Cited by 75Helminth infection and controlParasites and Host InteractionsBird parasitology and diseases

Immunopathogenesis of Ascaridia galli infection in layer chicken

Schwarz, Anna, Gauly, Matthias, Abel, Hansjörg, Daş, Gürbüz, Humburg, Julia, Rohn, Karl, Breves, Gerhard, Rautenschlein, Silke·2011·Developmental & Comparative Immunology

Abstract

Gastro-intestinal nematode infections in mammals are associated with local T lymphocyte infiltrations, Th2 cytokine induction, and alterations in epithelial cell secretion and absorption. This study demonstrates that Ascaridia (A.) galli infection in chicken also elicits local gut-associated immune reactions and changes in the intestinal electrogenic nutrient transport. In A. galli-infected birds we observed infiltrations of different T cell populations in the intestinal lamina propria and accumulation of CD4+ lymphocytes in the epithelium. The Th2 cytokines IL-4 and IL-13 dominated the intestinal immune reactions following A. galli infection. A. galli-specific systemic IgY antibodies were detected after two weeks post infection, and did only poorly correlate with detected worm numbers. Electrogenic transport of alanin and glucose was impaired in A. galli-infected chicken. Our data provide circumstantial evidence that local immune responses and electro-physiological intestinal functions may be connected and contribute to the elimination of worm infection.

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Crossref · 10.1016/j.dci.2011.02.012

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Authors
Schwarz, A., Gauly, M., Abel, H., Daş, G., Humburg, J., Rohn, K., Breves, G., & Rautenschlein, S.
Affiliations
  • University of Veterinary Medicine Hannover, Foundation (DE)
  • University of Göttingen (DE)
Corresponding author
Rautenschlein, Silke
Venue
Developmental & Comparative Immunology
Publisher
Elsevier BV
Published
2011-07
Volume
35
Issue
7
Pages
774-784
ISSN
0145-305X (ISSN-L)
OpenAlex
W1969342975
Cited by
75
References
57
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 6 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 5
FWCI
7.49
Type
journal article
Language
en
Open access
closed
Locations
  • Developmental & Comparative Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • GRO (submittedVersion)
  • Open Research (University of Surrey) (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
Keywords
Ascaridia galli, laying hens, gastrointestinal nematode infection, immunopathogenesis, Th2 cytokines, IL-4, IL-13, CD4+ T cells, intestinal lamina propria, T cell infiltration, IgY antibodies, alanine transport, glucose transport, intestinal epithelium, host-parasite immune interaction
MeSH terms
Animals, Ascaridia, Ascaridiasis, Cells, Cultured, Chickens, Immunoglobulins, Mucous Membrane, CD4-Positive T-Lymphocytes, Interleukin-4, T-Lymphocyte Subsets, Interleukin-13, Immunity, Mucosal

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