Immunopathogenesis of Ascaridia galli infection in layer chicken
Abstract
Gastro-intestinal nematode infections in mammals are associated with local T lymphocyte infiltrations, Th2 cytokine induction, and alterations in epithelial cell secretion and absorption. This study demonstrates that Ascaridia (A.) galli infection in chicken also elicits local gut-associated immune reactions and changes in the intestinal electrogenic nutrient transport. In A. galli-infected birds we observed infiltrations of different T cell populations in the intestinal lamina propria and accumulation of CD4+ lymphocytes in the epithelium. The Th2 cytokines IL-4 and IL-13 dominated the intestinal immune reactions following A. galli infection. A. galli-specific systemic IgY antibodies were detected after two weeks post infection, and did only poorly correlate with detected worm numbers. Electrogenic transport of alanin and glucose was impaired in A. galli-infected chicken. Our data provide circumstantial evidence that local immune responses and electro-physiological intestinal functions may be connected and contribute to the elimination of worm infection.
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Animal studies showed that Ascaris impairs glucose-alanine transport in the host intestine.
“Animal studies showed that Ascaris impairs glucose–alanine transport in the host intestine.”
From Intestinal Parasitic Infection and Nutritional Status in Children under Five Years Old: A Systematic Review (2022) · cites this paper as [66]
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Fauziah, N., Aviani, J. K., Agrianfanny, Y. N., & Fatimah, S. N. (2022) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed7110371 · Cited by 122 · see citing works
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Self-citation
- Authors
- Schwarz, A., Gauly, M., Abel, H., Daş, G., Humburg, J., Rohn, K., Breves, G., & Rautenschlein, S.
- Affiliations
- University of Veterinary Medicine Hannover, Foundation (DE)
- University of Göttingen (DE)
- Corresponding author
- Rautenschlein, Silke
- Venue
- Developmental & Comparative Immunology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 35
- Issue
- 7
- Pages
- 774-784
- ISSN
- 0145-305X (ISSN-L)
- OpenAlex
- W1969342975
- Cited by
- 75
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 6 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 5
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental & Comparative Immunology (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Keywords
- Ascaridia galli, laying hens, gastrointestinal nematode infection, immunopathogenesis, Th2 cytokines, IL-4, IL-13, CD4+ T cells, intestinal lamina propria, T cell infiltration, IgY antibodies, alanine transport, glucose transport, intestinal epithelium, host-parasite immune interaction
- MeSH terms
- Animals, Ascaridia, Ascaridiasis, Cells, Cultured, Chickens, Immunoglobulins, Mucous Membrane, CD4-Positive T-Lymphocytes, Interleukin-4, T-Lymphocyte Subsets, Interleukin-13, Immunity, Mucosal
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