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Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism
Open accessAbstract
Bone morphogenetic proteins (BMPs) regulate many processes in embryonic development as well as in the maintenance of normal tissue function later in adult life. However, the role of this family of proteins in formation of adipose tissue has been underappreciated in the field of developmental biology. With the growing epidemic of obesity, improved knowledge of adipocyte development and function is urgently needed. Recently, there have been significant advances in understanding the role of different members of the BMP superfamily in control of adipocyte differentiation and systemic energy homeostasis. This review summarizes recent progress in understanding how BMPs specify adipose cell fate in stem/progenitor cells and their potential role in energy metabolism. We propose that BMPs provide instructive signals for adipose cell fate determination and regulate adipocyte function. These findings have opened up exciting opportunities for developing new therapeutic approaches for the treatment of obesity and its many associated metabolic disorders.
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“BMPs are a family of developmental regulators belonging to the TGF-β superfamily, which promote adipogenesis at different stages 100.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [100]
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Self-citation
Metadata
- Authors
- Schulz, T. J., & Tseng, Y.-H.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- Tseng, Yu-Hua
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 20
- Issue
- 5-6
- Pages
- 523-531
- ISSN
- 1359-6101 (ISSN-L)
- PMC
- PMC2799934
- OpenAlex
- W2054468779
- Cited by
- 154
- References
- 110
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 11 · 2020: 4 · 2019: 14 · 2018: 6 · 2017: 14 · 2016: 6 · 2015: 14 · 2014: 15 · 2013: 17 · 2012: 12
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077097, P30DK040561)
- National Center for Research Resources (UL1RR025758)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- bone morphogenetic proteins, adipogenesis, energy homeostasis, adipose tissue development, cell fate determination, stem/progenitor cells, obesity, metabolic disorders, BMP signaling
- MeSH terms
- Adipose Tissue, Animals, Cell Differentiation, Energy Metabolism, Humans, Models, Biological, Bone Morphogenetic Proteins, Adipogenesis, Bone Morphogenetic Protein Receptors
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