Radial Patterning of Arabidopsis Shoots by Class III HD-ZIP and KANADI Genes

Emery, John F.; Floyd, Sandra K.; Alvarez, John; Eshed, Yuval; Hawker, Nathaniel P.; Izhaki, Anat; Baum, Stuart F.; Bowman, John L.

doi:10.1016/j.cub.2003.09.035

Cited by 1,143Plant Molecular Biology ResearchDevelopmental Biology and Gene RegulationPlant Parasitism and Resistance

Radial Patterning of Arabidopsis Shoots by Class III HD-ZIP and KANADI Genes

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Emery, John F., Floyd, Sandra K., Alvarez, John, Eshed, Yuval, Hawker, Nathaniel P., Izhaki, Anat, Baum, Stuart F., Bowman, John L.·2003·Current Biology

DOI 10.1016/j.cub.2003.09.035

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Abstract

Background Shoots of all land plants have a radial pattern that can be considered to have an adaxial (central)-abaxial (peripheral) polarity. In Arabidopsis, gain-of-function alleles of PHAVOLUTA and PHABULOSA, members of the class III HD-ZIP gene family, result in adaxialization of lateral organs. Conversely, loss-of-function alleles of the KANADI genes cause an adaxialization of lateral organs. Thus, the class III HD-ZIP and KANADI genes comprise a genetic system that patterns abaxial-adaxial polarity in lateral organs produced from the apical meristem. Results We show that gain-of-function alleles of REVOLUTA, another member of the class III HD-ZIP gene family, are characterized by adaxialized lateral organs and alterations in the radial patterning of vascular bundles in the stem. The gain-of-function phenotype can be obtained by changing only the REVOLUTA mRNA sequence and without changing the protein sequence; this finding indicates that this phenotype is likely mediated through an interference with microRNA binding. Loss of KANADI activity results in similar alterations in vascular patterning as compared to REVOLUTA gain-of-function alleles. Simultaneous loss-of-function of PHABULOSA, PHAVOLUTA, and REVOLUTA abaxializes cotyledons, abolishes the formation of the primary apical meristem, and in severe cases, eliminates bilateral symmetry; these phenotypes implicate these three genes in radial patterning of both embryonic and postembryonic growth. Conclusions Based on complementary vascular and leaf phenotypes of class III HD-ZIP and KANADI mutants, we propose that a common genetic program dependent upon miRNAs governs adaxial-abaxial patterning of leaves and radial patterning of stems in the angiosperm shoot. This finding implies that a common patterning mechanism is shared between apical and vascular meristems.

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The effect of REV on axillary meristem formation may be secondary, and the primary function of REV is the control of radial patterning.
“However, its effect on axillary meristem formation may be secondary and the primary function of REV is the control of radial patterning (Emery et al., 2003; Bennett and Leyser, 2006).”
From Shaping plant architecture (2015) · cites this paper as Emery et al., 2003

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Authors: Emery, J. F., Floyd, S. K., Alvarez, J., Eshed, Y., Hawker, N. P., Izhaki, A., Baum, S. F., & Bowman, J. L.
Affiliations: University of California, Davis (US)
Corresponding author: Bowman, John L.
ORCID: Alvarez, John
Eshed, Yuval
Hawker, Nathaniel P.
Bowman, John L.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2003-10
Volume: 13
Issue: 20
Pages: 1768-1774
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2003.09.035
OpenAlex: W2002212941
Cited by: 1,143
References: 31
Citations by year: 2026: 23 · 2025: 24 · 2024: 33 · 2023: 30 · 2022: 62 · 2021: 38 · 2020: 54 · 2019: 42 · 2018: 42 · 2017: 59 · 2016: 38 · 2015: 56 · 2014: 46 · 2013: 59 · 2012: 63
FWCI: 79.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3577 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (00 77984, 99 86054)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
Keywords: radial patterning, adaxial-abaxial polarity, REVOLUTA, microRNA binding, vascular patterning, cotyledon development, apical meristem, bilateral symmetry, shoot development, Arabidopsis thaliana
MeSH terms: Base Sequence, Models, Molecular, Molecular Sequence Data, Phylogeny, Transcription Factors, Arabidopsis, Plant Shoots, Body Patterning, Gene Expression Profiling, Arabidopsis Proteins, MicroRNAs

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Radial Patterning of Arabidopsis Shoots by Class III HD-ZIP and KANADI Genes

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