
Denarier, É., Ecklund, K. H., Berthier, G., Favier, A., Gory‐Fauré, S., Macedo, L. D., Delphin, C., Andrieux, A., Markus, S. M., & Boscheron, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.13.039982 · Cited by 2
Bovyn, M. J., Reddy, B., Gross, S., & Allard, J. F. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/686147 · Cited by 2
Coil-to-Helix Transition at the Nup358-BicD2 Interface Activates BicD2 for Dynein RecruitmentPreprint
Gibson, J. M., Cui, H., Ali, M. Y., Zhao, X., Debler, E., Zhao, J., Trybus, K. M., Solmaz, S. R., & Wang, C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.06.443034 · Cited by 2
Beaudet, D., Berger, C. L., & Hendricks, A. G. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.10.495679 · Cited by 2
Renganathan, B., Moore, A., Yeo, W.-H., Petruncio, A., Ackerman, D., Wiegel, A. V., The CellMap Team, Pasolli, H. A., Xu, C. S., Shtengel, G. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.10.598346 · Cited by 2
Motor Mutants bring Wild-Type Motors to a Halt Stochastically
Kumar, E. A., Tsao, D., & Diehl, M. R. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.04.067 · Cited by 1
Reconstitution of Organelle Transport Along Microtubules In Vitro
Beaudet, D., & Hendricks, A. G. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2958-1_8 · Cited by 1
Microtubule motors of opposite polarity cooperate rather than compete in cargo transport
Markus, S. M. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01524-6 · Cited by 1
14-3-3θ phosphorylation at S232 reduces its interactome and regulates axonal trafficking
Pair, F. S., Pattanayak, R., Mobley, J. A., Kojima, K., Gannon, M. A., Ekkatine, R., Stone, W. J., Scholz, K., & Yacoubian, T. A. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052405 · Cited by 1
Singh, K., Das, S., Rai, D., Sutradhar, S., Sarkar, A., Howard, J., & Ray, K. (2026) · Journal of Cell Science · doi:10.1242/jcs.264782 · Cited by 1
Mechanisms and economy of molecular machines
Klumpp, S. (2012) · Physica Scripta · doi:10.1088/0031-8949/2012/t151/014066 · Cited by 1
Hendricks, A. G., Lazarus, J. E., & Holzbaur, E. L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb1210-1126 · Cited by 1
Visualizing In Vitro Trafficking
Murray, J. W. (2012) · Neuromethods · doi:10.1007/978-1-62703-266-7_2 · Cited by 1
Correlative Live-Cell and Super-Resolution Microscopy and Its Biological Applications
(2016) · Series in cellular and clinical imaging · doi:10.1201/9781315372884-15 · Cited by 1
Human dynein–dynactin is a fast processive motor in living cells
Verma, V., Wadsworth, P., & Maresca, T. J. (2026) · eLife · doi:10.1101/2023.11.28.569102 · Cited by 1
Shee, A., Sabharwal, V., Koushika, S. P., Nandi, A., & Chaudhuri, D. (2025) · Physical review. E · doi:10.1103/physreve.111.064404 · Cited by 1
Kita, T., Sugie, R., Suzuki, Y., & Niwa, S. (2025) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2025.102440 · Cited by 1
Single-molecule dynein motor mechanics in vitro
Yıldız, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809470-9.00005-9 · Cited by 2
Measuring Transport of Motor Cargos
Conway, L., & Ross, J. L. (2014) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-0856-9_11 · Cited by 1
Intracellular Transport: Force Controls Motor Switching at Filament Junctions
Rock, R. S. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.002 · Cited by 1
Seminars in Cell & Developmental Biology
Granger, E., McNee, G. S., Allan, V., & Woodman, P. G. (2014) · Cited by 1
Mechanisms of Cooperation in Systems of Multiple Processive Motors
Driver, J. W. (2011) · Rice Research Repository (Rice University) · Cited by 1
Stick-slip motion and universal statistics of cargo transport within living cellsPreprint
Shen, Y., Yan, C., Huang, P., Ori-McKenney, K. M., Lai, P., & Tong, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.19.654995 · Cited by 1
Morin, M., Rodrigues, S., Seiler, C., Ouni, E., Mazaud, D., Moindjie, H., Poüs, C., Aumeier, C., Schauer, K., & Nahmias, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.29.685374 · Cited by 1
Cooperative mechanisms in coupled motor proteins transport
Uppulury, K. (2012) · Rice Research Repository (Rice University)
Biophysical Studies of Axonal Transport
Conway, L. (2021) · ScholarWorks@UMassAmherst (University of Massachusetts Amherst) · doi:10.7275/5474848.0
Titus, M. A. (2011) · EMBO Reports · doi:10.1038/embor.2011.26
Mathematisch-naturwissenschaftlichen Fakultät, I. (2014)
Methods for Analysis of AP-3/Rabin4’ in Regulation of Lysosome Distribution
Ivan, V., & van der Sluijs, P. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2569-8_21
The Role of Trim58 in Erythropoiesis
Thom, C. S. (2014) · ScholarlyCommons (University of Pennsylvania)
The Emerging Role of Mitochondrial Dynamics in Cardiovascular Disease
Marín-García, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00015-9
Uppulury, V. (2013) · Rice Research Repository (Rice University)
Collective behavior of molecular motors
Neetz, M. (2012) · Qucosa (Saxon State and University Library Dresden)
Molecular Mechanisms Of Mrna Transport By A Class V Myosin And Cytoplasmic Dynein
Sladewski, T. E. (2017) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
MICROTUBULE GLIDING AT THE BOUNDARY OF KINESIN AND DYNEIN PATTERNED SURFACE
Ikuta, J., Kamisetty, N. K., Shintaku, H., Kotera, H., & Yokokawa, R. (2013)
Unravelling 3D cargo transport dynamics at the microtubule network with super-resolution microscopy
Vilanova, I. V. (2016) · UPCommons institutional repository (Universitat Politècnica de Catalunya) · doi:10.5821/dissertation-2117-105822
Bidirectional cargo transport by microtubule-based molecular motors
Hoffman, M. T. (2012) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Biophysical properties of dynein in vivo
Shubeita, G. T., Reddy, B. J. N., & Gross, S. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809470-9.00006-0
Unravelling motor protein organization on lysosomal membranes with super-resolution microscopy
Cordier, G. A. (2018) · UPCommons institutional repository (Universitat Politècnica de Catalunya) · doi:10.5821/dissertation-2117-117629
Regulation of KIF1A motility via polyglutamylation of tubulin C-terminal tailsPreprint
Lessard, D. V., Zinder, O. J., Hotta, T., Verhey, K. J., Ohi, R., & Berger, C. L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/410860
Study of a kinesin adaptor in axonal transport and synapse formation
Dehaghi, T. K. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7310
Dynein catch bond as a mediator of codependent bidirectional cellular transportPreprint
Puri, P., Gupta, N., Chandel, S., Naskar, S., Nair, A., Chaudhuri, A., Mitra, M. K., & Muhuri, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/250175
Neuromuscular Junction Defects in a Mouse Model of Charcot-Marie-Tooth Disease Type 2O
Sabblah, T. T. (2018) · Journal of International Crisis and Risk Communication Research
Mechanisms of Regulation of Cytoplasmic Dynein
Htet, Z. M. (2019) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Feng, Q., Gicking, A. M., & Hancock, W. O. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2019.11.1076
Layton, B. (2015) · Pan Stanford eBooks · doi:10.1201/b18093-9
Dias, P. G. G. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/3xwd-bf33
Motility of Microtubules Driven by Kinesin in a Viscoelastic Media on Au Nano-Pillar Substrate
Furukawa, M., Kaneko, T., & Yokokawa, R. (2020) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/mems46641.2020.9056332
Kaplan, L., & Cui, B. (2020) · Neuromethods · doi:10.1007/978-1-0716-0532-5_8
Vesicle Navigation of Microtubule Ends Distinguished by A Single Rate-Constant ModelPreprint
Gramlich, M. W., Balseiro-Gómez, S., Tabei, S. M. A., Parkes, M., & Yogev, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.21.214023
ORP1L regulates dynein clustering on endolysosmal membranes in response to cholesterol levelsPreprint
Thakur, S., Relich, P. K., Sorokina, E. M., Gyparaki, M. T., & Lakadamyali, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.28.273037
Mechanisms of Dynamic Recruitment of the ESCRT Pathway in Axons
Birdsall, V. (2020) · doi:10.7916/d8-6ef2-j580
Microtubule-based control of glioma cell migration mechanics
Prahl, L. S. (2018) · University of Minnesota Digital Conservancy (University of Minnesota)
Akhmanova, A. S. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.8685958.9200056
Hempstead, B. L. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.715297841.790852859
Delivery and Removal: Probing cargo sorting and degradation using inducible tools
Janssen, A. F. J. (2019) · Utrecht University Repository (Utrecht University) · doi:10.33540/925
Barral, Y., & Caudron, F. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717952971.793459370
Debold, E. P. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735525885.793561703
Sasai, M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734151349.793576320
Histone Deacetylase 6 at Crossroads of Invection and Innate Immunity
Moreno-Gonzalo, O. (2018) · doi:10.4321/repisalud.7741
The interplay of active and passive mechanisms in slow axonal transport
Maiya, R., Dey, S., Ray, K., & Menon, G. I. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.12.011
Measuring Axonal Cargo Transport in Mouse Primary Cortical Cultured Neurons
Sobu, Y., & Suzuki, T. (2023) · Journal of Visualized Experiments · doi:10.3791/64999
The third Japan-U.S. symposium on motor proteins and associated single-molecule biophysics
Shima, T., & Hayashi, K. (2023) · Biophysics and Physicobiology · doi:10.2142/biophysico.bppb-v20.0037
Human dynein–dynactin is a fast processive motor in living cellsPreprint
Verma, V., Wadsworth, P., & Maresca, T. J. (2024) · eLife · doi:10.7554/elife.94963
Human dynein-dynactin is a fast processive motor in living cellsPreprint
Verma, V., Wadsworth, P., & Maresca, T. J. (2024) · eLife · doi:10.7554/elife.94963.1
Mitra, A., Das, A., & Kunwar, A. (2024) · Rivista Del Nuovo Cimento · doi:10.1007/s40766-024-00061-0
Baldin, S., Carmone, C., Valetti, G., Rosa, R. D., & Barbiero, I. (2025) · FEBS Journal · doi:10.1111/febs.70230
Cell cycle-regulated tug-of-war between microtubule motors positions major trafficking organellesPreprint
Sawant, A. V., & Kaverina, I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.01.679872
Calcium-Regulated Mitochondria Remodeling by Myo19 is Required for Filopodia Tip-ExtensionPreprint
Li, S., Boris, I. S., & Henn, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.04.680418
DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2, and -3Preprint
Noell, C. R., Ma, T.-C., Jiang, R., McKinley, S. A., & Hancock, W. O. (2025) · eLife · doi:10.7554/elife.108837
Metadata
- Authors
- Hendricks, A. G., Perlson, E., Ross, J. L., Schroeder, H. W., Tokito, M., & Holzbaur, E. L. F.
- Affiliations
- University of Pennsylvania (US)
- University of Massachusetts Amherst (US)
- Corresponding author
- Holzbaur, Erika L.F.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 20
- Issue
- 8
- Pages
- 697-702
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC2908734
- OpenAlex
- W1972398314
- Cited by
- 423
- References
- 29
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 16 · 2023: 19 · 2022: 13 · 2021: 24 · 2020: 26 · 2019: 28 · 2018: 36 · 2017: 31 · 2016: 30 · 2015: 20 · 2014: 36 · 2013: 27 · 2012: 38
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (1f32gm075754-01)
- National Institute of General Medical Sciences (GM-48661, P01GM087253, GM087253, F32 GM075754, R01GM048661, GM071339, 1F32GM075754, T32GM071339)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › stochastic dynamics and bifurcation
- Keywords
- kinesin, dynein, motor coordination, tug-of-war model, directional switching, processive motility, in vitro reconstitution, particle tracking
- MeSH terms
- Dynactin Complex, Animals, Biological Transport, Dyneins, Mice, Transgenic, Microtubule-Associated Proteins, Microtubules, Neurons, Recombinant Fusion Proteins, Stress, Mechanical, Kinesins, Transport Vesicles, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review