Control of Chemokine Gradients by the Retinal Pigment Epithelium
Open accessAbstract
PURPOSE: Proinflammatory cytokines in degenerative diseases can lead to the loss of normal physiology and the destruction of surrounding tissues. In the present study, the physiological responses of human fetal retinal pigment epithelia (hfRPE) were examined in vitro after polarized activation of proinflammatory cytokine receptors. METHODS: Primary cultures of hfRPE were stimulated with an inflammatory cytokine mixture (ICM): interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma. Western blot analysis and immunofluorescence were used to determine the expression/localization of the cytokine receptors on hfRPE. Polarized secretion of cytokines was measured. A capacitance probe technique was used to measure transepithelial fluid flow (J(V)) and resistance (R(T)). RESULTS: IL-1R1 was mainly localized to the apical membrane and TNFR1 to the basal membrane, whereas IFN-gammaR1 was detected on both membranes. Activation by apical ICM induced a significant secretion of angiogenic and angiostatic chemokines, mainly across the hfRPE apical membrane. Addition of the ICM to the basal but not the apical bath significantly increased net fluid absorption (J(V)) across the hfRPE within 20 minutes. Similar increases in J(V) were produced by a 24-hour exposure to ICM, which significantly decreased total R(T). CONCLUSIONS: Chemokine gradients across the RPE can be altered (1) through an ICM-induced change in polarized chemokine secretion and (2) through an increase in ICM-induced net fluid absorption. In vivo, both of these factors could contribute to the development of chemokine gradients that help mediate the progression of inflammation/angiogenesis at the retina/RPE/choroid complex.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Accumulation and aggregation of toxic protein and lipid debris could cause RPE damage and release of chemokines and cytokines.
“This, in turn, could cause RPE damage and release of chemokines and cytokines (139).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [139]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works
The many roles of chemokines and chemokine receptors in inflammation
Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523 · see citing works
Hageman, G. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00010-6 · Cited by 1,265 · see citing works
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
Crabb, J. W., Miyagi, M., Gu, X., Shadrach, K., West, K. A., Sakaguchi, H., Kamei, M., Hasan, A., Yan, L., Rayborn, M. E., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222551899 · Cited by 1,208 · see citing works
A role for local inflammation in the formation of drusen in the aging eye
Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087 · see citing works
Tartaglia, L. A., & Goeddel, D. V. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90116-o · Cited by 1,043 · see citing works
Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response
Müller, W. A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00117-0 · Cited by 824 · see citing works
Proudfoot, A. E. I., Handel, T. M., Johnson, Z., Lau, E. K., LiWang, P. J., Clark‐Lewis, I., Borlat, F., Wells, T. N. C., & Kosco‐Vilbois, M. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0334864100 · Cited by 788 · see citing works
Mig and IP-10: CXC chemokines that target lymphocytes
Farber, J. M. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.61.3.246 · Cited by 788 · see citing works
Miyamoto, K., Khosrof, S., Bursell, S., Rohan, R. M., Murata, T., Clermont, A. C., Aiello, L. P., Ogura, Y., & Adamis, A. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10836 · Cited by 787 · see citing works
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
Gehrs, K. M., Anderson, D. H., Johnson, L. V., & Hageman, G. S. (2006) · Annals of Medicine · doi:10.1080/07853890600946724 · Cited by 633 · see citing works
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
Ambati, J., Anand, A., Fernandez, S., Sakurai, E., Lynn, B. C., Kuziel, W. A., Rollins, B. J., & Ambati, B. K. (2003) · Nature Medicine · doi:10.1038/nm950 · Cited by 631 · see citing works
Combadière, C., Feumi, C., Raoul, W., Keller, N., Rodéro, M., Pézard, A., Lavalette, S., Houssier, M., Jonet, L., Picard, E., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31692 · Cited by 618 · see citing works
Achieving Stability of Lipopolysaccharide-Induced NF-κB Activation
Covert, M. W., Leung, T., Gaston, J. E., & Baltimore, D. (2005) · Science · doi:10.1126/science.1112304 · Cited by 603 · see citing works
Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity
Werner, S. L., Barken, D. M., & Hoffmann, A. (2005) · Science · doi:10.1126/science.1113319 · Cited by 506 · see citing works
Microglia activation in retinal degeneration
Langmann, T. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0207114 · Cited by 496 · see citing works
Molecular cloning and expression of the human interferon-γ receptor
Aguet, M., Dembić, Z., & Merlin, G. (1988) · Cell · doi:10.1016/0092-8674(88)90050-5 · Cited by 477 · see citing works
Grossniklaus, H. E., Ling, J. X., Wallace, T. M., Dithmar, S., Lawson, D., Cohen, C., Elner, V. M., Elner, S. G., & Sternberg, P. (2002) · PubMed · Cited by 434 · see citing works
The cell surface receptors for interleukin-1α and interleukin-1β are identical
Dower, S., Kronheim, S. R., Hopp, T. P., Cantrell, M., Deeley, M. C., Gillis, S. A., Henney, C. S., & Urdal, D. L. (1986) · Nature · doi:10.1038/324266a0 · Cited by 415 · see citing works
Maminishkis, A., Chen, S., Jalickee, S., Banzon, T., Shi, G., Wang, F. E., Ehalt, T., Hammer, J. A., & Miller, S. S. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-1622 · Cited by 401 · see citing works
Self-citationDemircan, N., Safran, B. G., Soylu, M., Özcan, A. A., & Sızmaz, S. (2005) · Eye · doi:10.1038/sj.eye.6702138 · Cited by 397 · see citing works
Stamatovic, S. M., Keep, R. F., Kunkel, S. L., & Andjelkovic, A. V. (2003) · Journal of Cell Science · doi:10.1242/jcs.00755 · Cited by 381 · see citing works
Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis.
Motro, B., Itin, A., Sachs, L., & Keshet, E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.8.3092 · Cited by 346 · see citing works
MCP‐1 (CCL2) protects human neurons and astrocytes from NMDA or HIV‐tat‐induced apoptosis
Eugenin, E. A., D’Aversa, T. G., Lopez, L., Calderon, T. M., & Berman, J. W. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01775.x · Cited by 288 · see citing works
Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis
Nakazawa, T., Hisatomi, T., Nakazawa, C., Noda, K., Maruyama, K., She, H., Matsubara, A., Miyahara, S., Nakao, S., Yin, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608167104 · Cited by 272 · see citing works
Holtkamp, G. M., Kijlstra, A., Peek, R., & de Vos, A. F. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00017-3 · Cited by 254 · see citing works
Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy
Yuuki, T., Kanda, T., Kimura, Y., Kotajima, N., Tamura, J., Kobayashi, I., & Kishi, S. (2001) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00155-6 · Cited by 248 · see citing works
Hageman, G. S., Hancox, L. S., Taiber, A. J., Gehrs, K. M., Anderson, D. H., Johnson, L. V., Radeke, M. J., Kavanagh, D., Richards, A., Atkinson, J. P., et al. (2006) · Annals of Medicine · doi:10.1080/07853890601097030 · Cited by 246 · see citing works
Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy
Elner, S. G., Elner, V. M., Jaffe, G. J., Stuart, A. R., Kunkel, S. L., & Strieter, R. M. (1995) · Current Eye Research · doi:10.3109/02713689508998529 · Cited by 228 · see citing works
Multiplex Bead Immunoassay Analysis of Aqueous Humor Reveals Distinct Cytokine Profiles In Uveitis
Curnow, J., Francesco Falciani, B., Durrani, O. M., Cheung, C. M. G., Ross, E. J., Wloka, K., Rauz, S., Wallace, G. R., Salmon, M., & Murray, P. I. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0444 · Cited by 223 · see citing works
Tuo, J., Bojanowski, C. M., Zhou, M., Shen, D., Ross, R. J., Rosenberg, K. I., Cameron, D. J., Yin, C., Kowalak, J. A., Zhuang, Z., et al. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0051 · Cited by 205 · see citing works
Zeng, H.-Y., Zhu, X. A., Zhang, C., Yang, L.-P., Wu, L.-M., & Tso, M. O. M. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0118 · Cited by 203 · see citing works
Fahey, J. V., Schaefer, T. M., Channon, J. Y., & Wira, C. R. (2005) · Human Reproduction · doi:10.1093/humrep/deh806 · Cited by 192 · see citing works
Hernández, C., Segura, R., Fonollosa, A., Carrasco, E., Francisco, G., & Simó, R. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01538.x · Cited by 189 · see citing works
The retinal pigment epithelium : function and disease
Marmor, M. F., & Wolfensberger, T. J. (1998) · Cited by 185 · see citing works
Monocyte Activation in Patients With Age-Related Macular Degeneration
Cousins, S. W. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.7.1013 · Cited by 178 · see citing works
Analysis of the role of chemokines in angiogenesis
Bernardini, G., Ribatti, D., Spinetti, G., Morbidelli, L., Ziche, M., Santoni, A., Capogrossi, M. C., & Napolitano, M. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00420-9 · Cited by 172 · see citing works
Development and Role of Tight Junctions in the Retinal Pigment Epithelium
Rizzolo, L. J. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)58004-6 · Cited by 164 · see citing works
(2006) · PubMed · Cited by 158 · see citing works
Foxman, E. F., Zhang, M.-F., Hurst, S., Muchamuel, T., Shen, D., Wawrousek, E., Chan, C.-C., & Gery, I. (2002) · Journal of Immunology · doi:10.4049/jimmunol.168.5.2483 · Cited by 155 · see citing works
THE TOXIC EFFECTS OF GLUTAMATE AND RELATED COMPOUNDS IN THE RETINA AND THE BRAIN
Olney, J. W. (1982) · Retina · doi:10.1097/00006982-198200000-00020 · Cited by 154 · see citing works
Cytokine Profile in Aqueous Humor and Sera of Patients with Infectious or Noninfectious Uveitis
Takase, H., Futagami, Y., Yoshida, T., Kamoi, K., Sugita, S., Imai, Y., & Mochizuki, M. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0836 · Cited by 152 · see citing works
Izumi‐Nagai, K., Nagai, N., Ozawa, Y., Mihara, M., Ohsugi, Y., Kurihara, T., Koto, T., Satofuka, S., Inoue, M., Tsubota, K., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061018 · Cited by 152 · see citing works
Polarized secretion of IL-6 and IL-8 by human retinal pigment epithelial cells
Holtkamp, G. M., van Rossem, M., de Vos, A. F., Willekens, B., Peek, R., & Kijlstra, A. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00560.x · Cited by 146 · see citing works
The polarity of the retinal pigment epithelium
Marmorstein, A. D. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.21202.x · Cited by 139 · see citing works
Leukocyte–epithelial interactions
Zen, K., & Parkos, C. A. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00103-0 · Cited by 135 · see citing works
Age-related macular degeneration and the immune response: implications for therapy
Nussenblatt, R. B., & Ferris, F. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.06.025 · Cited by 130 · see citing works
Peterson, W. M., Meggyesy, C., Yu, K., & Miller, S. S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02324.1997 · Cited by 130 · see citing works
Self-citationCytokines and Chemokines as Regulators of Angiogenesis in Health and Disease
Benelli, R., Lorusso, G., Albini, A., & Noonan, D. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777947461 · Cited by 125 · see citing works
Chemokines in acute anterior uveitis
Verma, M. J., Lloyd, A. R., Rager, H., Strieter, R. R., Kunkel, S. L., Taub, D. D., & Wakefield, D. (1997) · Current Eye Research · doi:10.1076/ceyr.16.12.1202.5034 · Cited by 120 · see citing works
Activation of Potassium and Chloride Channels by Tumor Necrosis Factor α
Nietsch, H. H., Roe, M. W., Fiekers, J. F., Moore, A. L., & Lidofsky, S. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002535200 · Cited by 116 · see citing works
van Kooij, B., Rothová, A., Rijkers, G. T., & de Groot-Mijnes, J. D. F. (2006) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.02.052 · Cited by 115 · see citing works
Canataroglu, H., Varinli, İ., Özcan, A. A., et al. (2005) · Ocular Immunology and Inflammation · doi:10.1080/09273940490518900 · Cited by 114 · see citing works
Petzelbauer, P., Watson, C. A., Watson, C. A., et al. (1995) · Cytokine · doi:10.1006/cyto.1995.0031 · Cited by 111 · see citing works
Higgins, G. T., Wang, J. H., Dockery, P., Cleary, P. E., & Redmond, H. P. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0742 · Cited by 109 · see citing works
Kijlstra, A., Heij, E. C. L., & Hendrikse, F. (2005) · Ocular Immunology and Inflammation · doi:10.1080/09273940590909185 · Cited by 106 · see citing works
Mechanisms of TNF-α stimulation of amiloride-sensitive sodium transport across alveolar epithelium
Fukuda, N., Jayr, C., Lazrak, A., et al. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.6.l1258 · Cited by 106 · see citing works
Maminishkis, A., Jalickee, S., Blaug, S., Rymer, J., Yerxa, B. R., Peterson, W. M., & Miller, S. S. (2002) · PubMed · Cited by 105 · see citing works
Self-citationXia, M., & Hyman, B. T. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00463-5 · Cited by 105 · see citing works
The electrogenic sodium pump of the frog retinal pigment epithelium
Miller, S. S., Steinberg, R. H., & Oakley, B. (1978) · The Journal of Membrane Biology · doi:10.1007/bf01944224 · Cited by 103 · see citing works
Self-citationEpinephrine stimulates fluid absorption across bovine retinal pigment epithelium.
Edelman, J. L., & Miller, S. S. (1991) · PubMed · Cited by 97 · see citing works
Self-citationNAP-1IL-8 induces up-regulation of CR1 receptors in human neutrophil leukocytes
Paccaud, J. P., Schifferli, J. A., & Baggiolini, M. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91929-m · Cited by 93 · see citing works
Control of chemokine production at the blood-retina barrier
Crane, I. J., Wallace, C. A., Mckillop‐Smith, S., & Forrester, J. V. (2000) · Immunology · doi:10.1046/j.0019-2805.2000.01105.x · Cited by 77 · see citing works
Comparison of three multiplex cytokine analysis systems: Luminex, SearchLight™ and FAST Quant®
Lash, G. E., Scaife, P. J., Innes, B. A., Otun, H. A., Robson, S., Searle, R. F., & Bulmer, J. N. (2006) · Journal of Immunological Methods · doi:10.1016/j.jim.2005.12.007 · Cited by 75 · see citing works
Pathogenesis of age-related macular degeneration
Tezel, T. H., Bora, N. S., & Kaplan, H. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.07.004 · Cited by 71 · see citing works
Interferon-Induced Protein 10 and Interleukin 8
Elner, S. G. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.12.1597 · Cited by 70 · see citing works
David, P., Lusky, M., & Teichberg, V. I. (1988) · Experimental Eye Research · doi:10.1016/s0014-4835(88)80054-x · Cited by 68 · see citing works
Elia, N., Tapponnier, M., Matthay, M. A., et al. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200206-618oc · Cited by 67 · see citing works
Holtkamp, G. M., de Vos, A. F., Peek, R., & Kijlsta, A. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01016.x · Cited by 65 · see citing works
Xu, H., Manivannan, A., Dawson, R., Crane, I. J., Mack, M., Sharp, P., & Liversidge, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6915 · Cited by 63 · see citing works
PDGF-C and -D Induced Proliferation/Migration of Human RPE Is Abolished by Inflammatory Cytokines
Li, R., Maminishkis, A., Wang, F. E., & Miller, S. S. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0327 · Cited by 60 · see citing works
Self-citationInflammation in the pathogenesis of age-related macular degeneration
Kanda, A., Abecasis, G. R., & Swaroop, A. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.131581 · Cited by 55 · see citing works
Macrophages eyed in macular degeneration
Forrester, J. V. (2003) · Nature Medicine · doi:10.1038/nm1103-1350 · Cited by 51 · see citing works
Bolus Contaminant Dispersion in Oscillatory Tube Flow With Conductive Walls
Jiang, Y., & Grotberg, J. B. (1993) · Journal of Biomechanical Engineering · doi:10.1115/1.2895507 · Cited by 44 · see citing works
Acidification stimulates chloride and fluid absorption across frog retinal pigment epithelium
Edelman, J. L., Lin, H., & Miller, S. S. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.4.c946 · Cited by 39 · see citing works
Self-citationVoloboueva, L. A., Killilea, D. W., Atamna, H., & Ames, B. N. (2007) · The FASEB Journal · doi:10.1096/fj.07-8396com · Cited by 33 · see citing works
Momma, Y., Nagineni, C. N., Chin, M. S., Srinivasan, K., Detrick, B., & Hooks, J. J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0980 · Cited by 31 · see citing works
Effect of Inflammatory Stimuli on Airway Ion Transport
Galietta, L. J. V., Folli, C., Caci, E., et al. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.2306017 · Cited by 28 · see citing works
Adenylate cyclase stimulation alters transport in frog retinal pigment epithelium
Hughes, B. A., Miller, S. S., & Farber, D. B. (1987) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1987.252.4.c385 · Cited by 28 · see citing works
Self-citationChemokines: New, Key Players in the Pathobiology of Pancreatic Cancer
Hedin, K. E. (2002) · International Journal of Gastrointestinal Cancer · doi:10.1385/ijgc:31:1-3:23 · Cited by 23 · see citing works
Differential expression of retinal pigment epithelium (RPE) IP-10 and interleukin-8
Elner, S. G., DelMonte, D., Bian, Z.-M., et al. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.01.013 · Cited by 20 · see citing works
New Molecular Histopathologic Insights Into the Pathogenesis of Age-related Macular Degeneration
Handa, J. T. (2006) · International Ophthalmology Clinics · doi:10.1097/iio.0b013e31802bd546 · Cited by 14 · see citing works
Adnexal and Anterior Segment Manifestations of HIV/AIDS
Ali, R., Kim, J. Y., & Henderson, B. A. (2007) · International Ophthalmology Clinics · doi:10.1097/iio.0b013e318036bcc4 · Cited by 13 · see citing works
Takase, H., Yu, C., Ham, D., Chan, C., Chen, J., Vistica, B. P., Wawrousek, E. F., Durum, S. K., Egwuagu, C. E., & Gery, I. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205719 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [41]Snedecor GW, Cochran WG. Statistical Methods. 8th ed. Iowa State University Press; Ames, IA: 1989. [Google Scholar]
Cited by
Sorted by citations
Transcriptome analysis and molecular signature of human retinal pigment epithelium
Strunnikova, N. V., Maminishkis, A., Barb, J. J., Wang, F., Zhi, C., Sergeev, Y., Chen, W., Edwards, A. O., Stambolian, D., Abecasis, G., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq129 · Cited by 269 · see citing works
Self-citationSonoda, S., Spee, C., Barron, E., Ryan, S. J., Kannan, R., & Hinton, D. R. (2009) · Nature Protocols · doi:10.1038/nprot.2009.33 · Cited by 272 · see citing works
Swaroop, A., Chew, E. Y., Bowes Rickman, C., & Abecasis, G. R. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164350 · Cited by 270 · see citing works
Zanzottera, E. C., Messinger, J. D., Ach, T., Smith, R. T., Freund, K. B., & Curcio, C. A. (2015) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-16431 · Cited by 164 · see citing works
Balaratnasingam, C., Yannuzzi, L. A., Curcio, C. A., Morgan, W. H., Querques, G., Capuano, V., Souied, E., Jung, J., & Freund, K. B. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-19816 · Cited by 144 · see citing works
Zanzottera, E. C., Messinger, J. D., Ach, T., Smith, R. T., & Curcio, C. A. (2015) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-16432 · Cited by 110 · see citing works
Vogt, S. D., Curcio, C. A., Wang, L., Li, C.-M., McGwin, G., Medeiros, N. E., Philp, N. J., Kimble, J. A., & Read, R. W. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.06.002 · Cited by 104 · see citing works
Claudin-19 and the barrier properties of the human retinal pigment epithelium
Peng, S., Rao, V. S., Adelman, R. A., & Rizzolo, L. J. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5984 · Cited by 99 · see citing works
Gordiyenko, N. V., Fariss, R. N., Zhi, C., & MacDonald, I. M. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-4117 · Cited by 69 · see citing works
STARNES, A. C., HUISINGH, C., MCGWIN, G., SLOAN, K. R., ABLONCZY, Z., SMITH, R. T., CURCIO, C. A., & ACH, T. (2016) · Visual Neuroscience · doi:10.1017/s0952523815000310 · Cited by 46 · see citing works
Kutty, R. K., Samuel, W., Abay, R., Cherukuri, A., Nagineni, C. N., Duncan, T., Jaworski, C., Vijayasarathy, C., & Redmond, T. M. (2015) · Cytokine · doi:10.1016/j.cyto.2015.03.016 · Cited by 31 · see citing works
- Authors
- Shi, G., Maminishkis, A., Banzon, T., Jalickee, S., Li, R., Hammer, J., & Miller, S. S.
- Affiliations
- National Institutes of Health (US)
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2008-10-01
- Volume
- 49
- Issue
- 10
- Pages
- 4620
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- PMC
- PMC2574653
- OpenAlex
- W2032878302
- Cited by
- 102
- References
- 84
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 12
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Investigative Ophthalmology & Visual Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1z01ey000419-05, Z01 EY000419)
- National Eye Institute (Z01EY000435)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- retinal pigment epithelium, chemokine gradients, inflammatory cytokines, interleukin-1 receptor, TNF receptor, interferon-gamma receptor, transepithelial electrical resistance, fluid absorption, angiogenesis, inflammation, choroid, cytokine receptors
- MeSH terms
- Interferon gamma Receptor, Biological Transport, Active, Body Water, Cell Membrane, Drug Combinations, Fetus, Humans, Interferon-gamma, Microscopy, Fluorescence, Pigment Epithelium of Eye, Tumor Necrosis Factor-alpha, Blotting, Western, Receptors, Interferon, Cell Culture Techniques, Receptors, Tumor Necrosis Factor, Type I, Receptors, Interleukin-1 Type I, Interleukin-1beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
