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Cited by 117Frailty in Older AdultsNutrition and Health in AgingGenetics, Aging, and Longevity in Model Organisms

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty

Open access
Qu, Tao, Yang, Huanle, Walston, Jeremy D., Fedarko, Neal S., Leng, Sean X.·2009·Cytokine
DOI 10.1016/j.cyto.2009.02.015PMC PMC3159181
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Abstract

Frailty is an important geriatric syndrome that predicts disability and mortality. Substantial evidence suggests inflammation marked by elevated IL-6 levels as a key pathophysiologic factor that contributes to frailty. CXCL-10, a potent pro-inflammatory chemokine, has increased levels with age and is implicated in several inflammatory conditions. To better understand molecular mechanisms of inflammation activation in frailty, we evaluated monocytic expression of CXCL-10 and other inflammatory pathway genes by pathway-specific gene array analysis and quantitative RT-PCR. Frailty status was determined by the validated criteria. Sixteen pairs of community-dwelling frail and age-, race-, and sex-matched non-frail participants (mean age 83 years, range 72-94) completed the study. Here we report that frail participants had higher CXCL-10 expression levels than matched non-frail controls (1.05+/-0.88 versus 0.53+/-0.39, p=0.04). CXCL-10 expression correlated with IL-6 levels only in frail participants (Spearman correlation coefficient r=0.52, p=0.03). Furthermore, frailty-associated CXCL-10 upregulation was highly correlated with IL-6 elevation, both measured by frail-over-non-frail ratios (r=0.93, p<0.0001). These findings suggest upregulated monocytic expression of CXCL-10 as an important molecular mechanism that contributes to inflammation activation in frail older adults. Therapeutic implications include potential development of CXCL-10-based interventional strategies for the prevention and treatment of frailty in older adults.

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Crossref · 10.1016/j.cyto.2009.02.015

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Metadata

Authors
Qu, T., Yang, H., Walston, J. D., Fedarko, N. S., & Leng, S. X.
Affiliations
Johns Hopkins University (US)
Corresponding author
Leng, Sean X.
ORCID
Venue
Cytokine
Publisher
Elsevier BV
Published
2009-06
Volume
46
Issue
3
Pages
319-324
ISSN
1043-4666 (ISSN-L)
DOI
10.1016/j.cyto.2009.02.015
PMC
PMC3159181
OpenAlex
W2016068403
Cited by
117
References
33
Citations by year
2026: 1 · 2025: 3 · 2024: 9 · 2023: 5 · 2022: 20 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 3 · 2017: 13 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 1
FWCI
3.56
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cytokine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R21AG024235, K23AG028963)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
frailty, CXCL10, interleukin-6, inflammation, older adults, geriatric syndromes, chemokines, frailty biomarkers
MeSH terms
Adult, Aged, Aged, 80 and over, Female, Humans, Monocytes, Syndrome, Interleukin-6, Up-Regulation, Frail Elderly, Gene Expression Profiling, Microarray Analysis, Chemokine CXCL10

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