Cited by 291Circadian rhythm and melatoninHypothalamic control of reproductive hormonesDevelopmental Biology and Gene Regulation

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A Molecular Switch for Photoperiod Responsiveness in Mammals

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Dardente, Hugues, Wyse, Cathy A., Birnie, Mike J., Dupré, Sandrine M., Loudon, Andrew S.I., Lincoln, Gerald A., Hazlerigg, David G.·2010·Current Biology

DOI 10.1016/j.cub.2010.10.048

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Abstract

Seasonal synchronization based on day length (photoperiod) allows organisms to anticipate environmental change. Photoperiodic decoding relies on circadian clocks, but the underlying molecular pathways have remained elusive [1]. In mammals and birds, photoperiodic responses depend crucially on expression of thyrotrophin β subunit RNA (TSHβ) in the pars tuberalis (PT) of the pituitary gland [2-4]. Now, using our well-characterized Soay sheep model [2], we describe a molecular switch governing TSHβ transcription through the circadian clock. Central to this is a conserved D element in the TSHβ promoter, controlled by the circadian transcription factor thyrotroph embryonic factor (Tef). In the PT, long-day exposure rapidly induces expression of the coactivator eyes absent 3 (Eya3), which synergizes with Tef to maximize TSHβ transcription. The pineal hormone melatonin, secreted nocturnally, sets the phase of rhythmic Eya3 expression in the PT to peak 12 hr after nightfall. Additionally, nocturnal melatonin levels directly suppress Eya3 expression. Together, these effects form a switch triggering a strong morning peak of Eya3 expression under long days. Species variability in the TSHβ D element influences sensitivity to TEF, reflecting species variability in photoperiodic responsiveness. Our findings define a molecular pathway linking the circadian clock to the evolution of seasonal timing in mammals.

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Authors: Dardente, H., Wyse, C. A., Birnie, M. J., Dupré, S. M., Loudon, A. S. I., Lincoln, G. A., & Hazlerigg, D. G.
Affiliations: University of Aberdeen (GB)
University of Manchester (GB)
The Queen's Medical Research Institute (GB)
Corresponding author: Dardente, Hugues
Hazlerigg, David G.
ORCID: Dardente, Hugues
Wyse, Cathy A.
Dupré, Sandrine M.
Loudon, Andrew S.I.
Lincoln, Gerald A.
Hazlerigg, David G.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2010-12
Volume: 20
Issue: 24
Pages: 2193-2198
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2010.10.048
OpenAlex: W2062566674
Cited by: 291
References: 35
Citations by year: 2026: 9 · 2025: 16 · 2024: 17 · 2023: 23 · 2022: 17 · 2021: 32 · 2020: 21 · 2019: 9 · 2018: 19 · 2017: 23 · 2016: 6 · 2015: 18 · 2014: 25 · 2013: 21 · 2012: 18
FWCI: 8.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 959 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
HAL (submittedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders: Biotechnology and Biological Sciences Research Council (BB/G003033/1)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: photoperiod, circadian clock, pars tuberalis, melatonin, seasonal timing, Soay sheep
MeSH terms: Animals, Base Sequence, DNA-Binding Proteins, Humans, Mammals, Melatonin, Molecular Sequence Data, Pituitary Gland, Promoter Regions, Genetic, Seasons, Sheep, Transcription, Genetic, Sequence Alignment, Protein Tyrosine Phosphatases, Photoperiod, Thyrotropin, beta Subunit, Basic-Leucine Zipper Transcription Factors, Circadian Clocks

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A Molecular Switch for Photoperiod Responsiveness in Mammals

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