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Copper: An essential metal in biology
Open accessAbstract
Summary Life on Earth has evolved within a complex mixture of organic and inorganic compounds. While organic molecules such as amino acids, carbohydrates and nucleotides form the backbone of proteins and genetic material, these fundamental components of macromolecules are enzymatically synthesized and ultimately degraded. Inorganic elements, such as copper (Cu), iron and zinc, once solubilized from the Earth's crust, are neither created nor destroyed and therefore their homeostatic regulation is under strict control. In the fascinating field of ‘metals in biology', by virtue of direct interactions with amino acid side-chains within polypeptide chains, metals play unique and critical roles in biology, promoting structures and chemistries that would not otherwise be available to proteins alone.
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Cites
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Cited by
The metabolic roots of senescence: mechanisms and opportunities for intervention
Wiley, C. D., & Campisi, J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00483-8 · Cited by 691
Copper bioavailability, uptake, toxicity and tolerance in plants: A comprehensive review
Kumar, V., Pandita, S., Singh Sidhu, G. P., Sharma, A., Khanna, K., Kaur, P., Bali, A. S., & Setia, R. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2020.127810 · Cited by 594
Copper environmental toxicology, recent advances, and future outlook: a review
Rehman, M., Liu, L., Wang, Q., Saleem, M. H., Bashir, S., Ullah, S., & Peng, D. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-05073-6 · Cited by 561
Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases
(2018) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 455
The neglected role of copper ions in wound healing
Kornblatt, A. P., Nicoletti, V. G., & Travaglia, A. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.02.012 · Cited by 221
Metadata
- Authors
- Festa, R. A., & Thiele, D. J.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 21
- Issue
- 21
- Pages
- R877-R883
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1997854913
- Cited by
- 1,186
- References
- 1
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 624 d)
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- Festa, R. A., & Thiele, D. J. (2011). Copper: An essential metal in biology. Current Biology. https://doi.org/10.1016/j.cub.2011.09.040
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
