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Effects of Omega-3 Fatty Acids on Immune Cells

Gutiérrez, Saray, Svahn, Sara L, Johansson, Maria E·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20205028PMC PMC6834330
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Abstract

Alterations on the immune system caused by omega-3 fatty acids have been described for 30 years. This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although the mechanisms for such regulation are diverse. First, as a constitutive part of the cellular membrane, omega-3 fatty acids can regulate cellular membrane properties, such as membrane fluidity or complex assembly in lipid rafts. In recent years, however, a new role for omega-3 fatty acids and their derivatives as signaling molecules has emerged. In this review, we describe the latest findings describing the effects of omega-3 fatty acids on different cells from the immune system and their possible molecular mechanisms.

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Metadata

Authors
Gutiérrez, S., Svahn, S. L., & Johansson, M. E.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-10-11
Volume
20
Issue
20
Pages
5028
ISSN
1422-0067
DOI
10.3390/ijms20205028
PMC
PMC6834330
Cited by
525
References
12
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Hjärt-Lungfonden (20180590)
  • Stiftelsen Lars Hiertas Minne (NA)
  • Stiftelsen Tornspiran (NA)
  • Emil and Wera Cornells foundation (NA)
  • Wilhelm and Martina Lundgren foundation (NA)
  • Fru Mary von Sydows stiftelse (NA)

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