The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
A Mutually Inhibitory Interaction between Auxin and Cytokinin Specifies Vascular Pattern in Roots
Open accessAbstract
BACKGROUND Whereas the majority of animals develop toward a predetermined body plan, plants show iterative growth and continually produce new organs and structures from actively dividing meristems. This raises an intriguing question: How are these newly developed organs patterned? In Arabidopsis embryos, radial symmetry is broken by the bisymmetric specification of the cotyledons in the apical domain. Subsequently, this bisymmetry is propagated to the root promeristem. RESULTS Here we present a mutually inhibitory feedback loop between auxin and cytokinin that sets distinct boundaries of hormonal output. Cytokinins promote the bisymmetric distribution of the PIN-FORMED (PIN) auxin efflux proteins, which channel auxin toward a central domain. High auxin promotes transcription of the cytokinin signaling inhibitor AHP6, which closes the interaction loop. This bisymmetric auxin response domain specifies the differentiation of protoxylem in a bisymmetric pattern. In embryonic roots, cytokinin is required to translate a bisymmetric auxin response in the cotyledons to a bisymmetric vascular pattern in the root promeristem. CONCLUSIONS Our results present an interactive feedback loop between hormonal signaling and transport by which small biases in hormonal input are propagated into distinct signaling domains to specify the vascular pattern in the root meristem. It is an intriguing possibility that such a mechanism could transform radial patterns and allow continuous vascular connections between other newly emerging organs.
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Cites
Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation
Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens, G., & Friml, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00924-3 · Cited by 2,633
Self-citationThe PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
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Self-citationEfflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
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An Auxin-Dependent Distal Organizer of Pattern and Polarity in the Arabidopsis Root
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Self-citationThe PLETHORA Genes Mediate Patterning of the Arabidopsis Root Stem Cell Niche
Aida, M., Beis, D., Heidstra, R., Willemsen, V., Blilou, I., Galinha, C., Nussaume, L., Noh, Y.-S., Amasino, R., & Scheres, B. (2004) · Cell · doi:10.1016/j.cell.2004.09.018 · Cited by 1,213
Self-citationZuo, J., Niu, Q., & Chua, N. (2000) · The Plant Journal · doi:10.1046/j.1365-313x.2000.00868.x · Cited by 1,177
Radial Patterning of Arabidopsis Shoots by Class III HD-ZIP and KANADI Genes
Emery, J. F., Floyd, S. K., Alvarez, J., Eshed, Y., Hawker, N. P., Izhaki, A., Baum, S. F., & Bowman, J. L. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.035 · Cited by 1,143
A Genetic Framework for the Control of Cell Division and Differentiation in the Root Meristem
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Cited by
The Plant Vascular System: Evolution, Development and Functions F
Lucas, W. J., Groover, A., Lichtenberger, R., Furuta, K., Yadav, S., Helariutta, Y., He, X., Fukuda, H., Kang, J., Brady, S. M., et al. (2013) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12041 · Cited by 772
Self-citationRůžička, K., Zhang, M., Campilho, A., Bodi, Z., Kashif, M., Saleh, M., Eeckhout, D., El‐Showk, S., Li, H., Zhong, S., et al. (2017) · New Phytologist · doi:10.1111/nph.14586 · Cited by 486
Self-citationHigh levels of auxin signalling define the stem-cell organizer of the vascular cambium
Smetana, O., Mäkilä, R., Lyu, M., Amiryousefi, A., Sánchez Rodríguez, F., Wu, M.-F., Solé-Gil, A., Leal Gavarrón, M., Siligato, R., Miyashima, S., et al. (2019) · Nature · doi:10.1038/s41586-018-0837-0 · Cited by 336
Self-citationStem cell function during plant vascular development
Miyashima, S., Sebastian, J., Lee, J., & Helariutta, Y. (2013) · The EMBO Journal · doi:10.1038/emboj.2012.301 · Cited by 295
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Metadata
- Authors
- Bishopp, A., Help, H., El-Showk, S., Weijers, D., Scheres, B., Friml, J., Benková, E., Mähönen, A. P., & Helariutta, Y.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 21
- Issue
- 11
- Pages
- 917-926
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2163913684
- Cited by
- 441
- References
- 49
- FWCI
- 33.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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