The DOI matches its Crossref record; 225 of the 225 references it cites were found in a registry or an index.
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Open accessAbstract
CD4(+) T helper (Th) cells are critical for proper immune cell homeostasis and host defense, but are also major contributors to pathology of autoimmune and inflammatory diseases. Since the discovery of the Th1/Th2 dichotomy, many additional Th subsets were discovered, each with a unique cytokine profile, functional properties, and presumed role in autoimmune tissue pathology. This includes Th1, Th2, Th17, Th22, Th9, and Treg cells which are characterized by specific cytokine profiles. Cytokines produced by these Th subsets play a critical role in immune cell differentiation, effector subset commitment, and in directing the effector response. Cytokines are often categorized into proinflammatory and anti-inflammatory cytokines and linked to Th subsets expressing them. This article reviews the different Th subsets in terms of cytokine profiles, how these cytokines influence and shape the immune response, and their relative roles in promoting pathology in autoimmune and inflammatory diseases. Furthermore, we will discuss whether Th cell pathogenicity can be defined solely based on their cytokine profiles and whether rigid definition of a Th cell subset by its cytokine profile is helpful.
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Effects of Omega-3 Fatty Acids on Immune Cells
Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205028 · Cited by 525
Chiurchiù, V., Leuti, A., Dalli, J., Jacobsson, A., Battistini, L., Maccarrone, M., & Serhan, C. N. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7483 · Cited by 359
Immunoporosis: Immunology of Osteoporosis—Role of T Cells
Srivastava, R. K., Dar, H. Y., & Mishra, P. K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00657 · Cited by 331
The Role of Inflammation in Age-Related Macular Degeneration
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Metadata
- Authors
- Raphael, I., Nalawade, S., Eagar, T. N., & Forsthuber, T. G.
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 74
- Issue
- 1
- Pages
- 5-17
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2046864860
- Cited by
- 1,160
- References
- 225
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- green
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