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The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity
Open accessAbstract
The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.
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Hoffman, W., Lakkis, F. G., & Chalasani, G. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09430915 · Cited by 482
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Laurent, S. A., Hoffmann, F. S., Kuhn, P.-H., Cheng, Q., Chu, Y., Schmidt-Supprian, M., Hauck, S. M., Schuh, E., Krumbholz, M., Rübsamen, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8333 · Cited by 377
Varzaneh, F. N., Keller, B., Unger, S., Aghamohammadi, A., Warnatz, K., & Rezaei, N. (2014) · Journal of Clinical Immunology · doi:10.1007/s10875-014-0053-0 · Cited by 62
Lunde, S., Kristoffersen, E. K., Sapkota, D., Risa, K., Dahl, O., Bruland, O., Mella, O., & Fluge, Ø. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161226 · Cited by 22
Metadata
- Authors
- Vincent, F. B., Saulep-Easton, D., Figgett, W. A., Fairfax, K. A., & Mackay, F.
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 24
- Issue
- 3
- Pages
- 203-215
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2104769463
- Cited by
- 445
- References
- 2
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Vincent, F. B., Saulep-Easton, D., Figgett, W. A., Fairfax, K. A., & Mackay, F. (2013). The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity. Cytokine & Growth Factor Reviews. https://doi.org/10.1016/j.cytogfr.2013.04.003
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