Cited by 158Sleep and Wakefulness ResearchMemory and Neural MechanismsNeural dynamics and brain function

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Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory

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Swift, Kevin M., Gross, Brooks A., Frazer, Michelle A., Bauer, David S., Clark, Kyle J.D., Vazey, Elena M., Aston-Jones, Gary, Li, Yong, Pickering, Anthony E., Sara, Susan J., Poe, Gina R.·2018·Current Biology

DOI 10.1016/j.cub.2018.09.054PMC PMC7556718

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Abstract

Sleep is critical for proper memory consolidation. The locus coeruleus (LC) releases norepinephrine throughout the brain except when the LC falls silent throughout rapid eye movement (REM) sleep and prior to each non-REM (NREM) sleep spindle. We hypothesize that these transient LC silences allow the synaptic plasticity that is necessary to incorporate new information into pre-existing memory circuits. We found that spontaneous LC activity within sleep spindles triggers a decrease in spindle power. By optogenetically stimulating norepinephrine-containing LC neurons at 2 Hz during sleep, we reduced sleep spindle occurrence, as well as NREM delta power and REM theta power, without causing arousals or changing sleep amounts. Stimulating the LC during sleep following a hippocampus-dependent food location learning task interfered with consolidation of newly learned locations and reconsolidation of previous locations, disrupting next-day place cell activity. The LC stimulation-induced reduction in NREM sleep spindles, delta, and REM theta and reduced ripple-spindle coupling all correlated with decreased hippocampus-dependent performance on the task. Thus, periods of LC silence during sleep following learning are essential for normal spindle generation, delta and theta power, and consolidation of spatial memories.

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Authors: Swift, K. M., Gross, B. A., Frazer, M. A., Bauer, D. S., Clark, K. J. D., Vazey, E. M., Aston-Jones, G., Li, Y., Pickering, A. E., Sara, S. J., & Poe, G. R.
Affiliations: University of Michigan (US)
University of California, Los Angeles (US)
University of Massachusetts Amherst (US)
University of Bristol (GB)
Collège de France (FR)
Corresponding author: Poe, Gina R.
ORCID: Vazey, Elena M.
Li, Yong
Pickering, Anthony E.
Sara, Susan J.
Poe, Gina R.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2018-11
Volume: 28
Issue: 22
Pages: 3599-3609.e4
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2018.09.054
PMC: PMC7556718
OpenAlex: W2899315813
Cited by: 158
References: 62
Citations by year: 2026: 19 · 2025: 34 · 2024: 21 · 2023: 25 · 2022: 19 · 2021: 19 · 2020: 12 · 2019: 8 · 2018: 1
FWCI: 5.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Bristol Research (University of Bristol) (acceptedVersion, cc-by-nc-nd)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Explore Bristol Research (submittedVersion, cc-by-nc-nd)
Funders: NIMH (R01 60670, br088373)
Wellcome Senior Clinical
University of Michigan Systems and Integrative Biology T32
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: locus coeruleus, norepinephrine, sleep spindles, memory consolidation, spatial memory, REM sleep, NREM sleep, hippocampus-dependent learning, memory reconsolidation, optogenetic stimulation, synaptic plasticity
MeSH terms: Memory Consolidation, Place Cells, Sleep, Slow-Wave, Animals, Brain, Electroencephalography, Hippocampus, Locus Coeruleus, Male, Sleep, Sleep Stages, Sleep, REM, Theta Rhythm, Rats, Long-Evans, Rats, CA1 Region, Hippocampal, Spatial Memory

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Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory

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