Cited by 102T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune DisordersImmune Response and Inflammation

Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates

Kaur, Kulwant, Chowdhury, Shimul, Greenspan, Neil S., Schreiber, John R.·2007·Blood

Abstract

Neonates have an increased rate of infection with encapsulated bacteria compared with older children and adults because of diminished antibody responses to T-independent (TI) antigens such as bacterial polysaccharides. Because the interactions of tumor necrosis factor (TNF) family ligands BAFF and APRIL with the TNF family receptors (TNFRs) TACI, BCMA, and BAFF-R are crucial to TI antibody responses, we measured the expression of these receptors on adult and cord blood–derived term and preterm neonatal B cells. Preterm neonatal B cells expressed less TACI, BCMA, and BAFF-R compared with adult B cells and had significantly less proliferation compared with adult B cells after stimulation with human recombinant BAFF and anti-IgM in an assay in which TACI-Fc fusion protein inhibits B-cell proliferation. In addition, neonatal dendritic cells had diminished expression of B7–1, B7–2, and CD40 compared with adult cells. Finally, neonatal B cells, particularly preterm B cells, exhibited markedly decreased production of IgG and IgA in response to CD40L and IL-10. Overall, this study shows that maturational delay in TNFR expression particularly by preterm neonatal B cells may interfere with effective antibody responses to TI antigens, cognate T- and B-cell interactions and normal isotype switching.

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Crossref · 10.1182/blood-2007-01-069245

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Authors
Kaur, K., Chowdhury, S., Greenspan, N. S., & Schreiber, J. R.
Affiliations
  • University of Minnesota (US)
  • Case Western Reserve University (US)
Venue
Blood
Published
2007-10-15
Volume
110
Issue
8
Pages
2948-2954
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2027616862
Cited by
101
References
50
Citations by year
2026: 7 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 5 · 2012: 4
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Minnesota
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (AI 32596, R01AI032596, AI 46661)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
preterm infants, BAFF, APRIL, TACI, BCMA, BAFF-R, B cells, dendritic cells, CD80, CD86, CD40, CD40 ligand, IL-10, IgG, IgA, class switch recombination, umbilical cord blood, neonatal immunity
MeSH terms
Adult, Antibody Formation, B-Lymphocytes, Dendritic Cells, Enzyme-Linked Immunosorbent Assay, Fetal Blood, Flow Cytometry, Humans, Immunoglobulin A, Immunoglobulin G, Infant, Newborn, Infant, Premature, Lymphocyte Activation, T-Lymphocytes, Gene Expression, Receptors, Tumor Necrosis Factor, Reverse Transcriptase Polymerase Chain Reaction, Cell Proliferation, B-Cell Activating Factor, Tumor Necrosis Factor Ligand Superfamily Member 13

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