The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth
Open accessAbstract
Summary Throughout life, adult organs continually adapt to variable environmental factors. Adaptive mechanisms must fundamentally differ from homeostatic maintenance, but little is known about how physiological factors elicit tissue remodeling. Here, we show that specialized stem cell responses underlie the adaptive resizing of a mature organ. In the adult Drosophila midgut, intestinal stem cells interpret a nutrient cue to ‘break homeostasis’ and drive growth when food is abundant. Activated in part by niche production of insulin, stem cells direct a growth program through two altered modes of behavior: accelerated division rates and predominance of symmetric division fates. Together, these altered modes produce a net increase in total intestinal cells, which is reversed upon withdrawal of food. Thus, tissue renewal programs are not committed to maintain cellular equilibrium; stem cells can remodel organs in response to physiological triggers.
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Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
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The Digestive Tract of Drosophila melanogaster
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Metadata
- Authors
- O'Brien, L. E., Soliman, S. S., Li, X., & Bilder, D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 147
- Issue
- 3
- Pages
- 603-614
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2028133785
- Cited by
- 440
- References
- 51
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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