The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25
Open accessAbstract
Summary The recently discovered mitochondrial calcium uniporter (MCU) promotes Ca2+ accumulation into the mitochondrial matrix [1, 2]. We identified in silico miR-25 as a cancer-related MCU-targeting microRNA family and demonstrate that its overexpression in HeLa cells drastically reduces MCU levels and mitochondrial Ca2+ uptake, while leaving other mitochondrial parameters and cytosolic Ca2+ signals unaffected. In human colon cancers and cancer-derived cells, miR-25 is overexpressed and MCU accordingly silenced. miR-25-dependent reduction of mitochondrial Ca2+ uptake correlates with resistance to apoptotic challenges and can be reversed by anti-miR-25 overexpression. Overall, the data demonstrate that microRNA targeting of mitochondrial Ca2+ signaling favors cancer cell survival, thus providing mechanistic insight into the role of mitochondria in tumorigenesis and identifying a novel therapeutic target in neoplasia.
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
Cited by
The machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
Self-citationEnjoy the Trip: Calcium in Mitochondria Back and Forth
De Stefani, D., Rizzuto, R., & Pozzan, T. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034216 · Cited by 423
Self-citationMitochondrial calcium exchange in physiology and disease
Garbincius, J. F., & Elrod, J. W. (2022) · Physiological Reviews · doi:10.1152/physrev.00041.2020 · Cited by 412
The mitochondrial calcium uniporter regulates breast cancer progression via HIF ‐1α
Tosatto, A., Sommaggio, R., Kummerow, C., Bentham, R. B., Blacker, T. S., Berecz, T., Duchen, M. R., Rosato, A., Bogeski, I., Szabadkai, G., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606255 · Cited by 258
Self-citationLa Rovere, R. M. L., Roest, G., Bultynck, G., & Parys, J. B. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.04.005 · Cited by 257
Metadata
- Authors
- Marchi, S., Lupini, L., Patergnani, S., Rimessi, A., Missiroli, S., Bonora, M., Bononi, A., Corrà, F., Giorgi, C., De Marchi, E., Poletti, F., Gafà, R., Lanza, G., Negrini, M., Rizzuto, R., & Pinton, P.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 23
- Issue
- 1
- Pages
- 58-63
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1967184808
- Cited by
- 228
- References
- 2
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Marchi, S., Lupini, L., Patergnani, S., Rimessi, A., Missiroli, S., Bonora, M., Bononi, A., Corrà, F., Giorgi, C., De Marchi, E., Poletti, F., Gafà, R., Lanza, G., Negrini, M., Rizzuto, R., & Pinton, P. (2013). Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25. Current Biology. https://doi.org/10.1016/j.cub.2012.11.026
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