Update on the role of Interleukin 17 in rheumatologic autoimmune diseases

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,438 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

The nuclear receptor superfamily: the second decade

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835 · see citing works

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608 · see citing works

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265 · see citing works

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works

Transforming growth factor-β induces development of the TH17 lineage

Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087 · see citing works

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669 · see citing works

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,199 · see citing works

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works

Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

Zheng, Y., Danilenko, D., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., & Ouyang, W. (2007) · Nature · doi:10.1038/nature05505 · Cited by 2,034 · see citing works

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

Leonardi, C. L., Kimball, A. B., Papp, K. A., Yeilding, N. M., Guzzo, C. A., Wang, Y., Li, S., Dooley, L. T., & Gordon, K. B. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60725-4 · Cited by 1,870 · see citing works

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669 · see citing works

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605 · see citing works

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061775 · Cited by 1,554 · see citing works

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

Ye, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522 · see citing works

STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600321200 · Cited by 1,494 · see citing works

Structure and signalling in the IL-17 receptor family

Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475 · see citing works

Interleukin-17 and Type 17 Helper T Cells

Miossec, P., Korn, T., & Kuchroo, V. K. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0707449 · Cited by 1,409 · see citing works

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

Papp, K. A., Langley, R. G. B., Lebwohl, M., Krueger, G. G., Szapary, P. O., Yeilding, N. M., Guzzo, C. A., Hsu, M.-C., Wang, Y., Li, S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60726-6 · Cited by 1,358 · see citing works

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6173 · Cited by 1,272 · see citing works

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

Lowes, M. A., Kikuchi, T., Fuentes‐Duculan, J., Cardinale, I. R., Zaba, L. C., Haider, A. S., Bowman, E. P., & Krueger, J. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701213 · Cited by 1,075 · see citing works

Human IL-17: a novel cytokine derived from T cells

Yao, Z., Painter, S. L., Fanslow, W. C., Ulrich, D., Macduff, B. M., Spriggs, M. K., & Armitage, R. J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.12.5483 · Cited by 1,021 · see citing works

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,009 · see citing works

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses

Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.009 · Cited by 1,004 · see citing works

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A.-M., Painter, S. L., Comeau, M. R., Cohen, J. I., & Spriggs, M. K. (1995) · Immunity · doi:10.1016/1074-7613(95)90070-5 · Cited by 995 · see citing works

An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

Eberl, G., Marmon, S., Sunshine, M. J., Rennert, P. D., Choi, Y., & Littman, D. R. (2003) · Nature Immunology · doi:10.1038/ni1022 · Cited by 986 · see citing works

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

Leonardi, C. L., Matheson, R. T., Zachariae, C. O. C., Cameron, G. S., LI, L. C., Edson‐Heredia, E., Braun, D., & Banerjee, S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109997 · Cited by 933 · see citing works

Interleukin-17 family and IL-17 receptors

Moseley, T. A., Haudenschild, D. R., Rose, L., & Reddi, A. H. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00002-9 · Cited by 917 · see citing works

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

Hueber, W., Patel, D. D., Dryja, T., Wright, A. M., Koroleva, I., Bruin, G., Antoni, C., Draelos, Z., Gold, M. H., the Psoriasis Study Group, et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001107 · Cited by 860 · see citing works

Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial

McInnes, I. B., Kavanaugh, A., Gottlieb, A. B., Puig, L., Rahman, P., Ritchlin, C. T., Brodmerkel, C. M., Li, S., Wang, Y., Mendelsohn, A. M., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60594-2 · Cited by 799 · see citing works

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

Crispín, J. C., Oukka, M., Bayliss, G. P., Cohen, R. A., van Beek, C., Stillman, I. E., Kyttaris, V. C., Juang, Y., & Tsokos, G. C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8761 · Cited by 795 · see citing works

CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene

Rouvier, É., Luciani, M., Mattéi, M., Denizot, F., & Golstein, P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5445 · Cited by 776 · see citing works

IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during <i>Mycobacterium tuberculosis</i> Infection

Lockhart, E., Green, A. M., & Flynn, J. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4662 · Cited by 767 · see citing works

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

Durant, L. R., Watford, W. T., Ramos, H. L., Laurence, A. D. J., Vahedi, G., Wei, L., Takahashi, H., Sun, H., Kanno, Y., Powrie, F. M., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.003 · Cited by 731 · see citing works

Treatment with a neutralizing anti‐murine interleukin‐17 antibody after the onset of collagen‐induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

Lubberts, E., Koenders, M. I., Oppers‐Walgreen, B., van den Bersselaar, L., Roo, C. J. J. C., Joosten, L. A. B., & van den Berg, W. B. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20001 · Cited by 709 · see citing works

The development of inflammatory TH-17 cells requires interferon-regulatory factor 4

Brüstle, A., Heink, S., Huber, M., Rosenplänter, C., Stadelmann, C., Yu, P., Arpaia, E., Mak, T. W., Kamradt, T., & Lohoff, M. D. (2007) · Nature Immunology · doi:10.1038/ni1500 · Cited by 691 · see citing works

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

Zaba, L. C., Cardinale, I. R., Gilleaudeau, P., Sullivan-Whalen, M. M., Suárez‐Fariñas, M., Fuentes‐Duculan, J., Novitskaya, I., Khatcherian, A., Bluth, M. J., Lowes, M. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071094 · Cited by 676 · see citing works

Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial

Ritchlin, C. T., Rahman, P., Kavanaugh, A., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204655 · Cited by 664 · see citing works

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease

Qian, Y., Liu, C., Hartupee, J., Altuntas, C. Z., Gulen, M. F., Jane-wit, D., Xiao, J., Lu, Y., Giltiay, N., Liu, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1439 · Cited by 614 · see citing works

IL-17: prototype member of an emerging cytokine family

Aggarwal, S., & Gurney, A. L. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.1.1 · Cited by 598 · see citing works

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

Yang, X.-P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H.-W., Wei, L., Vahedi, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.1995 · Cited by 583 · see citing works

Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

Richardson, B., Scheinbart, L., Strahler, J. R., Gross, L. A., Hanash, S., & Johnson, M. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780331109 · Cited by 565 · see citing works

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding

Hymowitz, S. G., Filvaroff, E. H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R. F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5332 · Cited by 548 · see citing works

IL-17, Produced by Lymphocytes and Neutrophils, Is Necessary for Lipopolysaccharide-Induced Airway Neutrophilia: IL-15 as a Possible Trigger

Ferretti, S., Bonneau, O., Dubois, G. R., Jones, C. E., & Trifilieff, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2106 · Cited by 542 · see citing works

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity

Wong, C. K., Lit, L. C. W., Tam, L., Li, E. K. M., Wong, P. T. Y., & Lam, C. W. K. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.01.019 · Cited by 535 · see citing works

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

Pène, J., Chevalier, S., Preisser, L., Vénéreau, E., Guilleux, M.-H., Ghannam, S., Molès, J., Danger, Y., Ravon, E., Saux, S. L., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7423 · Cited by 529 · see citing works

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

Zhang, F., Meng, G., & Strober, W. (2008) · Nature Immunology · doi:10.1038/ni.1663 · Cited by 501 · see citing works

Resident Vδ1+ γδ T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production

Shibata, K., Yamada, H., Hara, H., Kishihara, K., & Yoshikai, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4466 · Cited by 481 · see citing works

Induction of IL-17+ T Cell Trafficking and Development by IFN-γ: Mechanism and Pathological Relevance in Psoriasis

Kryczek, I., Bruce, A. T., Gudjonsson, J. E., Johnston, A., Aphale, A., Vatan, L., Szeliga, W., Wang, Y., Liu, Y., Welling, T. H., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4733 · Cited by 464 · see citing works

Interleukin-17 and Lung Host Defense against Klebsiella pneumoniae Infection

Ye, P., Garvey, P. B., Zhang, P., Nelson, S., Bagby, G. J., Summer, W. R., Schwarzenberger, P. O., Shellito, J. E., & Kolls, J. K. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.3.4424 · Cited by 459 · see citing works

Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and RORγt and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion1

Rachitskaya, A., Hansen, A., Horai, R., Li, Z., Villasmil, R., Luger, D., Nussenblatt, R., & Caspi, R. (2008) · Journal of Immunology · doi:10.4049/jimmunol.180.8.5167 · Cited by 444 · see citing works

The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α

Zhu, S., Pan, W. Q., Song, X., Liu, Y., Shao, X., Tang, Y., Liang, D., He, D., Wang, H., Liu, W., et al. (2012) · Nature Medicine · doi:10.1038/nm.2815 · Cited by 424 · see citing works

IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells

Aarvak, T., Chabaud, M., Miossec, P., & Natvig, J. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1246 · Cited by 410 · see citing works

Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study

Papp, K. A., Langley, R. G. B., Sigurgeirsson, B., Abe, M., Baker, D. R., Konno, P., Hämmerle, S. P., Thurston, H. J., Papavassilis, C., & Richards, H. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12110 · Cited by 360 · see citing works

Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor

Chang, S. H., Park, H., & Dong, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600256200 · Cited by 356 · see citing works

Distinct regulation of interleukin‐17 in human T helper lymphocytes

Chen, Z. J., Tato, C. M., Muul, L. M., Laurence, A. D. J., & O’Shea, J. J. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22866 · Cited by 351 · see citing works

Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F

Kuestner, R. E., Taft, D. W., Haran, A. C., Brandt, C. S., Brender, T., Lum, K. D., Harder, B., Okada, S. L., Ostrander, C. D., Kreindler, J. L., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5462 · Cited by 349 · see citing works

Magnetic resonance imaging-determined synovial membrane volume as a marker of disease activity and a predictor of progressive joint destruction in the wrists of patients with rheumatoid arthritis

́stergaard, M., Hansen, M. S., Stoltenberg, M., Gideon, P., Klarlund, M., Jensen, K. E., & Lorenzen, I. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199905)42:5 · Cited by 323 · see citing works

Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells

Wright, J. F., Guo, Y., Quazi, A., Luxenberg, D. P., Bennett, F., Ross, J. F., Qiu, Y., Whitters, M. J., Tomkinson, K. N., Dunussi-Joannopoulos, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700499200 · Cited by 319 · see citing works

The Human IL-17F/IL-17A Heterodimeric Cytokine Signals through the IL-17RA/IL-17RC Receptor Complex

Wright, J. F., Bennett, F., Li, B., Brooks, J., Luxenberg, D. P., Whitters, M. J., Tomkinson, K. N., Fitz, L. J., Wolfman, N. M., Collins, M. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2799 · Cited by 317 · see citing works

Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors

Adamopoulos, I., Chao, C.-C., Geissler, R., Laface, D., Blumenschein, W., Iwakura, Y., Mcclanahan, T., & Bowman, E. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2936 · Cited by 316 · see citing works

Blocking of Interleukin-17 during Reactivation of Experimental Arthritis Prevents Joint Inflammation and Bone Erosion by Decreasing RANKL and Interleukin-1

Koenders, M. I., Lubberts, E., Oppers‐Walgreen, B., van den Bersselaar, L., Helsen, M. M. A., Padova, F. E. D., Boots, A. M. H., Gram, H., Joosten, L. A. B., & van den Berg, W. B. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62961-6 · Cited by 310 · see citing works

Analysis of IL-17+cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

Appel, H., Maier, R., Wu, P., Scheer, R., Hempfing, A., Kayser, R., Thiel, A., Radbruch, A., Loddenkemper, C., & Sieper, J. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3370 · Cited by 309 · see citing works

The Role of IL-23/IL-17 Axis in Lupus Nephritis

Zhang, Z., Kyttaris, V. C., & Tsokos, G. C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900385 · Cited by 303 · see citing works

Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation

Akimzhanov, A. M., Yang, X. O., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600322200 · Cited by 302 · see citing works

Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing γδ T Cells

Roark, C. L., French, J. D., Taylor, M. A., Bendele, A. M., Born, W. K., & O’Brien, R. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5576 · Cited by 300 · see citing works

Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials

Kavanaugh, A., Ritchlin, C. T., Rahman, P., Puig, L., Gottlieb, A. B., Li, S., Wang, Y., Noonan, L., Brodmerkel, C. M., Song, M., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204741 · Cited by 295 · see citing works

Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study

Genovese, M. C., Durez, P., Richards, H. B., Supronik, J., Dokoupilová, E., Vi, M., Aelion, J. A., Lee, S., Codding, C. E., Kellner, H. L., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201601 · Cited by 292 · see citing works

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

Huber, M., Brüstle, A., Reinhard, K., Guralnik, A., Walter, G. J., Mahiny, A. J., von Löw, E., & Lohoff, M. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809077106 · Cited by 281 · see citing works

A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses

Chang, S. H., & Dong, C. (2007) · Cell Research · doi:10.1038/cr.2007.35 · Cited by 280 · see citing works

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

Chen, Z., Laurence, A., & O'Shea, J. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.015 · Cited by 274 · see citing works

Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

Shen, F., & Gaffen, S. L. (2008) · Cytokine · doi:10.1016/j.cyto.2007.11.013 · Cited by 255 · see citing works

The role of Toll-like receptors in rheumatoid arthritis

Huang, Q., & Pope, R. M. (2009) · Current Rheumatology Reports · doi:10.1007/s11926-009-0051-z · Cited by 248 · see citing works

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study

Rich, P., Sigurgeirsson, B., Thaçi, D., Ortonne, J. ‐., Paul, C. F., Schopf, R. E., Morita, A., Roseau, K., Harfst, E., Guettner, A., et al. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12112 · Cited by 245 · see citing works

A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors

Genovese, M. C., Greenwald, M., Cho, C., Berman, A., Jin, L., Cameron, G. S., Benichou, O., Xie, L., Braun, D., Berclaz, P., et al. (2014) · Arthritis &amp; Rheumatology · doi:10.1002/art.38617 · Cited by 211 · see citing works

Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6– lpr/lpr Mice

Kyttaris, V. C., Zhang, Z., Kuchroo, V. K., Oukka, M., & Tsokos, G. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903595 · Cited by 189 · see citing works

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomised, double-blind, placebo-controlled, phase II regimen-finding study

Rich, P., Sigurgeirsson, B., Thaçi, D., Ortonne, J. ‐., Paul, C. F., Schopf, R. E., Morita, A., Roseau, K., Harfst, E., Guettner, A., et al. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12070 · Cited by 189 · see citing works

IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor

Chen, Q., Yang, W., Gupta, S. K., Biswas, P. S., Smith, P., Bhagat, G., & Pernis, A. B. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.011 · Cited by 185 · see citing works

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

Lubberts, E., Joosten, L. A. B., van de Loo, F. A. J., Schwarzenberger, P. O., Kolls, J., & van den Berg, W. B. (2002) · Inflammation Research · doi:10.1007/bf02684010 · Cited by 152 · see citing works

Supplementary Materials for Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

Hueber, W., Patel, D. D., Dryja, T. P., Wright, A., Bruin, G. J. M., Antoni, C., Gold, M. H., Durez, P., Tak, P. P., Go, J. J., et al. (2010) · Cited by 151 · see citing works

Foxp3+ Regulatory T Cells Promote T Helper 17 Cell Development In Vivo through Regulation of Interleukin-2

Chen, Y., Haines, C. J., Gutcher, I., Hochweller, K., Blumenschein, W. M., McClanahan, T. K., Hämmerling, G. J., Li, M. O., Cua, D. J., & McGeachy, M. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.011 · Cited by 148 · see citing works

Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA

Metawi, S. A., Abbas, D., Kamal, M. M., et al. (2011) · Clinical Rheumatology · doi:10.1007/s10067-011-1737-y · Cited by 148 · see citing works

EXPRESSION OF IL-17 IN HUMAN MEMORY CD45RO+T LYMPHOCYTES AND ITS REGULATION BY PROTEIN KINASE A PATHWAY

Shin, H. C. K., Benbernou, N., Esnault, S. J., & Guenounou, M. (1999) · Cytokine · doi:10.1006/cyto.1998.0433 · Cited by 143 · see citing works

Tumor necrosis factor–interleukin‐17 interplay induces S100A8, interleukin‐1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: Rationale for combination treatment during arthritis

Koenders, M. I., Marijnissen, R. J., Devesa, I., Lubberts, E., Joosten, L. A. B., Roth, J., van Lent, P. L. E. M., van de Loo, F. A. J., & van den Berg, W. B. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30418 · Cited by 138 · see citing works

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation

Ghizzoni, M., Haisma, H. J., Maarsingh, H., & Dekker, F. J. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.03.009 · Cited by 136 · see citing works

Staphylococcus aureus Infection of Mice Expands a Population of Memory γδ T Cells That Are Protective against Subsequent Infection

Murphy, A. G., O’Keeffe, K. M., Lalor, S. J., Maher, B. M., Mills, K. H. G., & McLoughlin, R. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303420 · Cited by 136 · see citing works

Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis

Koenders, M. I., Joosten, L. A. B., & van den Berg, W. B. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.058529 · Cited by 132 · see citing works

The IL-17 Family Cytokines in Immunity and Disease

Pappu, R., Ramirez-Carrozzi, V. R., Ota, N., Ouyang, W., & Hu, Y. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9369-6 · Cited by 127 · see citing works

Cutting Edge: Evidence for Ligand-Independent Multimerization of the IL-17 Receptor

Kramer, J. M., Yi, L., Shen, F., Maitra, A., Jiao, X., Jin, T., & Gaffen, S. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.711 · Cited by 115 · see citing works

Synovial Fibroblasts Directly Induce Th17 Pathogenicity via the Cyclooxygenase/Prostaglandin E2 Pathway, Independent of IL-23

Paulissen, S. M. J., van Hamburg, J. P., Davelaar, N., Asmawidjaja, P. S., Hazes, J. M. W., & Lubberts, E. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300274 · Cited by 113 · see citing works

IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation

Lee, S.-Y., Kwok, S., Son, H., et al. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4179 · Cited by 110 · see citing works

Interleukin 17 synergises with tumour necrosis factor α to induce cartilage destruction in vitro

van Bezooijen, R. L., van der Wee-Pals, L., Papapoulos, S. E., & Löwik, C. W. G. M. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.10.870 · Cited by 108 · see citing works

One-year Efficacy and Safety Results of Secukinumab in Patients With Rheumatoid Arthritis: Phase II, Dose-finding, Double-blind, Randomized, Placebo-controlled Study

Genovese, M. C., Durez, P., Richards, H. B., Supronik, J., Dokoupilová, E., Aelion, J. A., Lee, S., Codding, C. E., Kellner, H. L., Ikawa, T., et al. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.130637 · Cited by 96 · see citing works

IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?

Biswas, P. S., Bhagat, G., & Pernis, A. B. (2009) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00864.x · Cited by 81 · see citing works

Systematic Review of Interleukin-12, Interleukin-17, and Interleukin-23 Pathway Inhibitors for the Treatment of Moderate-to-Severe Chronic Plaque Psoriasis

Tausend, W., Downing, C. P., & Tyring, S. K. (2014) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2013.13125 · Cited by 76 · see citing works

Nlrp-3-Driven Interleukin 17 Production by γδT Cells Controls Infection Outcomes during Staphylococcus aureus Surgical Site Infection

Maher, B. M., Mulcahy, M. E., Murphy, A. G., Wilk, M. M., O’Keeffe, K. M., Geoghegan, J. A., Lavelle, E. C., & McLoughlin, R. M. (2013) · Infection and Immunity · doi:10.1128/iai.01026-13 · Cited by 71 · see citing works

Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity

Mühl, H., Bachmann, M., & Pfeilschifter, J. M. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01559.x · Cited by 66 · see citing works

The role of epigenetic mechanisms and processes in autoimmune disorders

Greer, J. M., & McCombe, P. (2012) · Biologics · doi:10.2147/btt.s24067 · Cited by 64 · see citing works

Cutting Edge: Identification of a Pre-Ligand Assembly Domain (PLAD) and Ligand Binding Site in the IL-17 Receptor

Kramer, J. M., Hanel, W. G., Shen, F., Isik, N., Malone, J. P., Maitra, A., Sigurdson, W. J., Swart, D., Tocker, J. E., Jin, T., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6379 · Cited by 59 · see citing works

IL-17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts

Katz, Y., Nadiv, O., Rapoport, M. J., & Loos, M. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01199.x · Cited by 53 · see citing works

Differential Regulation of the IL-17 Receptor by γc Cytokines

Lindemann, M. J., Hu, Z., Benczik, M., Liu, K. D., & Gaffen, S. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801357200 · Cited by 42 · see citing works

Interleukin 17 (IL-17) Increases the Expression of Toll-like Receptor-2, 4, and 9 by Increasing IL-1β and IL-6 Production in Autoimmune Arthritis

Lee, J., Cho, M., Kim, J., Moon, Y., Oh, H., Kim, G.-T., Ryu, S. S., BAEK, S.-H., Lee, S. H., Kim, H., et al. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.080169 · Cited by 33 · see citing works

Ustekinumab for the treatment of psoriatic arthritis

Wofford, J., & Menter, A. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.878649 · Cited by 14 · see citing works

Rheumatology and the health of the workforce

Hadler, N. M. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200109)44:9 · Cited by 12 · see citing works

The Role of the Immune System in Autism Spectrum Disorder

Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533 · see citing works

Innate lymphoid cell-derived cytokines in autoimmune diseases

Li, S., Yang, D., Peng, T., Wu, Y., Tian, Z., & Ni, B. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.05.001 · Cited by 19 · see citing works

Periods till psoriatic arthritis onset and diagnosis in Russian patients with moderate to severe psoriasis (according to psoriasis patient registry)

Kubanov, A. A., & Bogdanova, E. V. (2023) · Vestnik dermatologii i venerologii · doi:10.25208/vdv1371 · Cited by 1 · see citing works

Risk factors and predictors of psoriatic arthritis in patients with psoriasis

Azevedo, V. F., & Buiar, P. G. (2013) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962013000200008 · Cited by 11 · see citing works

Cardiovascular Comorbidities of Psoriasis and Psoriatic Arthritis: A Report from the GRAPPA 2012 Annual Meeting

Armstrong, A. W., Gelfand, J. M., Boehncke, W., & Armstrong, E. J. (2013) · The Journal of Rheumatology · doi:10.3899/jrheum.130457 · Cited by 27 · see citing works

Influence of age of onset of psoriasis on prevalence and clinical characteristics of psoriatic arthritis (according to the registry of patients with psoriasis)

Kubanov, A. A., & Bogdanova, E. V. (2022) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2022-445-449

Prevalence of Psoriasis and Psoriatic Arthritis and Patient Perceptions of Severity in Sweden, Norway and Denmark: Results from the Nordic Patient Survey of Psoriasis and Psoriatic Arthritis

Danielsen, K., Duvetorp, A., Iversen, L., et al. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-3017 · Cited by 34 · see citing works