Cited by 154Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesTGF-β signaling in diseases

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Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

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Schulz, Tim J., Tseng, Yu-Hua·2009·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2009.10.019PMC PMC2799934

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Abstract

Bone morphogenetic proteins (BMPs) regulate many processes in embryonic development as well as in the maintenance of normal tissue function later in adult life. However, the role of this family of proteins in formation of adipose tissue has been underappreciated in the field of developmental biology. With the growing epidemic of obesity, improved knowledge of adipocyte development and function is urgently needed. Recently, there have been significant advances in understanding the role of different members of the BMP superfamily in control of adipocyte differentiation and systemic energy homeostasis. This review summarizes recent progress in understanding how BMPs specify adipose cell fate in stem/progenitor cells and their potential role in energy metabolism. We propose that BMPs provide instructive signals for adipose cell fate determination and regulate adipocyte function. These findings have opened up exciting opportunities for developing new therapeutic approaches for the treatment of obesity and its many associated metabolic disorders.

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Authors: Schulz, T. J., & Tseng, Y.-H.
Affiliations: Joslin Diabetes Center (US)
Corresponding author: Tseng, Yu-Hua
ORCID: Schulz, Tim J.
Tseng, Yu-Hua
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2009-10
Volume: 20
Issue: 5-6
Pages: 523-531
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2009.10.019
PMC: PMC2799934
OpenAlex: W2054468779
Cited by: 154
References: 110
Citations by year: 2026: 2 · 2025: 7 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 11 · 2020: 4 · 2019: 14 · 2018: 6 · 2017: 14 · 2016: 6 · 2015: 14 · 2014: 15 · 2013: 17 · 2012: 12
FWCI: 1.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077097, P30DK040561)
National Center for Research Resources (UL1RR025758)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: bone morphogenetic proteins, adipogenesis, energy homeostasis, adipose tissue development, cell fate determination, stem/progenitor cells, obesity, metabolic disorders, BMP signaling
MeSH terms: Adipose Tissue, Animals, Cell Differentiation, Energy Metabolism, Humans, Models, Biological, Bone Morphogenetic Proteins, Adipogenesis, Bone Morphogenetic Protein Receptors

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Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

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