The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Enjoy the Trip: Calcium in Mitochondria Back and Forth
Abstract
In the last 5 years, most of the molecules that control mitochondrial Ca 2+homeostasis have been finally identified. Mitochondrial Ca 2+uptake is mediated by the Mitochondrial Calcium Uniporter (MCU) complex, a macromolecular structure that guarantees Ca 2+accumulation inside mitochondrial matrix upon increases in cytosolic Ca 2+. Conversely, Ca 2+release is under the control of the Na+/Ca 2+exchanger, encoded by the NCLX gene, and of a H+/Ca 2+antiporter, whose identity is still debated. The low affinity of the MCU complex, coupled to the activity of the efflux systems, protects cells from continuous futile cycles of Ca 2+across the inner mitochondrial membrane and consequent massive energy dissipation. In this review, we discuss the basic principles that govern mitochondrial Ca 2+homeostasis and the methods used to investigate the dynamics of Ca 2+concentration within the organelles. We discuss the functional and structural role of the different molecules involved in mitochondrial Ca 2+handling and their pathophysiological role.
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Cites
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Metadata
- Authors
- De Stefani, D., Rizzuto, R., & Pozzan, T.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2016-06-02
- Volume
- 85
- Issue
- 1
- Pages
- 161-192
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2199978366
- Cited by
- 423
- References
- 170
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- De Stefani, D., Rizzuto, R., & Pozzan, T. (2016). Enjoy the Trip: Calcium in Mitochondria Back and Forth. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-060614-034216
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