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Stem Cell Dynamics in Response to Nutrient Availability
Open accessAbstract
Summary When nutrient availability becomes limited, animals must actively adjust their metabolism to allocate limited resources and maintain tissue homeostasis [1–3]. However, it is poorly understood how tissues maintained by adult stem cells respond to chronic changes in metabolism. To begin to address this question, we fed flies a diet lacking protein (protein starvation) and assayed both germline and intestinal stem cells. Our results revealed a decrease in stem cell proliferation and a reduction in stem cell number; however, a small pool of active stem cells remained. Upon re-feeding, stem cell number increased dramatically, indicating that the remaining stem cells are competent to respond quickly to changes in nutritional status. Stem cell maintenance is critically dependent upon intrinsic and extrinsic factors that act to regulate stem cell behaviour [4]. Activation of the insulin/IGF signalling (IIS) pathway in stem cells and adjacent support cells in the germ line was sufficient to suppress stem cell loss during starvation. Therefore, our data indicate that stem cells can directly sense changes in the systemic environment to coordinate their behaviour with the nutritional status of the animal, providing a paradigm for maintaining tissue homeostasis under metabolic stress.
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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562
FoxO3 Regulates Neural Stem Cell Homeostasis
Renault, V. M., Rafalski, V. A., Morgan, A. A., Salih, D. A. M., Brett, J. O., Webb, A. E., Villeda, S. A., Thekkat, P. U., Guillerey, C., Denko, N. C., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.09.014 · Cited by 586
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Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
Miguel-Aliaga, I., Jasper, H., & Lemaitre, B. (2018) · Genetics · doi:10.1534/genetics.118.300224 · Cited by 491
PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
Guo, L., Karpac, J., Tran, S. L., & Jasper, H. (2014) · Cell · doi:10.1016/j.cell.2013.12.018 · Cited by 462
Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth
O'Brien, L. E., Soliman, S. S., Li, X., & Bilder, D. (2011) · Cell · doi:10.1016/j.cell.2011.08.048 · Cited by 440
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy
Nakada, D., Oguro, H., Levi, B. P., Ryan, N., Kitano, A., Saitoh, Y., Takeichi, M., Wendt, G. R., & Morrison, S. J. (2014) · Nature · doi:10.1038/nature12932 · Cited by 408
Maintaining Tissue Homeostasis: Dynamic Control of Somatic Stem Cell Activity
Biteau, B., Hochmuth, C. E., & Jasper, H. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.10.004 · Cited by 314
Metadata
- Authors
- McLeod, C. J., Wang, L., Wong, C., & Jones, D. L.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 20
- Issue
- 23
- Pages
- 2100-2105
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2081003476
- Cited by
- 181
- References
- 2
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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