The circadian clock and glucocorticoids – interactions across many time scales

Dickmeis, Thomas; Weger, Benjamin D.; Weger, Meltem

doi:10.1016/j.mce.2013.05.012

Cited by 144Circadian rhythm and melatoninEstrogen and related hormone effectsStress Responses and Cortisol

The circadian clock and glucocorticoids – interactions across many time scales

Dickmeis, Thomas, Weger, Benjamin D., Weger, Meltem·2013·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2013.05.012

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Abstract

Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stress response and regulate many physiological processes, including metabolism and immune response. Their release into the blood is highly dynamic and occurs in about hourly pulses, the amplitude of which is modulated in a daytime dependent fashion. In addition, in many species seasonal changes in basal glucocorticoid levels have been reported. In their target tissues, glucocorticoids bind to cytoplasmic receptors of the nuclear receptor superfamily. Upon binding, these receptors regulate transcription in a highly dynamic fashion, which involves stochastic binding to regulatory DNA elements on a time scale of seconds and heat shock protein mediated receptor-ligand complex recycling within minutes. The glucocorticoid hormone system interacts with another highly dynamic system, the circadian clock. The circadian clock is an endogenous biological timing mechanism that allows organisms to anticipate regular daily changes in their environment. It regulates daily rhythms of glucocorticoid release by a variety of mechanisms, modulates glucocorticoid signaling and is itself influenced by glucocorticoids. Here, we discuss mechanisms, functions and interactions of the circadian and glucocorticoid systems across time scales ranging from seconds (DNA binding by transcriptional regulators) to years (seasonal rhythms).

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The current literature provides additional evidence about alternative sources of these cycles.
“In fact, the current literature provides additional evidence about those alternative sources (9).”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
The suprachiasmatic nucleus (SCN) projects the circadian rhythm through both the paraventricular nucleus (PVN) of the hypothalamus and adrenal gland.
“Based on the literature, the suprachiasmatic nucleus (SCN) projects the circadian rhythm through both the paraventricular nucleus (PVN) of the hypothalamus and adrenal gland (9).”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
The suprachiasmatic nucleus (SCN) of the hypothalamus controls the circadian system, but it is not limited to SCN.
“The current understanding of the system is that the suprachiasmatic nucleus (SCN) of the hypothalamus controls the circadian system, but it is not limited to SCN (9).”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
The circadian clock includes the SCN and cellular clocks in almost all tissues of the body which regulate the system in a hierarchical manner.
“In sum, the circadian clock includes the SCN and cellular clocks in almost all tissues of the body which regulate the system in a hierarchical manner.”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]
The literature of the circadian clock claims that circadian cycles are regulated by neural signals from the SCN to the PVN of the hypothalamus and by SCN projection to the adrenal gland through the autonomic nervous system.
“It is also consistent with the literature of the circadian clock (9) which claims that the circadian cycles is regulated by neural signals from the SCN to the PVN of the hypothalamus and by SCN projection to the adrenal gland through the autonomic nervous system.”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [9]

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Liver-Selective Transgene Rescue of Hypothalamic-Pituitary-Adrenal Axis Dysfunction in 11β-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice
Paterson, J. M., Holmes, M. C., Kenyon, C. J., Carter, R., Mullins, J. J., & Seckl, J. R. (2006) · Endocrinology · doi:10.1210/en.2006-0603 · Cited by 46 · see citing works
Glucocorticoid Regulation of Clock Gene Expression in the Mammalian Limbic Forebrain
Segall, L. A., & Amir, S. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9341-1 · Cited by 45 · see citing works
Oscillatory control of signalling molecules
Paszek, P., Jackson, D. A., & White, M. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.08.004 · Cited by 45 · see citing works
Pulsatile adrenocorticotropic hormone: An overview
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Glucocorticoid receptor mutants: man-made tools for functional research
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Circadian clock signals in the adrenal cortex
Ota, T., Fustin, J., Yamada, H., Doi, M., & Okamura, H. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.010 · Cited by 44 · see citing works
Origins and consequences of transcriptional discontinuity
Suter, D. M., Molina, N., Naef, F., & Schibler, U. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.09.004 · Cited by 43 · see citing works
The daily rhythm of the secretion of corticotrophin and corticosterone in rats and mice.
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Rhythmic changes in rate of the mammalian heart and heart cells during prolonged isolation
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Phase Relation between Episodic Fluctuations of Spontaneous Locomotor Acitivty and Plasma Corticosterone in Rats with Suprachiasmatic Nuclei Lesions
Watanabe, K., & Hiroshige, T. (2008) · Neuroendocrinology · doi:10.1159/000123200 · Cited by 40 · see citing works
Visualization of glucocorticoid receptor in the brain of green fluorescent protein–glucocorticoid receptor knockin mice
Usuku, T., Nishi, M., Morimoto, M., Brewer, J. A., Muglia, L. J., Sugimoto, T., & Kawata, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.071 · Cited by 39 · see citing works
Intracellular Regeneration of Glucocorticoids by 11 -Hydroxysteroid Dehydrogenase (11 -HSD)-1 Plays a Key Role in Regulation of the Hypothalamic-Pituitary-Adrenal Axis: Analysis of 11 -HSD-1-Deficient Mice
Harris, H. J. (2001) · Endocrinology · doi:10.1210/en.142.1.114 · Cited by 33 · see citing works
REV-ERBs: More Than the Sum of the Individual Parts
Stratmann, M., & Schibler, U. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.006 · Cited by 31 · see citing works
Circadian Timekeeping and Multiple Timescale Neuroendocrine Rhythms
Bonnefont, X. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01955.x · Cited by 27 · see citing works
Circadian and Glucocorticoid Regulation of Rev-erb Expression in Liver
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Corticosterone and Activity: The Long Arms of the Clock Talk Back
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Editorial: Ultradian, Circadian, and Stress-Related Hypothalamic-Pituitary-Adrenal Axis Activity--A Dynamic Digital-to-Analog Modulation
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A Role for the Forebrain in Mediating Time-of-Day Differences in Glucocorticoid Counterregulatory Responses to Hypoglycemia in Rats
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Steroid hormone pulsing drives cyclic gene expression
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A New Histone Code for Clocks?
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Circadian Clock Proteins and Immunity
Curtis, A. M., Bellet, M. M., Sassone‐Corsi, P., & O'Neill, L. A. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.002 · Cited by 640 · see citing works
The microbiome: a key regulator of stress and neuroinflammation
Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.001 · Cited by 508 · see citing works
A users guide to HPA axis research
Spencer, R. L., & Terrence Deak, B. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.014 · Cited by 408 · see citing works
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works
“activity synchronized with circadian and ultradian rhythms (Dallman et al., 1994; Dickmeis et al., 2013; Tsigos and Chrousos, 2002a).”
Background
Regulation and Role of Transcription Factors in Osteogenesis
Chan, W. C. W., Tan, Z., To, M. K.-T., & Chan, D. T.-M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115445 · Cited by 265 · see citing works
Interaction between circadian rhythms and stress
Koch, C. E., Leinweber, B., Drengberg, B. C., Blaum, C. M., & Oster, H. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.09.001 · Cited by 256 · see citing works
From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis
Bermúdez‐Humarán, L. G., Salinas, E., Ortíz, G. G., Ramírez-Jirano, L. J., Morales, J. A., & Bitzer-Quintero, O. K. (2019) · Nutrients · doi:10.3390/nu11040890 · Cited by 172 · see citing works
Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on Health
Nicolaides, N. C., Charmandari, E., Kino, T., & Chrousos, G. P. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00070 · Cited by 149 · see citing works
Circadian Clocks, Stress, and Immunity
Dumbell, R., Matveeva, O., & Oster, H. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00037 · Cited by 143 · see citing works
Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility
Sciarra, F., Franceschini, E., Campolo, F., Gianfrilli, D., Pallotti, F., Paoli, D., Isidori, A. M., & Venneri, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113943 · Cited by 125 · see citing works
Adrenal Clocks and the Role of Adrenal Hormones in the Regulation of Circadian Physiology
Leliavski, A., Dumbell, R., Ott, V., & Oster, H. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414553971 · Cited by 119 · see citing works
Glucocorticoid hormones are both a major circadian signal and major stress signal: How this shared signal contributes to a dynamic relationship between the circadian and stress systems
Spencer, R. L., Chun, L. E., Hartsock, M. J., & Woodruff, E. R. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.005 · Cited by 113 · see citing works
Genetic disruption of the core circadian clock impairs hippocampus-dependent memoryPreprint
Wardlaw, S. M., Phan, T., Saraf, A., Chen, X., & Storm, D. R. (2014) · Learning & Memory · doi:10.1101/lm.035451.114 · Cited by 113 · see citing works
Stem cells and the circadian clock
Weger, M., Diotel, N., Dorsemans, A.-C., Dickmeis, T., & Weger, B. D. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.09.012 · Cited by 97 · see citing works
Self-citation
Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health
Plano, S. A., Casiraghi, L. P., Moro, P. G., Paladino, N., Golombek, D. A., & Chiesa, J. J. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00558 · Cited by 95 · see citing works
Circadian clocks, cognition, and Alzheimer's disease: synaptic mechanisms, signaling effectors, and chronotherapeutics
Hoyt, K. R., & Obrietan, K. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00537-9 · Cited by 77 · see citing works
Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders
Barandas, R., Landgraf, D., McCarthy, M. J., & Welsh, D. K. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0637-2 · Cited by 68 · see citing works
Fixing the broken clock in adrenal disorders: focus on glucocorticoids and chronotherapy
Minnetti, M., Hasenmajer, V., Pofi, R., Venneri, M. A., Alexandraki, K., & Isidori, A. M. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0066 · Cited by 71 · see citing works
Clock genes alterations and endocrine disorders
Angelousi, A. G., Kassi, E. N., Ansari, N. N., Weickert, M. O., Randeva, H. S., & Kaltsas, G. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12927 · Cited by 65 · see citing works
Stress System Activation in Children and Adolescents With Autism Spectrum Disorder
Makris, G., Agorastos, A., Chrousos, G. P., & Pervanidou, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.756628 · Cited by 61 · see citing works
Review of the direct and indirect effects of hyperglycemia on the HPA axis in T2DM and the co-occurrence of depression
Mosili, P., Mkhize, B. C., Sibiya, N. H., Ngubane, P. S., & Khathi, A. (2024) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2022-003218 · Cited by 62 · see citing works
Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity
Gans, I. M., Hartig, E. I., Zhu, S., Tilden, A. R., Hutchins, L. N., Maki, N. J., Graber, J. H., & Coffman, J. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68040-z · Cited by 51 · see citing works
Circadian clock communication during homeostasis and ageing
Mortimer, T., Smith, J. G., Muñoz‐Cánoves, P., & Benitah, S. A. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00802-3 · Cited by 54 · see citing works
Modeling the hypothalamus-pituitary-adrenal axis: A review and extension
Hosseinichimeh, N., Rahmandad, H., & Wittenborn, A. K. (2015) · Mathematical Biosciences · doi:10.1016/j.mbs.2015.08.004 · Cited by 51 · see citing works
“This is consistent with the fact that SCN projects the circadian rhythm through both the PVN of the hypothalamus and adrenal gland (9).”
BackgroundInfluential
The Circadian Clock Drives Mast Cell Functions in Allergic Reactions
Christ, P., Sowa, A. S., Froy, O., & Lorentz, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01526 · Cited by 52 · see citing works
Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences
Malicki, M., Karuga, F. F., Szmyd, B. M., Sochal, M., & Gabryelska, A. (2022) · Metabolites · doi:10.3390/metabo13010060 · Cited by 49 · see citing works
The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
Astiz, M., Heyde, I., Fortmann, M. I., Boßung, V., Roll, C., Stein, A., Grüttner, B., Göpel, W., Härtel, C., Obleser, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17429-5 · Cited by 44 · see citing works
Corticosterone and timing of migratory departure in a songbird
Eikenaar, C., Müller, F., Leutgeb, C., Hessler, S., Konstantin, L., Taylor, P. D., & Schmaljohann, H. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2016.2300 · Cited by 44 · see citing works
Performing a hepatic timing signal: glucocorticoids induce gper1a and gper1b expression and repress gclock1a and gbmal1a in the liver of goldfish
Sánchez‐Bretaño, A., Callejo, M., Montero, M., Alonso-Gómez, A. L., Delgado, M. J., & Isorna, E. (2015) · Journal of Comparative Physiology B · doi:10.1007/s00360-015-0936-2 · Cited by 43 · see citing works
Crosstalking between the “gut-brain” hormone ghrelin and the circadian system in the goldfish. Effects on clock gene expression and food anticipatory activity
Nisembaum, L. G., de Pedro, N., Delgado, M. J., & Isorna, E. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.03.016 · Cited by 39 · see citing works
Impact of Heat Stress on Blood, Production, and Physiological Indicators in Heat-Tolerant and Heat-Sensitive Dairy Cows
Chen, X., Shu, H., Sun, F., Yao, J., & Gu, X. (2023) · Animals · doi:10.3390/ani13162562 · Cited by 36 · see citing works
TIMP3 is a CLOCK‐dependent diurnal gene that inhibits the expression of UVB‐induced inflammatory cytokines in human keratinocytes
Park, S., Kim, K., Bae, I., Lee, S. H., Jung, J.-Y., Lee, T. R., & Cho, E. (2017) · The FASEB Journal · doi:10.1096/fj.201700693r · Cited by 36 · see citing works
Sleep disturbances and female infertility: a systematic review
Li, J., Huang, Y.-L., Xu, S., & Wang, Y. (2024) · BMC Women s Health · doi:10.1186/s12905-024-03508-y · Cited by 35 · see citing works
Interactions between psychosocial stress and the circadian endogenous clock
Helfrich‐Förster, C. (2017) · PsyCh Journal · doi:10.1002/pchj.202 · Cited by 32 · see citing works
The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp
Knoedler, J. R., Ávila-Mendoza, J., Subramani, A., & Denver, R. J. (2020) · Journal of Biological Rhythms · doi:10.1177/0748730420913205 · Cited by 33 · see citing works
Coordination between Prefrontal Cortex Clock Gene Expression and Corticosterone Contributes to Enhanced Conditioned Fear Extinction Recall
Woodruff, E. R., Chun, L. E., Hinds, L. R., Varra, N. M., Tirado, D., Morton, S. J., McClung, C. A., & Spencer, R. L. (2018) · eNeuro · doi:10.1523/eneuro.0455-18.2018 · Cited by 32 · see citing works
Biological clock function is linked to proactive and reactive personality types
Tudorache, C., Slabbekoorn, H., Robbers, Y., Hin, E., Meijer, J. H., Spaink, H. P., & Schaaf, M. J. M. (2018) · BMC Biology · doi:10.1186/s12915-018-0618-0 · Cited by 32 · see citing works
Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids
Ayyar, V. S., Almon, R. R., Jusko, W. J., & DuBois, D. C. (2015) · Physiological Reports · doi:10.14814/phy2.12382 · Cited by 32 · see citing works
Consequences of early adverse rearing experience(EARE) on development: insights from non-human primate studies.
Zhang, B. (2017) · PubMed Central · doi:10.13918/j.issn.2095-8137.2017.002 · Cited by 31 · see citing works
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., & Challet, É. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00009-3 · Cited by 32 · see citing works
Intraindividual variability in cortisol: Approaches, illustrations, and recommendations
Segerstrom, S. C., Sephton, S. E., & Westgate, P. M. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.026 · Cited by 31 · see citing works
Corticosterone Injection Impairs Follicular Development, Ovulation and Steroidogenesis Capacity in Mice Ovary
Wei, Y., Li, W., Meng, X., Zhang, L., Shen, M., & Liu, H. (2019) · Animals · doi:10.3390/ani9121047 · Cited by 30 · see citing works
Perinatal Programming of Circadian Clock-Stress Crosstalk
Astiz, M., & Oster, H. (2018) · Neural Plasticity · doi:10.1155/2018/5689165 · Cited by 28 · see citing works
Chronic Stress, Physiological Adaptation and Developmental Programming of the Neuroendocrine Stress System
Coffman, J. A. (2020) · Future Neurology · doi:10.2217/fnl-2019-0014 · Cited by 31 · see citing works
Diel variation in corticosterone and departure decision making in migrating birds
Eikenaar, C., Schäfer, J., Hessler, S., Packmor, F., & Schmaljohann, H. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104746 · Cited by 28 · see citing works
Environmental level of the antidepressant venlafaxine induces behavioral disorders through cortisol in zebrafish larvae (Danio rerio)
Tang, Y., Mi, P., Li, M., Zhang, S., Li, J., & Feng, X. (2020) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2020.106942 · Cited by 28 · see citing works
Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain
Al-Safadi, S., Branchaud, M., Rutherford, S., & Amir, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130085 · Cited by 28 · see citing works
Circadian Clocks and the Interaction between Stress Axis and Adipose Function
Kolbe, I., Dumbell, R., & Oster, H. (2015) · International Journal of Endocrinology · doi:10.1155/2015/693204 · Cited by 26 · see citing works
Capture effects in wild boar: a multifaceted behavioural investigation
Brogi, R., Brivio, F., Bertolucci, C., Benazzi, M., Luccarini, S., Cappai, N., Bottero, E., Pedrazzoli, C., Columbano, N., Apollonio, M., et al. (2019) · Wildlife Biology · doi:10.2981/wlb.00497 · Cited by 26 · see citing works
NREM sleep hypersomnia and reduced sleep/wake continuity in a neuroendocrine mouse model of anxiety/depression based on chronic corticosterone administration
Dantec, Y. L., Hache, G., Guilloux, J., Guiard, B. P., David, D. J. P., Adrien, J., & Escourrou, P. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.050 · Cited by 26 · see citing works
Effects of circadian disruption on methamphetamine consumption in methamphetamine-exposed rats
Doyle, S. E., Feng, H., Garber, G., Menaker, M., & Lynch, W. J. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3845-2 · Cited by 26 · see citing works
Circadian Clock, Glucocorticoids and NF-κB Signaling in Neuroinflammation- Implicating Glucocorticoid Induced Leucine Zipper as a Molecular Link
Srinivasan, M., & Walker, C. L. (2022) · ASN NEURO · doi:10.1177/17590914221120190 · Cited by 25 · see citing works
Circannual changes in stress and feeding hormones and their effect on food-seeking behaviors
Cahill, S. P., Tuplin, E. W. N., & Holahan, M. R. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00140 · Cited by 25 · see citing works
Circadian dysfunction and cardio-metabolic disorders in humans
MARHEFKOVÁ, N., Sládek, M., Sumová, A., & Dubský, M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1328139 · Cited by 31 · see citing works
Steroid Hormone Receptors and Signal Transduction Processes
Klinge, C. M. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_9 · Cited by 24 · see citing works
The adrenal gland circadian clock exhibits a distinct phase advance in spontaneously hypertensive rats
Tanaka, S., Ueno, T., Tsunemi, A., Nagura, C., Tahira, K., Fukuda, N., Soma, M., & Abe, M. (2018) · Hypertension Research · doi:10.1038/s41440-018-0148-8 · Cited by 24 · see citing works
The first-line cluster headache medication verapamil alters the circadian period and elicits sex-specific sleep changes in mice
Burish, M. J., Han, C., Mawatari, K., Wirianto, M., Kim, E., Ono, K., Parakramaweera, R., Chen, Z., & Yoo, S. H. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1892127 · Cited by 24 · see citing works
Stress-induced glucocorticoids alter the Leydig cells' timing and steroidogenesis-related systems
Medar, M. L., Andrić, S. A., & Kostic, T. S. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111469 · Cited by 23 · see citing works
Effect of a mindfulness exercise on stress in veterinary students performing surgery
Stevens, B. S., Royal, K. D., Ferris, K. K., Taylor, A. J., & Snyder, A. M. (2019) · Veterinary Surgery · doi:10.1111/vsu.13169 · Cited by 23 · see citing works
Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids
Chen, Q., Li, C., Gong, Z., Chan, E. C. Y., Snyder, S. A., & Lam, S. H. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.01.036 · Cited by 23 · see citing works
Non-Canonical Effects of ACTH: Insights Into Adrenal Insufficiency
Hasenmajer, V., Bonaventura, I., Minnetti, M., Sada, V., Sbardella, E., & Isidori, A. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.701263 · Cited by 23 · see citing works
Seasonal effects on plasma cortisol concentrations in the Bedouin buck: circadian studies and response to ACTH
CHERGUI, N., Mormède, P., Foury, A., Khammar, F., & Amirat, Z. (2016) · animal · doi:10.1017/s1751731116001671 · Cited by 21 · see citing works
Patient-specific modeling of the neuroendocrine HPA-axis and its relation to depression: ultradian and circadian oscillations
Gudmand-Hoeyer, J., Timmermann, S., & Ottesen, J. T. (2014) · Mathematical Biosciences · doi:10.1016/j.mbs.2014.07.013 · Cited by 22 · see citing works
Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells.
Nürnberg, E., Horschitz, S., Schloss, P., & Meyer-Lindenberg, A. (2018) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.04.017 · Cited by 17 · see citing works
Human fertility and sleep disturbances: A narrative review
Spaggiari, G., Romeo, M., Casarini, L., Granata, A. R. M., Simoni, M., & Santi, D. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.06.009 · Cited by 21 · see citing works
Frank Beach Award Winner: The centrality of the hypothalamic-pituitary-adrenal axis in dealing with environmental change across temporal scales
Dantzer, B. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105311 · Cited by 19 · see citing works
Aging-Related Mechanisms Contribute to Corticosteroid Insensitivity in Elderly Asthma
Ford, M. L., Ruwanpathirana, A., Lewis, B. W., & Britt, R. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076347 · Cited by 17 · see citing works
White light emitting diode induces autophagy in hippocampal neuron cells through GSK-3-mediated GR and RORα pathways
Yang, Y., Jia, Y., Sun, Q., Dong, H., & Zhao, R. (2019) · Aging · doi:10.18632/aging.101878 · Cited by 17 · see citing works
Survival and growth of C57BL/6J mice lacking the BK channel, Kcnma1: lower adult body weight occurs together with higher body fat
Halm, S., Bottomley, M., Almutairi, M. M., Fulvio, M. D., & Halm, D. (2017) · Physiological Reports · doi:10.14814/phy2.13137 · Cited by 18 · see citing works
Chronic stress alters adrenal clock function in a sexually dimorphic manner
Stagl, M., Bozsik, M., Karow, C., Wertz, D., Kloehn, I., Pillai, S. B., Gasser, P. J., Gilmartin, M. R., & Evans, J. A. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0146 · Cited by 15 · see citing works
The role of the Glucocorticoid Receptor in the Regulation of Diel Rhythmicity
Jaikumar, G., Slabbekoorn, H., Sireeni, J., Schaaf, M. J. M., & Tudorache, C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112991 · Cited by 14 · see citing works
Endocrine regulation of fueling by hyperphagia in migratory birds
Eikenaar, C. (2017) · Journal of Comparative Physiology A · doi:10.1007/s00359-017-1152-1 · Cited by 15 · see citing works
Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice
Walter, L. M., Koch, C. E., Betts, C., Ahlskog, N., Meijboom, K. E., van Westering, T. L. E., Hazell, G., Bhomra, A., Claus, P., Oster, H., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy249 · Cited by 13 · see citing works
Distress and quality of life in an ethnically diverse sample awaiting breast cancer surgery
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Circadian Expression of TIMP3 Is Disrupted by UVB Irradiation and Recovered by Green Tea Extracts
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Glucocorticoids and the circadian clock
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Self-citation
Mutual interaction between glucocorticoids and the circadian clock
Astrová, A. (2025) · Digital Repository (National Repository of Grey Literature)
Glucocorticoids and circadian clock control of cell proliferation: At the interface between three dynamic systems
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Self-citation
Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks
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Authors: Dickmeis, T., Weger, B. D., & Weger, M.
Affiliations: Karlsruhe Institute of Technology (DE)
Corresponding author: Dickmeis, Thomas
ORCID: Dickmeis, Thomas
Weger, Benjamin D.
Weger, Meltem
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2013-11
Volume: 380
Issue: 1-2
Pages: 2-15
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2013.05.012
OpenAlex: W2027635336
Cited by: 144
References: 188
Citations by year: 2026: 9 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 7 · 2020: 14 · 2019: 8 · 2018: 13 · 2017: 17 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 1
FWCI: 1.21
Type: journal article
Language: en
Open access: closed
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: circadian clock, glucocorticoids, glucocorticoid receptor, nuclear receptor superfamily, seasonal rhythms, transcriptional regulation, stress response, steroid hormone signaling
MeSH terms: Adrenal Glands, Animals, Gene Expression Regulation, Glucocorticoids, Humans, Seasons, Transcription, Genetic, Signal Transduction, Feedback, Physiological, Circadian Clocks

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The circadian clock and glucocorticoids – interactions across many time scales

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